培美曲塞联合顺铂治疗非小细胞肺癌的临床价值分析

Feifei Zhao
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引用次数: 0

摘要

目的:分析培美曲塞联合顺铂治疗非小细胞肺癌(NSCLC)的临床价值。方法:于2021年5月至2022年8月在胜利油田中心医院招募69例患者,分为观察组(n = 35)和对照组(n = 34)。分别采用顺铂联合培美曲塞(观察组)和顺铂联合吉西他滨(对照组)治疗,比较两组治疗效果。结果:两组患者疾病控制率比较,差异无统计学意义(P > 0.05);观察组患者治疗后免疫功能指标均显著高于对照组(P < 0.05);两组患者恶心、呕吐、脱发发生率差异无统计学意义(P > 0.05),但血液毒性发生率显著低于对照组(P < 0.05)。结论:培美曲塞联合顺铂治疗NSCLC患者效果理想,可改善患者生活质量,减少不良反应,具有临床推广价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical Value Analysis of Pemetrexed Combined with Cisplatin in the Treatment of Non-Small Cell Lung Cancer
Objective: To analyze the clinical value of pemetrexed combined with cisplatin in the treatment of non-small cell lung cancer (NSCLC). Methods: Sixty-nine patients in Shengli Oilfield Central Hospital were recruited between May 2021 and August 2022 and separated into the observation group (n = 35) and the control group (n = 34). Cisplatin combined with pemetrexed (the observation group) and cisplatin combined with gemcitabine (the control group) were used for treatment, respectively, and the therapeutic effects of the two groups were compared. Results: There was no significant difference in the disease control rate between the two groups (P > 0.05); the immune function indexes of the patients in the observation group were significantly higher than those in the control group after treatment (P < 0.05); there was no significant difference in the incidence of nausea and vomiting as well as hair loss (P > 0.05), but the incidence of blood toxicity in the observation group was significantly lower than that in the control group (P < 0.05). Conclusion: Pemetrexed plus cisplatin in NSCLC patients has an ideal effect, and it can improve the quality of life of patients and reduce adverse reactions, which has clinical promotion value.
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