The Sign of clinical medicine最新文献

Lung Damage Prevention of Ethanolic Extract of Propolis and Synbiotics in Inhalation Anthrax Model 蜂胶乙醇提取物及合生剂对吸入性炭疽模型肺损伤的预防作用

The Sign of clinical medicine Pub Date : 2023-07-13 DOI: 10.20961/tscm.v1i1.55203

Wisnu Sanjaya, Dhani Redhono Harioputro, Yulyani Werdiningsih

{"title":"Lung Damage Prevention of Ethanolic Extract of Propolis and Synbiotics in Inhalation Anthrax Model","authors":"Wisnu Sanjaya, Dhani Redhono Harioputro, Yulyani Werdiningsih","doi":"10.20961/tscm.v1i1.55203","DOIUrl":"https://doi.org/10.20961/tscm.v1i1.55203","url":null,"abstract":"Introduction: Inflammatory response and oxidative stress can be found in inhalation anthrax characterized by the increased level of serum Tumor Necrosis Factor Alpha (TNF-α) and Malondialdehyde (MDA). Ethanolic Extract of Propolis (EEP) and synbiotics were known to have anti-inflammatory and antioxidant properties. This study aimed to determine the effects of EEP and synbiotics on the level of TNF-α and MDA in inhalation anthrax model.Methods: This was an experimental study with post-test only control group design on 40 samples of Rattus norvegicus with inhalation anthrax. Samples were randomized into 5 groups: control (K), antibiotic and EEP (P1), antibiotic and synbiotic (P2), EEP (P3), and synbiotics(P4). The value of TNF-α and MDA were measured 7 days after the spore’s inhalation and 14th day since the given treatment. To compare the effects of EEP and synbiotics, we used the two-way ANOVA continued by the LSD post-hoc test (if the data normally distributed) or the Kruskal Wallis continued by the Mann Whitney test (if the data not normally distributed).Results: EEP and synbiotics significantly reduced the level of TNF-α and MDA compared to control group. P2 showed the highest changes on TNF-α and MDA, which TNF-α was decreasing from 14.2825 ± 0.41623 to 8.4363 ± 0.44938 pg/ml and MDA changed from 14.2825 ± 0.41623 to 2.9638 ± 0.39885 nmol/ml. Followed by P4, P1, and P3 groups. Conclusion: EEP and synbiotics have significant impacts on reducing TNF-α and MDA in model of inhalational anthrax.","PeriodicalId":247410,"journal":{"name":"The Sign of clinical medicine","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131244803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Snail Mucus (Achatina Fulica) on The Degree of Kidney Interstitial Fibrosis In Lupus Nephritis Mice Model 蜗牛黏液对狼疮性肾炎模型小鼠肾间质纤维化程度的影响

The Sign of clinical medicine Pub Date : 2023-07-13 DOI: 10.20961/tscm.v1i1.53930

A. Nurudhin, Z. Adnan, Yulyani Werdiningsih, N. Prabowo, Fathina Nisa Rabbani

{"title":"The Effect of Snail Mucus (Achatina Fulica) on The Degree of Kidney Interstitial Fibrosis In Lupus Nephritis Mice Model","authors":"A. Nurudhin, Z. Adnan, Yulyani Werdiningsih, N. Prabowo, Fathina Nisa Rabbani","doi":"10.20961/tscm.v1i1.53930","DOIUrl":"https://doi.org/10.20961/tscm.v1i1.53930","url":null,"abstract":"Introduction:cytotoxic drugs dominate SLE therapy, so new therapies with minimum side effects are needed. Snail (Achatina Fulica) mucus contains two types of protein; heparan and acharan sulfate. The snail mucus has significant potential benefits, but its use in lupus nephritis has never been examined.Methods:This research used an experimental model. It used mice for the experiment. The mice were divided into five groups: control, untreated lupus, standard therapy (methylprednisolone), snail mucus therapy, and a combination of standard therapy and snail mucus. Renal histology was examined at the end of the fifth month. Data were analyzed using the Shapiro-Wilk, ANOVA, and Tukey Post Hoc tests.Results: The level of interstitial fibrosis between the standard therapy group and the snail mucus group showed an MD value of -0.13 with a p-value of 1.00, meaning there is no significant difference between the level of interstitial fibrosis in the two groups. The comparison between the standard therapy group and the combination of the standard therapy group showed an MD value of 0.64 with a p-value of 0.992, which means that the combination of standard therapy tends to decrease the level of interstitial fibrosis. Conclusion: The administration of snail mucus in combination with standard therapy affects the decrease in the level of interstitial fibrosis in mice model lupus.","PeriodicalId":247410,"journal":{"name":"The Sign of clinical medicine","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130938193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Pancreatitis In Type 2 Diabetes Mellitus With Multiple Stones In The Cystic Ductus 2型糖尿病合并胆囊管内多发结石的急性胰腺炎

The Sign of clinical medicine Pub Date : 2023-07-13 DOI: 10.20961/tscm.v1i1.55863

