Tumor BiologyPub Date : 2022-01-01DOI: 10.3233/TUB-229004
{"title":"Erratum to: SMAD4 and its role in pancreatic cancer.","authors":"","doi":"10.3233/TUB-229004","DOIUrl":"https://doi.org/10.3233/TUB-229004","url":null,"abstract":"","PeriodicalId":23364,"journal":{"name":"Tumor Biology","volume":"44 1","pages":"237"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10369580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unfavorable prognosis and clinical consequences of APOBEC3B expression in breast and other cancers: A systematic review and meta-analysis.","authors":"Sima Jafarpour, Maryam Yazdi, Reza Nedaeinia, Sepideh Ghobakhloo, Rasoul Salehi","doi":"10.3233/TUB-211577","DOIUrl":"https://doi.org/10.3233/TUB-211577","url":null,"abstract":"<p><strong>Introduction: </strong>Controversy exists regarding the association of apolipoprotein B mRNA editing enzyme catalytic subunit 3B APOBEC3B, (A3B) overexpression and poor prognosis, metastasis, and chemotherapy drug resistance in cancers. Here we conducted a systematic review and meta-analysis to determine its prognostic value and clinicopathological features in breast cancer and some other malignancies.</p><p><strong>Materials and methods: </strong>PubMed, Scopus, Cochrane Library, Web of Science, and EMBASE were searched up to Feb 2022 for the association of A3B with breast, ovarian, gastrointestinal and lung cancers. The pooled hazard ratios with 95% confidence interval (CI) were evaluated to assess disease-free survival (DFS), overall survival (OS), and recurrence-free survival (RFS) in cancers under study.</p><p><strong>Results: </strong>Over 3700 patients were included in this meta-survey. Elevated levels of A3B were significantly related to low OS (pooled HR = 1.30; 95% CI:1.09-1.55, P < 0.01), poor DFS (pooled HR = 1.66; 95% CI:1.17-2.35, P < 0.01) and poor RFS (HR = 1.51, 95% CI:1.11-2.04, P = 0.01). Subgroup analysis revealed that high A3B expression was associated with poor OS in lung (HR = 1.85, 95% CI: 1.40-2.45), and breast cancers (HR = 1.38, 95% CI: 1.00-1.89). High expression of A3B did not display any significant association with clinicopathologic features.</p><p><strong>Conclusion: </strong>APOBEC3B overexpression is related to poor OS, DFS and RFS only in some cancer types and no generalized role could be predicted for all cancers.</p>","PeriodicalId":23364,"journal":{"name":"Tumor Biology","volume":" ","pages":"153-169"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33462097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tumor BiologyPub Date : 2021-11-09DOI: 10.3233/tub-219009
T. Ram
{"title":"Erratum to: Galectin-3: A factotum in carcinogenesis bestowing an archery for prevention","authors":"T. Ram","doi":"10.3233/tub-219009","DOIUrl":"https://doi.org/10.3233/tub-219009","url":null,"abstract":"","PeriodicalId":23364,"journal":{"name":"Tumor Biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49217127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tumor BiologyPub Date : 2021-07-01DOI: 10.1158/1538-7445.AM2021-2992
Jonathan T. Lei, Chen Huang, R. R. Srinivasan, S. Vasaikar, L. Dobrolecki, Alaina N. Lewis, Christina Sallas, S. Hilsenbeck, C. Osborne, M. Rimawi, M. Ellis, V. Petrosyan, Alexander B. Saltzman, A. Malovannaya, G. Wulf, D. Kraushaar, Tao Wang, G. Echeverria, Bing Zhang, M. Lewis
{"title":"Abstract 2992: Proteogenomic characterization of triple-negative breast cancer patient-derived xenografts reveals molecular correlates of differential chemotherapy response and potential therapeutic targets to overcome resistance","authors":"Jonathan T. Lei, Chen Huang, R. R. Srinivasan, S. Vasaikar, L. Dobrolecki, Alaina N. Lewis, Christina Sallas, S. Hilsenbeck, C. Osborne, M. Rimawi, M. Ellis, V. Petrosyan, Alexander B. Saltzman, A. Malovannaya, G. Wulf, D. Kraushaar, Tao Wang, G. Echeverria, Bing Zhang, M. Lewis","doi":"10.1158/1538-7445.AM2021-2992","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2992","url":null,"abstract":"","PeriodicalId":23364,"journal":{"name":"Tumor Biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44882064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tumor BiologyPub Date : 2021-07-01DOI: 10.1158/1538-7445.AM2021-3145
Nathan P. McMahon, Allison Solanki, Jocelyn A. Jones, Lei G. Wang, K. Tichauer, K. Samkoe, Summer L. Gibbs
