Turkish Journal of Biochemistry最新文献_第7页

Improvement of the post-analytical phase by means of an algorithm based autoverification 通过基于算法的自动核查改进后分析阶段

Turkish Journal of Biochemistry Pub Date : 2023-11-16 DOI: 10.1515/tjb-2023-0057

N. S. Yılmaz, Bayram Şen, Burak Arslan, Tuba Saadet Deveci Bulut, B. Narlı, N. Afandiyeva, Gülce Koca, Canan Yılmaz, Ozlem Gulbahar

{"title":"Improvement of the post-analytical phase by means of an algorithm based autoverification","authors":"N. S. Yılmaz, Bayram Şen, Burak Arslan, Tuba Saadet Deveci Bulut, B. Narlı, N. Afandiyeva, Gülce Koca, Canan Yılmaz, Ozlem Gulbahar","doi":"10.1515/tjb-2023-0057","DOIUrl":"https://doi.org/10.1515/tjb-2023-0057","url":null,"abstract":"Abstract Objectives Autoverification (AV) is releasing laboratory results using predefined rules. AV standardizes the verification of laboratory results, improves turnaround time (TAT), detects errors in the total test process, and enables effective use of laboratory staff. In this study, we aimed to evaluate the outcomes of implementing the AV in a tertiary hospital. Methods The study was performed in Gazi University Health Research and Application Hospital, Core Biochemistry Laboratory, between August 2017 and October 2019. Step by step, AV algorithms were designed and implemented via middleware for 29 clinical biochemistry tests. A comprehensive validation was performed before the AV system was run. Initially, AV system was tested with datasets and simulated patients (dry testing). Next, samples that may violate AV rules were tested anonymously with no-named trial barcodes (wet testing). Finally, validation of the system was performed with real patients, while the AV was running in the background but not active (i.e., while the manual verification was still going on). After all these steps were successful, the system was started. Results In the daytime, AV rates were ≥75 % for 23 of 29 tests. In night-shift, AV rates were ≥70 % for 16 of 25 tests. Report-based performance was found 26 % for daytime. TAT in the daytime decreased after AV implementation. Conclusions Although this is the first time we have implemented the AV, a significant percentage of the tests have been verified. However, approaches that will increase the percentage of report-based verification will enhance the efficiency of autoverification.","PeriodicalId":23344,"journal":{"name":"Turkish Journal of Biochemistry","volume":"59 3","pages":"626 - 633"},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139268707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of a single dialysis session on serum hepcidin levels 单次透析对血清肝磷脂水平的影响

Turkish Journal of Biochemistry Pub Date : 2023-09-08 DOI: 10.1515/tjb-2023-0009

Hamdi Oğuzman, Buket Kın Tekçe, H. Tekçe, G. Bugdayci

{"title":"The effects of a single dialysis session on serum hepcidin levels","authors":"Hamdi Oğuzman, Buket Kın Tekçe, H. Tekçe, G. Bugdayci","doi":"10.1515/tjb-2023-0009","DOIUrl":"https://doi.org/10.1515/tjb-2023-0009","url":null,"abstract":"Abstract Objectives Hepcidin plays an important role in regulating iron metabolism. Elevated levels of hepcidin in renal failure contribute to the development of anemia. We aimed to evaluate the association between hepcidin and inflammation in hemodialysis patients and how dialysis affects hepcidin levels. Methods Hepcidin clearance with hemodialysis was investigated by measuring hepcidin concentrations by enzyme-linked immunosorbent assay (ELISA) method before and after hemodialysis of 40 patients in a single dialysis session. Hemogram parameters and ferritin, iron, total iron binding capacity (TIBC), and C-reactive protein (CRP) were measured and evaluated their relations with predialysis hepcidin levels. Results Hepcidin levels decreased significantly with dialysis treatment (p=0.009). Median hepcidin concentration before dialysis was measured as 330 ng/mL (83–459) and post-dialysis median hepcidin concentration was 250 ng/mL (94–384). There was a significant correlation between predialysis hepcidin levels and ferritin (r=0.858, p<0.001), TIBC (r=−0.451, p=0.004), and MCV (r=0.384, p=0.016). It was found that increases in ferritin levels in time were positively correlated with hepcidin before dialysis. Conclusions We think that understanding the removal of the hepcidin by dialysis, which causes a decrease in the amount of iron available in the anemia, is important in managing future therapy.","PeriodicalId":23344,"journal":{"name":"Turkish Journal of Biochemistry","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74104098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

miR-564 and miR-718 expressions are downregulated in colorectal cancer tissues miR-564和miR-718在结直肠癌组织中表达下调

