中国修复重建外科杂志最新文献

{"title":"[Lapidus arthrodesis combined with middle metatarsal base rotation osteotomy in treatment of hallux valgus with metatarsus adductus].","authors":"Lin Shang, Zhiqiang Lü, Shijun Zhao, Litao Chu, Chenqi Li, Fu Gao, Junjie Lu, Wei Zhang","doi":"10.7507/1002-1892.202509084","DOIUrl":"10.7507/1002-1892.202509084","url":null,"abstract":"<p><strong>Objective: </strong>To explore effectiveness of the Lapidus arthrodesis combined with the middle metatarsal base rotation osteotomy in the treatment of hallux valgus (HV) with metatarsus adductus (MA).</p><p><strong>Methods: </strong>Between February 2023 and September 2024, 18 patients (18 feet) of HV with MA were underwent Lapidus arthrodesis combined with the middle metatarsal base rotation osteotomy. There were 5 males and 13 females with an age of 50-68 years (mean, 55.3 years). The foot deformity was characterized by severe HV, redness and swelling at the utricle, and the corpus callosum on the plantar side of the forefoot. The preoperative American Orthopaedic Foot and Ankle Society (AOFAS) score was 44.2±3.8 and visual analogue scale (VAS) score was 7.1±0.9 after walking 1 km. The AOFAS score and VAS score were adopted to evaluate the postoperative function of the foot. The hallux valgus angle (HVA), metatarsus adductus angle (MAA), intermetatarsal angle (IMA), and distal metatarsal articular angle (DMAA) were measured after operation.</p><p><strong>Results: </strong>All incisions healed by first intention. All patients were followed up 12-26 months (mean, 18 months). At last follow-up, the AOFAS score and VAS score after walking 1 km were 84.2±3.9 and 2.0±0.8, respectively, showing significant differences when compared with preoperative scores ( <i>P</i><0.05). Imaging review showed that the osteotomy sites all healed, with a healing time of (10.25±2.15) weeks. At last follow-up, the HVA, MAA, IMA, and DMAA were significantly lower than preoperative ones ( <i>P</i><0.05). During follow-up, all patients exhibited diffuse swelling of the feet, 10 patients experienced stiffness in the great toe, 1 foot showed numbness caused by medial plantar cutaneous nerve injury, and 1 foot of skin irritation caused by internal fixation.</p><p><strong>Conclusion: </strong>For HV with MA, the Lapidus arthrodesis combined with middle metatarsal base rotation osteotomy can effectively correct deformity and relieve pain.</p>","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"40 4","pages":"578-583"},"PeriodicalIF":0.0,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Spontaneous facet joint fusion and stability assessment following isolated posterior internal fixation for lumbar burst fractures].","authors":"Xinwei Fu, Yuanxuan Li, Yao Chen, Chaohua Yang, Qing Wang, Jin Yang","doi":"10.7507/1002-1892.202511068","DOIUrl":"10.7507/1002-1892.202511068","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the impact of spontaneous facet joint fusion (SFJF) on lumbar motion function following isolated posterior internal fixation for lumbar burst fractures, characterize SFJF radiographically, and explore the indications for implant removal.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Patients who underwent implant removal after posterior internal fixation for lumbar burst fractures between January 2018 and September 2024 were retrospectively reviewed. A total of 137 patients (330 segments) met the selection criteria and were enrolled, including 89 males and 48 females, with a median age of 50.0 years (range, 18-71 years). There were 98 patients with two segments, 22 with three segments, and 17 with four segments. Baseline characteristics were included, such as gender, age, AO fracture type, and visual analogue scale (VAS) score for back pain and Oswestry disability index (ODI) at last follow-up. Based on radiographic assessment, facet joint (FJ) fusion was graded as grade 1 (non-fusion), grade 2 (SFJF), or grade 3 (SFJF). Segmental range of motion (ROM) was measured, motion loss rate was calculated, and functional motion status was determined. Intergroup comparisons were performed for baseline characteristics and radiographic parameters. Factors influencing SFJF were analyzed, and the segmental distribution, temporal pattern of SFJF, and its impact on segmental stability were evaluated.