Zaporozhye Medical Journal最新文献

{"title":"ST-segment elevation myocardial infarction and the clinical significance of differentiated electrocardiogram","authors":"V. Tashchuk, O. Malinevska-Biliichuk, P. Ivanchuk, O. S. Polianska","doi":"10.14739/2310-1210.2023.3.267269","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.3.267269","url":null,"abstract":"Aim. To evaluate the markers of changing dynamics recorded by digital processing of routine ECG using own diagnostic complex software “Smart-ECG” in patients with ST-segment elevation myocardial infarction (STEMI) based on the results of a 40-day follow-up.\u0000Materials and methods. The main group consisted of 20 patients with STEMI according to the ESC guidelines (2017) (mean age of males 56.11 ± 11.62, n = 10; mean age of females 58.22 ± 13.11, n = 10). ECG were analyzed using own developed diagnostic complex software “Smart-ECG” on the 1st, 10th, 40th day after STEMI. The first derivative of T wave – ratio of maximum velocity (MVR), inclination angle (β) and inclination height (H) of ST segment was calculated. The control group – 20 apparently healthy people.\u0000Results. MVR indicators decreased by 61.90 %, 68.20 % and 51.48 % on the 1st, 10th and 40th day, respectively, after STEMI as compared to those of the control group (p < 0.01). At the moment of the maximum ST segment elevation, the height (H) of ST inclination was 347.7 % increased (p < 0.01); on the 40th day, H was 25 % increased, close to control indicators, with ST segment shift to isoline (р > 0.05). During the acutest period, the angle β increased by 172.2 % (p < 0.01) and then decreased by 15.8 % at the recovery phase, but insignificantly.\u0000Conclusions. Self-developed medical software “Smart-ECG” for qualitative evaluation of ECG is an effective tool to diagnose pathological changes in the myocardium, makes it possible to improve the specificity, sensitivity and prognostic significance of ECG in STEMI. The significant decrease in MVR has been detected at all stages of STEMI, which was associated with a violation of electrogenesis in the repolarization phase; the critical increase in ST slope indicators (angle β and height H) on the 1st day has been found as a characteristic of ST elevation, as well as its decrease on the 40th day as a sign of reduced potential difference between healthy and damaged areas of the myocardium during the recovery stage.","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77956751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personality profile characteristics of patients with somatoform and anxiety-phobic disorders with phenomena of reduced criticality","authors":"M. Khomitskyi, M. Kondratenko","doi":"10.14739/2310-1210.2023.3.265368","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.3.265368","url":null,"abstract":"The aim: to study the personality characteristics and their relationship with reduced criticality manifestations by examining the personality profile of patients with somatoform and anxiety-phobic disorders.\u0000Materials and methods. A prospective clinical study involved 102 patients: 54 patients with somatoform disorder and 48 patients with anxiety-phobic disorder. Research methods: clinical-psychopathological, clinical-anamnestic, clinical-catamnestic, clinical-psychophenomenological and medical statistical analysis.\u0000Results. As the study result, the peculiarities of the personal characteristics of patients with somatoform and anxiety-phobic disorders and their connection with reduced criticality manifestations have been established. The most common clinical types of accentuations in patients with somatoform disorder have been revealed (“sticking-demonstrative” (16.67 % of the group), “sticking-exalted” (11.11 %), “anxious-demonstrative” (9.26 %) and “demonstrative” (9.26 %) as well as a characteristic pronounced (p < 0.05) reduction in criticality (mainly due to the phenomenon of alexithymia). The prevailing types of accentuation among the contingent with anxiety-phobic disorder (“anxious” (14.58 %) and “anxious-pedantic” (12.50 %)) had a connection (p < 0.01) with a mild degree of reduced criticality.\u0000Conclusions. Based on the differences found in the personality characteristics of patients with somatoform and anxiety-phobic disorders, variations in the degree of severity and pathogenetic mechanisms of reduced criticality have been revealed. The obtained results offer the potential to develop a personalized system for correction of reduced criticality, the use of which would improve the treatment results in patients with somatoform and anxiety-phobic disorders.\u0000 ","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82227508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of metabolic syndrome in the development of polycystic ovary syndrome in adolescence","authors":"N. Avramenko, O. Kabachenko, D. Y. Barkovskyi, К. Sierykh","doi":"10.14739/2310-1210.2023.3.251479","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.3.251479","url":null,"abstract":"The review article presents an analysis of the metabolic syndrome problem in children and adolescents, its role in the development of polycystic ovary syndrome (PCOS) in accordance with the latest International guidelines and modern literature. The urgency of the problem lies in the rapid spread of overweight among children in the world and, consequently, the growth of alimentary-dependent pathology. One of the major consequences of weight problems is metabolic syndrome (MS).