Volume 5 - 2020, Issue 9 - September最新文献

{"title":"Influence of hormonal stimulation and intermittent cold exposure on the mechanisms of formation of polycystic ovarian syndrome","authors":"I. Kuzmina","doi":"10.26565/2617-409x-2022-9-05","DOIUrl":"https://doi.org/10.26565/2617-409x-2022-9-05","url":null,"abstract":"Introduction. Polycystic ovary syndrome (PCOS) is one of the most pressing problems in gynecological endocrinology. The aim of the study was to elucidate the morphological changes in the ovaries of rats under various types of hormonal exposure in experimental modeling of PCOS. Materials and methods. To study three working experimental models were developed, associated with the introduction of various hormonal drugs into the body of an animal. Model I-st consisted of subcutaneous administration of an estrogen-containing drug at a dose of 3 mg for 25 days. Model II-d involved the development of PCOS by daily subcutaneous administration of 3 mg of dehydroandrostenediol sulfate. The III model - the formation of PCOS in 5 immature rats using dopamine phytoanalogues at a dose of 3 mg subcutaneously for 25 days. The animals were divided into 3 groups: group 1 - rats that were induced with experimental PCOS and kept in a vivarium at a temperature of +23°C (n=8), group 2 - animals that, against the background of experimental PCOS, were exposed to cold exposure (CE) for 4 hours in a chamber with a constant light regime and a temperature of + 4 °C for 25 days (n = 8); group 3 - intact control (n = 8) - healthy rats without PCOS, which were kept in a vivarium at a temperature of + 23°C. Results. Histological examination of the ovaries of group 1 rats revealed morphological changes in the ovaries characteristic of PCOS. The morphological structure of the ovaries corresponded to type II PCOS. In rats of group 3, macroscopically, the ovaries were slightly reduced in size compared to the control group. The levels of adiponectin and leptin as markers of the functional ovarian tissue of PCOS model experiments.When studying the effect of CE on the body of experimental animals, their effect on the formation of tissue cell hyperplasia as a characteristic sign of PCOS was determined. Conclusions. Studies have shown that the formation of PCOS, as well as structural changes in the ovaries, significantly depend on hormonal regulation disorders.","PeriodicalId":23709,"journal":{"name":"Volume 5 - 2020, Issue 9 - September","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78907846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Machine Learning Approaches for Bitcoin Ransomware Payment Detection Systems","authors":"Kirat Jadhav","doi":"10.38124/ijisrt20sep784","DOIUrl":"https://doi.org/10.38124/ijisrt20sep784","url":null,"abstract":"Cryptocurrencies have revolutionized the process of trading in the digital world. Roughly one decade since the induction of the first bitcoin block, thousands of cryptocurrencies have been introduced. The anonymity offered by the cryptocurrencies also attracted the perpetuators of cybercrime. This paper attempts to examine the different machine learning approaches for efficiently identifying ransomware payments made to the operators using bitcoin transactions. Machine learning models may be developed based on patterns differentiating such cybercrime operations from normal bitcoin transactions in order to identify and report attacks. The machine learning approaches are evaluated on bitcoin ransomware dataset. Experimental results show that Gradient Boosting and XGBoost algorithms achieved better detection rate with respect to precision, recall and F-measure rates when compared with k-Nearest Neighbor, Random Forest, Naïve Bayes and Multilayer Perceptron approaches","PeriodicalId":23709,"journal":{"name":"Volume 5 - 2020, Issue 9 - September","volume":"249 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75853570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameliorative Efficacy of Ethanolic Extracts of Curcuma longa (turmeric) Roots and Cassia occidentalis Leaves on Potassium Induced Kidney Damage in Albino Rats","authors":"Nnama T.N, Anibueze C.I.P, Okwara B.O, Okafor M.C","doi":"10.38124/ijisrt20sep746","DOIUrl":"https://doi.org/10.38124/ijisrt20sep746","url":null,"abstract":"The emphasis of harmful health challenges caused by preserved food or processed food is a global problem and the need to reduce its effect on the vital organs in the body has been the subject of great concern to researchers. The present study seeks to evaluate the efficacy of ethanolic extracts of Curcuma longa (turmeric) roots and Cassia occidentalis leaves on potassium induced kidney damage in albino rats. Fifty adult male rats weighing about 100g-200g classified into ten groups (I-X) were used in the study. Group1 served as control and were administered only with distilled water and rat feeds ad libitum all throughout the experiment. Group II served as negative (-ve) control and were administered 50mg/kg bodyweight of potassium bromate orally. Groups III, IV, VII and VIII received 50mg/kg bodyweight of potassium bromate for two weeks thereafter received 50mg/kg bodyweight with 500mg and 1000mg/kg body weight of ethanolic root extract of Curcuma longa and leaves extract Cassia occidentalis respectively for two weeks. Groups V, VI, and IX and X received 500mg and 1000mg/kg bodyweight of ethanolic root extract of Curcuma longa and leaves extract Cassia occidentalis for two weeks thereafter received 50mg/kg bodyweight of potassium bromate withethanolic root extract of Curcuma longa and leaves extract Cassia occidentalis respectively for two weeks. The rats at the end of 28 days were anaesthetised, blood samples were