Turkish Journal of Biochemistry Pub Date : 2023-09-05 DOI: 10.1515/tjb-2023-0015

Deniz Mihcioglu, Erkan Elihan, Alper Aytekin, T. Gurer

{"title":"miR-564 and miR-718 expressions are downregulated in colorectal cancer tissues","authors":"Deniz Mihcioglu, Erkan Elihan, Alper Aytekin, T. Gurer","doi":"10.1515/tjb-2023-0015","DOIUrl":"https://doi.org/10.1515/tjb-2023-0015","url":null,"abstract":"Abstract Objectives MicroRNAs (miRNAs) are small RNAs that are involved in regulating gene expression and have an important role in biological pathways such as differentiation, migration, cell proliferation, and other cellular processes. Previous studies have shown that miR-564 and miR-718 are either downregulated or upregulated in various cancers. The purpose of this study was to examine the levels of expression of miR-564 and miR-718 in colorectal cancer (CRC) patients’ tumor and non-tumor tissues. Methods The study group consisted of tumor and non-tumor tissues obtained from a total of 80 CRC patients. The expression levels of miRNAs were determined using quantitative Real-Time Polymerase Chain Reaction (RT-qPCR). Additionally, using bioinformatics analysis, the transcription factors (TFs) that are associated with miR-564 and miR-718 were identified as well as the GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment pathway analysis of these miRNAs. Results According to the findings of RT-qPCR, both miR-564 and miR-718 expression levels were significantly downregulated in CRC (p<0.001). There was a statistically significant correlation between the expression levels of miR-564 and miR-718 (p=0.006). Both miR-564 and miR-718 regulated TFs including E2F1, HIFIA, BRD4, KDM2B, ESR1, MYC, PHF8, RUNX1, TCF12 and YY1. According to KEGG analysis, miR-564 and miR-718 were associated with Hippo and FoxO signaling pathways, respectively (p<0.05). Conclusions miR-564 and miR-718 may have function as tumor suppressors and may be biomarkers for the diagnosis of CRC.","PeriodicalId":23344,"journal":{"name":"Turkish Journal of Biochemistry","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78543348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between plasma concentration of pigment epithelium-derived factor and diabetic retinopathy 血浆色素上皮衍生因子浓度与糖尿病视网膜病变的关系

Turkish Journal of Biochemistry Pub Date : 2023-09-05 DOI: 10.1515/tjb-2023-0078

Tayfun Şahin, A. Karabulut

{"title":"The association between plasma concentration of pigment epithelium-derived factor and diabetic retinopathy","authors":"Tayfun Şahin, A. Karabulut","doi":"10.1515/tjb-2023-0078","DOIUrl":"https://doi.org/10.1515/tjb-2023-0078","url":null,"abstract":"Abstract Objectives Diabetic retinopathy (DRP) is one of the most common microvascular complications of diabetes. The pigment epithelium-derived factor (PEDF) is a protein that is one of the most potent angiogenesis inhibitors. The effect of blood PEDF concentration on DRP formation remains unclear. The present study aimed to determine whether the plasma concentration of PEDF is effective on the appearance of DRP. Methods The present study consisted of 62 patients with diabetes mellitus and 20 healthy participants. The patient group included 28 patients with non-proliferative DRP, 13 with proliferative DRP, and 21 diabetic patients without DRP. The PEDF levels in patient serum samples were detected through the ELISA method. The body mass index of the participants was calculated. Results Serum PEDF levels of diabetic patients (1.533 ± 0.233 μg/mL) were found to be lower (2.163 ± 0.343 μg/mL) than healthy participants (p=0.002). The PEDF levels were similar in the DRP and non-DRP groups (p=0.337). The plasma PEDF level decreased along with the progression of DRP (p=0.001). Conclusions The PEDF concentration in the blood decreases along with the increase of DRP grade. Decreased blood concentration of PEDF may be important to predict microvascular complications. Agents containing PEDF may be used intraocularly/systemically for therapeutic purposes to prevent vascular complications of diabetes in the near future.","PeriodicalId":23344,"journal":{"name":"Turkish Journal of Biochemistry","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87819288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and association of sIgA in saliva and Pseudomonas aeruginosa infection in TB patients: a cross-sectional study 结核患者唾液中sIgA的流行及其与铜绿假单胞菌感染的关系:一项横断面研究

