Turkish neurosurgery最新文献_第9页

Endoscopic Third Ventriculostomy vs. Ventriculoperitoneal Shunt for Obstructive Hydrocephalus: A Meta-Analysis of Randomized Controlled Trials. 内镜下第三脑室切开术与脑室腹膜分流术治疗梗阻性脑积水：随机对照试验的荟萃分析。

IF 0.8 4区医学

Turkish neurosurgery Pub Date : 2023-01-01 DOI: 10.5137/1019-5149.JTN.40204-22.2

Wei Kong, Changyou Yin, Yue Lv, Wei Zhao, Guotai Tang, Yanbin Wang

{"title":"Endoscopic Third Ventriculostomy vs. Ventriculoperitoneal Shunt for Obstructive Hydrocephalus: A Meta-Analysis of Randomized Controlled Trials.","authors":"Wei Kong, Changyou Yin, Yue Lv, Wei Zhao, Guotai Tang, Yanbin Wang","doi":"10.5137/1019-5149.JTN.40204-22.2","DOIUrl":"10.5137/1019-5149.JTN.40204-22.2","url":null,"abstract":"OBJECTIVE With neurosurgeons' mastery, endoscopic third ventriculostomy (ETV) and extracranial shunting, two surgical options for patients with noncommunicating hydrocephalus, have substantially enhanced. However, which method of these 2 surgical methods could be more beneficial and safe for obstructive hydrocephalus is controversy. Herein, in patients with noncommunicating hydrocephalus, we did a meta-analysis to investigate the safety and efficacy of the two surgical therapies. METHODS Randomized controlled trials (RCTs) of ETV and VPS for obstructive hydrocephalus were searched systematically by using MEDLINE, EMBASE, and the Cochrane Controlled Trials Register. Reference lists of retrieving studies were also perused. Infection following surgery, postoperative CSF leakage, mortality and success following surgery were the main outcomes. RESULTS Six RCTs evaluating ETV and VPS were observed from among 841 studies evaluated. Especially in comparison to VPS, ETV was accompanied with decreased incidences of infection following surgery (risk ratio [RR] 0.19, 95% confidence interval [CI]: 0.08-0.43, P = 0.0001); postoperative cerebrospinal fluid leakage (RR 5.10, 95% CI: 1.19-21.89, P = 0.03) compared with ventriculoperitoneal shunt; VPS had no incidence on mortality rates as compared to ETV (RR 0.64, 95% CI: 0.26-1.56, P = 0.32). CONCLUSIONS In comparison to ETV, VPS had no significant effect on the incidence rate of mortality, but ETV has more benefits in terms of major complications, such as infection following surgery, and postoperative CSF leakage, than VPS for patients with noncommunicating hydrocephalus, according to the above meta-analysis.","PeriodicalId":23395,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"960-966"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10488506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes Mellitus-Mediated MALAT1 Expression Induces Glioblastoma Aggressiveness. 糖尿病介导的MALAT1表达诱导胶质母细胞瘤侵袭性

IF 0.8 4区医学

Turkish neurosurgery Pub Date : 2023-01-01 DOI: 10.5137/1019-5149.JTN.41845-22.2

Aysen Akkurt Kocaeli, Secil Ak Aksoy, Melis Ercelik, Gulcin Tezcan, Cagla Tekin, Hasan Kocaeli, Ahmet Bekar, Mevlut Ozgur Taskapilioglu, Sahsine Tolunay, Berrin Tunca