collected and the kidneys were harvested. The result of biochemical analysis revealed significant decrease in the level of biochemical parameters following administration of 500mg/ kg and 1000mg/kg body weight of Curcuma longa and Cassia occidentalis ethanolic leaf extract for curative and protective purpose when compared with group II (+ve control) that received 50mg/kg body weight of potassium bromate. Histological findings revealed restoration and protection of the extracts on the kidney architecture of male albino rats. Results obtained thus showed that oral administration of ethanolic root extracts of Curcuma longa and leaf extract of Cassia occidentalis may possess preventive and therapeutic purpose against kidney damage","PeriodicalId":23709,"journal":{"name":"Volume 5 - 2020, Issue 9 - September","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82371416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electronic Commerce: Validity of the Digital Contract Based on Indonesia Legislation Perspective","authors":"Sunaryo, Hanifah Nuraini","doi":"10.38124/ijisrt20sep412","DOIUrl":"https://doi.org/10.38124/ijisrt20sep412","url":null,"abstract":"Technological developments in the economic sector, a transaction renewal known as electronic commerce. Transactions that occur in e-commerce are categorized as digital contracts. The use of digital contracts in Indonesia does not escape a number of problems, which is legal. Legal issues that appear in this digital transaction are related to the element of validity. Digital contracts as a new type of contract cannot be equated with conventional contracts, because there are different limitations. This condition resulted in the implementation of digital contracts being facilitated thoroughly by regulations. This paper will examine legal issues in the implementation of digital contracts and understand the legality of digital contracts based on legal instruments in Indonesia.","PeriodicalId":23709,"journal":{"name":"Volume 5 - 2020, Issue 9 - September","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77874436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Ownership Structure and Income Management on Corporate Social Responsibility Disclosure","authors":"F. F. Farhah, Iranti Safriyana","doi":"10.38124/ijisrt20sep722","DOIUrl":"https://doi.org/10.38124/ijisrt20sep722","url":null,"abstract":"The purpose of this study is to provide evidence of the influence of managerial ownership, institutional ownership, foreign ownership, and earnings management of corporate social responsibility disclosure. The sample used was 15 companies with a purposive sampling method. The data used in this study uses secondary data in the form of annual financial reports and annual reports of manufacturing companies listed on the Indonesia Stock Exchange 2014-2017. The study results found that managerial ownership, institutional ownership, and earnings management have no significant impact on corporate social responsibility disclosure. However, foreign ownership has a significant effect on corporate social responsibility disclosure.","PeriodicalId":23709,"journal":{"name":"Volume 5 - 2020, Issue 9 - September","volume":"138 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78580901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of CRISPR/Cas9 in Genetic Manipulation of ROS1 and EGFR Genes using Synthego Platform","authors":"M. Goenka, Aniket De, A. Biswas","doi":"10.38124/ijisrt20sep592","DOIUrl":"https://doi.org/10.38124/ijisrt20sep592","url":null,"abstract":"Mutations and fusions in kinase enzymes are often observed in cancer prognosis. The growth and survival of tumor cells depend on the activation of kinase enzymes which when activated unrestrained can lead to the uncontrolled division of malignant lung cells. Thus, their inhibition is viewed as a promising and effective anti-cancer therapy. ROS1 and EGFR are two tyrosine kinases that have been explored as the genes responsible for Non-Small Cell Lung Cancer (NSCLC). By interrupting the unchecked division of these genes, the development of malignant lung cancer cells can be blocked. The results show 4 of the top-line RNAs for altering the gene quality as well as the target sequences relevant to cleavage by that gRNA, 4 for each gene. We propose a genetic approach of controlling the ROS1 and EGFR genes guided by CRISPR/Cas-9 to guarantee fewer symptoms and an increasingly powerful treatment, by the use of computational tools.","PeriodicalId":23709,"journal":{"name":"Volume 5 - 2020, Issue 9 - September","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76456143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Health Care Behavior Differences Between Dental and Biomedical Engineering Students Comparing Oral Care of Dental and Engineering Students","authors":"Ayşe Koçak-Büyükdere, Sarkis Sözkes, M. Bozkurt","doi":"10.38124/IJISRT20SEP590","DOIUrl":"https://doi.org/10.38124/IJISRT20SEP590","url":null,"abstract":"The aim of the study was to compare the oral hygiene habits of students from different provinces and universities, from the dental faculty and biomedical engineering. Another aim was to analyze development of dental care habits during growth in relation to education both the parent and the student himself. University students were asked to answer the survey on voluntary basis. 