World Journal of Biology Pharmacy and Health Sciences最新文献

{"title":"Review for QSAR studies and drug design of selected heterocyclic nucleus of antitubercular drugs","authors":"R ROBIN JIYO, M VETRIVEL RAJAN, M. HARI SANKERJI","doi":"10.30574/wjbphs.2024.17.2.0056","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.2.0056","url":null,"abstract":"This review article explores the pressing issue of drug-resistant strains of Mycobacterium tuberculosis, which have emerged due to the widespread and uncontrolled use of antibiotics in clinical settings over several decades. In response to this challenge, various methods have been developed for synthesizing new antitubercular compounds. Among these, the fragment-based drug discovery (FBDD) approach has shown promise as an effective strategy. One class of compounds that has exhibited significant potential in combating tuberculosis is 1,2-diazoles. The article discusses the importance of these compounds and their potential as future antitubercular drugs. Additionally, it delves into the various strategies employed in drug development, emphasizing the relevance and efficacy of FBDD. Analytical methods play a crucial role in characterizing antitubercular antibiotics, and the article highlights liquid chromatography and voltammetry as preferred techniques for determining these compounds. The redox (oxidation/reduction) properties of antituberculars make them amenable to analysis using electrochemical methods, with voltammetry being particularly suitable. Furthermore, the article underscores the significance of utilizing voltammetry for quantifying different categories of antibiotics in both dosage forms and human body fluids. The affordability of this method makes it particularly advantageous for developing countries, providing a cost-effective approach to monitor and assess the presence of antitubercular drugs. Overall, the review article offers valuable insights into the current strategies for addressing drug resistance in tuberculosis and highlights the potential of 1,2-diazoles as future antitubercular agents.","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"153 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140417808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UV spectrophotometric determination of chlorthalidone in tablet dosage form by using single point standardization method","authors":"Alfa Jain, Harshada Sanap, Reshma Devkate, S. Sangale","doi":"10.30574/wjbphs.2024.17.2.0064","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.2.0064","url":null,"abstract":"The current research endeavors to elucidate the creation of an uncomplicated, highly sensitive, swift, precise, and cost-effective UV-accepted spectrophotometric method for the quantitative assessment of Chlorthalidone. This is achieved through the utilization of a visible spectrophotometric approach employing single-point standardization and calibration plot methods, for pharmaceutical dosage forms. The equipment employed includes a double-beam UV-visible spectrophotometer, specifically the Shimadzu Model UV1800, with 1cm quartz cells and 0.2 M Sodium hydroxide serving as the solvent. Notably, an absorption maximum is identified at 219 nm. The developed method strictly adheres to Beer’s law. In the case of single-point standardization, the percentage of Chlorthalidone detected falls below the labeled claimed limit. Simultaneously, the tablet formulation is subjected to a percentage purity test using the calibration plot method, revealing that the observed quantity of Chlorthalidone is below the labeled content. This suggests a potential discrepancy in the marketed product of Chlorthalidone, indicating a probable deficiency in the therapeutic effect of the formulation due to the lower amount of Chlorthalidone present. The overall efficacy of the product hinges on the quality assurance of its constituents.","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"8 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reviewing business analytics in healthcare management: USA and African perspectives","authors":"Israel Osejie Okoduwa, Jeremiah Olawumi Arowoogun, Kehinde Feranmi Awonuga, Bankole Ibrahim Ashiwaju, Jane Osareme Ogugua","doi":"10.30574/wjbphs.2024.17.2.0047","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.2.0047","url":null,"abstract":"This comprehensive review explores the application and impact of business analytics in healthcare management, focusing on the distinctive perspectives of the United States and Africa. In an era where data-driven decision-making is paramount, healthcare organizations globally are increasingly turning to business analytics to enhance efficiency, improve patient outcomes, and optimize resource allocation. The review begins by examining the state of business analytics in healthcare management within the United States, a pioneer in adopting advanced analytics solutions. The analysis encompasses the utilization of predictive modeling, data mining, and artificial intelligence to streamline operations, enhance clinical decision-making, and improve patient care. Case studies and success stories from leading healthcare institutions in the USA illustrate the transformative power of business analytics in areas such as patient risk