Journal of Annals of Bioengineering最新文献

{"title":"Radar Technology as a Mechanism for Clinical Gait Analysis: A Review","authors":"Ocimum Scientific Publishers Pty Ltd","doi":"10.33513/BIOE/2001-12","DOIUrl":"https://doi.org/10.33513/BIOE/2001-12","url":null,"abstract":"Walking gait, coordinated by the brain, nerves and musculoskeletal system, is the most common mode of human locomotion and is something that healthy individuals typically carry out every day. Illness or disease affecting these regions may alter gait, leading to declines in an individual’s capacity to function. Consequently, more accessible clinical gait analysis has become important for those affected. The purpose of this review is to gather the most current literature regarding the use of radar, a novel method, for clinical gait analysis. Researchers have found that using radar for clinical gait analysis is more mobile and less invasive than current gold standard methods. Literature tells us that moving forward, research on radar must expand from temporal parameter measurement to spatial parameter measurement as well. Advancements in spatial parameter detection are imperative for radar to reach its potential to positively impact clinical populations.","PeriodicalId":243433,"journal":{"name":"Journal of Annals of Bioengineering","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123492334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different Types of Orthoses in the Management of Genu-recurvatum, What are the Best Choices?","authors":"M. Karimi, Ocimum Scientific Publishers Pty Ltd","doi":"10.33513/bioe/1901-09","DOIUrl":"https://doi.org/10.33513/bioe/1901-09","url":null,"abstract":"Background: Knee joint hyper extension, also named as genu-recurvatum, has been reported in hemiplegic subjects, cerebral palsy, poliomyelitis and other neurological conditions. Although various types of treatment approaches such as use of orthoses, physical therapy and surgery have been used for these patients, clinicians usually prefer to treat it by use of different types of orthoses. Therefore, the aim of this review was to detect the best orthoses used to manage genu-recurvatum.","PeriodicalId":243433,"journal":{"name":"Journal of Annals of Bioengineering","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117047672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra Scale-Down Characterization And Stability Of Monoclonal Fusion Proteins Used To Treat Cancer","authors":"Ocimum Scientific Publishers Pty Ltd","doi":"10.33513/bioe/1901-07","DOIUrl":"https://doi.org/10.33513/bioe/1901-07","url":null,"abstract":"","PeriodicalId":243433,"journal":{"name":"Journal of Annals of Bioengineering","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115950396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viscoelastic Hemostatic Assays - A Quest for Holy Grail of Coagulation Monitoring in Trauma Care","authors":"Ocimum Scientific Publishers Pty Ltd","doi":"10.33513/BIOE/1901-06","DOIUrl":"https://doi.org/10.33513/BIOE/1901-06","url":null,"abstract":"","PeriodicalId":243433,"journal":{"name":"Journal of Annals of Bioengineering","volume":"195 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115647547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Gait Analysis for Assessing Bilateral Lower Extremity Function: A Case Study","authors":"Ocimum Scientific Publishers Pty Ltd","doi":"10.33513/BIOE/1901-05","DOIUrl":"https://doi.org/10.33513/BIOE/1901-05","url":null,"abstract":"","PeriodicalId":243433,"journal":{"name":"Journal of Annals of Bioengineering","volume":"123 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130892432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicochemical Properties of Nanoparticles and Their Effect on Transport across the Microvasculature","authors":"Myron Larrick, N. Nosoudi, P. SurINder, Singh, J. Ramirez-Vick","doi":"10.33513/bioe/1901-03","DOIUrl":"https://doi.org/10.33513/bioe/1901-03","url":null,"abstract":"In the past couple of decades nanomedicine has become a well-defined area of interdisciplinary science, in which advances in nanotechnology are allowing the incorporation of multiple therapeutic, sensing and targeting agents into nanostructured materials. This is reflected by the large number of promising nanomedical formulations being currently evaluated by the US Food and Drug Administration. A problem with many, if not all of these, is that mathematical modeling, as a tool to narrow the design parameter space to obtain an optimal formulation, is not part of the design process. Adoption of these tool will bring nanomedicine closer to pharmaceutics, a field in which mathematical modeling has been an essential part of the design process for many