{"title":"Diabetes Mellitus-Mediated MALAT1 Expression Induces Glioblastoma Aggressiveness.","authors":"Aysen Akkurt Kocaeli, Secil Ak Aksoy, Melis Ercelik, Gulcin Tezcan, Cagla Tekin, Hasan Kocaeli, Ahmet Bekar, Mevlut Ozgur Taskapilioglu, Sahsine Tolunay, Berrin Tunca","doi":"10.5137/1019-5149.JTN.41845-22.2","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.41845-22.2","url":null,"abstract":"Aim: To describe the role of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in glioblastoma (GB) progression in patients concurrently diagnosed with diabetes mellitus (DM).Material and methods: Formalin-fixed paraffin-embedded (FFPE) tumor samples of 47 patients diagnosed with GB only and 13 patients diagnosed with GB and DM (GB-DM) were enrolled in this study. Data for p53 and Ki67 immunohistochemical staining of the tumors and blood HbA1c levels of patients with DM were retrospectively collected. MALAT1 expression was assessed using quantitative real-time polymerase chain reaction.Results: The coexistence of GB and DM induced the nuclear expression of p53 and Ki67 compared with GB only. MALAT1 expression was higher in GB-DM tumors than in GB only tumors. The expression of MALAT1 and HbA1c levels were positively correlated. Additionally, MALAT1 was positively correlated with tumoral p53 and Ki67. The disease-free survival of patients with GB-DM with high MALAT1 expression was shorter than that of those diagnosed with GB only and with a lower MALAT1 expression.Conclusion: Our findings suggest that one of the mechanisms of the facilitating effect of DM on GB tumor aggressiveness is via MALAT1 expression.","PeriodicalId":23395,"journal":{"name":"Turkish neurosurgery","volume":"33 5","pages":"821-827"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10271287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prospective Analysis of Cerebral Edema Admission and Clinical Outcome in Ruptured Intracranial Aneurysm. 颅内动脉瘤破裂患者脑水肿入院及临床转归的前瞻性分析。

IF 0.8 4区医学

Turkish neurosurgery Pub Date : 2023-01-01 DOI: 10.5137/1019-5149.JTN.41935-22.2

Dan Zimelewicz Oberman, Nícollas Nunes Rabelo, Leonardo Zumerkorn Pipek, Joao Telles, Natalia Camargo Barbat, Antônio Coelho, Marcia Harumy Yoshikawa, Guilherme Bittencourt Barbosa, Manoel Jacobsen Teixeira, Eberval Gadelha Figueiredo

{"title":"Prospective Analysis of Cerebral Edema Admission and Clinical Outcome in Ruptured Intracranial Aneurysm.","authors":"Dan Zimelewicz Oberman, Nícollas Nunes Rabelo, Leonardo Zumerkorn Pipek, Joao Telles, Natalia Camargo Barbat, Antônio Coelho, Marcia Harumy Yoshikawa, Guilherme Bittencourt Barbosa, Manoel Jacobsen Teixeira, Eberval Gadelha Figueiredo","doi":"10.5137/1019-5149.JTN.41935-22.2","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.41935-22.2","url":null,"abstract":"Aim: To evaluate the association between global cerebral edema (GCE) after subarachnoid hemorrhage (SAH) and its impact on functional outcome evaluated by the modified Rankin scale (mRS).Material and methods: This is a prospective cohort study with patients who were admitted to the hospital due to SAH. During the period from January 2018 to November 2019, 107 patients with intracranial aneurysms were enrolled. Using univariate and multivariate analysis, we sought to identify predictors and evaluated the impact of GCE on outcome after 6 months using the mRS.Results: GCE was present in 54 (50.5%) patients, of which 27 (25.2%) were mild, 20 (18.7%) moderate and 7 (6.5%) were severe. Univariate analysis identified high Hunt-Hess and Glasgow coma scale on clinical admission as predictors factors of GCE (p < 0.05), and higher modified Fisher scale as a radiological predictor of Glasgow coma scale (p < 0.05). Thirty-three (30.8%) patients were deceased at 6 months. Death or severe disability were predicted by higher age, poor clinical scale on admission and severe GCE (p < 0.05).Conclusion: GCE on admission is independently associated with poor clinical outcomes at discharge, and six months after SAH. Given its strong association with poor clinical grade on admission, GCE should be considered a straightforward and radiological important marker of early brain injury, with ominous implications.","PeriodicalId":23395,"journal":{"name":"Turkish neurosurgery","volume":"33 4","pages":"610-617"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9845993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Validation of a Nomogram for Predicting Overall Survival in Pediatric Patients with Atypical Teratoid/Rhabdoid Tumors. 预测非典型Teratoid/Rabdoid肿瘤儿童患者总体生存率的诺模图的开发和验证。

