Zhonghua nei ke za zhi最新文献

{"title":"[Expert consensus on technical strategies for interventional treatment of acute large vessel occlusive stroke in China].","authors":"","doi":"10.3760/cma.j.cn112138-20220819-00608","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20220819-00608","url":null,"abstract":"<p><p>Ischemic stroke caused by acute large vessel occlusion is associated with high rates of disability and mortality. Endovascular interventional therapy is evidently an effective treatment for occlusion of large cerebral vessels within the relevant time window, but there is no established methodological standard for recanalization interventional therapy. The Professional Committee of Interventional Neurology in Chinese Research Hospital Association organized cerebrovascular disease experts in China and developed the expert consensus described herein, to provide a reference for clinicians to formulate technical strategies for recanalization of acute cerebral vascular occlusion.</p>","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 8","pages":"931-938"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10300847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Paget's disease of bone with SQSTM1 and HNRNPA2B1 gene mutations: report of 2 cases].","authors":"X H Tao,&nbsp;T Xu,&nbsp;Q Lu,&nbsp;W D Yang,&nbsp;Y Q Hu,&nbsp;W Z Fu,&nbsp;H Yue,&nbsp;Z L Zhang","doi":"10.3760/cma.j.cn112138-20220901-00648","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20220901-00648","url":null,"abstract":"畸形性骨炎是一种临床罕见的慢性进展性代谢性骨病，目前病因不明，其主要特征为骨吸收增加，随之代偿性新骨形成增加，临床表现为碱性磷酸酶升高、骨痛、骨骼畸形，易出现病理性骨折。本文报道2例罕见的畸形性骨炎分别由SQSTM1基因及HNRNPA2B1基因突变所致，分析2例患者的临床表现并复习相关文献，以期提高临床医生对该病的认识和诊治水平，并为后续开展分子诊断和基因筛查提供依据。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 8","pages":"1021-1025"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9980093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects of biologics on psychological status and quality of life in patients with inflammatory bowel disease: a multicenter study].","authors":"S C Wei,&nbsp;C Liu,&nbsp;M Chen,&nbsp;Y H Cai,&nbsp;X H Wu,&nbsp;M L Chen,&nbsp;J X Zhang,&nbsp;D Xiang,&nbsp;Z C Liu,&nbsp;C Q Jiang,&nbsp;J Shi,&nbsp;K C Wu,&nbsp;W G Dong","doi":"10.3760/cma.j.cn112138-20220818-00603","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20220818-00603","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the effects of biologics on psychological status and quality of life in patients with inflammatory bowel disease (IBD). <b>Methods:</b> A cross-sectional survey was conducted in 42 hospitals in 22 provinces (autonomous regions and municipalities directly under the central government) from September 2021 to May 2022. General clinical information and the use of biologics were obtained from adult patients diagnosed with IBD who voluntarily participated in the study. Psychological status was evaluated using the Generalized Anxiety Disorder (GAD-7), Patient Health Questionnaire-9 (PHQ-9), Pittsburgh Sleep Quality Index (PSQI), and Inflammatory Bowel Disease Questionnaire (IBDQ) assessment tools. Counts were analyzed via the Chi-square test, and datasets that were not normally distributed were analyzed via nonparametric tests. <i>P</i><0.05 was considered statistically significant. <b>Results:</b> A total of 2 478 valid questionnaires were collected. The GAD-7 score of the biologics group was significantly lower than that of the non-use group [6 (2, 9) vs. 7 (3, 10), <i>Z</i>=-3.49, <i>P</i><0.001]. IBDQ scores [183 (158, 204) vs. 178 (152, 198), <i>Z</i>=-4.11, <i>P</i><0.001], intestinal symptom scores [61 (52, 67) vs. 58 (49, 65), <i>Z</i>=-5.41, <i>P</i><0.001], systemic symptom scores [28 (24, 32) vs. 27 (23, 31), <i>Z</i>=-2.37, <i>P</i>=0.018], emotional ability scores [69 (58, 77) vs. 67 (56, 75), <i>Z</i>=-3.58, <i>P</i><0.001] and