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Postoperative CT revealed that the FJ fusion were rated as grade 1 in 53 patients (190 segments, 57.6%), grade 2 in 49 patients (86 segments, 26.1%), and grade 3 in 35 patients (54 segments, 16.4%). Accordingly, 84 patients (140 segments, 42.4%) were classified as SFJF. Patients with SFJF were younger and had a higher proportion of males, showing significant differences ( &lt;i&gt;P&lt;/i&gt;&lt;0.05). However, there was no significant difference in AO fracture classification between patients with and without SFJF ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). At last follow-up, the SFJF patients exhibited higher VAS scores ( &lt;i&gt;P&lt;/i&gt;&lt;0.05), but no significant difference was observed in ODI ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). At last follow-up, no significant difference was observed in the distribution of SFJF grades among the 330 segments ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). The incidence of SFJF increased significantly from 17.9% at 3 months to 39.7% at 6 months postoperatively ( &lt;i&gt;P&lt;/i&gt;&lt;0.05), with no further significant increase at last follow-up (42.4%, &lt;i&gt;P&lt;/i&gt;&gt;0.05). Among SFJF patients with flexion-extension X-ray films, 45 patients with 115 segments were analyzed, including 75 SFJF segments (47 grade 2 and 28 grade 3). Grade 2 and grade 3 segments showed significantly lower ROM than grade 1 segments ( &lt;i&gt;P&lt;/i&gt;&lt;0.05). Compared with grade 2 segments, grade 3 segments exhibited significantly lower ROM, reduced motion function, and higher motion loss rate ( &lt;i&gt;P&lt;/i&gt;&lt;0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The incidence of SFJF following posterior internal fixation for lumba","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"40 4","pages":"630-636"},"PeriodicalIF":0.0,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Interpretation of the Expert Consensus for Full Course Management of Plexiform Neurofibroma (2025 Edition)].","authors":"Group Of Neurofibromatosis Plastic And Reconstructive Surgery Society Of Chinese Medical Association, China Rare Disease Alliance Neurofibromatosis Expert Committee","doi":"10.7507/1002-1892.202602027","DOIUrl":"10.7507/1002-1892.202602027","url":null,"abstract":"<p><p>Neurofibromatosis type 1 (NF1), an autosomal dominant genetic disorder resulting from mutations in the NF1 gene, is frequently characterized by the development of plexiform neurofibromas (PNFs). A paradigm shift in the management of PNFs has occurred following the successful development of mitogen-activated protein kinase kinase inhibitors. In light of these advancements, the Expert Consensus for Full Course Management of Plexiform Neurofibroma (2025 Edition) was published by the Group of Neurofibromatosis, Plastic and Reconstructive Surgery Society of Chinese Medical Association in 2025. This consensus provides recommendations on the diagnosis, screening, surgical management, medical therapy, disease surveillance, as well as patient education and psychosocial support for NF1-associated PNFs. This article aims to interpret and discuss full course management of PNF in this consensus to provide references for clinical practice.</p>","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"40 4","pages":"519-525"},"PeriodicalIF":0.0,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Short-term effectiveness study and finite element analysis of high tibial osteotomy for knee varus with medial meniscus posterior root tear in middle aged and older populations].","authors":"Yelong Tao, Wei Liu, Youhua Wang, Jianbo Fan","doi":"10.7507/1002-1892.202512056","DOIUrl":"10.7507/1002-1892.202512056","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the short-term effectiveness of high tibial osteotomy (HTO) for treatment of middle aged and older populations with varus knee combined with medial meniscus posterior root tear (MMPRT), and to evaluate the biomechanical changes in the knee joint after operation based on finite element analysis.</p><p><strong>Methods: </strong>A retrospective analysis of clinical data was conducted on 35 patients (35 knees) admitted between June 2021 and October 2023, who met the inclusion criteria for varus knee combined with MMPRT. There were 17 males and 18 females with a mean age of 59.2 years (range, 48-65 years). Open wedge HTO was performed to correct the alignment in all patients. X-ray films and MRI were conducted before operation and at 3, 6, and 12 months after operation to assess changes in lower limb alignment and joint structure. And the femorotibial angle, medial proximal tibial angle (MPTA), posterior tibial slope angle (PTSA), weight-bearing line ratio (WBLR), as well as the Lysholm score, Hospital for Special Surgery (HSS) score, and visual analogue scale (VAS) score for pain were compared between pre- and post-operation. Finite element models were reconstructed based on knee CT data from a healthy volunteer to simulate changes in stress distribution at the knee joint before and after HTO, and to analyze postoperative mechanical improvement characteristics.</p><p><strong>Results: </strong>All 35 patients underwent successful operations. Postoperatively, 3 cases of incisional fat liquefaction and 2 cases of mild superficial wound infection occurred; no complication such as deep vein thrombosis of the lower extremities, severe infection, or neurovascular injury was observed. All patients were followed up 12-14 months (mean, 13.0 months). Imaging reexamination revealed that all osteotomies had achieved radiographic union, with no complication such as osteotomy loss, significant collapse, or plate fracture. At 12 months after operation, the femorotibial angle, MPTA, WBLR, and PTSA were all significantly higher than preoperative levels ( <i>P<</i>0.05). Compared with preoperative values, the Lysholm score and HSS score gradually increased, while the VAS score decreased at 3, 6, and 12 months, with significant differences between different time points ( <i>P<</i>0.05). Finite element analysis showed that the stress distribution in the medial and lateral compartments of the knee joint tended toward equilibrium after HTO. Medial cartilage contact stress decreased by approximately 40% compared to preoperative levels, and stress concentration in the medial meniscus was significantly reduced.