Oncology Treatment Discovery最新文献

Analysis of Lung Nodules and Lung Cancer Detection by Low-Dose Spiral CT of The Chest During Health Check-Up 健康体检中胸部低剂量螺旋 CT 的肺结节和肺癌检测分析

Oncology Treatment Discovery Pub Date : 2024-05-14 DOI: 10.26689/otd.v2i1.6687

Meijuan Ma, Fen Yang

{"title":"Analysis of Lung Nodules and Lung Cancer Detection by Low-Dose Spiral CT of The Chest During Health Check-Up","authors":"Meijuan Ma, Fen Yang","doi":"10.26689/otd.v2i1.6687","DOIUrl":"https://doi.org/10.26689/otd.v2i1.6687","url":null,"abstract":"Objective: To analyze the detection of lung nodules and lung cancer by low-dose spiral computed tomography (CT) of the chest in the population during health checkups. Methods: A total of 1,000 cases were selected for the data study and the data were retrospectively analyzed to detect lung nodules. They were divided into groups according to age, gender, and size of nodules, and the detection of lung nodules and lung cancer was compared. Results: A total of 268 lung nodules were detected, and the detection rates between genders were not significant (P > 0.05). The detection rate of lung nodules increased with age and stabilized after 60 years. When analyzing the size of lung nodules, there were 65 cases of nodules over 8mm. The patients were followed up for 18 months, with 36 cases of visits indicating lung cancer. A total of 10 cases were detected, including 7 cases of adenocarcinoma. Conclusion: Low-dose spiral CT chest examination during checkups can detect lung cancer early so that high-risk lung nodules can be dealt with promptly. Underlying lung adenocarcinoma can also be discovered. Individuals more than 40 years of age should regularly conduct low-dose spiral CT chest examinations to detect the presence of lung nodules or lung cancer as early as possible.","PeriodicalId":250949,"journal":{"name":"Oncology Treatment Discovery","volume":"10 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140979629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy Analysis of Laparoscopic Myomectomy and Open Myomectomy in the Treatment of Uterine Fibroids 腹腔镜子宫肌瘤切除术与开放式子宫肌瘤切除术治疗子宫肌瘤的疗效分析

Oncology Treatment Discovery Pub Date : 2023-06-26 DOI: 10.26689/otd.v1i1.5061

Yaqin Yang, Liping Zhao

{"title":"Efficacy Analysis of Laparoscopic Myomectomy and Open Myomectomy in the Treatment of Uterine Fibroids","authors":"Yaqin Yang, Liping Zhao","doi":"10.26689/otd.v1i1.5061","DOIUrl":"https://doi.org/10.26689/otd.v1i1.5061","url":null,"abstract":"Objective: To compare and analyze the effects of myomectomy by laparotomy and laparoscopy for uterine fibroids. Methods: 60 patients with uterine fibroids treated in the past 3 years (January 2020 to December 2022) were randomly divided into two groups according to the surgical plans, with 30 cases in each group. Patients in the control group underwent laparotomy, whereas those in the observation group underwent laparoscopic surgery. The effects were compared and analyzed. Results: Compared with the control group, the observation group had shorter surgery, time to first passage of flatus, and hospital stay; less intraoperative blood loss; lower complication rate; and higher postoperative quality-of-life score (P < 0.05). Although there was no significant difference between the two groups in terms of substance P (SP), interleukin 6 (IL-6), and prostaglandin E2 (PGE2) before surgery (P > 0.05), there was an increase in each index after surgery, but the increase in the observation group was less, as compared to the control group; the observation group had significantly lower levels of each index (P < 0.05). Conclusion: There are two common surgical approaches for myomectomy, laparotomy and laparoscopy. In comparison, the laparoscopic approach, a minimally invasive procedure, can optimize surgery-related indicators, reduce surgical trauma response, and reduce complications. It benefits patients by delivering favorable surgical outcomes and improving postoperative quality of life.","PeriodicalId":250949,"journal":{"name":"Oncology Treatment Discovery","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127424075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Value Analysis of Pemetrexed Combined with Cisplatin in the Treatment of Non-Small Cell Lung Cancer 培美曲塞联合顺铂治疗非小细胞肺癌的临床价值分析

Oncology Treatment Discovery Pub Date : 2023-06-26 DOI: 10.26689/otd.v1i1.5054

Feifei Zhao

{"title":"Clinical Value Analysis of Pemetrexed Combined with Cisplatin in the Treatment of Non-Small Cell Lung Cancer","authors":"Feifei Zhao","doi":"10.26689/otd.v1i1.5054","DOIUrl":"https://doi.org/10.26689/otd.v1i1.5054","url":null,"abstract":"Objective: To analyze the clinical value of pemetrexed combined with cisplatin in the treatment of non-small cell lung cancer (NSCLC). Methods: Sixty-nine patients in Shengli Oilfield Central Hospital were recruited between May 2021 and August 2022 and separated into the observation group (n = 35) and the control group (n = 34). Cisplatin combined with pemetrexed (the observation group) and cisplatin combined with gemcitabine (the control group) were used for treatment, respectively, and the therapeutic effects of the two groups were compared. Results: There was no significant difference in the disease control rate between the two groups (P > 0.05); the immune function indexes of the patients in the observation group were significantly higher than those in the control group after treatment (P < 0.05); there was no significant difference in the incidence of nausea and vomiting as well as hair loss (P > 0.05), but the incidence of blood toxicity in the observation group was significantly lower than that in the control group (P < 0.05). Conclusion: Pemetrexed plus cisplatin in NSCLC patients has an ideal effect, and it can improve the quality of life of patients and reduce adverse reactions, which has clinical promotion value.","PeriodicalId":250949,"journal":{"name":"Oncology Treatment Discovery","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128676266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PET/CT in Staging and Treatment Evaluation of Non-Small Cell Lung Cancer PET/CT在非小细胞肺癌分期及治疗评价中的应用