IF 0.8 4区医学

Turkish neurosurgery Pub Date : 2023-01-01 DOI: 10.5137/1019-5149.JTN.33034-20.2

Yao Liu, Xiao Peng, Tingting Zeng

{"title":"Development and Validation of a Nomogram for Predicting Overall Survival in Pediatric Patients with Atypical Teratoid/Rhabdoid Tumors.","authors":"Yao Liu, Xiao Peng, Tingting Zeng","doi":"10.5137/1019-5149.JTN.33034-20.2","DOIUrl":"10.5137/1019-5149.JTN.33034-20.2","url":null,"abstract":"Aim: To construct a reliable prediction model for pediatric atypical teratoid/rhabdoid tumor (ATRT) patients.Material and methods: Population-based data of patients diagnosed with intracranial ATRT were extracted from the National Cancer Institute?s Surveillance, Epidemiology, and End Results database. These patients were randomly assigned into training and validation cohorts at a ratio of 2:1. Univariable and multivariable Cox analyses were conducted to determine independent factors of overall survival (OS). A nomogram was then developed using the covariates with the best prognostic value, and the predictive performance of the nomogram was assessed by calibration curves, concordance index, time-dependent receiver operating characteristic curve analysis, and decision curve analysis.Results: A total of 267 cases were included. The OS rates at 6 months, 1 year, and 3 years were 61.6%, 50.1%, and 35.4%, respectively. The results of multivariable Cox analysis showed that tumor extension, surgery type, radiotherapy, and chemotherapy were independent prognostic indicators. A nomogram integrating these factors was established to predict the 6-month, 1-year, and 3-year OS rates. This prediction model was validated in the validation cohort. The nomogram had favorable predictive performance and discrimination ability.Conclusion: We developed and validated a novel nomogram with favorable discrimination ability to predict prognosis for newly diagnosed pediatric ATRT patients. Although additional validation is required, this may be a useful tool in clinical decision making.","PeriodicalId":23395,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"936-944"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39432066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effects of focal cerebellar injury on fracture healing and oxidative stress in rat model: an experimental animal study 局灶性小脑损伤对大鼠骨折愈合及氧化应激影响的实验动物研究

4区医学

Turkish neurosurgery Pub Date : 2023-01-01 DOI: 10.5137/1019-5149.jtn.44200-23.2

Fatih Dogar, Kaan Gurbuz, Duran Topak, Aysun Okcesiz, Ayse Eken, Emine Kilinc, Mustafa Arik, Okkes Bilal, Mustafa Abdullah Ozdemir, Mikail Telek

引用次数: 0

Evaluation of the effect of granulocyte–macrophage colony stimulating factor on spinal fusion in a rat model of spinal surgery 评价粒细胞-巨噬细胞集落刺激因子对脊柱外科大鼠脊柱融合的影响

4区医学

Turkish neurosurgery Pub Date : 2023-01-01 DOI: 10.5137/1019-5149.jtn.44636-23.2

Mehmet Fatih Aksay, Emre Bal, Bekir Eray Kilinc, Ahmet Onur Akpolat

引用次数: 0

Evaluation of the effect of tenoxicam on neural tube defect using an embryo culture system 用胚胎培养系统评价替诺昔康治疗神经管缺损的效果

4区医学

Turkish neurosurgery Pub Date : 2023-01-01 DOI: 10.5137/1019-5149.jtn.45237-23.2

Burak Bahadir, Onur Ozgural, Orkhan Mammadkhanli, Eray Serhat Aktan, Derya Ozdemir Tas, Eda Aslanbaba Bahadir, Mustafa Agahan Unlu

引用次数: 0

Comparison of Long-Term Follow-Up Outcomes Between Minimally Invasive and Open Surgery for Single-Level Lumbar Fusion. 微创与开放手术治疗单节段腰椎融合术的长期随访结果比较。

IF 0.8 4区医学

Turkish neurosurgery Pub Date : 2023-01-01 DOI: 10.5137/1019-5149.JTN.40281-22.4

Tae Seok Jeong, Seong Son, Sang Gu Lee, Woo Kyung Kim, Byung Rhae Yoo, Woo Seok Kim