social ability scores [26 (22, 29) vs. 25 (22, 29), <i>Z</i>=-2.52, <i>P</i>=0.012] in the biologics group were significantly higher than in the non-use group. GAD-7 scores [5 (2, 9) vs. 6 (3, 10), <i>Z</i>=-3.50, <i>P</i><0.001] and PSQI scores [6 (4, 9) vs. 6 (4, 9), <i>Z</i>=-2.55, <i>P</i>=0.011] were significantly lower in the group using infliximab than in the group not using it. IBDQ scores were significantly higher in patients using vedolizumab than in those not using it [186 (159, 205) vs. 181 (155, 201), <i>Z</i>=-2.32, <i>P</i>=0.021] and were also significantly higher in the group treated with adalimumab than in the group not treated with adalimumab [187 (159, 209) vs. 181 (155, 201), <i>Z</i>=-2.16, <i>P</i>=0.030]. However, ustekinumab had no significant effect on any of the scores. <b>Conclusion:</b> The use of biologics is strongly associated with improvements in anxiety status and quality of life in IBD patients.</p>","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 8","pages":"1000-1006"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10300848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application and prospect of telehealth in the management of cardiovascular disease].","authors":"L Zhou,&nbsp;C S Ma,&nbsp;Y Kong,&nbsp;L He,&nbsp;C Jiang","doi":"10.3760/cma.j.cn112138-20220913-00676","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20220913-00676","url":null,"abstract":"心血管疾病发病率致死率高，位居我国疾病负担首位。互联网医疗有利于实现对心血管病患者的全病程管理，可缓解实体医疗资源不足、地域分布不均衡等问题。本文主要综述了互联网医疗应用于心血管慢性病管理的基础、应用现状和未来发展。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 8","pages":"1034-1038"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9980095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Associations between serum GDF15 and glycolipid metabolism disorder in metabolic associated fatty liver patients].","authors":"X Li,&nbsp;X M Yu,&nbsp;E H Li,&nbsp;P H Chen,&nbsp;L M Zheng,&nbsp;S Zhang","doi":"10.3760/cma.j.cn112138-20220822-00614","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20220822-00614","url":null,"abstract":"<p><p><b>Objective:</b> To investigate relationships between serum growth differentiation factor 15 (GDF15) and glycolipid metabolism in patients with metabolic associated fatty liver disease (MAFLD). <b>Methods:</b> The current investigation was a cross-sectional study. A total of 333 patients from the Fengxian District Central Hospital were recruited into the study after physical examination from February 2020 to February 2021. There were 107 patients with MAFLD and type 2 diabetes mellitus (T2DM), including 54 males and 53 females with a mean age of (57±11) years. There were 65 patients with simple MAFLD only, including 32 men and 33 women with a mean age of (49±5) years. There were 105 patients with T2DM only, including 53 men and 52 women, with a mean age of (56±10) years. A control group of 56 people without MAFLD or diabetes,28 male, 28 female, mean age (48±6) years, was also included in the study. Serum GDF15 was measured via enzyme-linked immunosorbent assays. IBM SPSS 26.0 was used for statistical analysis. Logistic regression was used to evaluate relationships between GDF15 and metabolic abnormalities in MAFLD patients. <b>Results:</b> GDF15 progressively increased in the control [385 (296, 484) ng/L], nonobese MAFLD [388 (319, 435) ng/L], obese MAFLD [426 (354, 527) ng/L], T2DM [664 (483, 900) ng/L], and MAFLD+T2DM groups [770 (560, 1 074) ng/L](<i>H</i>=113.82, <i>P</i>=0.001). There was no significant difference in serum GDF15 between the simple MAFLD [406 (339, 524) ng/L] and control group (<i>U</i>=1 505.50, <i>P</i>=0.132). GDF15 was significantly higher in the MAFLD+T2DM group than in the T2DM-only group (<i>U</i>=4 573.50, <i>P</i>=0.019). In logistic regression analysis increased GDF15 was associated