Oncology Treatment Discovery Pub Date : 2023-05-17 DOI: 10.26689/otd.v1i1.4950

Rosanna Morales Guzmán-Barrón, Edgar Amorín Kajatt, Richard Ledesma Vásquez, S. C. Zambrano

引用次数: 0

Prevalence of End-of-Life Signs and Symptoms in Glioblastoma Patients: A Descriptive and Retrospective Study 胶质母细胞瘤患者生命末期体征和症状的患病率:一项描述性和回顾性研究

Oncology Treatment Discovery Pub Date : 2023-05-17 DOI: 10.26689/otd.v1i1.4951

Liliana Frazão Vasconcelos, Mafalda Monteiro Ferreira, J. B. Bandeira Costa

{"title":"Prevalence of End-of-Life Signs and Symptoms in Glioblastoma Patients: A Descriptive and Retrospective Study","authors":"Liliana Frazão Vasconcelos, Mafalda Monteiro Ferreira, J. B. Bandeira Costa","doi":"10.26689/otd.v1i1.4951","DOIUrl":"https://doi.org/10.26689/otd.v1i1.4951","url":null,"abstract":"Introduction: Glioblastoma is often associated with a poor prognosis. The end-of-life signs and symptoms of these people differ from the rest of the cancer population. Objective: To identify the main signs and symptoms present in the last seven days of life of patients with glioblastoma in a neurological oncology service. Methods: A descriptive and retrospective study was carried out. The sample included patients diagnosed with glioblastoma with medical and nursing records of the last seven days of life that were admitted to the Neurology service and admitted to the institution by the neuro-oncology consultation between 2019 and 2020. Data was collected from the medical records of the patients. Results: Medical records of 17 patients were selected for this study. The main signs and symptoms present in the last seven days of their lives were decreased level of consciousness (94%), rare and unexpected events (94%), respiratory dysfunction (88%), and loss of swallowing ability (76%). Conclusion: The objectives of this study were achieved. However, it is important to conduct studies in this population with more representative samples, since most literature is focused on the oncologic population in general.","PeriodicalId":250949,"journal":{"name":"Oncology Treatment Discovery","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122847801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomarkers of Acute Appendicitis Severity: Diagnostic Test Study 急性阑尾炎严重程度的生物标志物:诊断试验研究

Oncology Treatment Discovery Pub Date : 2023-04-19 DOI: 10.26689/otd.v1i1.4030

L. Vargas-Rodríguez, Jonathan F Barrera-Jerez, Kelly A Avila-Avila, David A Rodriguez-Mongui, B. R. Muñoz-Espinosa

{"title":"Biomarkers of Acute Appendicitis Severity: Diagnostic Test Study","authors":"L. Vargas-Rodríguez, Jonathan F Barrera-Jerez, Kelly A Avila-Avila, David A Rodriguez-Mongui, B. R. Muñoz-Espinosa","doi":"10.26689/otd.v1i1.4030","DOIUrl":"https://doi.org/10.26689/otd.v1i1.4030","url":null,"abstract":"Appendicitis (AA) is one of the most frequent abdominal surgical pathologies in the world, with appendectomy being the most frequently performed emergency surgery worldwide. This study was conducted to determine the possible biomarkers to detect the severity in AA for diagnostic purposes, and for the timely management of appendicitis and, thereby avoiding possible complications. This research was conducted based on a randomized sampling, where a total of 239 patients diagnosed with AA at the Hospital Regional de Orinoquia, Colombia was recruited for this study. Blood count, C–reactive protein (CRP), and neutrophil/lymphocyte ratio (NLR) records were analyzed, further their relationship with the surgical findings of AA described by Guzman–Valdivia was established. The study showed that, in the emergency department, these reactants are capable of making an approximate diagnosis and as biomarkers of the severity of AA, with CRP>15mg/dL (diagnostic accuracy 76.15%), and the percentage of neutrophils>85% (diagnostic accuracy 61.09%) being the best initial operative performance. For complications, such as intestinal perforation, CRP>15mg/dL and neutrophil percentage>85% were found statistically to be the biomarkers with the highest predictive performance, with OR 14.46, and OR 2.17, respectively, which is consistent with the findings described by Guzman–Valdivia. In conclusion, elevated level of CRP and neutrophil percentage>85 is the acute phase reactants with the best diagnostic characteristics and predictors of possible complications of AA.","PeriodicalId":250949,"journal":{"name":"Oncology Treatment Discovery","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129578369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adenomatoid Odontogenic Tumor in Mandible 下颌骨腺瘤样牙源性肿瘤

Oncology Treatment Discovery Pub Date : 2011-06-01 DOI: 10.26689/otd.v1i1.4021

R. A. Azevedo, Júnior Bráulio Carneiro, Lucio Costa Safira Andrade, C. Castro

引用次数: 0

Keratocystic Odontogenic Tumor 角化囊性牙源性肿瘤

Oncology Treatment Discovery Pub Date : 2010-03-01 DOI: 10.26689/otd.v1i1.4020

Alexandre Aires Braga de Lira, Belisse Brandão da Cunha, Hiarles Barreto Sampaio Brito, G. Godoy, L. Queiroz

引用次数: 0