</p><p><strong>Conclusion: </strong>HTO can significantly alleviate knee pain in middle aged and older populations with varus knee combined with MMPRT, improve the distribution of knee joint forces, and promote the recovery of joint function.</p>","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"40 4","pages":"563-570"},"PeriodicalIF":0.0,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Zeta-focal bone lengthening for bone defects after fracture-related infection: a two-case based research].","authors":"Yusufu Aihemaitijiang, Wumaierjiang Yiliyaer, Maimaiti Xiayimaierdan, Yushan Maimaiaili, Abula Abulaiti, Yongqing Xu","doi":"10.7507/1002-1892.202512082","DOIUrl":"10.7507/1002-1892.202512082","url":null,"abstract":"<p><strong>Objective: </strong>To summarize the clinical experiences of using Zeta-focal bone lengthening to treat bone defects caused by fracture-related infection (FRI) in two cases, and to preliminarily explore its feasibility and efficacy.</p><p><strong>Methods: </strong>In 2023, two male patients with bone defects caused by FRI were treated, aged 19 and 40 years, respectively. After admission, stage Ⅰ treatment consisted of thorough debridement and infection control based on bacterial culture and drug susceptibility test results. The lengths of bone defects were 6 cm and 22 cm, respectively. When the erythrocyte sedimentation rate and inflammatory markers returned to normal ranges, stage Ⅱ treatment (debridement and reconstruction with Zeta-focal bone lengthening) was performed. Distraction was initiated at 7 days after the second-stage operation. Docking of the bone segments was achieved at 11 and 40 days of distraction, respectively, and obvious mineralization in the distraction zones was observed at 65 and 104 days postoperatively. The external fixator was removed after radiographic evidence of cortical continuity at four sites was confirmed on anteroposterior and lateral X-ray films. The external fixation time was 112 and 357 days, respectively, and the external fixation indexes were 18.5 and 17.9 days/cm, respectively. Complications during the distraction period were observed. During follow-up, bone healing and functional recovery were evaluated with the Paley D score, the Association for the Study and Application of the Method of Ilizarov (ASAMI) score, the Lower Extremity Functional Scale (LEFS), and the American Orthopaedic Foot & Ankle Society (AOFAS) score.</p><p><strong>Results: </strong>Both patients completed the two-stage treatment. Their hospital stays were 21 and 16 days, respectively. Only mild pin-tract reactions occurred during the distraction period. Both patients were followed up for 18 months. At last follow-up, 2 patients achieved excellent functional results according to the ASAMI score, and bone healing was rated as excellent by the Paley D score. In 1 patient, the LEFS score was 76 and the AOFAS score was 95. The other patient was not scored because of knee arthrodesis.</p><p><strong>Conclusion: </strong>Under the prerequisites of strict infection control and individualized segmental design, Zeta-focal bone lengthening can achieve effective reconstruction of infectious bone defects and significantly reduce the external fixation time and the external fixation index.</p>","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"40 4","pages":"604-609"},"PeriodicalIF":0.0,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Experimental investigation of skin tissue-derived extracellular vesicles isolated from type 2 diabetic foot ulcers in impaired wound healing].","authors":"Ronghua Li, Yan Zhou, Junzhe Chen, Liangliang Wang, Xichao Jian, Fang Qi, Chengliang Deng, Zairong Wei, Zhiyuan Liu","doi":"10.7507/1002-1892.202509067","DOIUrl":"10.7507/1002-1892.202509067","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To isolate extracellular vesicles (EVs) from the wound-edge skin tissue of type 2 diabetic foot ulcers and to investigate their effect on wound healing in mice.