stratification, resource optimization, and population health management. Contrastingly, the review delves into the unique challenges and opportunities that characterize the adoption of business analytics in healthcare across the African continent. Despite facing resource constraints and varying levels of technological infrastructure, African nations are increasingly recognizing the potential of analytics to address pressing healthcare challenges. The discussion encompasses initiatives and collaborations aimed at leveraging data analytics to improve healthcare delivery, disease surveillance, and resource management in the African context. The comparative analysis between the USA and Africa highlights the diversity of approaches and contexts in implementing business analytics in healthcare management. Factors such as data accessibility, infrastructure development, and cultural considerations emerge as critical determinants shaping the successful integration of analytics tools in healthcare decision-making. The review underscores the pivotal role of business analytics in reshaping healthcare management practices, while acknowledging the need for tailored strategies that align with the specific challenges and opportunities inherent in the USA and African healthcare landscapes. This study provides valuable insights for policymakers, healthcare administrators, and researchers seeking to navigate the evolving landscape of healthcare analytics on both a global and regional scale.","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"15 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling adjusted for age and menopause statuses dependent on PET/CT scan for ovarian cancer diagnosis and staging","authors":"Anas Mussallem Mohammed Zboun, Abeer Abdulkareem Mahmoud Alsmadi, Hana Salem Ahmed Al-Soudi, Taghreed Mohammad Atallah Aldajeh, Ahmad Zuhier Qasim Momani, Khaled MG Alkhawaldeh","doi":"10.30574/wjbphs.2024.17.2.0091","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.2.0091","url":null,"abstract":"Aims: The main objective of this observational study is to develop a linear regression model that incorporates age, menopausal status, and family history to predict the risk and severity of ovarian cancer. Methods: In early 2023, the King Hussein Medical Centre's gynaecological clinic began using PET/CT scanning and histopathological analysis to identify ovarian cancer cases. The data was then used to strategize interventions for each patient. The study aimed to assess the probability of ovarian cancer in female patients by analysing their age, menopausal onset, and family history. Patients were classified as pre-menopausal or post-menopausal, and PET/CT scan results were converted into FIGO classifications. Histopathological findings were analysed using ROC and binary logistic regression analyses. The study also used multiple linear regression to determine correlations and variations in the estimated Federation of Obstetrics and Gynaecology (FIGO) grade for females with suspected ovarian cancer. The research developed a pragmatic model to forecast ovarian cancer likelihood and severity levels. Results: The study examined 105 patients with suspected ovarian cancer at King Hussein Medical Centre between 2021 and mid-2023. Only 97 patients (92.38%) had matched FIGO-derived PET/CT scans with biopsy-based histopathological positivity. The optimal FIGO grade was 3.5, with a sensitivity of 77.2%, a specificity of 76.92%, a positive predictive value of 95.95%, a negative predictive value of 32.26%, an accuracy index of 77.14%, and a Youden index of 54.10%. Conclusion: A regression-based model was developed to triage the risk of ovarian cancer. This model enables us to early prioritise suspected females who should undergo PET/CT at the clinic level, with a high positive predictive value of over 90%.","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"73 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140421430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impacts of curbside feedback mechanisms on recycling performance of households in the United States","authors":"Akan Ime Ibokette, Enoch Joseph Aboi, Amina Catherine Ijiga, Solomon Ileanaju Ugbane, Michael Olumubo Odeyemi, Esther Ene Umama","doi":"10.30574/wjbphs.2024.17.2.0102","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.2.0102","url":null,"abstract":"As environmental issues continue to rise and global understanding of the effects of uncontrolled waste production grows, recycling has become an essential part of sustainable waste management methods. The implementation of curbside feedback mechanisms has emerged as a progressive strategy to enhance household recycling performance in the United States. This paper explores the four most popular types of feedback mechanisms (Contamination alerts/penalty, Smart Bins, Mobile Apps, and Incentive Programs) across the United States, their impacts on recycling performance (specifically on recycling participation, reduction in contamination rates, and recycling accuracy), the challenges associated with their acceptance and usage, and the recommended future directions aimed at improving the functionalities of these curbside feedback mechanisms. A comprehensive literature review synthesizes