\u0000There are still no clear MS criteria for children and adolescents. IDF suggests using IDF criteria for adults. Priority in the pathogenesis of MS is given to insulin resistance (IR), which is associated with puberty. The problem of IR assessment remains. HOMA-IR and QUICKI methods are not considered reliable tests to determine IR, so the assessment is based on clinical signs (hyperglycemia, dyslipidemia, abdominal obesity, hypertension).\u0000Obesity and IR can be predictors of PCOS, which can often be associated with puberty. Pathological signs of the syndrome typical for adults in adolescence may be a manifestation of the physiological course of puberty. Obligative criteria for the diagnosis of PCOS in adolescence are irregular menstruation/oligomenorrhea, proven biochemically and clinically hyperandrogenemia).\u0000First-line therapy for PCOS in adolescents with MS is weight loss and dosed exercise, which helps to normalize a hormonal balance. Drug treatment may include insulin-sensitizing drugs (metformin), antiandrogens (spironlactone, flutamide, cyproterone acetate), 5-alpha-reductase inhibitors (finasteride), combined oral contraceptives, inositol. Prevention of overweight, obesity in children can prevent the development of IR and, accordingly, associated MS and PCOS, reproductive health disorders. Prevention measures are aimed at avoiding maternal obesity, gestational diabetes, malnutrition and smoking during pregnancy, promoting breastfeeding and physical activity.","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89639149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem cells in the context of colon carcinogenesis (a literature review)","authors":"M. Shyshkin","doi":"10.14739/2310-1210.2023.2.272160","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.2.272160","url":null,"abstract":"Aim. To analyze the latest literature data on stem cells in general, intestinal stem cells in particular, as well as cancer stem cells in the context of colon carcinogenesis.\u0000Over the past decade, a significant amount of data confirming the existence of cancer stem cells, their importance in cancer progression, resistance to current treatment regimens, and the occurrence of relapses has been accumulated. These cells are a small fraction of cancer cells that initiate tumor growth and provide tumor tissue heterogeneity. In addition, these cells are distinguished by a significant resistance to effects of various cytotoxic factors. Therefore, the possibility of isolating cancer stem cells and further targeted action are highly important for enabling a complete tumor eradication.\u0000A study on intestinal stem cells has always been in the focus of stem cell biology researchers’ attention because intestinal stem cells are an example of an active cell population that provides regular rapid renewal of the epithelium, which is constantly exposed to toxic, bacterial, and other aggressive factors. Accordingly, colon carcinogenesis is a convenient model for studying the role of stem cells in tumorigenesis.\u0000At the same time, there are two main current schemes of colon carcinogenesis, which are acknowledged – these are so-called “bottom-up” and “top-down” modes of transformed cell spreading. The “bottom-up” scheme was substantiated first, proving to be in good agreement with modern ideas about the structure of intestinal crypts. However, a little later, reports about the possibility of the “top-down” direction began to appear: differentiated cells located in the superficial parts of the intestinal crypts, undergoing mutations, could dedifferentiate and return to the basal parts; a pathological increase in the surface epithelial cells proliferation level was possible as well, leading to an increase in the luminal surface area, formation of grooves mimicking the intestinal crypts.\u0000This review provides the latest data on stem cells in general, in particular on intestinal stem cells, as well as on cancer stem cells in the context of colon carcinogenesis. We also analyze the latest literature data on the possibility of isolating cancer stem cells in colon carcinomas using molecular markers, difficulties associated with this process, and issues that are still unresolved.\u0000Conclusions. Today, there is no doubt about the existence and importance of cancer stem cells in carcinomas. Quite a lot of molecular markers of cancer stem cells have been identified and studied. It is worth noting that certain aspects of cancer stem cells can not be studied one-sidedly but require a multidimensional analysis.","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72793742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors of lumbosacral radiculopathy chronicity","authors":"L. A. Dziak, O. Shulha, V. Suk","doi":"10.14739/2310-1210.2023.2.273614","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.2.273614","url":null,"abstract":"Assessment of chronic factors of acute lumbosacral radiculopathy is an urgent problem due to the disease impact on the quality of life of patients, possible loss of work capacity and disability.