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Effect of fabomotizole on brain gene expression in MR rats upon open field test 法莫替唑对MR大鼠脑基因表达的影响
Доклады Академии наук Pub Date : 2019-09-26 DOI: 10.31857/s0869-56524883329-332
Y. Vakhitova, U. S. Kuzmina, M. Voronin, L. Zainullina, S. Seredenin
{"title":"Effect of fabomotizole on brain gene expression in MR rats upon open field test","authors":"Y. Vakhitova, U. S. Kuzmina, M. Voronin, L. Zainullina, S. Seredenin","doi":"10.31857/s0869-56524883329-332","DOIUrl":"https://doi.org/10.31857/s0869-56524883329-332","url":null,"abstract":"Selective anxiolytic fabomotisol (Afobazol®) has affinity for the Sigma-1 chaperone receptor site, quinone reductase 2 (NQO2) and MAO-A regulatory sites, and melatonin receptor type 1 (MT1 receptor). The analysis of the effect of fabomotisol on the gene expression profile in the brain of MR (Maudsley Reactive) rats was carried out when modeling emotional stress in the open field test. A change in the expression of 14 genes was found, the results of the functional annotation of which show that the mechanisms of action of fabomotisol may be associated with the regulation of translation of proteins (Rpl5, Rpl15, Ncl, Ybx1), synaptic functions (Cplx2, Dlg4, Syngap1, Add1, Rab8b, Klc1, Chn1) and cellular metabolism (Akr1d1, Bcat1, Pkm).","PeriodicalId":24047,"journal":{"name":"Доклады Академии наук","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89076857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alb-Cenomanian granitoid magmatism and copper ore genesis of the Sikhote-Alin 锡霍特-阿林白-塞诺曼期花岗质岩浆作用与铜矿成因
Доклады Академии наук Pub Date : 2019-09-26 DOI: 10.31857/s0869-56524883298-302
A. Khanchuk, А И Ханчук, V. Ivanov, Владимир Иванов, E. K. Ignatiev, Е К Игнатьев, S. Kovalenko, С В Коваленко, D. Semenova, Д В Семенова
{"title":"Alb-Cenomanian granitoid magmatism and copper ore genesis of the Sikhote-Alin","authors":"A. Khanchuk, А И Ханчук, V. Ivanov, Владимир Иванов, E. K. Ignatiev, Е К Игнатьев, S. Kovalenko, С В Коваленко, D. Semenova, Д В Семенова","doi":"10.31857/s0869-56524883298-302","DOIUrl":"https://doi.org/10.31857/s0869-56524883298-302","url":null,"abstract":"Late Albian-early Cenomanin epoch of Au-Cu porphyry mineralization has been distinguished within the Sikhote-Alin. It is associated with the Alb-Cenomanian granitic rocks which emplacement coincided with the processes of orogeny and neoformation of continental lithosphere caused by compressive stress in the setting of transform continental margins of that time. The intrusion of the granitic magma into the crust of Jurassic accretionary wedge terranes and Early Cretaceous terrane of epicontinental turbidite basin provoked development of Au-Mo-Cu and Cu-Au-W ore genesis, respectively. U-Pb dating of zircons from host granites of the Malmuzh Au-Cu deposit yielded Alb-Cenomania age of 100-95 Ma. This age harmonizes with the age data reported by other researchers on the granitic rocks of East and Southeast Asia which are productive for hydrothermal mineral deposits of copper, gold, tin and other metals. Such age consistency suggests that there is Albian-Cenomanian metallogenic megabelt extending throughout the entire East Asian continental margin.","PeriodicalId":24047,"journal":{"name":"Доклады Академии наук","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74491805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-equilibrium thermodynamics and stoichiography in studying solid-phase preparation processes of functional materials 非平衡热力学和化学在研究功能材料固相制备过程中的应用
Доклады Академии наук Pub Date : 2019-09-26 DOI: 10.31857/s0869-56524883272-276
V. Malakhov, В В Малахов, V. Parmon, Валентин Николаевич Пармон
{"title":"Non-equilibrium thermodynamics and stoichiography in studying solid-phase preparation processes of functional materials","authors":"V. Malakhov, В В Малахов, V. Parmon, Валентин Николаевич Пармон","doi":"10.31857/s0869-56524883272-276","DOIUrl":"https://doi.org/10.31857/s0869-56524883272-276","url":null,"abstract":"The application of the general principles of the non-equilibrium thermodynamics and stoichiography allows obtaining novel information on the solid-phase transformations happening in multielement and heterophase substances and materials. Without the solid-phase standards, the use of stoichiography allows detecting, identifying and quantitative determining known and unknown crystalline and amorphous phases being of constant or variable composition. For the first time, reliable results concerning evolution of solid products during preparation of the Mo-V-Te-Nb-O catalyst of propane ammoxidation are presented.","PeriodicalId":24047,"journal":{"name":"Доклады Академии наук","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90513870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of the block element method in the problem to predict the preparation of tsunami 块体单元法在海啸准备预报问题中的应用
Доклады Академии наук Pub Date : 2019-09-26 DOI: 10.31857/s0869-56524883256-262
V. Babeshko, O. V. Evdokimova, O. M. Babeshko