findings from important journals and examines the current state of recycling, the role of behavioral science in recycling, and the factors influencing household recycling performance which are attitude and perception, knowledge and awareness, convenience and infrastructure, social norms and peer influence, etc. It gives insights into the four most common types of curbside feedback mechanisms across the United States. The methodology identifies geographical locations in the US where the curbside feedback mechanism is implemented, and data are gathered from relevant stakeholders. The obtained data is analyzed before and after the introduction of curbside feedback mechanisms, and then these data (qualitative and quantitative) are used to assess the significance of observed changes. The findings showed that Smart Bins with sensors showed 20% increase in participation in 6 months, Cart warnings brought about 15% increase in recycling participation in 4 months while cart refusals produced 20% increase in participation in 3 months, Mobile App with education module showed 25% increase in participation in 3 months, financial incentives revealed 25% increase in recycling participation. The findings further showed Cart warnings showed 25% reduction in contamination in 6 months while cart refusals showed 30% reduction in the first 3 months, Smart bins with sensors showed 15% reduction in contamination rate in 6 months, Mobile App with real-time feedback showed 15% reduction in contamination rate in 2 months, financial incentives showed 15% reduction of contamination in 6 months. Cart warnings showed 20% improvement in recycling accuracy in 4 months, refusal showed 25% in 3 months, on comparison, refusal showed 22% better than warnings. Smart Bins with real-time monitoring showed 15% improvement in 3 months, Mobile App with real-time feedback showed 15% improvement in 2 months, and financial incentives showed 15% improvement in recycling accuracy in 6 months.","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"22 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140421512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic cholecystectomy in obese diabetic women","authors":"Sadam Hussain, Amna Abbasi","doi":"10.30574/wjbphs.2024.17.2.0067","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.2.0067","url":null,"abstract":"Background: Diabetes mellitus is associated with an increased risk of complications after abdominal surgery. We evaluated retrospectively the impact of preoperative risk factors and outcome of diabetic patients after laparoscopic cholecystectomy (LC) compared with open cholecystectomy (OC) for symptomatic gallstones. Objective: To determine Laparoscopic cholecystectomy in obese diabetic women Methods: A cross-sectional study was conducted at Shifa International hospital Islamabad Pakistan, which was performed between April 2020 and March 2022. The total number of patients in our study were 100. The number of female patients were 95 and male were 5. In 100 consecutive patients who underwent for blood tests and some diagnostic tests too. We included only old age people in our study age above than 40 years. We took BMI for every patients. Data was tabulated and analyzed by SPSS. Results: In a current study total 100 patients were enrolled. The minimum age of patients were 40 and the maximum age of the patients were 80. The mean age were 11.81±10.2 years. The minimum BMI were 30 and maximum BMI were 40. The mean BMI were 3.041±13.5. The minimum Operation hours were 1 and maximum Operation hours were 2. The mean of the operation hours were 1.045±3.76. Fig 1, shows us gender distribution, in which 95 were female patients while 5 were male patients. The frequency of male patients were 95 and the percentage were 95. The frequency of female patients were 5 and its percentage were 5. The frequency of nausea patients were 16 and its percentage were 16. The frequency of vomiting patients were 84 and its percentage were 84. The frequency of sever right abdominal patients was present in 97 patients and was not present in 3 patients. The frequency of diabetes mellitus 97 and its percentage were 97 while the frequency of diabetes mellitus were not present in 3 patients. 75% of patients were cholelithiasis while 25% of patients were not affected by cholelithiasis. The second figure shows 18 % of patients have choledocholithiasis and 82 % of patients were not affected by this disease. The third figure shows that 3% of patients have cholecystitis while 97% of patients were not affected by this type of disease. The fourth figure shows that type 2 Diabetes mellitus were present in 97% of patients while were not present in 3% of patients. Conclusion: Laparoscopic cholecystectomy as a new technique for the treatment of cholecystectomy. The main benefit of laparoscopic cholecystectomy for diabetic patients is that the wound recovers fast and its no major complications. In our study females were as compared to males. The operation time is from 1 to 2 hours on laparoscopic Cholecystectomy.","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"10 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140423096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the environmental health and safety risks of