\u0000The aim of the work is to identify chronicity factors of acute compressive lumbosacral radiculopathy depending on the severity of degenerative-dystrophic changes in the spine and pathomorphological changes in the zone of disc-radicular conflict based on complex clinical-neurological, neuro-orthopedic, neuroimaging, neurophysiological and statistical methods of examination.\u0000Materials and methods. 100 patients with acute lumbosacral radiculopathy were examined. The patients were divided into two groups: 45 patients with radiculopathy and both discogenic pathology and stenotic process in the spinal canal and/or lateral openings, and 55 patients with radiculopathy developed secondary to a pathology between the vertebral disc at the level of one vertebromotor segment. All the patients underwent neurological, neuroorthopedic, neurophysiological examinations. The study was conducted in two stages – 3–7 days and one months after the disease onset.\u0000Results. On the basis of comprehensive clinical, neuroimaging, neurophysiological examinations and statistical processing of the obtained data, factors affecting the chronicity of acute compressive lumbosacral radiculopathy were identified: age (rs = 0.25, P = 0.012), sex (rs = 0.25, P = 0.012), pain syndrome severity according to the VAS (rs = 0.25, P = 0.011), the presence of a neuropathic component of pain according to the PainDETECT questionnaire (rs = 0.74, P < 0.001), biomechanical disorders of the spine during the Schober test (rs = -0.41, P < 0.001), lateroflexion (rs = -0.30, P = 0.003), extension (rs = 0.28, p = 0.004), damage to Aβ fibers (rs = -0.36, P = 0.009), Aδ-fibers (rs = -0.38, P = 0.006), C-fibers (rs = -0.37, P = 0.008), allodynia (rs = 0.38, P < 0.001), hyperalgesia (rs = -0.24, p = 0.014), muscular-tonic syndrome index (rs = 0.26, p = 0.008), the presence of lumbar canal stenosis (rs = 0.42, P < 0.001), spondyloarthrosis (rs = 0.22, P = 0.028), spondylolisthesis (rs = 0.20, P = 0.047).\u0000Conclusions. The conducted study has revealed the main factors contributing to the development of acute lumbosacral radiculopathy chronicity. The presence of a neuropathic component of pain in the mechanism of pain syndrome development in the acute period of the disease and the involvement of C-fibers in the pathological process in the late stages of the disease are among the important markers contributing to the disease prolongation. Assessment of the factors that determine the chronicity of the course in the acute period of the disease allows to prescribe complex differential therapy at the early stage of the disease.","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87752472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The debut of Schamberg disease (a clinical case)","authors":"S. Matviienko","doi":"10.14739/2310-1210.2023.2.273497","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.2.273497","url":null,"abstract":"A group of pigmented purpuric dermatoses includes a list of skin diseases characterized by multiple petechial hemorrhages, purpura, and increased skin pigmentation (yellow, brown, or red patchy).\u0000Schamberg disease is the most common representative of this group with a benign, chronic and recurrent course of idiopathic origin. The lesions are often asymptomatic or associated with mild pruritus, usually occurring on the lower extremities. The diagnosis is not a dilemma, as it is made based on clinical examinations and identification of the classical rash morphology, but is also emphasizing the role of a wide range of specialists in the evaluation and treatment of this pathological condition.\u0000The aim of the study. To analyze a clinical case of the debut of Schamberg disease.\u0000Results. Considering the sporadic nature and rarity of the disease, the clinical case of Schamberg disease diagnosed in a 53-year-old man who visited a pediatrician concerning his child’s illness is presented. The probable cause of the disease debut was a complex trigger effect (a long-term use of diclofenac sodium, drinking alcohol on the eve).