years. Nanoparticle delivery occurs mainly through the microvasculature, comprised of arterioles, capillaries, and venules ranging in diameter from 100 to 300 µm, 5 to 10 µm, and 7 to 50 µm, respectively. The study of how nanoparticle design parameters affect their transport properties as it pertains to targeting and drug delivery has become a growing field in the development of nanomedical formulations. The physicochemical properties of nanoparticles, such as size, shape and surface charge can be optimized to improve their performance in these applications. For instance, it allows modulation of interactions with the immune system, better control over blood clearance and interactions with target tissue, permitting effective delivery of payload within cells or tissues. Their ability to target and enter tissues from the microvasculature is highly dependent on their behavior under blood flow. Here we present a review of the current approaches to mathematical modeling of nanoparticle transport across the vasculature and its effects on targeting efficacy. center of the showing Adhesion Model developed for Ligand-receptor pair to Model showed that for a 50% predicted probability of adhesion with increased NP diameter there is a need for an increased amount of ligands in order to bind to the vessel wall; Design maps were created to show where adhesion occurs and can provide how to design NPs based upon size, surface characteristics of ligand-receptor density and affinity and how to prevent NP endocytosed.","PeriodicalId":243433,"journal":{"name":"Journal of Annals of Bioengineering","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128867462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Influence of a New Design of Orthosis on the Loads Applied On the Knee Joint","authors":"Kamali M. J Ann Bioeng","doi":"10.33513/bioe/1901-01","DOIUrl":"https://doi.org/10.33513/bioe/1901-01","url":null,"abstract":"Background: Knee osteoarthritis influences the ability of the subjects during standing and walking. Although knee offloading orthosis reduces the loads applied on the knee joint and decrease knee pain, most of the subjects discontinue brace use due to stretching the ligaments structure of the knee joints, and tendency of the brace to migrate distally. Therefore, a new type of orthosis was developed to overcome the aforementioned problem. The aim of this research was to check the influence of this orthosis on reducing the loads applied on the knee joint. Method: A group of normal subjects was recruited in this study to walk with and without the orthosis. A Kistler force plate and Qualisys motion analysis system were used to collect the kinetic and kinematic parameters. The difference between walking parameters under two conditions was evaluated by paired t test. The p-value of difference was set at 0.05. Results: There was no difference between spatiotemporal gait parameters during walking with and without the orthosis (P-value>0.05). The adductor moment applied on the knee joint was 0.433±0.138 and 0.478±0.143 N.m/BW while walking with and without the orthosis, respectively (P-value=0.006). There was a slight increase in the hip adductor moment while walking with orthosis. Conclusion: The new design of the orthosis reduces the loads applied on the knee joint through the hip joint. The new orthosis decreases the loads applied on the knee joint without any negative influences on the walking performance.","PeriodicalId":243433,"journal":{"name":"Journal of Annals of Bioengineering","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126350185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the Bioprocessing of ADEPT Fusion Proteins using Ultra Scale-Down Techniques","authors":"P. Blas","doi":"10.33513/bioe/1901-02","DOIUrl":"https://doi.org/10.33513/bioe/1901-02","url":null,"abstract":"Today with the advancement of modern medicine we are increasingly facing an aging community with a variety of complicated disease like the various forms of Cancer. Although man made synthetic chemicals can treat simple diseases, scientists predict that a new range of therapeutics containing antibody fragments and fusions proteins, may be important because of their ability to target specific sites. The new family of complicated biopharmaceuticals, such as fusions of larger molecules are more likely to be fragile and delicate to the unforgiving large-scale manufacturing environments. So new research needs to be conducted into where the damage may be occurring and how to stop it from happening.","PeriodicalId":243433,"journal":{"name":"Journal of Annals of Bioengineering","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126966454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}