{"title":"Abstract 3145: TRIPODD: a novel fluorescence imaging platform for in situ quantification of drug distribution and therapeutic response","authors":"Nathan P. McMahon, Allison Solanki, Jocelyn A. Jones, Lei G. Wang, K. Tichauer, K. Samkoe, Summer L. Gibbs","doi":"10.1158/1538-7445.AM2021-3145","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-3145","url":null,"abstract":"","PeriodicalId":23364,"journal":{"name":"Tumor Biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44898617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tumor BiologyPub Date : 2021-07-01DOI: 10.1158/1538-7445.AM2021-2755
Kyung-Ho Pyo, H. K. Lee, H. Jo, Wongeun Lee, S. Heo, S. Lim, Dong Kwon Kim, Chun-Bong Synn, Y. Byeon, Young Seob Kim, B. Ahn, M. Hong, S. Lim, H. Kim, B. Cho
{"title":"Abstract 2755: Single-cell RNA sequencing reveals priming professional antigen-presenting macrophages and chemokine expressing T cells in tumor microenvironment by AXL inhibitor, SKI-G-801","authors":"Kyung-Ho Pyo, H. K. Lee, H. Jo, Wongeun Lee, S. Heo, S. Lim, Dong Kwon Kim, Chun-Bong Synn, Y. Byeon, Young Seob Kim, B. Ahn, M. Hong, S. Lim, H. Kim, B. Cho","doi":"10.1158/1538-7445.AM2021-2755","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2755","url":null,"abstract":"","PeriodicalId":23364,"journal":{"name":"Tumor Biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44961716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tumor BiologyPub Date : 2021-07-01DOI: 10.1158/1538-7445.AM2021-2995
Gabriela Vazquez Rodriguez, Z. Ali, Anna Erkstam, J. Schueler, A. Fahlgren, Lasse D. Jensen
{"title":"Abstract 2995: Zebrafish tumor-derived xenografts established from breast cancer pdx models predict treatment outcome and dissemination risk with superior sensitivity and specificity","authors":"Gabriela Vazquez Rodriguez, Z. Ali, Anna Erkstam, J. Schueler, A. Fahlgren, Lasse D. Jensen","doi":"10.1158/1538-7445.AM2021-2995","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2995","url":null,"abstract":"","PeriodicalId":23364,"journal":{"name":"Tumor Biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45028725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tumor BiologyPub Date : 2021-07-01DOI: 10.1158/1538-7445.AM2021-2936
J. Tien, Seema Chugh, Andrew Goodrum, Yun-Chien Cheng, Lisha Wang, R. Mannan, Xiaoming Wang, Vijaya L. Dommeti, Yuping Zhang, A. Xu, Fengyun Su, Xuhong Cao, Sunita Shankar, A. Chinnaiyan
{"title":"Abstract 2936: Ago2 induces Kras signaling and promotes tumor progression in mouse models of lung adenocarcinoma","authors":"J. Tien, Seema Chugh, Andrew Goodrum, Yun-Chien Cheng, Lisha Wang, R. Mannan, Xiaoming Wang, Vijaya L. Dommeti, Yuping Zhang, A. Xu, Fengyun Su, Xuhong Cao, Sunita Shankar, A. Chinnaiyan","doi":"10.1158/1538-7445.AM2021-2936","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2936","url":null,"abstract":"","PeriodicalId":23364,"journal":{"name":"Tumor Biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45205911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tumor BiologyPub Date : 2021-07-01DOI: 10.1158/1538-7445.AM2021-2830
M. Tobi, F. Antaki, MaryAnn Rambus, E. Levi, H. Talwar, M. Lawson, B. McVicker
{"title":"Abstract 2830: Effect of tobacco and alcohol intake on the future development of liver metastasis","authors":"M. Tobi, F. Antaki, MaryAnn Rambus, E. Levi, H. Talwar, M. Lawson, B. McVicker","doi":"10.1158/1538-7445.AM2021-2830","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2830","url":null,"abstract":"","PeriodicalId":23364,"journal":{"name":"Tumor Biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49062030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tumor BiologyPub Date : 2021-07-01DOI: 10.1158/1538-7445.AM2021-2771
Lakshmi Chandramohan, Q. Au, M. Nagy, E. Parnell, T. Peters
{"title":"Abstract 2771: Comprehensive analysis of immuno oncology markers in the tumor microenvironment of solid tumor samples using GeoMxTMdigital spatial profiler (DSP) and MultiOmyxTMhyperplexed immunofluorescence (IF)","authors":"Lakshmi Chandramohan, Q. Au, M. Nagy, E. Parnell, T. Peters","doi":"10.1158/1538-7445.AM2021-2771","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2771","url":null,"abstract":"","PeriodicalId":23364,"journal":{"name":"Tumor Biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49252112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}