Turkish Journal of Biochemistry Pub Date : 2023-08-31 DOI: 10.1515/tjb-2023-0046

Keqiang Wan, Chang Su, Fang Yin, Caoyuan Yao

{"title":"Prevalence and association of sIgA in saliva and Pseudomonas aeruginosa infection in TB patients: a cross-sectional study","authors":"Keqiang Wan, Chang Su, Fang Yin, Caoyuan Yao","doi":"10.1515/tjb-2023-0046","DOIUrl":"https://doi.org/10.1515/tjb-2023-0046","url":null,"abstract":"Abstract Objectives Pseudomonas aeruginosa is pathogenic in immunocompromised individuals. It has several complex mechanisms for evading human immunity. The objective of the study was to examine the secretory immunoglobulin A (sIgA) mediated immune response in saliva to detect P. aeruginosa in pulmonary tuberculosis. Methods The infection with P. aeruginosa was categorized according to the Leeds criteria in the final 86 individuals who were proven to have pulmonary tuberculosis by polymerase chain reaction. Levels of serum immunoglobulin G (IgG) and sIgA which are specific to P. aeruginosa were measured using the method of ELISA. Results Patients in the “free of infection (patients who were infected with P. aeruginosa in the lower respiratory tract at the beginning of the study later became negative)” and “intermittent colonized (patients who were infected with P. aeruginosa throughout the study)” groups had substantially higher median baseline sIgA levels in saliva and a much greater proportion of sIgA positive than patients who were never colonized (patients who were found to be P. aeruginosa negative throughout the study) (p=0.038). Median baseline IgG level was 10.7 (1.7–145.0), 8.3 (2.5–22.9), and 6.7 (3.3–17.1) for the patients categorized as “intermittent colonization”, “free of infection” and “never colonized”, respectively. After 3 years of study, sIgA level was found in significant high level among the patients with infection of P. aeruginosa (p=0.003). Conclusions Secretory IgA may be readily collected from saliva and is a useful diagnostic technique for determining whether P. aeruginosa infection has occurred.","PeriodicalId":23344,"journal":{"name":"Turkish Journal of Biochemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83367918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring nanotechnology-based approaches using miRNAs to treat neurodegenerative disorders 探索基于纳米技术的方法，使用mirna治疗神经退行性疾病

Turkish Journal of Biochemistry Pub Date : 2023-08-31 DOI: 10.1515/tjb-2023-0086

Gohar Mushtaq, Ibrahim W. Hasani, Fouad Al-Daoud, A. Unnisa, Yahya A. Mutair, Samer Kabba, Yaser Alkanash