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Twenty 8-week-old male db/db mice were used to establish a full-thickness skin defect wound with a diameter of 1.0 cm on the back, and divided into GW4869 (hydrochloride hydrate) group and DMSO group (control group), with 10 mice in each group. The wound healing rate was calculated on days 3, 6, 9, and 12 after injection. HE staining was used to observe epithelialization and inflammatory cell infiltration on days 7 and 12 after injection. Masson staining was used to observe collagen fiber formation. Immunofluorescence staining was used to detect CD206 and interleukin 1β (IL-1β) expressions in wound tissues. Skin tissues from the wound edge of 30 patients with type 2 diabetic foot ulcer were collected for tissue cutting, enzyme dissociation, gradient size exclusion, differential centrifugation combined with ultra-high speed centrifugation to extract tissue EVs (Dia-EVs), which were identified by transmission electron microscopy and particle size analysis. Twenty 8-week-old male C57BL/6 mice were used to establish a full-thickness skin defect wound with a diameter of 1.0 cm on the back, and divided into Dia-EVs group and PBS group, with 10 mice in each group. The wound healing rate was calculated on days 3, 5, 7, 9, and 12 after injection. HE staining was used to observe epithelialization and inflammatory cell infiltration on days 7 and 12 after injection. Masson staining was used to observe collagen fiber formation. Immunofluorescence staining was used to detect CD206 and IL-1β expressions in wound tissues. &lt;i&gt;In vitro&lt;/i&gt; experiments were conducted using RAW264.7 cells, which were divided into three groups: the control group [cultured in PRMI 1640 medium containing 10% fetal bovine serum (FBS)], the M1 group [induced with PRMI 1640 medium containing 10%FBS, 200 ng/mL lipopolysaccharide, and 20 ng/mL interferon γ (IFN-γ) for 48 hours], and the Dia-EVs group (treated with PRMI 1640 medium containing 10%FBS and 40 μg/mL Dia-EVs for 48 hours). The expression levels of CD206 and IL-1β in each group of cells were observed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In db/db mice experiment, on days 3, 6, 9, and 12 after injection, the wound healing rate of the GW4869 group was significantly faster than that of the DMSO group ( &lt;i&gt;P&lt;/i&gt;&lt;0.05). On day 7 after injection, inflammatory cell infiltration in the DMSO group was obvious, and the number of inflammatory cells was significantly higher than that in the GW4869 group ( &lt;i&gt;P&lt;/i&gt;&lt;0.05). Masson staining showed no obvious new collagen formation in either group. On day 12 after injection, HE staining showed that the GW4869 injection group had completed epithelialization without obvious inflammatory cell infiltration, while the DMSO injection group still had a large number of inflammatory cells in","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"40 4","pages":"664-674"},"PeriodicalIF":0.0,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Impact of surgeon's dominant hand-side consistency with surgical approach on operational efficiency of unilateral biportal endoscopic lumbar discectomy: a prospective cohort study].","authors":"Wenqing Li, Meng Gao, Linlin Zhang, Qihua Yu, Xiaolong Chen","doi":"10.7507/1002-1892.202512075","DOIUrl":"10.7507/1002-1892.202512075","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the impact of the surgeon's dominant hand-side on the operational efficiency and safety of primary lumbar discectomy under unilateral biportal endoscopy (UBE).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A prospective cohort study was conducted in 60 patients with single-level lumbar disc herniation who underwent UBE lumbar discectomy between August 2024 and August 2025 by the same right-handed surgeon, including 30 patients with non-dominant (right approach) (non-matched group) and 30 patients with dominant (left approach) (matched group). No significant difference was observed between the two groups in baseline data including gender, age, body mass index, herniated segment distribution, disease duration, and preoperative visual analogue scale (VAS) score and Oswestry disability index (ODI) ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). The total operation time, core endoscopic operation time, intraoperative blood loss, and related complications were recorded and compared between the two groups. A self-developed surgeon's operational fluency assessment score was used for auxiliary subjective evaluation. VAS score and ODI were used to assess pain and functional improvement preoperatively and at 1 and 3 months postoperatively. The modified MacNab criteria was used to evaluate overall surgical outcomes at 3 months postoperatively.