{"title":"Application of the block element method in the problem to predict the preparation of tsunami","authors":"V. Babeshko, O. V. Evdokimova, O. M. Babeshko","doi":"10.31857/s0869-56524883256-262","DOIUrl":"https://doi.org/10.31857/s0869-56524883256-262","url":null,"abstract":"The model of preparation of the starting ocean earthquake is created for vertical impacts on the ocean layer and lithospheric plates, and the conditions of occurrence of a tsunami are found.","PeriodicalId":24047,"journal":{"name":"Доклады Академии наук","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80833688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of migratory seismicity in the lithosphere of the Baikal rift zone 贝加尔湖裂谷带岩石圈迁移地震活动性研究
Доклады Академии наук Pub Date : 2019-09-26 DOI: 10.31857/s0869-56524883313-318
A. Klyuchevskii, A. Kakourova
{"title":"Investigation of migratory seismicity in the lithosphere of the Baikal rift zone","authors":"A. Klyuchevskii, A. Kakourova","doi":"10.31857/s0869-56524883313-318","DOIUrl":"https://doi.org/10.31857/s0869-56524883313-318","url":null,"abstract":"The study of migrating seismicity was carried out according to data on 52700 earthquakes of representative energy classes KР ≥ 8, which occurred in the lithosphere of the Baikal Rift Zone (BRZ) from 1964 to 2013. M = 2143 quasilinear chains of earthquakes are distinguished and the basic laws of the space-time and energy distribution are established. In the epicentral field of the BRZ seismicity, there are chains of “seismic migration” and chains formed by chance (“pseudo-migration”). To identify the migrating seismicity, the seismic migration activity index (ISMA) was used, which characterizes the seismic migration / pseudo-migration ratio at a given level of significance, obtained maps of the distribution of the index over the territory and graphs of changes over years. The results of the study indicate a direct link between the migrating BRZ seismicity and the location and activation of rifting attractor structures (RAS).","PeriodicalId":24047,"journal":{"name":"Доклады Академии наук","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90548943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural connections between Urals and West Siberia: the common stage on the boundary of Permian and Triassic periods 乌拉尔与西西伯利亚的构造联系:二叠纪和三叠纪交界的共同阶段
Доклады Академии наук Pub Date : 2019-09-26 DOI: 10.31857/s0869-56524883294-297
V. Smirnov, В Н Смирнов, K. Ivanov, Константин Сергеевич Иванов
{"title":"Structural connections between Urals and West Siberia: the common stage on the boundary of Permian and Triassic periods","authors":"V. Smirnov, В Н Смирнов, K. Ivanov, Константин Сергеевич Иванов","doi":"10.31857/s0869-56524883294-297","DOIUrl":"https://doi.org/10.31857/s0869-56524883294-297","url":null,"abstract":"40Ar/39Ar-dating of the micas from the schists and blastomylonites collected from the fault which separates the Eastern zone of the Middle Urals dipped under the cover of the West Siberian plate from the open part of the geologic structures of the Urals, showed that the last phase of deformation was represented by a submeridional sinistral strike-slip faults with the age of 251 Ma. The appearance of the analyzed deformations practically exactly coincides in time with the formation of the grabens of meridional strike at the base of the West Siberian plate. ","PeriodicalId":24047,"journal":{"name":"Доклады Академии наук","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77842422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
An analysis of adaptive reactions in healthy subjects who have prolonged contact with tuberculosis patients 长期接触肺结核病人的健康受试者的适应性反应分析
Доклады Академии наук Pub Date : 2019-09-26 DOI: 10.31857/s0869-56524883342-344
I. Litvinov, И С Литвинов, D. A. Dolgikh, Д.А. Долгих
{"title":"An analysis of adaptive reactions in healthy subjects who have prolonged contact with tuberculosis patients","authors":"I. Litvinov, И С Литвинов, D. A. Dolgikh, Д.А. Долгих","doi":"10.31857/s0869-56524883342-344","DOIUrl":"https://doi.org/10.31857/s0869-56524883342-344","url":null,"abstract":"Prolonged contact of healthy subjects with Mycobacterium tuberculosis can change their blood formula and immune status, thus reflecting adaptive reactions to constant antigenic load. The peripheral blood analysis of health care workers (HCWs) in a tuberculosis hospital demonstrates changes in cell populations which prevent development of tuberculosis, in particular, CD4+ Т cells and CD3+ Т cells. It is shown that the number of the memory CD4+ Т cells specific to M.tuberculosis antigens which produce interferon gamma depends on the duration of work contact with tuberculosis patients. The HCWs blood characteristics usage as a control for tuberculosis patients is discussed.","PeriodicalId":24047,"journal":{"name":"Доклады Академии наук","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77927017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure and age of the fluorite-berillium deposit of the field Rainbow, Western Sayan Mountains: to the problem of assessment of metallogenic prospects of the territory 西萨颜山彩虹田萤石-铍矿床的构造与年龄——论本区成矿前景评价问题
