Zeitschrift fur Geburtshilfe und Perinatologie最新文献

[Prolonged pregnancy--prostaglandins as the cause of labor onset]. 【妊娠期延长——前列腺素是引发分娩的原因】。

Zeitschrift fur Geburtshilfe und Perinatologie Pub Date : 1994-10-01

W Rath

{"title":"[Prolonged pregnancy--prostaglandins as the cause of labor onset].","authors":"W Rath","doi":"","DOIUrl":"","url":null,"abstract":"The causes of prolonged pregnancy are still largely unknown and their investigation requires a detailed observation of potential birth-initiating stimuli on the endocrine and biomolecular level. A large number of clinical and biochemical studies point to the central importance of prostaglandins for the beginning of human birth. The main places of origin of the intensified prostaglandin formation and release are the amnion and the decidua which has \"macrophage-like\" properties and functions. The superordinate regulation and trigger mechanisms for intensified uterine prostaglandin production has not been sufficiently investigated either. Possible factors currently being debated include local changes in estrogen and progesterone biosynthesis in fetal membranes and decidua, subclinical inflammatory reactions with the activation of macrophages and the consecutive release of cytokines, and a loss of maternal immune tolerance with a time-determined rejection reaction. In addition, the substances inhibiting and stimulating prostaglandin synthesis have been detected in the amniotic fluid, fetal membranes and decidua. The fetus itself also plays an important part in the initiation of labor. Prolongation may be due to anatomic functional disturbances of the one hand which prevent the activation of the fetal hypothalamic-hypophyseal-adrenal axis and the release of the birth-initiating stimuli originating in the fetus; on the other hand, an elevated immune tolerance with a delayed rejection reaction or the lack of \"bacterial stimulus\" may inhibit the activation of the macrophages and hence the formation of cytokines. The consequences would be the development and release of a quantity of prostaglandins from the fetal membranes and decidua insufficient to overcome the pregnancy-maintaining safety systems.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":23919,"journal":{"name":"Zeitschrift fur Geburtshilfe und Perinatologie","volume":"198 5-6","pages":"207-14"},"PeriodicalIF":0.0,"publicationDate":"1994-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18719568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Symposium on Uterine Contraction and Beginning of Labor. Aachen, September 1993]. 子宫收缩与分娩开始研讨会。亚琛，1993年9月]。

Zeitschrift fur Geburtshilfe und Perinatologie Pub Date : 1994-10-01

引用次数: 0

[Role of the cervix uteri at labor onset from ultrasound studies]. [超声检查在临产时宫颈的作用]。

Zeitschrift fur Geburtshilfe und Perinatologie Pub Date : 1994-10-01

E Reinold, W Eppel, E Asseryanis, P Frigo, B Schurz

引用次数: 0

[Uterine contraction and labor onset. Overview]. 子宫收缩，阵痛开始。概述)。

Zeitschrift fur Geburtshilfe und Perinatologie Pub Date : 1994-10-01

H Jung

引用次数: 0

[Significance of the site of uterine contraction for labor progress and duration of pregnancy]. 【子宫收缩部位对产程及妊娠持续时间的意义】。

Zeitschrift fur Geburtshilfe und Perinatologie Pub Date : 1994-10-01

L Spätling, R Danders, C Behrens, A Hasenburg, F Fallenstein

引用次数: 0

Role of progesterone during pregnancy: models of parturition and preeclampsia. 孕激素在妊娠中的作用:分娩模型和先兆子痫。

Zeitschrift fur Geburtshilfe und Perinatologie Pub Date : 1994-10-01

K Chwalisz, R E Garfield

引用次数: 0

[Adrenergic beta-2 receptors and cyclic AMP in lymphocytes and their relationship to uterine contractility]. 淋巴细胞中肾上腺素能β -2受体和环AMP及其与子宫收缩性的关系。

Zeitschrift fur Geburtshilfe und Perinatologie Pub Date : 1994-10-01

U von Mandach

引用次数: 0

[Biochemical principles of cervix ripening and dilatation]. [子宫颈成熟和扩张的生化原理]。

Zeitschrift fur Geburtshilfe und Perinatologie Pub Date : 1994-10-01

W Rath, R Osmers, H W Stuhlsatz, B C Adelmann-Grill

{"title":"[Biochemical principles of cervix ripening and dilatation].","authors":"W Rath, R Osmers, H W Stuhlsatz, B C Adelmann-Grill","doi":"","DOIUrl":"","url":null,"abstract":"The central function of the cervix to maintain pregnancy is biochemically characterized by an increased synthesis of collagen, proteins, glycosaminoglycans (GAG) and fibronectin within the extracellular matrix, thus leading to an increase of cervical volume without significant changes of cervical consistency. During the time of cervical ripening we found a marked reduction of collagen concentration, a 2.5-fold increase in GAG content, a significant fall in dermatan sulfate concentrations from 41% to 15% of total GAG content, a 12-fold increase in hyaluronate concentrations, and a marked reduction in fibronectin, demonstrated by immunhistochemical methods. Thus, the loss of collagen and sulfated GAGs may facilitate distensibility in the ripened cervix, while the significant gain in hyaluronate associated with hydratation may explain the soft and swollen consistency. In this connection increased hyaluronate concentrations and degradation of fibronectin may play a trigger role for subsequent cervical dilatation. The dramatic changes of the cervix during parturition occurring within a few hours require the rapid activation and action of catabolic enzyme systems. Our studies showed a significant increase of sialidase-, collagenase- and elastase activities during cervical dilatation. These proteinases originate from polymorphonuclear leucocytes (pml), which accumulate in cervical capillaries at the onset of labor; this is followed by a massive leucocyte infiltration of the cervical stroma at the beginning of cervical dilatation and a degranulation of the pml at further dilatation, thus releasing collagenase and other proteinases. This process is limited by the immediate post partum insudation of the cervix by plasma containing highly potent proteinase inhibitors. The clinical aim of our basic biochemical studies is to develop new concepts in the causal treatment of cervical pathology during pregnancy.","PeriodicalId":23919,"journal":{"name":"Zeitschrift fur Geburtshilfe und Perinatologie","volume":"198 5-6","pages":"186-95"},"PeriodicalIF":0.0,"publicationDate":"1994-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18718966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Prostaglandins and labor onset]. [前列腺素与阵痛]。

Zeitschrift fur Geburtshilfe und Perinatologie Pub Date : 1994-10-01

H P Zahradnik, W Schäfer, B Wetzka, M Breckwoldt

引用次数: 0

[Infection and uterine contraction]. [感染和子宫收缩]。

Zeitschrift fur Geburtshilfe und Perinatologie Pub Date : 1994-10-01

M Winkler

引用次数: 0