\u0000Conclusions. The report is aimed at drawing attention to Schamberg disease (Schamberg purpura) as a diagnostic and therapeutic challenge not only for general practitioners, internal medicine specialists but also for dermatologists, phlebologists, hematologists in particular.","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78097484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whether exercises and testosterone replacement therapy support a treatment for cardiovascular and atherosclerotic patients with iliac artery stenosis and low total testosterone and high-density lipoprotein cholesterol after endovascular procedure?","authors":"S. Solaković, Nina Solaković, A. Jogunčić, H. Spahović, Fedja Hajrulahović, R. Pavlović, Mensur Vrcić, E. Solaković, Amina Godinjak, I. Skrypchenko, O. Dorofieieva, K. Yarymbash","doi":"10.14739/2310-1210.2023.2.268513","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.2.268513","url":null,"abstract":"Serum levels of testosterone (ST) and high-density lipoprotein (HDL) are generally associated with atherosclerosis in male patients over 50 years with critic iliac stenosis (TASC II A and B) and cardiovascular disease with significant changes in HDL and low-density lipoprotein (LDL). In addition to the standard therapy, combined medicamentous therapy and adequate model of exercise are also important factors as medicines can improve HDL levels and primary bypass and endovascular potency impacting positively on improvement of ST or it can be the following testosterone replacement therapy (TRT) comprising cardiovascular disease prevention and vascular treatment as adjunct therapy options after endovascular and vascular surgical procedures.\u0000The aim of the study is to identify the association between HDL and ST after surgical and endovascular intervention on the iliac segment (TASCII A and B), as well as cardiovascular risk factors with modified medium activity (MET) <6 with short interval increase over >6 (MET), with total duration of 30–60 minutes. It also attempts to remodel a patient behavioral pattern, optimize ST levels and link them to outcomes and patency of vascular procedures on the iliac segment.\u0000Materials and methods. 108 selected male patients with cardiovascular disease combined with metabolic syndrome and critical iliac artery stenosis (TASC II A and B) were examined during 2014–2018, 4 years after invasive and minimal invasive treatment (54 patients were treated with surgical Dacron reconstruction and 54 patients – with endovascular treatment on short segment of critical iliac artery stenosis (TASC II A and B).\u0000Results. In the total population, no difference was observed in changes of constraint-induced movement therapy between the standard exercise group and the control one after 4 years from baseline. However, there was no significant interaction between the effect of exercise trainings and primary bypass potency within 4 years.\u0000Conclusions. Primary effects of endovascular procedure and Dacron bypass revascularization raise the risk of elevated testosterone levels after 4 years of group training but does not provide adequate answers to questions as to whether higher levels of ST have any major influence on primary bypass potency preventing further progression of cardiovascular disease and general symptomatic and asymptomatic atherosclerosis. However, exercise and TRT can be potential adjunctive therapeutic options for a future supporting postsurgical and endovascular illiac treatment in cardiovascular patients with low testosterone levels.","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86325401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of the personal profile of active servicemen with dissomnic manifestations","authors":"G. V. Guk","doi":"10.14739/2310-1210.2023.2.263865","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.2.263865","url":null,"abstract":"Aim: to study specifics of psychopathogenesis and the influence of personal characteristics on the pathopsychological content of dissomnic manifestations in active servicemen of the Armed Forces of Ukraine by examining the personal profile.\u0000Materials and methods. In total, 64 active servicemen of the Armed Forces of Ukraine with inorganic sleep disorders were included in a prospective clinical study on the basis of Military Hospital of Military Unit 3309 (Zaporizhzhia) and served as the study group; the comparison group included 40 patients who were treated at the Department of Borderline Conditions of “Regional Clinical Institution for the Provision of Psychiatric Care” of Zaporizhzhia Regional Council and had sleep disorders within neurotic mental disorders. To achieve the aim of the study, anamnestic, clinical-psychopathological, psychodiagnostic, clinical-psychophenomenological and clinical-statistical methods were used. As a psychodiagnostic tool, the Methodology for studying personality accentuations of K. Leonhard and G. Shmishek was chosen.\u0000Results. The most common types of accentuation in active servicemen with dyssomnic manifestations were sticking (18.75 % of the contingent), dysthymic (17.19 %) and hyperthymic (9.38 %). The most frequent combined clinical types of accentuations were “dysthymic-sticking” (9.38 %), “anxious-dysthymic” (4.69 %) and “hyperthymic-demonstrative” (3.13 %).