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Transactions of the Association of American Physicians最新文献

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Antisense oligonucleotides directed at cell cycle regulatory genes as strategy for restenosis therapy. 针对细胞周期调控基因的反义寡核苷酸作为再狭窄治疗的策略。
Transactions of the Association of American Physicians Pub Date : 1993-01-01
R Morishita, G H Gibbons, K E Ellison, M Nakajima, H von der Leyen, L Zhang, Y Kaneda, T Ogihara, V J Dzau
{"title":"Antisense oligonucleotides directed at cell cycle regulatory genes as strategy for restenosis therapy.","authors":"R Morishita, G H Gibbons, K E Ellison, M Nakajima, H von der Leyen, L Zhang, Y Kaneda, T Ogihara, V J Dzau","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"106 ","pages":"54-61"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19032085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon-gamma and bacterial lipopolysaccharide. 小鼠编码钙非依赖性一氧化氮合酶基因的启动子可被干扰素- γ和细菌脂多糖诱导。
Transactions of the Association of American Physicians Pub Date : 1993-01-01
Q W Xie, C Nathan
{"title":"Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon-gamma and bacterial lipopolysaccharide.","authors":"Q W Xie,&nbsp;C Nathan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have proved that iNOS is regulated by induction of transcription. The induction of iNOS mRNA requires synthesis of an intermediary protein(s) and probably involves action of a protein kinase or kinases. We have cloned and sequenced a 1.7-kilobase pair fragment from the 5'-flanking region of the iNOS gene and proved that this region contains a promoter which confers inducibility of iNOS by LPS and IFN-gamma.</p>","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"106 ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18527624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the role of transmembrane helix three of the thyrotropin-releasing hormone (TRH) receptor in directly binding TRH. 促甲状腺激素释放激素(TRH)受体跨膜螺旋3在直接结合TRH中的作用分析。
Transactions of the Association of American Physicians Pub Date : 1993-01-01
J H Perlman, L Laakkonen, C N Thaw, R Osman, M C Gershengorn
{"title":"Analysis of the role of transmembrane helix three of the thyrotropin-releasing hormone (TRH) receptor in directly binding TRH.","authors":"J H Perlman,&nbsp;L Laakkonen,&nbsp;C N Thaw,&nbsp;R Osman,&nbsp;M C Gershengorn","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"106 ","pages":"162-7"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19032079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The real crisis in clinical investigation. 临床研究的真正危机。
Transactions of the Association of American Physicians Pub Date : 1993-01-01
J D Wilson
{"title":"The real crisis in clinical investigation.","authors":"J D Wilson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"106 ","pages":"cxxvi-cxxxiii"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19030724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of the human immunodeficiency virus type 1 long terminal repeat: interactions of thyroid hormone receptor with retinoid-X receptor, nuclear factor kappa B, Sp1, and Tat. 人类免疫缺陷病毒1型长末端重复序列的调控:甲状腺激素受体与类维甲酸x受体、核因子κ B、Sp1和Tat的相互作用
Transactions of the Association of American Physicians Pub Date : 1993-01-01
V Desai-Yajnik, H H Samuels
{"title":"Regulation of the human immunodeficiency virus type 1 long terminal repeat: interactions of thyroid hormone receptor with retinoid-X receptor, nuclear factor kappa B, Sp1, and Tat.","authors":"V Desai-Yajnik,&nbsp;H H Samuels","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"106 ","pages":"13-32"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19030731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human monoclonal antibodies against Cryptosporidium parvum generated by hypo-osmolar electrofusion. 低渗透电熔制备人小隐孢子虫单克隆抗体。
Transactions of the Association of American Physicians Pub Date : 1993-01-01
T P Flanigan, A Wisnewski, P M Wiest, J Johnson, S Tzipori, D Hamer, N Lam, T F Kresina