with increased risks of simple MAFLD [odds ratio (<i>OR</i>)=2.202], T2DM (<i>OR</i>=29.656), and MAFLD+T2DM(<i>OR</i>=58.197). In patients with MAFLD, serum GDF15 was higher in the FIB4 index>1.45 group [773 (534, 1 162) ng/L] than in the FIB4 index<1.45 group [527 (389, 787) ng/L] (<i>U</i>=1 709.50, <i>P</i><0.001). Increased GDF15 was associated with an increased risk of advanced liver fibrosis (<i>OR</i>=2.388). <b>Conclusion:</b> In patients with simple MAFLD, GDF15 level was not significantly higher than in the control group. In the T2DM-only group and the MAFLD+T2DM group GDF15 was significantly higher than in the control group. Increased serum GDF15 was associated with increased risk and severity of MAFLD complicated with abnormal glucose and lipid metabolism. High GDF15 increased the risk of advanced fibrosis in MAFLD patients.</p>","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 8","pages":"987-992"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10282725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Correlation analysis of anterior pituitary hormone and tumor size in patients with pituitary adenomas].","authors":"Y P Wang,&nbsp;Y J Li,&nbsp;B Li,&nbsp;L Zang,&nbsp;K Chen,&nbsp;J Du,&nbsp;J T Dou,&nbsp;Z H Lyu,&nbsp;W J Gu,&nbsp;Y M Mu","doi":"10.3760/cma.j.cn112138-20221019-00765","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20221019-00765","url":null,"abstract":"<p><p><b>Objective:</b> To summarize the correlation between anterior pituitary function and tumor size in patients with different hormone-secreting pituitary adenomas. <b>Methods:</b> This was a retrospective case series study. The clinical data of 1 946 patients with pituitary adenoma hospitalized in the First Medical Center of Chinese PLA General Hospital from January 1, 2005, to December 31, 2020, were collected. The correlation between tumor size and anterior pituitary hormone levels was analyzed using Spearman rank correlation analysis in different types of pituitary adenomas. <b>Results:</b> The median age of the 1 946 patients was 45.1 years, of which 857 (44.0%) were men. The maximum tumor diameter of the patients [<i>M</i> (<i>Q</i>₁, <i>Q</i>₃)] was 22 (14, 30) mm. Tumor size in nonfunctioning adenomas (<i>n</i>=1 191) was negatively correlated with adrenocorticotropic hormone (ACTH) (<i>r</i>=-0.11, <i>P</i><0.001), growth hormone (<i>r</i>=-0.13, <i>P</i><0.001), and luteinizing hormone (men: <i>r</i>=-0.26, <i>P</i><0.001, women: <i>r</i>=-0.31, all <i>P</i><0.001). The tumor size of somatotropic adenomas (<i>n</i>=297) was positively correlated with growth hormone (<i>r</i>=0.46, <i>P</i><0.001), but negatively correlated with male testosterone (<i>r</i>=-0.41, <i>P</i><0.001). The tumor size of ACTH-secreting pituitary adenomas (<i>n</i>=155) was positively correlated with the ACTH level at 8∶00 AM (<i>r</i>=0.25, <i>P</i><0.001); however, no correlation was found with cortisol at 8∶00 AM (<i>P</i>>0.05). The tumor size of prolactinomas (<i>n</i>=303) was positively correlated with the prolactin level (men: <i>r</i>=0.34, <i>P</i>=0.001; women: <i>r</i>=0.13, <i>P</i>=0.070). <b>Conclusions:</b> The correlation between the function of the anterior pituitary and size of the tumor depends on the cellular origin of the pituitary adenoma and specific type of hormone secretion. In somatotroph adenomas, ACTH-secreting pituitary adenomas, and prolactinomas, there is a positive correlation between tumor size and level of hormones secreted by the corresponding tumors. In patients with nonfunctioning adenomas, the tumor size was negatively correlated with the hormone levels of the pituitary-adrenal and pituitary-growth hormone axes.