244 students have answered the questions; gender, year of birth, study level, education of their parents, their toothbrushing habit and oral health level awareness were questioned in detail. Of the 244 volunteers, 122 study at the faculty of dentistry, whereas the other 122 study at the biomedical engineering faculty. While 53.7% of all participants brush their teeth after breakfast and 94.3% brush before bedtime, 81.1% of dentistry students brush twice a day, whereas the ratio of biomedical students brushing twice a day is 59.8%. On the one hand, 99.2% of dentistry students brush their teeth before going to bed whereas, biomedical students were 89.3%, which indicates a significant difference. Dental floss utilization among dental students was higher than the biomedical students, and the difference was statistically significant. For self-assessment of their oral hygiene habits, both groups have evaluated themselves between ordinary and well. Tooth brushing habit is initially adopted from the family. Correct brushing is established upon the guidance of the dentist. Therefore, teaching proper toothbrushing techniques to the families should be aimed. This will enable socially healthier oral hygiene, thus creating high awareness communities","PeriodicalId":23709,"journal":{"name":"Volume 5 - 2020, Issue 9 - September","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89529873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Just in Time Implementation and Total Quality Management Using Confirmatory Factor Analysis","authors":"Irawati Nursaningsih, Niken Sulistyowati","doi":"10.38124/IJISRT20SEP510","DOIUrl":"https://doi.org/10.38124/IJISRT20SEP510","url":null,"abstract":"There are research gaps and phenomena that occur in the era of globalization need to be done research that aims to know and evaluate the implementation of Just in time (JIT) and Total Quality Management (TQM) using Confirmatory Factor Analysis (CFA). The research was conducted at PT. XYZ. Resources are obtained through field observations, interviews, documentation and questionnaires using a sample of 180 respondents. Data is obtained from primary and secondary data sources. According to the level of explanation including qualitative descriptive research. The analysis technique used is descriptive analysis using Confirmatory Factor Analysis (CFA). The results showed that PT. XYZ has implemented JIT and TQM only found a few obstacles. This research has implications on managerial policy and can be used by management in determining company policies to produce JIT and TQM which both CFA Test Results show the highest standardize estimated value exists in the flexible workforce dimension which is the right way especially in the JIT section and an important initial role before the implementation process where the main focus is employees. While the implementation of good TQM the highest standardize estimated value is in the respect for employee’s dimension which is the right way especially in the TQM section.","PeriodicalId":23709,"journal":{"name":"Volume 5 - 2020, Issue 9 - September","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86203198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vietnamese Tourist Attraction in Term of AgroTourism Development, a Case Study at Tra Que Village, Quang Nam Province, Viet Nam","authors":"Ha Van Trung, S. Simaraks","doi":"10.38124/IJISRT20SEP586","DOIUrl":"https://doi.org/10.38124/IJISRT20SEP586","url":null,"abstract":"Agro-tourism is a form of rural tourism that has actively developed in recent years. Tra Que Vegetable Village has developed this type of tourism to meet the needs of visitors to visit and experience. However, Vietnamese tourists to experience agrotourism here are very few. The purpose of this study is to find out and determine the level of attraction to Vietnamese tourists in agro-tourism in Tra Que vegetable village. Participants responded questionnaire of the survey in term of participation levels in agricultural activities, and assessment of service quality and tourist's satisfaction reflecting after participating in the agro-tourism experience. The results indicate that most of the tourists participate partly in agricultural activities, the quality of service is good, and the level of visitor satisfaction is high. In general, the ability to attract Vietnamese tourists to agricultural tourism is high. Increasing visitor participation in agri-tourism activities will further enhance the ability to attract Vietnamese tourists in Tra Que Vegetable Village.","PeriodicalId":23709,"journal":{"name":"Volume 5 - 2020, Issue 9 - September","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85909798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Preterm Induction of Labour","authors":"Kritika Agrawal, Shubhangi Mande, Lakshmi Rachakonda","doi":"10.38124/IJISRT20SEP618","DOIUrl":"https://doi.org/10.38124/IJISRT20SEP618","url":null,"abstract":"Worldwide 20-30% of labour cases are induced. We conducted an analysis to evaluate the success of labour induction for indicated preterm birth A prospective observational study was conducted among 50 patients admitted in the Department of OBGY, MGM Medical College and Hospital, Aurangabad from 1st March 2019 to 31st March 2020. There was a total of 50 deliveries during this period. The preterm induction majorly includes 20-34 years as this is the commonest reproductive age group seen in our hospital. More number of Hindus underwent induction. Multigravida requires induction more as compared to primigravida. More number of patients were induced between 32-36 weeks, reason being PPROM, severe preeclampsia, IUD and severe FGR. Vaginal delivery is more likely irrespective of bishop score. Induction of labour remains relevant obstetrics procedure and its outcome will depend on proper choice of patients and close intrapartum monitoring","PeriodicalId":23709,"journal":{"name":"Volume 5 - 2020, Issue 9 - September","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72547581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}