solar energy production","authors":"Nwakamma Ninduwezuor-Ehiobu, Alex Olanrewaju Adekanmbi, Uchenna Izuka, Ayodeji Abatan, Emmanuel Chigozie Ani, Alexander Obaigbena","doi":"10.30574/wjbphs.2024.17.2.0080","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.2.0080","url":null,"abstract":"Solar energy production has gained significant traction as a promising alternative to fossil fuels, yet its widespread adoption raises questions regarding its environmental health and safety (EHS) risks. This review presents an overview of the current state of research in assessing these risks associated with solar energy production. Firstly, it examines the environmental impacts of solar energy, including the life cycle assessment of photovoltaic (PV) panels and solar thermal systems. Key considerations include the energy and resources required for manufacturing, transportation, installation, operation, and end-of-life disposal or recycling of solar panels. Furthermore, the potential for land use change, habitat disruption, and biodiversity loss due to large-scale solar installations is addressed. Secondly, the review discusses the safety risks associated with solar energy production, focusing on occupational health and safety hazards for workers involved in manufacturing, installation, maintenance, and decommissioning of solar energy systems. It examines exposure to hazardous materials such as lead, cadmium, and silicon during the manufacturing process, as well as the risks of falls, electrical hazards, and other workplace accidents during installation and maintenance activities. Moreover, the review highlights emerging technologies and best practices aimed at mitigating EHS risks in solar energy production. These include advancements in PV panel recycling technologies, improvements in manufacturing processes to reduce environmental impacts, and enhanced safety protocols and training for workers in the solar energy industry. While solar energy offers numerous environmental and economic benefits as a renewable energy source, it is essential to comprehensively assess and manage its EHS risks throughout the life cycle of solar energy systems. This review underscores the importance of ongoing research, innovation, and regulatory oversight to ensure the sustainable and safe deployment of solar energy technologies in the transition towards a low-carbon future.","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"84 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140423611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are liver abnormalities associated with hospital mortality in viral infections?","authors":"Mohammad Abu Zaid, Mohammad Mamoun Ali Allan, Ali Fayez Mohammad AL-Bourini, Tareq Said Mohammad Alamour, Hadeel Hamad Khazer Aljboor","doi":"10.30574/wjbphs.2024.17.2.0049","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.2.0049","url":null,"abstract":"Objective: Patients hospitalised with severe viral infections may have abnormal liver function. Multiple studies have linked systemic-disseminated viral infections to liver damage. The progression, medical significance, and impact of atypical liver chemical levels on hospitalised infections are unknown. Aims: This study addresses these concerns and examines how liver-related biochemical abnormalities affect viral infection patients' clinical outcomes. Methods: A retrospective study was conducted at the royal medical services’ institutions, focusing on patients admitted over two years. The primary purpose was to gather information about patients who underwent testing. Patients with abnormalities in liver indices, specifically alanine transferase (ALT) and aspartate aminotransferase (AST), were included in the study. Patients with an AST/ALT ratio greater than 2 were excluded. Patients were classified as either having a lower liver disease status (Status I) or a higher liver disease status (Status II). The classification of liver disease statuses was based on the LDH to AST ratio (below 6.5 or higher than 6.5). The study used independent T-tests, Chi Square Test, and multiple logistic regression to analyze non-parametric data. A significance level of 5% was chosen, and SPSS ver 25 was used for the study. The study aimed to determine the effects of gender, severity group at admission, and composite predictors on the likelihood of admitted viral infected patients having liver diseases. Results: MAOVA analysis revealed a significant difference in overall mortality among individuals infected with SARS-VIRAL, based on the LDH: AST 1 and LDH: AST 2 ratios. The statistical test yielded an F-value of 1204.283 with degrees of freedom (2, 778), and a p-value of less than .0005. Additionally, Wilk's Lambda was found to be 0.244, indicating a strong effect size (partial η2 = 0.756). Conclusion: The involvement of the liver in viral infections is directly correlated with mortality, as this correlation is very clear. Therefore, it is of the utmost importance to incorporate hepatic enzymes as a criterion when evaluating patients who have viral infections. This is because of the impact that elevated liver enzymes have on immune cells and, as a result, the overall clinical outcomes. Since this is the case, it is essential for viral patients to undergo daily