Recent Techniques and Applications in Ionizing Radiation Research最新文献

Relative Biological Effectiveness Studies Using 3 MeV Proton Beam from Folded Tandem Ion Accelerator: An Experimental and Theoretical Approach 折叠串联离子加速器3mev质子束的相对生物效应研究:实验和理论方法

Recent Techniques and Applications in Ionizing Radiation Research Pub Date : 2020-11-28 DOI: 10.5772/intechopen.94243

Rajesha K. Nairy, N. Bhat, K. Anjaria, U. Yadav, R. Chaurasia, K. Shirsath, Utkarsha N. Desai, Sanjay Gupta, B. K. Sapra, Narayana Yerol

{"title":"Relative Biological Effectiveness Studies Using 3 MeV Proton Beam from Folded Tandem Ion Accelerator: An Experimental and Theoretical Approach","authors":"Rajesha K. Nairy, N. Bhat, K. Anjaria, U. Yadav, R. Chaurasia, K. Shirsath, Utkarsha N. Desai, Sanjay Gupta, B. K. Sapra, Narayana Yerol","doi":"10.5772/intechopen.94243","DOIUrl":"https://doi.org/10.5772/intechopen.94243","url":null,"abstract":"Proton being the easiest light ion to accelerate and achieve desired beam profile, has been pursued as a popular particulate radiation for therapy applications. In the present study, Saccharomyces cerevisiae D7 strain was used to estimate the RBE values of the 3 MeV proton beam, and an attempt was made to derive mathematical formula for calculating RBE value with respect to the dose. Dosimetry studies were carried out using Fricke dosimetry and Semiconductor Surface Barrier detector to calibrate the absorbed doses of Gamma chamber-1200 and Folded Tandem Ion Accelerator respectively. Gold standard cell survival assay and gene conversion assay were used to compare gamma and proton radiation induced cell death and genetic endpoint. Multi target single hit model was used to derive mathematical formula for RBE estimation. The results show a linear survival-dose response after proton radiation and sigmoid survival-dose response after gamma radiation treatment. The calculated RBE value from the survival and gene conversion studies was 1.60 and 3.93, respectively. The derived mathematical formula is very useful in calculating RBE value, which varies from 3.61 to 1.80 with increasing dose. The estimated RBE value from the mathematical formula is comparable with the experimental values. With the help of the present mathematical formulation, RBE value at any dose can be calculated in the exponential and sigmoidal regions of the survival curve without actually extending the experiment in that dose region, which is not possible using conventional methods.","PeriodicalId":250970,"journal":{"name":"Recent Techniques and Applications in Ionizing Radiation Research","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114600836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biologically Effective Dose (BED) or Radiation Biological Effect (RBEf)? 生物有效剂量(BED)还是辐射生物效应(RBEf)?

Recent Techniques and Applications in Ionizing Radiation Research Pub Date : 2020-05-20 DOI: 10.5772/intechopen.92029

T. Frometa-Castillo, A. Pyakuryal, A. Wals-Zurita, A. Mesbahi

{"title":"Biologically Effective Dose (BED) or Radiation Biological Effect (RBEf)?","authors":"T. Frometa-Castillo, A. Pyakuryal, A. Wals-Zurita, A. Mesbahi","doi":"10.5772/intechopen.92029","DOIUrl":"https://doi.org/10.5772/intechopen.92029","url":null,"abstract":"The current radiosensitive studies are described with linear-quadratic (LQ) cell survival (S) model for one fraction with a dose d. As result of assuming all sublethally damaged cells (SLDCs) are completely repaired during the interfractions, that is, no presence of SLDCs, the survived cells are calculated for a n-fractionated regimen with the LQ S(n,D) model. A mathematically processed subpart of LQS(n,D) is the biologically effective dose (BED) that is used for evaluating a so-called “biological dose.” The interactions of ionizing radiation with a living tissue can produce partial death or sublethal damage from healthy or sublethally damaged cells. The proportions of the killed and sub-lethally damaged cells define the radiation biological effects (RBEfs). Computational simulations using RBEFs for fractionated regimens let calculating tumor control probability. While the derivation of the LQ S(n,D) considers a 100% cell repair, that is, 0% of sublethally damaged cells (SLDCs), the radiobiological simulators take into account the presence of SLDCs, as well as a cell repair <100% during the interfractions and interruption. Given “biological dose” does not exist, but RBEf, there was need for creating the BED. It is shown how some uses of BED, like the derivation of EQ2D expression, can be done directly with the LQ S(n,D).","PeriodicalId":250970,"journal":{"name":"Recent Techniques and Applications in Ionizing Radiation Research","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124613173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Production of the 103Pd via Cyclotron and Preparation of the Brachytherapy Seed 回旋加速器制备103Pd及近距离治疗种子的制备

Recent Techniques and Applications in Ionizing Radiation Research Pub Date : 2020-05-15 DOI: 10.5772/intechopen.92457

P. Saidi, M. Sadeghi

引用次数: 1

Influence of the Doping Ion Nature and Content on Defect Creation Processes under the Effect of Ionizing Radiation in Aluminoborosilicate Glasses 电离辐射作用下掺杂离子性质和含量对铝硼硅酸盐玻璃缺陷形成过程的影响

Recent Techniques and Applications in Ionizing Radiation Research Pub Date : 2020-04-29 DOI: 10.5772/intechopen.92317

E. Malchukova

引用次数: 2

Natural Radioactive Decay 自然放射性衰变

Recent Techniques and Applications in Ionizing Radiation Research Pub Date : 2020-04-14 DOI: 10.5772/intechopen.91899

Entesar H. Elaraby

引用次数: 0