{"title":"Human monoclonal antibodies against Cryptosporidium parvum generated by hypo-osmolar electrofusion.","authors":"T P Flanigan,&nbsp;A Wisnewski,&nbsp;P M Wiest,&nbsp;J Johnson,&nbsp;S Tzipori,&nbsp;D Hamer,&nbsp;N Lam,&nbsp;T F Kresina","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"106 ","pages":"86-90"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19032663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cloning and expression of the defective genes in delta-aminolevulinate dehydratase porphyria: compound heterozygosity in this hereditary liver disease. 氨基乙酰酸脱水酶卟啉症缺陷基因的克隆与表达:这种遗传性肝病的复合杂合性。
Transactions of the Association of American Physicians Pub Date : 1992-01-01
S Sassa, N Ishida, H Fujita, Y Fukuda, T Noguchi, M Doss, A Kappas
{"title":"Cloning and expression of the defective genes in delta-aminolevulinate dehydratase porphyria: compound heterozygosity in this hereditary liver disease.","authors":"S Sassa,&nbsp;N Ishida,&nbsp;H Fujita,&nbsp;Y Fukuda,&nbsp;T Noguchi,&nbsp;M Doss,&nbsp;A Kappas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cloning and expression of the defective genes for ALAD from a patient with inherited ADP were carried out. Two separate point mutations, termed G1 and G2, resulting in a single amino acid change in each ALAD allele, were identified. The G1 mutation (C718-->T) occurred in the allele within the substrate-binding site, producing an Arg240-->Trp substitution; the G2 mutation (G820-->A) occurred downstream of this site in the other allele, resulting in an Ala274-->Thr substitution. Using RT-PCR, the mother, the brother, and the sister were shown to have the G1 defect. Expression of the G1 cDNA in CHO cells produced ALAD protein with little activity; the G2 cDNA produced the enzyme with approximately 50% normal activity. Pulse-labeling studies demonstrated that the G1 enzyme had a normal half-life, while the G2 enzyme had a markedly decreased half-life. These data thus define two separate point mutations, one in each ALAD allele, as well as the altered properties of the two enzymic proteins encoded by the mutant genes in this patient.</p>","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"250-9"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12482675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human epsilon mRNAs using membrane sequence encode for two membrane forms of IgE and a novel second secreted IgE. 人类epsilon mrna使用膜序列编码两种膜形式的IgE和一种新的第二分泌IgE。
Transactions of the Association of American Physicians Pub Date : 1992-01-01
A Saxon, K Zhang, E E Max
{"title":"Human epsilon mRNAs using membrane sequence encode for two membrane forms of IgE and a novel second secreted IgE.","authors":"A Saxon,&nbsp;K Zhang,&nbsp;E E Max","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"93-9"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12483828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcriptional activation of fibroblast stromelysin-1 and collagenase gene expression by a novel lymphokine, leukoregulin. 一种新的淋巴因子白细胞素对成纤维细胞间溶素-1和胶原酶基因表达的转录激活。
Transactions of the Association of American Physicians Pub Date : 1992-01-01
A Mauviel, V M Kähäri, Y Q Chen, M Kurkinen, C H Evans, J Uitto
{"title":"Transcriptional activation of fibroblast stromelysin-1 and collagenase gene expression by a novel lymphokine, leukoregulin.","authors":"A Mauviel,&nbsp;V M Kähäri,&nbsp;Y Q Chen,&nbsp;M Kurkinen,&nbsp;C H Evans,&nbsp;J Uitto","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"100-9"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12482659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recombinant vaccinia virus with influenza hemagglutinin protects old mice from influenza infection. 流感血凝素重组痘苗病毒对老年小鼠流感感染的保护作用。
Transactions of the Association of American Physicians Pub Date : 1992-01-01
A Ben-Yehuda, D Ehleiter, A R Hu, M E Weksler
{"title":"Recombinant vaccinia virus with influenza hemagglutinin protects old mice from influenza infection.","authors":"A Ben-Yehuda,&nbsp;D Ehleiter,&nbsp;A R Hu,&nbsp;M E Weksler","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"177-81"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12482666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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