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Cytokines reprogram airway sensory neurons in asthma. 细胞因子对哮喘中的气道感觉神经元进行了重编程。
Welding International Pub Date : 2024-09-18 DOI: 10.1101/2023.01.26.525731
Théo Crosson, Shreyas Bhat, Jo-Chiao Wang, Clara Salaun, Eleanne Fontaine, Katiane Roversi, Herbert Herzog, Moutih Rafei, Rikard Blunck, Sebastien Talbot
{"title":"Cytokines reprogram airway sensory neurons in asthma.","authors":"Théo Crosson, Shreyas Bhat, Jo-Chiao Wang, Clara Salaun, Eleanne Fontaine, Katiane Roversi, Herbert Herzog, Moutih Rafei, Rikard Blunck, Sebastien Talbot","doi":"10.1101/2023.01.26.525731","DOIUrl":"10.1101/2023.01.26.525731","url":null,"abstract":"<p><p>Nociceptor neurons play a crucial role in maintaining the body's homeostasis by detecting and responding to potential dangers in the environment. However, this function can be detrimental during allergic reactions, since vagal nociceptors can contribute to immune cell infiltration, bronchial hypersensitivity, and mucus imbalance, in addition to causing pain and coughing. Despite this, the specific mechanisms by which nociceptors acquire pro-inflammatory characteristics during allergic reactions are not yet fully understood. In this study, we aimed to investigate the molecular profile of airway nociceptor neurons during allergic airway inflammation and identify the signals driving such reprogramming. Using retrograde tracing and lineage reporting, we identified a unique class of inflammatory vagal nociceptor neurons that exclusively innervate the airways. In the ovalbumin mouse model of airway inflammation, these neurons undergo significant reprogramming characterized by the upregulation of the NPY receptor <i>Npy1r</i>. A screening of cytokines and neurotrophins revealed that IL-1β, IL-13 and BDNF drive part of this reprogramming. IL-13 triggered <i>Npy1r</i> overexpression in nociceptors via the JAK/STAT6 pathway. In parallel, sympathetic neurons and macrophages release NPY in the bronchoalveolar fluid of asthmatic mice, which limits the excitability of nociceptor neurons. Single-cell RNA sequencing of lung immune cells has revealed that a cell-specific knockout of Npy1r in nociceptor neurons in asthmatic mice leads to an increase in airway inflammation mediated by T cells. Opposite findings were observed in asthmatic mice in which nociceptor neurons were chemically ablated. In summary, allergic airway inflammation reprograms airway nociceptor neurons to acquire a pro-inflammatory phenotype, while a compensatory mechanism involving NPY1R limits nociceptor neurons' activity.</p>","PeriodicalId":23605,"journal":{"name":"Welding International","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11429693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81638241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics analysis and monitoring of friction stir welded dissimilar AA5083/AA6061-T6 using acoustic emission technique 利用声发射技术分析和监测摩擦搅拌焊接异种 AA5083/AA6061-T6 的特性
Welding International Pub Date : 2024-07-24 DOI: 10.1080/09507116.2024.2376187
S. Kannaiyan, S. Murugesan, Dhamotharakannan Thirumalaikannan, Balasubramanian Visvalingam, B. P. Nagasai
{"title":"Characteristics analysis and monitoring of friction stir welded dissimilar AA5083/AA6061-T6 using acoustic emission technique","authors":"S. Kannaiyan, S. Murugesan, Dhamotharakannan Thirumalaikannan, Balasubramanian Visvalingam, B. P. Nagasai","doi":"10.1080/09507116.2024.2376187","DOIUrl":"https://doi.org/10.1080/09507116.2024.2376187","url":null,"abstract":"","PeriodicalId":23605,"journal":{"name":"Welding International","volume":"23 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141806232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Edge detection in x-ray images of drill mast welds based on an improved Scharr operator 基于改进型沙尔算子的钻杆焊缝 X 射线图像边缘检测
Welding International Pub Date : 2024-07-17 DOI: 10.1080/09507116.2024.2378818
Wenjun Qian
{"title":"Edge detection in x-ray images of drill mast welds based on an improved Scharr operator","authors":"Wenjun Qian","doi":"10.1080/09507116.2024.2378818","DOIUrl":"https://doi.org/10.1080/09507116.2024.2378818","url":null,"abstract":"","PeriodicalId":23605,"journal":{"name":"Welding International","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141828283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimentally validated numerical prediction of laser welding induced distortions of Al alloy parts for railcar body by inherent strain method combined with thermo-elastic-plastic FE model 利用固有应变法结合热塑 FE 模型，对轨道车车体铝合金部件激光焊接诱发变形进行实验验证的数值预测
Welding International Pub Date : 2024-06-07 DOI: 10.1080/09507116.2024.2354262
Hongxiao Wang, Chunsheng Wang, Jiancai Di, Zhangqi Yan, Liguo Liu
