The Open Cardiovascular and Thoracic Surgery Journal最新文献

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Cellular Cardiomyoplasty Using Different Stem Cells in a Single Center 单个中心使用不同干细胞的细胞心肌成形术

The Open Cardiovascular and Thoracic Surgery Journal Pub Date : 2009-01-02 DOI: 10.2174/1876533500801010012

Fumin Zhang, Z. Yiang, Yijiang Chen, Wen-zhu Ma, Xiang Gao, Chuanful Li, T. Ha, R. Kao

{"title":"Cellular Cardiomyoplasty Using Different Stem Cells in a Single Center","authors":"Fumin Zhang, Z. Yiang, Yijiang Chen, Wen-zhu Ma, Xiang Gao, Chuanful Li, T. Ha, R. Kao","doi":"10.2174/1876533500801010012","DOIUrl":"https://doi.org/10.2174/1876533500801010012","url":null,"abstract":"Cellular cardiomyoplasty is a procedure that uses live cells to replace, repair or enhance the biological function of a damaged or failing heart. Several types of autologous stem cells from adult human have been used for cellular car- diomyoplasty with encouraging outcomes. However, a direct comparison of different stem cells in a single clinical center has not been reported. We harvested stem cells from skeletal muscle (satellite cells) or bone marrow from different pa- tients and utilized for cellular cardiomyoplasty. Eighteen male patients, suffering acute myocardial infarction were evenly assigned to coronary artery bypass graft and autologous satellite cell implantation or percutaneous coronary intervention and autologous bone marrow cell intra coronary infusion. Cardiac functions were assessed before and at six months after the treatment. All patients who survived the procedures without obvious arrhythmia, had an uneventful recovery, and were discharged from the hospital. One patient from each group was not subjected to coronary artery bypass graft or percutane- ous coronary intervention. Significant improvement in NYHA classification and left ventricular ejection fraction were ob- served to a similar degree for both treatments at six month later. Comparable improvements in local contractility, blood perfusion, tissue viability, and wall thickness at infarct area for all patients who received either type of autologous stem cells were also found. Cellular cardiomyoplasty using either autologous satellite cells or autologous bone marrow cells has equal beneficial outcomes at six months follow-up. A longer follow-up time and large scale randomized controlled trail will be needed to determine the advantages of different stem cells.","PeriodicalId":238767,"journal":{"name":"The Open Cardiovascular and Thoracic Surgery Journal","volume":"126 19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132803248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Esophageal Cancer: Optimization of Management 食管癌:优化管理

The Open Cardiovascular and Thoracic Surgery Journal Pub Date : 2008-10-10 DOI: 10.2174/1876533500801010001

O. Kshivets

引用次数: 5

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