Vitamin C - an Update on Current Uses and Functions最新文献

Ascorbate as an Enzyme Cofactor 抗坏血酸作为一种酶辅助因子

Vitamin C - an Update on Current Uses and Functions Pub Date : 2020-01-23 DOI: 10.1201/9780429442025-5

M. Vissers, Andrew B Das

引用次数: 8

Introductory Chapter: Vitamin C 导论:维生素C

Vitamin C - an Update on Current Uses and Functions Pub Date : 2019-01-03 DOI: 10.5772/INTECHOPEN.83392

J. Leblanc

引用次数: 1

Vitamin C: An Epigenetic Regulator 维生素C:表观遗传调节剂

Vitamin C - an Update on Current Uses and Functions Pub Date : 2018-12-20 DOI: 10.5772/INTECHOPEN.82563

F. Pehlivan

{"title":"Vitamin C: An Epigenetic Regulator","authors":"F. Pehlivan","doi":"10.5772/INTECHOPEN.82563","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.82563","url":null,"abstract":"Vitamin C is an essential micronutrient, a free radical scavenger; while it has functions such as blocking oncogenic transformation induced by carcinogens. A different view of the potential action of vitamin C in cancer came from the discovery of its importance for activation of ten-eleven translocation (TET) enzymes that are involved in demethylation of DNA and histones. Aberrant DNA and histone methylation are hallmarks of all cancers and may result from altered expression or point mutations in the genes encoding these regulatory enzymes. Recent studies have shown that vitamin C potentiates the effects of DNA methyltransferase inhibi-tors. Epigenetic alterations, along with genetic mutations, are known to contribute to onset of cancer. Vitamin C is found to be a key mediator of the interface between genome and environment, regulating DNA demethylation as a cofactor for TET dioxygenases. It is shown that vitamin C drives active removal of DNA methylation by enhancing TET enzymes, which helps to erase DNA methylation and epigenetic memory encoded by it to improve reprogramming of differentiated cells to an embryonic-like state. Here, an overview of the role of vitamin C as an essential factor for epigenetic regulation and its potential in epigenetic therapy in cancer patients is provided.","PeriodicalId":23668,"journal":{"name":"Vitamin C - an Update on Current Uses and Functions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81757973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Vitamin C, Aged Skin, Skin Health 维生素C，老化皮肤，皮肤健康

Vitamin C - an Update on Current Uses and Functions Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.81268

P. Humbert, L. Louvrier, P. Saas, C. Viennet

{"title":"Vitamin C, Aged Skin, Skin Health","authors":"P. Humbert, L. Louvrier, P. Saas, C. Viennet","doi":"10.5772/INTECHOPEN.81268","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.81268","url":null,"abstract":"Vitamin C is an essential nutriment for humans. Vitamin C is known for its antioxidant potential. Vitamin C acts as a potent water-soluble antioxidant in biological fluids. Thus, topical vitamin C will not only reduce the risks of development of photoaging but also could reduce the risk of carcinogenesis. In addition to its antioxidant properties, vitamin C is essential for collagen synthesis. Vitamin C stimulates or restores several mechanisms which are either deficient or disturbed. Topical application of vitamin C partially restores the anatomical structure of the epidermal-dermal junction in young skin. A clinical trial confirmed for the first time that topical application of 5% vitamin C over a period of 6 months significantly improves the clinical appearance of photodamaged skin when compared to the vehicle alone. In inflammatory skin diseases, that is, atopic dermatitis and psoriasis, vitamin C levels into the dermis are reduced. Moreover, a randomized double-blind comparative study conducted in patients with Bateman purpura showed a significant improvement that vitamin C is probably one of the main topical anti-aging agents. In addition, the use of photo-protective sunscreen after UV irradiation prevents the decrease of acid ascorbic dermis concentration. Indeed, the ingestion of vitamin C has different benefits on skin such as wound healing, cutaneous aging, and prevention of skin cancer.","PeriodicalId":23668,"journal":{"name":"Vitamin C - an Update on Current Uses and Functions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86755060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3