{"title":"Exploring nanotechnology-based approaches using miRNAs to treat neurodegenerative disorders","authors":"Gohar Mushtaq, Ibrahim W. Hasani, Fouad Al-Daoud, A. Unnisa, Yahya A. Mutair, Samer Kabba, Yaser Alkanash","doi":"10.1515/tjb-2023-0086","DOIUrl":"https://doi.org/10.1515/tjb-2023-0086","url":null,"abstract":"Abstract MicroRNAs (miRNAs) are small non-coding molecules that play a pivotal part in brain development and the processes of establishment and maintenance of dendrites and neurite outgrowth by modulating gene expression. Dysregulation of miRNAs has been linked with neurological disorders. Exogenous miRNAs are unstable in the plasma due to degradation by nucleases; hence, choosing a harmless and effective delivery mode is crucial in the quest for miRNA-based therapeutics to treat neurological disorders. This review aims to shed light on the emerging role of nanotechnology-based approaches using miRNAs to treat neurodegenerative disorders. Nanotechnology encompasses a broad spectrum of applications, one of which is its role in developing nanoscale drug delivery systems. Nanotechnology-based drug delivery systems have attracted the attention of researchers due to the superiority of this mode over conventional treatment systems in terms of their favorable attributes such as bio-compatibility, bio-degradability, extremely small size, and the ability to cross the blood-brain barrier. This review explores nanotechnology-based approaches using miRNAs highlighting the use of viral vectors as well as non-viral vectors (such as exosomes, liposome nanoparticles, gold and magnetic nanoparticles, dendrimer-based nanoparticles, polymeric nanoparticles) to treat neurodegenerative disorders.","PeriodicalId":23344,"journal":{"name":"Turkish Journal of Biochemistry","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84724921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Within- and between-subject biological variation of hemostasis parameters in a study of 26 healthy individuals 26个健康个体的研究中，受试者内部和受试者之间止血参数的生物学变异

Turkish Journal of Biochemistry Pub Date : 2023-08-29 DOI: 10.1515/tjb-2023-0155

O. Zengi, K. T. Uçar

{"title":"Within- and between-subject biological variation of hemostasis parameters in a study of 26 healthy individuals","authors":"O. Zengi, K. T. Uçar","doi":"10.1515/tjb-2023-0155","DOIUrl":"https://doi.org/10.1515/tjb-2023-0155","url":null,"abstract":"Abstract Objectives The study aimed to estimate the biological variation (BV) of routine coagulation tests, including prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen, in a healthy population to enhance the accuracy of laboratory results and improve diagnosis and treatment decisions. Methods The study included 26 healthy volunteers over 10 weeks; samples were collected weekly. The within-subject BV (CVI) and between-subject BV (CVG) were calculated for each parameter, and the index of individuality (II) and reference change values (RCV) were determined. All tests were performed in duplicate on the Roche Cobas T-711 coagulation analyzer. Results Fibrinogen exhibited the highest BV, with a CVI of 11 % and CVG of 17.4 %. The aPTT test had a CVI of 5.8 %, a CVG of 8.4 %, and an II of 0.91. The PT test had a CVI of 3.2 %, a CVG of 5.8 %, and an II of 0.73. The RCV values ranged from −7.5 to 8.1 for PT, −12.7 to 14.6 for aPTT, and −22.7 to 29.4 for fibrinogen. Conclusions The study underscores the significant biological variation in routine hemostasis parameters, such as PT, APTT, and fibrinogen, which impacts clinical diagnoses and treatment decisions. Despite certain limitations, the findings offer valuable insights for clinicians and suggest that future research should include more parameters for a comprehensive understanding of biological variations in hemostasis testing.","PeriodicalId":23344,"journal":{"name":"Turkish Journal of Biochemistry","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86483929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Researching of resistance to etravirine in some HIV-1 low-level viremia strains by in-silico methods 一些HIV-1低水平病毒血症毒株对依曲维碱耐药性的计算机方法研究