{"title":"Comparison of Long-Term Follow-Up Outcomes Between Minimally Invasive and Open Surgery for Single-Level Lumbar Fusion.","authors":"Tae Seok Jeong, Seong Son, Sang Gu Lee, Woo Kyung Kim, Byung Rhae Yoo, Woo Seok Kim","doi":"10.5137/1019-5149.JTN.40281-22.4","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.40281-22.4","url":null,"abstract":"Aim: To evaluate, and to compare the clinical outcomes of minimally invasive surgery (MIS), and open surgery for single-level lumbar fusion over a minimum of 10-year follow-up.Material and methods: We included 87 patients who underwent spinal fusion at the L4 - L5 level between January 2004 and December 2010. Based on the surgical method, the patients were divided into the open surgery (n=44) and MIS groups (n=43). We evaluated baseline characteristics, perioperative comparisons, postoperative complications, radiologic findings, and patientreported outcomes.Results: The mean follow-up period was > 10 years in both groups (open surgery, 10.50 years; MIS, 10.16 years). The operative time was longer in the MIS group (4.37 h) than that in the open surgery group (3.34 h) (p=0.001). Estimated blood loss was lower in the MIS group (281.40 mL) than in the open surgery group (440.23 mL) (p < 0.001). Postoperative complications, including surgical site infection, adjacent segment disease, and pseudoarthrosis, did not differ between the groups. Plain radiographic findings of the lumbar spine did not differ between the two groups. Visual scores for back/leg pain and the Oswestry disability index did not differ between the two groups, preoperatively and at 6 months, 1, 5, and 10 years after surgery.Conclusion: After a minimum of the 10-year follow-up, postoperative complications and clinical outcomes did not differ significantly between patients who underwent open fusion and MIS fusion at the L4 - L5 level.","PeriodicalId":23395,"journal":{"name":"Turkish neurosurgery","volume":"33 4","pages":"642-649"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9844190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the Usefulness of Motor-Evoked Potential Changes in Disc Height Determination in Patients with Degenerative Disc Diseases Treated with Interbody Fusion. 评估运动诱发电位变化在行椎间融合术的退变性椎间盘病患者椎间盘高度测定中的作用。

IF 0.8 4区医学

Turkish neurosurgery Pub Date : 2023-01-01 DOI: 10.5137/1019-5149.JTN.41408-22.3

Yasin Sayar, Serkan Bayram, Turgut Akgul

{"title":"Assessing the Usefulness of Motor-Evoked Potential Changes in Disc Height Determination in Patients with Degenerative Disc Diseases Treated with Interbody Fusion.","authors":"Yasin Sayar, Serkan Bayram, Turgut Akgul","doi":"10.5137/1019-5149.JTN.41408-22.3","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.41408-22.3","url":null,"abstract":"Aim: To evaluate the effectiveness of improved motor-evoked potentials (MEPs) in treatment of degenerative disc diseases using the transforaminal lumbar interbody fusion (TLIF) technique.Material and methods: Data of one hundred and eleven patients who underwent TLIF were retrospectively reviewed. The inclusion criteria were preoperative radiculopathy and presence of neurological deterioration without previous surgery. Improved MEP amplitudes reaching the baseline MEP amplitudes of the contralateral side at the same level were used as the thresholds for determining the final disc height and cage size during surgery. Cage size, disc heights of the three areas, foraminal area, and global spinal and local balance were measured.Results: Twenty-two patients (3 male and 19 female) with a mean age of 61.9 ± 8.9 years were included into the study. The mean height of cages was 10.3 ± 1.4 mm (range, 8-14 mm). The mean improvement in MEP amplitude was 27 ± 11% (range, 15-50%). The anterior, middle, and posterior disc heights improved to 2 ± 1.6, 2.7 ± 1.7, and 1.7 ± 1.3 mm, respectively. The improvement in the middle disc height was significantly greater (p < 0.05). Segmental lordosis improved from 16.2° ± 10.7° to 19.4° ± 9.2°. Additionally, lumbar lordosis improved from 46.7° ± 14.6° to 51.2° ± 11.2° (p < 0.05). Cage height or improvements in disc height was not correlated with MEP changes. However, there was a positive correlation between ipsilateral foraminal area restoration and MEP changes (r=0.501; p < 0.01).Conclusion: Improved MEP amplitudes reaching the baseline MEP amplitudes of the contralateral side of the same spinal level might be a useful threshold for determining the final minimum disc height during TLIF surgery with satisfactory postoperative radiological results, including sagittal and segmental radiological parameters.","PeriodicalId":23395,"journal":{"name":"Turkish neurosurgery","volume":"33 4","pages":"676-682"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9845265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidental Ureteral Complication in Single-Center Consecutive Oblique Lateral Interbody Fusion Cases. 单中心连续斜侧椎体间融合术的输尿管并发症。

IF 0.8 4区医学

Turkish neurosurgery Pub Date : 2023-01-01 DOI: 10.5137/1019-5149.JTN.42599-22.3

Kang Hoon Lee, Dong Wuk Son, Bu Kwang Oh, Su Hun Lee, Jun Seok Lee, Young Ha Kim, Soon Ki Sung, Sang Weon Lee, Geun Sung Song

引用次数: 1