Effect of Chronic Kidney Disease on the Mortality Rate of Patient with Sepsis

Abstract

Introduction: Sepsis is a deathly disease caused by a dysregulation of the body's response to infection. The mortality rate of sepsis has been discovered to be almost equivalent to 20% of the global mortality rate. Comorbidity is one of the non-modifiable risk factors of sepsis. Chronic kidney disease is a comorbid risk factor for sepsis development. Decreasing GFR and albuminuria in chronic kidney disease is strongly associated with an increased mortality rate due to infection. Sepsis with chronic kidney disease shows a higher SOFA score than sepsis without chronic kidney disease. This study aims to determine the effect of chronic kidney disease on the mortality rate of patients with sepsis.

Methods: This study is an observational analytic study with a cross-sectional approach. The data retrieval used purposive sampling, and the sample comprised 90 respondents. Data were taken from medical records of the patients with sepsis hospitalized in Dr Moewardi Hospital from January 2016 to May 2021. Data were analyzed using the Chi-Square test.

Results: Chronic kidney disease significantly affected the sepsis mortality rate with p-value = 0.033 (p < 0.05). The prevalence ratio was 2.531 (95%CI, 1.07 – 5.97).

Conclusion: Chronic kidney disease significantly affects the increasing mortality rate of sepsis patients.

Keywords: Chronic kidney disease; Mortality; Sepsis,