Turkish Journal of Biochemistry Pub Date : 2023-08-25 DOI: 10.1515/tjb-2023-0166

O. Oflaz, H. Mergen, Tulin Demir

{"title":"Researching of resistance to etravirine in some HIV-1 low-level viremia strains by in-silico methods","authors":"O. Oflaz, H. Mergen, Tulin Demir","doi":"10.1515/tjb-2023-0166","DOIUrl":"https://doi.org/10.1515/tjb-2023-0166","url":null,"abstract":"Abstract Objectives Human immunodeficiency virus (HIV) is a significant infection that attacks immune system cells and integrates its genetic material into host cells. Left untreated, it leads to acquired immunodeficiency syndrome (AIDS). Antiretroviral therapy (ART) is used to control HIV infection. Etravirine (ETR) is an important non-nucleoside reverse transcriptase inhibitor (NNRTI) utilized in the treatment of HIV. Low-level viremia (LLW) is a serious clinical condition, and the underlying mechanisms remain incompletely understood. The aim of our study is to analyze and elucidate the resistance status of Lys104Gln, Lys102Gln, Lys101Arg-Lys104Arg, Ser191Phe, Ile94Leu-Lys104Arg, Lys104Glu-His235Leu, Ala98Ser and Val179Ile mutations using in-silico methods, which are identified as low-level viremic strains, because their resistance status to ETR is unknown. Methods Homology modeling was performed using the Swiss Model program. Molecular docking of ETR with the reverse transcriptase (RT) enzyme was conducted using the CB-Dock program developed by AutoDock Vina. Protein-ligand interaction analysis was carried out using the protein-ligand interaction profiler (PLIP). Results A98S and V179I mutations altered the physicochemical properties of the region, resulting in changes to the conformational structure of the NNRTI hydrophobic pocket compared to the wild-type and consequently decreased docking scores. Conclusions Based on the evaluation of literature data and in-silico analyses, it is believed that A98S and V179I mutations may alter the conformational structure of the hydrophobic pocket where ETR binds, potentially resulting in low-level resistance against ETR.","PeriodicalId":23344,"journal":{"name":"Turkish Journal of Biochemistry","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74018421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nasal fluid sample as a reliable matrix for determination of cytokine levels in childhood asthma 鼻液样本作为测定儿童哮喘细胞因子水平的可靠基质

Turkish Journal of Biochemistry Pub Date : 2023-08-17 DOI: 10.1515/tjb-2022-0147

Mojtaba Doulatpanah, Meltem Kocamanoğlu, E. Sözmen, G. Öztürk, E. Demir, F. Gülen, Y. Akcay

{"title":"Nasal fluid sample as a reliable matrix for determination of cytokine levels in childhood asthma","authors":"Mojtaba Doulatpanah, Meltem Kocamanoğlu, E. Sözmen, G. Öztürk, E. Demir, F. Gülen, Y. Akcay","doi":"10.1515/tjb-2022-0147","DOIUrl":"https://doi.org/10.1515/tjb-2022-0147","url":null,"abstract":"Abstract Objectives Childhood asthma is a chronic disease with high incidence worldwide. As a lifelong disease, asthma has episodes. Inflammation continues to occur in the clinical remission of asthma. It can be difficult to diagnose childhood asthma, especially in clinical remission. We hypothesized that some cytokines secreted to nasal fluid from the airway during inflammation might help diagnose clinical remission of asthma. Moreover, sampling nasal fluid is an easy and non-invasive procedure, so it may be a preferable sampling method. Methods We measured levels of some interleukins (ILs), which are IL-4, IL-5, IL-6, IL-12p70, IL-13, IL-33, granulocyte-macrophage colony-stimulating factor (GM-CSF), periostin and thymic stromal lymphopoietin (TSLP) by Luminex magnetic bead-based immunoassay in nasal fluid and in serum of asthmatic children in clinical remission. Results We found that IL-5, IL-6, IL-33, and periostin had elevated levels in nasal fluid. IL-5 and IL-33 had increased levels in the nasal fluid of the patients with immunoglobulin E (IgE) high and low phenotypes. While the nasal fluid TSLP levels were positively correlated with most of the increased serum cytokine levels of non-allergic asthmatic children, the nasal fluid GM-CSF levels were positively correlated with most of the increased serum cytokine levels of the allergic asthmatic children. Conclusions IL-5, IL-6, IL-33, and periostin had elevated levels in the nasal fluid of the patients in clinical remission. The nasal fluid GM-CSF levels of the allergic patients and nasal fluid TSLP levels of the non-allergic patients had a positive correlation with most of the serum cytokine levels. Thus, our results showed that nasal fluid might be a preferable biological sample to diagnose asthma in children.","PeriodicalId":23344,"journal":{"name":"Turkish Journal of Biochemistry","volume":"15 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91405518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical laboratory testing in the emergency department: a six-year analysis 急诊科临床实验室检测:六年分析

Turkish Journal of Biochemistry Pub Date : 2023-08-17 DOI: 10.1515/tjb-2022-0250

Attila Beştemir, Göksu Bozdereli Berikol

引用次数: 0