Доклады Академии наук Pub Date : 2019-09-26 DOI: 10.31857/s0869-56524883282-287
D. Lykhin, Д А Лыхин, V. Yarmolyuk, В В Ярмолюк, A. Vorontsov, А А Воронцов, A. Travin, А В Травин
{"title":"Structure and age of the fluorite-berillium deposit of the field Rainbow, Western Sayan Mountains: to the problem of assessment of metallogenic prospects of the territory","authors":"D. Lykhin, Д А Лыхин, V. Yarmolyuk, В В Ярмолюк, A. Vorontsov, А А Воронцов, A. Travin, А В Травин","doi":"10.31857/s0869-56524883282-287","DOIUrl":"https://doi.org/10.31857/s0869-56524883282-287","url":null,"abstract":"The age and geochemical parameters of the muscovite-fluorite-euclase-beryl Raduga deposit, which is located within the Kizir-Kazyr zone of rare-metal magmatism, are determined. In contrast to other deposits and ore occurrences of the zone, represented by alkaline granites characterized by rare metal mineralization, the Raduga deposit is associated with metasomatites in carbonate rocks. The age of the deposit, estimated at 40Ar/39Ar by the muscovite method of beryllium fluorite-muscovite greisens, is 469.3± 4.5Ma. It corresponds to the age of the ore-bearing alkaline granites of the zone. The dikes which occur within the deposit are identical by the composition to the dikes of rare-metal alkaline granitic massifs, one of which is located in a few kilometers from the deposit. The nature of the ore Be-Li mineralization of the deposit is in good agreement with the geochemical specialization of the Early Paleozoic Kizir-Kazyr metallogenic zone. The revealed features of the relationship between Raduga deposit and rare-metal deposits in alkaline granites suggests a variety of mechanisms involved in the formation of rare-metal deposits of the Kizir-Kazyr zone. Thus, it allows to expand approaches for prediction and exploration of rare-metal deposits in the region.","PeriodicalId":24047,"journal":{"name":"Доклады Академии наук","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74859336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Origin, sites and mobility of helium and argon isotopes in meliphanite 墨绿岩中氦、氩同位素的来源、位置和迁移率
Доклады Академии наук Pub Date : 2019-09-26 DOI: 10.31857/s0869-56524883303-306
L. Lyalina, Л М Лялина, I. Kamensky, И Л Каменский, I. Tolstikhin, И Н Толстихин
{"title":"Origin, sites and mobility of helium and argon isotopes in meliphanite","authors":"L. Lyalina, Л М Лялина, I. Kamensky, И Л Каменский, I. Tolstikhin, И Н Толстихин","doi":"10.31857/s0869-56524883303-306","DOIUrl":"https://doi.org/10.31857/s0869-56524883303-306","url":null,"abstract":"The similarity of U-Th-4He age of meliphanite and the age of regional metamorphism (1800 Ma) seems to indicate a good retention of radiogenic 4He in the mineral, but contradicts with the experience of U-Th-4He dating. To analyze this result 3He concentration was measured, which appeared to be very low, about 2 % of the totally produced 3He. Radiogenic 3,4He isotopes occupier radiation tracks. Intersections of these tracks with cleavage planes provide migration of He atoms from the mineral and 4He, produced due to U and Th decay, should be almost completely lost. Instead, meliphanite contains trapped He occurring in specific cavities of the crystalline structure. Extraction of He isotopes from meliphanite by its step-wise heating in vacuum confirmed this conclusion. Using U-Th-4He system for dating (as it is often done in thermochronology) can lead to incorrect results. Both isotopes, 3He and 4He, should be used to identify the origin of helium in minerals.","PeriodicalId":24047,"journal":{"name":"Доклады Академии наук","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75535893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sulfur isotope composition of Ru-Os sulfides from the Verkh-Neivinsky dunite-harzburgite massif (Middle Urals, Russia): new data 俄罗斯中乌拉尔Verkh-Neivinsky黑锌矿块体中Ru-Os硫化物硫同位素组成的新数据
Доклады Академии наук Pub Date : 2019-09-24 DOI: 10.31857/s0869-56524882185-188
V. V. Murzin, I. Badanina, K. Malitch, A. Ignatiev, T. Velivetskaya
{"title":"Sulfur isotope composition of Ru-Os sulfides from the Verkh-Neivinsky dunite-harzburgite massif (Middle Urals, Russia): new data","authors":"V. V. Murzin, I. Badanina, K. Malitch, A. Ignatiev, T. Velivetskaya","doi":"10.31857/s0869-56524882185-188","DOIUrl":"https://doi.org/10.31857/s0869-56524882185-188","url":null,"abstract":"This study presents the first data set of sulfurisotope compositions of primary Ru-Os sulfides, represented by laurite (RuS2) - erlichmanite (OsS2) series, within a primary platinum-group mineral (PGM) assemblage derived from the Verkh-Neivinsky dunite-harzburgite massif, a typical example of the mantle ophiolite association at the Middle Urals. The S-isotope signatures of Ru-Os sulfides studied are consistent with derivation of the ore material from a mantle source for Ru-Os sulfides.","PeriodicalId":24047,"journal":{"name":"Доклады Академии наук","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73078243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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