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;There was no significant difference in the total operation time and intraoperative blood loss between the two groups ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). The core endoscopic operation time of the matched group was significantly shorter than that of the non-matched group, and the operational fluency assessment score of the matched group was significantly higher than that of the non-matched group ( &lt;i&gt;P&lt;/i&gt;&lt;0.05). All patients were followed up 3-6 months, with an average of 4.2 months. Complications occurred in 2 cases (6.7%) in the matched group, including 1 case of dural tear and 1 case of postoperative transient nerve root palsy, and 1 case (3.3%) in the non-matched group, which was postoperative epidural hematoma. There was no significant difference in the incidence of complications between the two groups ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). The VAS scores and ODI of the two groups decreased at 1 and 3 months after operation, and improved further at 3 months after operation compared with 1 month after operation, and the differences were significant ( &lt;i&gt;P&lt;/i&gt;&lt;0.05), but there was no significant difference between the two groups after operation ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). Modified MacNab standard was used to evaluate the curative effect at 3 months after operation, and there was no significant difference in the evaluation grade and excellent and good rate between the two groups ( &lt;i&gt;P&lt;/i&gt;&gt;0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Consistency between the surgeon's dominant hand side and the surgical approach side significantly improves core endoscopic operational efficiency and surgical fluency in UBE lumbar discectomy, without comp","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"40 4","pages":"610-615"},"PeriodicalIF":0.0,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of preoperative lower-limb muscle strength on perioperative blood loss and early outcomes in total knee arthroplasty].","authors":"Hang Li, Kejia Zhu, Hui Zhang, Junqing Wang, Biao Wang, Yong Nie, Bin Shen","doi":"10.7507/1002-1892.202512049","DOIUrl":"10.7507/1002-1892.202512049","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the effect of preoperative lower-limb muscle strength on perioperative blood loss, postoperative pain, and functional recovery in patients undergoing total knee arthroplasty (TKA).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective analysis was conducted on the clinical data of 380 patients who underwent TKA and met the selection criteria between February 2023 and December 2024. Based on the gender-specific median of standardized preoperative lower-limb extensor isokinetic muscle strength (IMS), the patients were divided into a low-extensor strength group and a high-extensor strength group, with 190 cases in each group. The following data of the two groups were collected and compared, including age, gender, body mass index, comorbidities, surgical side, length of hospital stay, Kellgren-Lawrence grade, perioperative parameters [including hematocrit (Hct) and hemoglobin (Hb) levels within 1 week preoperatively and 2-3 days postoperatively, with the calculation of Hct loss and Hb loss (the difference between the pre- and post-operative measurements), and whether intraoperative allogeneic blood transfusion was performed], preoperative knee flexion and extension IMS, 5-time sit-to-stand (5-STS) test within 2 weeks preoperatively, as well as visual analogue scale (VAS) score for pain and active range of motion (AROM) within 2 weeks preoperatively and 1 day postoperatively. Pearson correlation analysis was used to analyze the correlation between preoperative lower-limb extensor IMS and TBL. Through multiple linear regression analysis, the effect of IMS on TBL was further explored after adjusting for confounding factors such as age, body mass index, hypertension, diabetes mellitus, coronary atherosclerotic heart disease, and chronic obstructive pulmonary disease.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;There was no significant difference between the two groups in age, gender, body mass index, surgical side, Kellgren-Lawrence grade, comorbidities, length of hospital stay, preoperative Hct and Hb levels, intraoperative allogeneic blood transfusion rate, and changes in VAS scores ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). The high-extensor strength group was superior to the low-extensor strength group in preoperative VAS scores, AROM, 5-STS, as well as postoperative Hct and Hb loss, and the changes of AROM and TBL were less than those in the low-extensor strength group, with all differences being significant ( &lt;i&gt;P&lt;/i&gt;&lt;0.05). Pearson correlation analysis showed a negative correlation between preoperative lower-limb extensor IMS and TBL ( &lt;i&gt;r&lt;/i&gt;=-0.460, &lt;i&gt;P&lt;/i&gt;=0.043). Multiple linear regression analysis showed that after adjustment, a lower TBL was associated with a higher preoperative lower-limb extensor IMS. Specifically, for every 1 N·m increase in preoperative lower-limb extensor IMS, TBL decreased by 9.973 mL. TBL was not significantly affected by other factors such as age, body mass index, and comorbidities.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/s","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"40 4","pages":"533-539"},"PeriodicalIF":0.0,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Bifunctional biomaterials: An innovative strategy for synergistic bone tumor therapy and bone regeneration].","authors":"Weike Feng, Bin Chang, Chunyang Wang, Bo Fan","doi":"10.7507/1002-1892.202510084","DOIUrl":"10.7507/1002-1892.202510084","url":null,"abstract":"<p><strong>Objective: </strong>To review research progress of bifunctional biomaterials in the treatment of bone tumors and bone defects in recent years, aiming to provide assistance for the further research of bifunctional biomaterials.