monitoring of their liver enzymes on a consistent basis.","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"132 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140423813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of body fitness in youth Wushu Athlete Saburai Lampung","authors":"Dewi Sri Sumardilah, Anggela Meylia Maharani, Reni Indriyani","doi":"10.30574/wjbphs.2024.17.2.0059","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.2.0059","url":null,"abstract":"In addition to having good technique, a wushu athlete who wants to achieve optimal performance must also have a high level of body fitness. One component that can be used to measure fitness is endurance (Endurance). VO2Max is a measure that can be used to assess endurance, which is the body's ability to be able to breathe oxygen optimally during strenuous physical activity. Research results (Zawawi, 2021)in wushu athletes in Kediri city showed that 42.86% of wushu athletes turned out to have (VO2Max) with less category. This study aims to determine the most dominant factors related to the body fitness of Saburai Lampung wushu adolescent athletes. The research design used was cross sectional with a total sample of the population, which was 20 people. Data collection was conducted by means of interviews to determine age, sex, smoking habits, and supplement use, while measurements were used to determine nutritional status, body type, and VO2Max. Bivariate analysis using correlation test Rank Spearman and multivariate analysis using multiple logistic regression tests. The results of this study showed that there were 6 people (30%) wushu athletes who had body fitness with less categories. Then there is a very strong relationship between age and VO2Max (p = 0.007; correlation coefficient = 0.728), there is a strong relationship between nutritional status and VO2Max (p = 0.004; correlation coefficient = 0.655), there is a very strong relationship between smoking and VO2Max (p = 0.009; correlation coefficient = -0.800), and there is a sufficient relationship between body type (somatotype) and VO2Max (p = 0.016; correlation coefficient = 0.480). Sex was not associated with VO2Max (p = 0.160), and supplement use was not associated with VO2Max (p = 0.124). Nutritional status is known to be the most dominant factor associated with VO2Max (p = 0.001; OR = 7.025). To increase VO2Max, Saburai Lampung wushu athletes need to maintain good nutritional status through the consumption of nutritious, diverse, and balanced foods every day.","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"492 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140417291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive tools for inflammatory bowel disease: A systematic review and meta-analysis of biochemical markers and intestinal ultrasound compared to endoscopy","authors":"Sagar Ahammed","doi":"10.30574/wjbphs.2024.17.2.0074","DOIUrl":"https://doi.org/10.30574/wjbphs.2024.17.2.0074","url":null,"abstract":"Despite endoscopy's gold standard status, non-invasive tools are revolutionizing Inflammatory Bowel Disease (IBD) management. This systematic review and meta-analysis compared the diagnostic accuracy of biochemical markers, intestinal ultrasound (US), and endoscopy in adults with IBD. This systematic review and meta-analysis aimed to compare the diagnostic accuracy of fecal calprotectin, C-Reactive Protein (CRP), Erythrocyte Sedimentation Rate (ESR), and bowel wall thickness measured by US with endoscopy in IBD patients. We searched electronic databases for most recent studies published between 2012 and 2023, identifying 25 studies comparing at least one non-invasive tool with endoscopy. We pooled sensitivity and specificity for relevant outcomes and conducted subgroup analyses to explore heterogeneity. 25 studies (n=5872 patients) met inclusion criteria. Fecal calprotectin emerged as a powerful diagnostic tool, with pooled sensitivity of 92.5% and specificity of 85.1% for IBD. But it’s performance was less consistent in differentiating active vs. inactive disease and predicting flares. Intestinal US proved reliable for diagnosis, particularly in Crohn's disease (pooled sensitivity 86.3%, specificity 78.9%), and showed promise in assessing activity and predicting treatment response. C-Reactive Protein and Erythrocyte Sedimentation Rate, though less accurate, provided additional information about disease status. Combining calprotectin and US further enhanced prediction accuracy, while decision tree analysis incorporating clinical data and both tools maximized prediction in ulcerative colitis. Non-invasive tools offer invaluable insights for IBD management, complementing and potentially reducing reliance on endoscopy. Standardizing methodologies and developing more specific markers, potentially aided by AI, holds immense potential for personalized, effective IBD care. This evolving landscape paves the way for a future where patients actively participate in their journey, empowered by the growing arsenal of non-invasive tools.","PeriodicalId":23738,"journal":{"name":"World Journal of Biology Pharmacy and Health Sciences","volume":"214 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140417862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}