\u0000Conclusions. As a result of the study, the characteristics of the personal profile and their influence on the pathopsychological content of dissomnic manifestations in active servicemen of the Armed Forces of Ukraine have been determined. The data obtained on the relationship between the personal profile characteristics and clinical types of dyssomnia would provide an opportunity to optimize measures for the detection and psychotherapeutic correction of dissomnic manifestations in active servicemen of the Armed Forces.","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89337968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Alzheimer’s disease in the Odesa region","authors":"I. Khubetova, D. A. Voloshchuk, К. А. Kosenko, Y. Vorokhta","doi":"10.14739/2310-1210.2023.2.270277","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.2.270277","url":null,"abstract":"The aim of the work was to study the epidemiology of Alzheimer’s disease in the Odesa region.\u0000Materials and methods. The study was carried out on the basis of the Regional Mental Health Center (Odesa) in 2016–2021. The data of the primary referral of patients with a verified diagnosis of Alzheimer’s disease were analyzed. Statistical processing of the obtained data was performed by frequency analysis methods using standard MS Excel packages (Microsoft Inc., USA). The population of the Odesa region was determined according to the State Statistics Service of Ukraine.\u0000Results. According to the retrospective analysis over the past 5 years, there was a constant increase in the number of identified patients with Alzheimer’s disease, from 4.9 cases per 100,000 population in 2016 to 6.0 cases in 2020 with a slight predominance of women in the structure of cases. Brain MRI was performed only in 29 (4.6 %) patients, EEG in 41 (6.5 %) patients. There were no cases of familial Alzheimer’s disease or early-onset Alzheimer’s disease. In 2020, Alzheimer’s and dementia deaths reached 14,196 or 2.54 % of total mortality in Ukraine.\u0000Conclusions. The prevalence of Alzheimer’s disease was 6.0 cases per 100,000 in the population of the Odesa region at the end of 2021, which was an order of magnitude less than the global average. The mean score on the MMSE scale was 18.6 ± 0.5. The analysis on subscales has shown the prevalence of memory, spatial orientation and verbal disorders. The Ukrainian population is characterized by the small number of patients of the older age group (3.3 %) and the predominance of female patients (59.4 %).","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81039824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purine metabolism state in patients with type 1 diabetes mellitus","authors":"А. О. Черняєва, B. А, CD Ю. І. Караченцев A, C. A, C. Л. Ю. С. B, A. Cherniaieva, M. R. Mykytiuk, Y. Karachentsev, O. Pliekhova, L. Y. Serhiienko","doi":"10.14739/2310-1210.2023.2.273721","DOIUrl":"https://doi.org/10.14739/2310-1210.2023.2.273721","url":null,"abstract":"The aim of the study. To carry out a comprehensive analysis of the purine metabolism (PM) state and assess its features in patients with type 1 diabetes mellitus (DM).\u0000Materials and methods. 181 patients with type 1 DM were examined (94 women and 87 men) aged 42.5 ± 12.1 years. Indicators of the carbohydrate metabolism state, creatinine (Cr) concentration by the method of Popper, purine bases (PBs) and the activity of xanthine oxidase (XO) by a photometric method, uric acid (UA) by a colorimetric method were determined in fasting venous blood. UA excretion was detected by the colorimetric method, Cr by an enzymatic method.\u0000Renal UA clearance (RCUA), fractional UA clearance (FCUA), total UA tubular reabsorption (TTRUA) and hypoxanthine-guanine-phosphoribosyltransferase (HGPRT) activity were calculated. The comparison group, representative in terms of age and sex, included 25 healthy volunteers.\u0000Results. PM changes in patients with type 1 DM were orientated towards an excessively increased catabolism and insufficient reutilization of PBs. The structure of the detected disorders was as follows: hyperuricemia (HU) (13.8 %), enhanced RCUA (42.8 %), increased XO activity (35.6 %) and inhibition of HGPRT activity (53.3 %). In about 56 % of the subjects, high concentrations of PBs were found, and HU was diagnosed only in every seventh subject.\u0000It was identified that PB concentrations were negatively correlated with the level of XO activity. RCUA and XO activity levels were revealed to be of the greatest informational value for assessing the PM state in patients with type 1 DM. RCUA was significantly associated with the level of UA excretion and HGPRT activity. Relationships of RCUA and FCUA with HbAc1 levels were established. The higher the level of HbAc1, the greater the clearance of RCUA was, especially FCUA, which led to a significant decrease in TTRUA.\u0000Conclusions. PM in type 1 DM is characterized by a high intensity, which is realized due to a decrease in anabolism, increased oxidation and suppression of PB reutilization. Uricemia inadequately reflects the level of UA production in patients with type 1 DM. The severity of PM disorders in type 1 DM patients is associated with the carbohydrate metabolism compensation state.","PeriodicalId":23832,"journal":{"name":"Zaporozhye Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73427665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}