H. Dewi, Adhizti Naluriannisa Edya Nugraha, Rianita Marthasari, Basundara Aditya Hernawan, Desy Puspa Putri, N. Prabowo

{"title":"Acute Pancreatitis In Type 2 Diabetes Mellitus With Multiple Stones In The Cystic Ductus","authors":"H. Dewi, Adhizti Naluriannisa Edya Nugraha, Rianita Marthasari, Basundara Aditya Hernawan, Desy Puspa Putri, N. Prabowo","doi":"10.20961/tscm.v1i1.55863","DOIUrl":"https://doi.org/10.20961/tscm.v1i1.55863","url":null,"abstract":"Introduction: Severe upper abdominal pain is one of the symptoms of acute pancreatitis that often occurs in other diseases, such as peptic ulcer, acute hepatitis, cholangitis, and cholecystitis. Gallstone-induced acute pancreatitis has considerable morbidity and mortality.Case illustration: A 50-year-old man came to the ED with a chief complaint of severe abdominal pain in the upper abdomen, VAS 8-9. His past medical history was unknown. On arrival, blood pressure was 141/102 mmHg, pulse was 98x/minute, and temperature was 36.4ºC. CT Scan of the abdomen showed pancreatitis and multiple stones in the cystic duct. Amylase and lipase serum results were 1897U/L and >3000 U/L.Discussion: In acute pancreatitis caused by gallstones, stones usually get stuck in the branches of the pancreaticobiliary duct. Obstruction at this location causes reflux of bile into the pancreatic duct. Smaller gallstones are more likely to induce pancreatitis because they migrate more easily between bile ducts. This patient was suspected of having a previously unknown history of DM, which contributed to the patient's worsening condition.Conclusion: Early management and treatment of triage, fluid resuscitation, and detection of local or systemic complications are essential. In pancreatitis due to gallstones, decisions about the need and timing of procedural intervention are critical. ","PeriodicalId":247410,"journal":{"name":"The Sign of clinical medicine","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124485449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Chronic Kidney Disease on the Mortality Rate of Patient with Sepsis 慢性肾脏疾病对脓毒症患者死亡率的影响

The Sign of clinical medicine Pub Date : 2023-07-13 DOI: 10.20961/tscm.v1i1.57829

Muhamad Ibnu Aziz, Evi Nurhayatun, Ratih Tri Kusumadewi, A. Susanto

{"title":"Effect of Chronic Kidney Disease on the Mortality Rate of Patient with Sepsis","authors":"Muhamad Ibnu Aziz, Evi Nurhayatun, Ratih Tri Kusumadewi, A. Susanto","doi":"10.20961/tscm.v1i1.57829","DOIUrl":"https://doi.org/10.20961/tscm.v1i1.57829","url":null,"abstract":"<div>Introduction: Sepsis is a deathly disease caused by a dysregulation of the body's response to infection. The mortality rate of sepsis has been discovered to be almost equivalent to 20% of the global mortality rate. Comorbidity is one of the non-modifiable risk factors of sepsis. Chronic kidney disease is a comorbid risk factor for sepsis development. Decreasing GFR and albuminuria in chronic kidney disease is strongly associated with an increased mortality rate due to infection. Sepsis with chronic kidney disease shows a higher SOFA score than sepsis without chronic kidney disease. This study aims to determine the effect of chronic kidney disease on the mortality rate of patients with sepsis.Methods: This study is an observational analytic study with a cross-sectional approach. The data retrieval used purposive sampling, and the sample comprised 90 respondents. Data were taken from medical records of the patients with sepsis hospitalized in Dr Moewardi Hospital from January 2016 to May 2021. Data were analyzed using the Chi-Square test.Results: Chronic kidney disease significantly affected the sepsis mortality rate with p-value = 0.033 (p < 0.05). The prevalence ratio was 2.531 (95%CI, 1.07 – 5.97).Conclusion: Chronic kidney disease significantly affects the increasing mortality rate of sepsis patients.Keywords: Chronic kidney disease; Mortality; Sepsis,</div>","PeriodicalId":247410,"journal":{"name":"The Sign of clinical medicine","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128367658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Difference Incident Rate Of Sepsis Between Hemodialysis Chronic Kidney Disease Patients With Heart Failure And Non-Heart Failure 血液透析慢性肾脏疾病合并心力衰竭与非心力衰竭患者脓毒症发生率的差异

The Sign of clinical medicine Pub Date : 2023-07-13 DOI: 10.20961/tscm.v1i1.55861

Sandya Naufal Budiyanto, Evi Nurhayatun, D. H. Prasetyo

{"title":"The Difference Incident Rate Of Sepsis Between Hemodialysis Chronic Kidney Disease Patients With Heart Failure And Non-Heart Failure","authors":"Sandya Naufal Budiyanto, Evi Nurhayatun, D. H. Prasetyo","doi":"10.20961/tscm.v1i1.55861","DOIUrl":"https://doi.org/10.20961/tscm.v1i1.55861","url":null,"abstract":"Introduction:Sepsis is one of the deadliest diseases in the world because it can cause 2-8 million deaths yearly. Chronic kidney disease (CKD) is one of the predisposing factors for sepsis. The more deteriorating the condition of a kidney, it can lead to cardio-renal syndrome interactions, resulting in heart diseases, including heart failure. Chronic kidney disease and heart failure theoretically have several mechanisms that could underlie the occurrence of sepsis. This study aimed to determine the difference in the incidence of sepsis in patients with heart failure and non-heart failure with hemodialysis CKD.Methods:This research is an analytic observational with a cross-sectional approach. The number of samples used reached 90 data. Sampling was carried out at Dr Hospital. Moewardi in the 2019-2021 period. The researcher used purposive sampling with inclusion and exclusion criteria in this study. The research sample was obtained from the patient's medical record data. Data analysis used SPSS 26 software and the Chi-square test for bivariate analysis.Results: There was no significant difference in the incidence of sepsis between patients with heart failure and non-heart failure with CKD hemodialysis with p-value of 0.581 (P>0.05).Conclusion: There was no significant difference in the incidence of sepsis between patients with heart failure and non-heart failure with CKD hemodialysis.","PeriodicalId":247410,"journal":{"name":"The Sign of clinical medicine","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115950619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0