{"title":"Experimentally validated numerical prediction of laser welding induced distortions of Al alloy parts for railcar body by inherent strain method combined with thermo-elastic-plastic FE model","authors":"Hongxiao Wang, Chunsheng Wang, Jiancai Di, Zhangqi Yan, Liguo Liu","doi":"10.1080/09507116.2024.2354262","DOIUrl":"https://doi.org/10.1080/09507116.2024.2354262","url":null,"abstract":"","PeriodicalId":23605,"journal":{"name":"Welding International","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141371351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding of thermal behaviour in keyhole plasma arc welding process through numerical modelling–an overview 通过数值建模了解锁孔等离子弧焊过程中的热行为--综述
Welding International Pub Date : 2024-05-14 DOI: 10.1080/09507116.2024.2349917
Kumud Ranjan, Sushovan Basak, Manoj Kr. Gopaliya
{"title":"Understanding of thermal behaviour in keyhole plasma arc welding process through numerical modelling–an overview","authors":"Kumud Ranjan, Sushovan Basak, Manoj Kr. Gopaliya","doi":"10.1080/09507116.2024.2349917","DOIUrl":"https://doi.org/10.1080/09507116.2024.2349917","url":null,"abstract":"","PeriodicalId":23605,"journal":{"name":"Welding International","volume":"89 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of post-weld heat treatment on mechanical and microstructural properties of high strength steel weld metal 焊后热处理对高强度钢焊接金属机械性能和微观结构性能的影响
Welding International Pub Date : 2024-05-07 DOI: 10.1080/09507116.2024.2348008
Ebrahim Harati, Ehsan Harati, Uchenna Onochie
{"title":"Effect of post-weld heat treatment on mechanical and microstructural properties of high strength steel weld metal","authors":"Ebrahim Harati, Ehsan Harati, Uchenna Onochie","doi":"10.1080/09507116.2024.2348008","DOIUrl":"https://doi.org/10.1080/09507116.2024.2348008","url":null,"abstract":"","PeriodicalId":23605,"journal":{"name":"Welding International","volume":"106 s414","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141002992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A study on effect of laser overlay welding parameters of stainless steel 301 LN: tensile test, microstructure analysis and microhardness evaluation 不锈钢 301 LN 激光堆焊参数的影响研究：拉伸试验、微观结构分析和显微硬度评估
Welding International Pub Date : 2024-04-19 DOI: 10.1080/09507116.2024.2342342
Payam Farhadipour, S. Dehghan, N. Barka, Asim Iltaf, Pedram Farhadipour
{"title":"A study on effect of laser overlay welding parameters of stainless steel 301 LN: tensile test, microstructure analysis and microhardness evaluation","authors":"Payam Farhadipour, S. Dehghan, N. Barka, Asim Iltaf, Pedram Farhadipour","doi":"10.1080/09507116.2024.2342342","DOIUrl":"https://doi.org/10.1080/09507116.2024.2342342","url":null,"abstract":"","PeriodicalId":23605,"journal":{"name":"Welding International","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140683850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of effect of post weld heat treatment on microhardness and microstructure of auto TIG welded stabilized SA213 TP347H weldments 研究焊后热处理对自动氩弧焊稳定化 SA213 TP347H 焊件显微硬度和显微组织的影响
Welding International Pub Date : 2024-04-19 DOI: 10.1080/09507116.2024.2342340
Pradip K. Gajjar, Bharat C. Khatri, Rajesh Jha
{"title":"Investigation of effect of post weld heat treatment on microhardness and microstructure of auto TIG welded stabilized SA213 TP347H weldments","authors":"Pradip K. Gajjar, Bharat C. Khatri, Rajesh Jha","doi":"10.1080/09507116.2024.2342340","DOIUrl":"https://doi.org/10.1080/09507116.2024.2342340","url":null,"abstract":"","PeriodicalId":23605,"journal":{"name":"Welding International","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140684413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A critical overview on fracture mechanical characterization on marine grade structural materials and its welds 海洋级结构材料及其焊缝的断裂力学特性分析综述
Welding International Pub Date : 2024-04-16 DOI: 10.1080/09507116.2024.2338405
Vysakh Kadayath Bijukumar, Mathiazhagan Andy, Satheesh Babu Perukkavungal Kollerithodiyil, Krishna Prasad Shaji
{"title":"A critical overview on fracture mechanical characterization on marine grade structural materials and its welds","authors":"Vysakh Kadayath Bijukumar, Mathiazhagan Andy, Satheesh Babu Perukkavungal Kollerithodiyil, Krishna Prasad Shaji","doi":"10.1080/09507116.2024.2338405","DOIUrl":"https://doi.org/10.1080/09507116.2024.2338405","url":null,"abstract":"","PeriodicalId":23605,"journal":{"name":"Welding International","volume":"20 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140697546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wire arc additive manufacturing using high-strength steel tubular and solid wires 使用高强度钢管和实心线材的线弧快速成型技术
Welding International Pub Date : 2024-04-15 DOI: 10.1080/09507116.2024.2337163
Ebrahim Harati, Bibu Jose, Mattias Igestrand
{"title":"Wire arc additive manufacturing using high-strength steel tubular and solid wires","authors":"Ebrahim Harati, Bibu Jose, Mattias Igestrand","doi":"10.1080/09507116.2024.2337163","DOIUrl":"https://doi.org/10.1080/09507116.2024.2337163","url":null,"abstract":"","PeriodicalId":23605,"journal":{"name":"Welding International","volume":"44 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140700261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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