</p><p><strong>Methods: </strong>A wide range of domestic and international literature on the preparation and properties of novel bifunctional biomaterials in recent years was reviewed, followed by summary and analysis. Carrier-functionalized materials, intrinsically active materials, and immune-engineered materials were summarized respectively, and discussions were conducted from aspects such as anti-tumor effects and controlled drug release.</p><p><strong>Results: </strong>Studies have revealed that, unlike traditional biomaterials, the novel bifunctional biomaterials can effectively inhibit the <i>in-situ</i> recurrence of bone tumors through precise drug delivery, external field-responsive tumor killing and immunomodulatory anti-tumor effects. Meanwhile, relying on osteoconduction, osteoinduction, and tissue engineering technologies, they promote new bone formation and bone functional reconstruction in bone defect areas.</p><p><strong>Conclusion: </strong>Novel multifunctional biomaterials can inhibit bone tumor cells and promote new bone formation at the site of bone defects.</p>","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"40 4","pages":"681-688"},"PeriodicalIF":0.0,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of composite graphene-protein hydrogels on neural regeneration after spinal cord injury in rats].","authors":"Zhenyu Zhang, Zhiyi Fan, Xuejie Wang, Zhe Zhu","doi":"10.7507/1002-1892.202510077","DOIUrl":"10.7507/1002-1892.202510077","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the role of composite graphene-protein hydrogels in repairing spinal cord injury (SCI) and promoting neural regeneration in rats.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A composite graphene-protein hydrogel was prepared using the radical copolymerization method. Its physical properties, including adhesion, were evaluated through shear testing, and cytotoxicity was assessed using the MTT assay. Twenty-four adult female Sprague-Dawley rats were randomly divided into four groups: sham surgery, injury, hydrogel, and hydrogel+graphene groups (6 rats per group). The sham surgery group only exposed the T &lt;sub&gt;10&lt;/sub&gt; spinal cord tissue. The other three groups underwent laminectomy combined with spinal cord tissue block resection to establish a T &lt;sub&gt;10&lt;/sub&gt; SCI model. Post-modeling, the hydrogel group and the hydrogel+graphene group received implants of the protein hydrogel and composite graphene-protein hydrogels, respectively, at the injury defect site. The injury group received no additional implant treatment. Postoperative survival rates were monitored across groups. Hindlimb motor function recovery was assessed weekly via Basso-Beattie-Bresnahan (BBB) scores during the 12-week postoperative period. At 12 weeks, motor-evoked potentials were measured to assess neurophysiological function. T &lt;sub&gt;10&lt;/sub&gt; spinal cord tissue was harvested for histopathological examination via HE staining, followed by immunofluorescence staining for glial fibrillary acidic protein (GFAP), Laminin, and 5-hydroxytryptamine (5-HT) immunofluorescence staining to observe glial scar formation and axonal regeneration at the injury site.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Shear testing and MTT assays demonstrated that the composite graphene-protein hydrogels exhibited excellent underwater adhesion and biocompatibility. All rats in each group survived until the end of the experiment. During 12-week postoperative period, the BBB scores in the hydrogel and hydrogel+graphene groups showed a sustained upward trend over time ( &lt;i&gt;P&lt;/i&gt;&lt;0.05). At 12 weeks after operation, BBB scores were significantly higher in the hydrogel and hydrogel+graphene groups than in the injury group, in the hydrogel+graphene group than in the hydrogel group, showing significant differences between groups ( &lt;i&gt;P&lt;/i&gt;&lt;0.05). Neurophysiological testing revealed that the motor evoked potential amplitude in the hydrogel+graphene group was significantly higher than that in the injury group and the hydrogel group ( &lt;i&gt;P&lt;/i&gt;&lt;0.05), with no significant difference compared to the sham surgery group ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). HE staining revealed that the hydrogel+graphene group exhibited spinal cord morphology most similar to the sham surgery group, with significantly restored tissue structural integrity and minimal vacuolation and inflammatory cell infiltration. Quantitative immunofluorescence analysis revealed that the relative fluorescence intensity of GFAP and Laminin in the injury gr","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"40 4","pages":"656-663"},"PeriodicalIF":0.0,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}