Vitamin K - Recent Advances, New Perspectives and Applications for Human Health [Working Title]最新文献

A Perspective of Diverse Synthetic Approaches and Biological Applications of Vitamin K 维生素K的多种合成方法及生物学应用展望

Vitamin K - Recent Advances, New Perspectives and Applications for Human Health [Working Title] Pub Date : 2021-09-15 DOI: 10.5772/intechopen.99565

Satyanarayana Battula

{"title":"A Perspective of Diverse Synthetic Approaches and Biological Applications of Vitamin K","authors":"Satyanarayana Battula","doi":"10.5772/intechopen.99565","DOIUrl":"https://doi.org/10.5772/intechopen.99565","url":null,"abstract":"Vitamin-K is a demanding multi-functional health product in the market and belongs to a class of isoprenoid molecules that comprises methylnaphthoquinone (MK) unit attached to an isoprene side chain. They are fat soluble and differ in the extent of side chain & obtained in the nature as vitamin K1 (phylloquinone), menaquinone/vitamin K2, and other lipoquinones. Owing to their owned polyprenyl side chain, they are hydrophobic/lipophilic in nature. Generally, the synthesis of vitamin K and its variants suffers with isomerization (for example 11 isomers were identified for cis/trans MK-7). Naturally, in bio-systems vitamin K produces through shikimic acid pathway and terpene biosynthetic pathway for the synthesis of menaquinone part & prenyl side chain parts respectively. Menadione or its auxiliaries are commonly being used as substrates to the synthesis of vitamin K variants through the involvement of condensation reactions, Friedel-Craft alkylation’s, Claisen rearrangement, Diels-Alder reactions and others. Importantly, organometallic reagents, such as Grignard, Gilman, organotelluride and other reagents could be the promising and consistent choice of substrate to the synthesis of various vitamin K’s. Vitamin K is well known for blood coagulation. As an antihaemorrhagic vitamin, it’s also being the current interest for the treatment of bone and vascular diseases. In addition, vitamin k is indispensable for the activation of vitamin K dependent (VKD) proteins and that are present almost in all tissues and responsible for hemostasis, bone mineralization, arterial calcification, apoptosis, phagocytosis, growth control, chemotaxis, and signal transduction. This chapter summarizes various synthetic approaches of vitamin K & derivatives and their biological functions.","PeriodicalId":23655,"journal":{"name":"Vitamin K - Recent Advances, New Perspectives and Applications for Human Health [Working Title]","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79565153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Menaquinone-7: Wide Ranging Physiological Relevance in Muscle and Nerve Health 甲基萘醌-7:肌肉和神经健康的广泛生理相关性

Vitamin K - Recent Advances, New Perspectives and Applications for Human Health [Working Title] Pub Date : 2021-09-08 DOI: 10.5772/intechopen.99809

D. Mehta, A. de Souza, Shashank S. Jadhav

引用次数: 1

Vitamin K Deficiency and Vascular Calcification. Is There Any Evidence about Its Impact on Coronary Artery Disease? 维生素K缺乏与血管钙化。有证据表明它对冠状动脉疾病有影响吗?

Vitamin K - Recent Advances, New Perspectives and Applications for Human Health [Working Title] Pub Date : 2021-08-12 DOI: 10.5772/intechopen.99335

T. Michailidis, A. Karakanas, N. Schizas, P. Keryttopoulos

{"title":"Vitamin K Deficiency and Vascular Calcification. Is There Any Evidence about Its Impact on Coronary Artery Disease?","authors":"T. Michailidis, A. Karakanas, N. Schizas, P. Keryttopoulos","doi":"10.5772/intechopen.99335","DOIUrl":"https://doi.org/10.5772/intechopen.99335","url":null,"abstract":"Nowadays cardiovascular disease remain globally the leading cause of mortality. Coronary artery disease is the predominant clinical entity related to fatal cardiovascular events, while its development is mostly associated with progressive atherosclerosis of the vessels combined with gradual vascular calcification. It is well described and understood that vascular calcification is strongly associated with the occurrence of CVD and increased mortality rates. Therefore, it is essential to understand the metabolic pathways leading to its formation in order to develop effective therapies. A group of vitamin-k dependent proteins seems to play a significant role on the prevention of the arterial wall. Several past studies have shown that in cases of vitamin-k deficiency the process of vessel calcification is accelerated. Vitamin-k depletion and high levels of uncarboxylated and dephosphorylated forms of the aforementioned proteins are considered as important factors that contribute significantly to this rapid progression. Promising studies are giving the stimulus for further research in the field of vitamin-k supplementation and the suspension of vascular calcification.","PeriodicalId":23655,"journal":{"name":"Vitamin K - Recent Advances, New Perspectives and Applications for Human Health [Working Title]","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89791719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiological and Cellular Functions of Vitamin K on Cardiovascular Function 维生素K对心血管功能的生理和细胞功能

Vitamin K - Recent Advances, New Perspectives and Applications for Human Health [Working Title] Pub Date : 2021-08-05 DOI: 10.5772/intechopen.99344

M. Aljafary, H. Alshwyeh, Nada Alahmadi, A. Shehzad, H. Tombuloglu, Zagit Z. Gaymalov, Abdelqader Homieda, E. Al-Suhaimi

{"title":"Physiological and Cellular Functions of Vitamin K on Cardiovascular Function","authors":"M. Aljafary, H. Alshwyeh, Nada Alahmadi, A. Shehzad, H. Tombuloglu, Zagit Z. Gaymalov, Abdelqader Homieda, E. Al-Suhaimi","doi":"10.5772/intechopen.99344","DOIUrl":"https://doi.org/10.5772/intechopen.99344","url":null,"abstract":"This chapter reviews the physiological and cellular functions of vitamin K in the cardiovascular system based on the latest pre-clinical and clinical evidence. Vitamin K belongs to a family of structurally similar fat-soluble vitamins, actively required by the body for the synthesis of essential proteins as well as regulate blood clotting, bone metabolism and calcium level. The authors emphasize the quintessential association between dietary vitamin K2 and cardiovascular diseases shown in various studies. The association, through the vitamin K - dependent hormones, plays a primary role in regulating calcification of different cell types, especially their role in calcification of the vascular endothelial cells. The consequences of vitamin K deficiency in the vascular system are unfavorable, shown in various clinical studies on statins - well-known inhibitors of vitamin K production in the body. New clinical insights suggest that vitamin K levels in the body and its dietary supplementation play a crucial role in cardiovascular disease prevention. There is negative influence of these antagonist’s pate in vascular composition and functions. Therefore, there is a need for prospective studies to make more in-depth exploration and increase the current understanding of this critical relationship to confidently apply such knowledge to prevent cardiovascular diseases and improve their outcomes.","PeriodicalId":23655,"journal":{"name":"Vitamin K - Recent Advances, New Perspectives and Applications for Human Health [Working Title]","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77921995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Overcoming the Photochemical Problem of Vitamin K in Topical Application 局部应用中维生素K光化学问题的解决

Vitamin K - Recent Advances, New Perspectives and Applications for Human Health [Working Title] Pub Date : 2021-08-03 DOI: 10.5772/intechopen.99310

S. Goto, S. Setoguchi, K. Matsunaga, J. Takata

引用次数: 0