ICBCB 2018Pub Date : 2018-03-12DOI: 10.1145/3194480.3194482
Long Cheng, Pengfei Yao, Jianwei Lu, Ke Hao, Zhongyang Zhang
{"title":"A Dynamic Pooling Approach to Extract Complete Allele Signal Information in Somatic Copy Number Alternations Detection","authors":"Long Cheng, Pengfei Yao, Jianwei Lu, Ke Hao, Zhongyang Zhang","doi":"10.1145/3194480.3194482","DOIUrl":"https://doi.org/10.1145/3194480.3194482","url":null,"abstract":"Accurately characterizing somatic copy number alterations (SCNAs) in cancers are of great importance in both deciphering tumorigenesis and progression and improving clinical diagnosis/treatment. Many computational methods in detecting SCNAs were proposed in recent years, and saas-CNV is among the best performers evaluated with empirical datasets. However, saas-CNV method inefficiently uses the allele dosage information in next-generation sequencing or microarray data. To this regard, we proposed and implemented a novel approach to extract the complete allele signal information for SCNA detection. Evaluated in an empirical dataset of hepatocellular carcinoma, we demonstrated the novel approach enhanced data signal-to-noise ratio, and resulted in improved detection of copy number alternations especially focal genome changes.","PeriodicalId":240229,"journal":{"name":"ICBCB 2018","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132323405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}