</p>","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 8","pages":"979-986"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10282729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress of renal-targeted nanopharmaceuticals in the treatment of acute kidney injury].","authors":"X W He,&nbsp;Y Liu,&nbsp;Q G Ao,&nbsp;Q L Cheng","doi":"10.3760/cma.j.cn112138-20221003-00726","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20221003-00726","url":null,"abstract":"急性肾损伤（AKI）具有发病率高、致死率高等特点，目前临床上缺乏有效的治疗方法。现应用的肾脏保护药物由于其生物利用度不高而难以有效治疗AKI。纳米药物载体（nanosized drug carriers，NDCs）的应用，可提高肾脏保护药物的生物利用度和靶向递送效率，以持续、受控的方式有效地将治疗剂靶向至所需组织，可延长肾脏保护剂的生物半衰期和血液循环时间，并减少其在健康组织中的脱靶毒性。本文综述了用于AKI治疗的肾脏纳米药物的研究现状，特别关注NDCs递送肾脏保护剂的肾组织靶向选择性机制、影响因素及其改善药物特性的作用，并对NDCs如何更好地治疗AKI 所面对的挑战及未来前景进行展望。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 8","pages":"1029-1033"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9980094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Progress in the application of uric acid-lowering treatments in amyotrophic lateral sclerosis].","authors":"Y N Zhao,&nbsp;J Y Fu,&nbsp;J He,&nbsp;D S Fan","doi":"10.3760/cma.j.cn112138-20220708-00498","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20220708-00498","url":null,"abstract":"尿酸是人体内嘌呤代谢的终产物，主要通过影响能量代谢、氧化应激、炎症反应等通路来影响肌萎缩侧索硬化症（ALS）的发生发展，但目前尿酸对于ALS的作用仍然存在争议。动物实验显示降尿酸药物黄嘌呤氧化酶抑制剂可以延缓动物模型发病、延长生存期、减缓体重下降、延缓运动能力下降，提示降尿酸药物，尤其是黄嘌呤酶抑制剂在ALS中应用的潜在可能性。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 7","pages":"885-890"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9800301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical analysis of the usefulness of letermovir for prevention of cytomegalovirus infection after haploidentical hematopoietic stem cell transplantation].","authors":"R Ma,&nbsp;Y He,&nbsp;H F Wang,&nbsp;L Bai,&nbsp;W Han,&nbsp;Y F Cheng,&nbsp;K Y Liu,&nbsp;L P Xu,&nbsp;X H Zhang,&nbsp;Y Wang,&nbsp;Y Y Zhang,&nbsp;F R Wang,&nbsp;X D Mo,&nbsp;C H Yan,&nbsp;X J Huang,&nbsp;Y Q Sun","doi":"10.3760/cma.j.cn112138-20221204-00904","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20221204-00904","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the efficacy and safety of letermovir in primary prophylaxis of cytomegalovirus (CMV) reactivation in patients receiving haploidentical hematopoietic stem cell transplantation. <b>Methods:</b> This retrospective, cohort study was conducted using data of patients who underwent haploidentical transplantation at Peking University Institute of Hematology and received letermovir for primary prophylaxis between May 1, 2022 and August 30, 2022. The inclusion criteria of the letermovir group were as follows: letermovir initiation within 30 days after transplantation and continuation for≥90 days after transplantation. Patients who underwent haploidentical transplantation within the same time period but did not receive letermovir prophylaxis were selected in a 1∶4 ratio as controls. The main outcomes were the incidence of CMV infection and CMV disease after transplantation as well as the possible effects of letermovir on acute graft versus host disease (aGVHD), non-relapse mortality (NRM), and bone marrow suppression. Categorical variables were analyzed by chi-square test, and continuous variables were analyzed by Mann-Whitney <i>U</i> test. The Kaplan-Meier method was used for evaluating incidence differences. <b>Results:</b> Seventeen patients were included in the letermovir prophylaxis group. The median patient age in the letermovir group was significantly greater than that in the control group (43 yr vs. 15 yr; <i>Z=-</i>4.28, <i>P</i><0.001). The two groups showed no significant difference in sex distribution and primary diseases, etc. (all <i>P</i>>0.05). The proportion of CMV-seronegative donors was significantly higher in the letermovir prophylaxis group in comparison with the control group (8/17 vs. 0/68, <i>χ</i>²=35.32, <i>P</i><0.001). Three out of the 17 patients in the letermovir group experienced CMV reactivation, which was significantly lower than the incidence of CMV reactivation in the control group (3/17 vs. 40/68, <i>χ</i>²=9.23, <i>P</i>=0.002), and no CMV disease development observed in the letermovir group. Letermovir showed no significant effects on platelet engraftment (<i>P</i>=0.105), aGVHD (<i>P</i>=0.348), and 100-day NRM (<i>P</i>=0.474). <b>Conclusions:</b> Preliminary data suggest that letermovir may effectively reduce the incidence of CMV infection after haploidentical transplantation without influencing aGVHD, NRM, and bone marrow suppression. Prospective randomized controlled studies are required to further verify these findings.</p>","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 7","pages":"826-832"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10104051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A comparative analysis of the clinical symptoms of benign paroxysmal positional vertigo between older and young and middle-aged patients].","authors":"R L Fang,&nbsp;Q Leng,&nbsp;Y Wang,&nbsp;M M Chen,&nbsp;Y Cui,&nbsp;X L Wu,&nbsp;Y Ju","doi":"10.3760/cma.j.cn112138-20221225-00956","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20221225-00956","url":null,"abstract":"<p><p><b>Objective:</b> To compare the differences in clinical symptoms and the time required for diagnosis of benign paroxysmal positional vertigo (BPPV) between older patients and young and middle-aged patients in the structured inquiry of dizziness history. <b>Methods:</b> The medical records of 6 807 patients diagnosed with BPPV from the Vertigo Database of Vertigo Clinical Diagnosis, Treatment, and Research Center of Beijing Tiantan Hospital, Capital Medical University, between January 2019 and October 2021 were retrospectively analyzed. The data included basic demographic information, clinical symptoms in a structured medical history questionnaire, and the time interval from the appearance of BPPV symptoms to diagnosis consultation. The patients were divided into the young and middle-aged group (<65 years old) and the older group (≥65 years old). The differences in clinical symptoms and consultation time were compared between these two groups. Categorical variables were represented by numbers (%), and compared using Chi-squared tests or Fisher's exact probability test for analysis; whereas, continuous variables conforming to normal distribution were represented by mean±standard deviation. Both data groups were compared and analyzed by Student's <i>t</i>-test. <b>Results:</b> The mean age of the older group was 65-92 (71±5) years, while the mean age of the middle-aged group was 18-64 (49±12) years. The incidence of vertigo (42.5% vs. 49.1%, <i>χ</i>²=23.69, <i>P</i><0.001); vertigo triggered by changes in position of the head or body (52.4% vs. 58.7%, <i>χ</i>²=22.31, <i>P</i><0.001); and autonomic symptoms (10.1% vs. 12.4%, <i>χ</i>²=7.09, <i>P</i>=0.008) were lower, but hearing loss (11.8% vs. 7.8%, <i>χ</i>²=27.36, <i>P</i><0.001) and sleep disorders (18.5% vs. 15.2%, <i>χ</i>²=11.13, <i>P</i>=0.001) were higher in the older group than in the young and middle-aged group. The time from the appearance of dizziness to diagnosis was commonly longer in the older patient group than the other group (55.0% vs. 38.5%, <i>χ</i>²=55.95, <i>P</i><0.001). <b>Conclusions:</b> Older patients with BPPV have more atypical symptoms and complex concomitant symptoms than young and middle-aged patients. For older patients with dizziness, positional testing is needed to confirm the possibility of BPPV even if the clinical symptoms are atypical.</p>","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 7","pages":"802-807"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10104052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}