Transplantation最新文献

{"title":"G-LERP/miR-374i-b Attenuates IRI and Suppresses Hepatocellular Carcinoma Progression.","authors":"Chang Xie, Nasha Qiu, Chao Wang, Jun Chen, Hui Zhang, Xinfeng Lu, Siyu Chen, Yiyang Sun, Zhengxing Lian, Haitao Hu, Hengkai Zhu, Xiao Xu","doi":"10.1097/TP.0000000000005412","DOIUrl":"10.1097/TP.0000000000005412","url":null,"abstract":"<p><strong>Background: </strong>Liver transplantation (LT) is the most effective therapeutic strategy for late-stage hepatocellular carcinoma (HCC), but it is prone to ischemia-reperfusion injury (IRI), leading to poor prognosis. Previous articles have reported that miR-374b-5p expression is increased in HCC tissues, and its relationship with IRI and HCC carcinoma progression is unclear.</p><p><strong>Methods: </strong>Previous reports have shown that miR-374b-5p expression is significantly upregulated in HCC tissues. The effect of miR-374b-5p on patient symptoms and prognosis were analyzed from The Cancer Genome Atlas database and liver specimens from LT patients. To further explore its therapeutic potential, a liver-targeted esterase-responsive gene delivery system (G-LERP/miR-374i-b) was developed to downregulate miR-374b-5p expression in the mouse hepatic IRI (HIRI) model. An orthotopic HCC model was further established to mimic the postoperative recurrence of HCC.</p><p><strong>Results: </strong>In this study, we found that miR-374b-5p expression correlates with tumor size and microvascular invasion based on patients' clinical information. Patients with low miR-374b-5p expression had a higher Milan criteria score and a lower Model for End-stage Liver Disease score. We verified the positive correlation between miR-374b-5p expression and the proliferation and invasion of HCC cells. Effective downregulation of miR-374b-5p simultaneously alleviated HIRI and reduced tumor burden by 56%, whereas miR-374b-5p upregulation promoted HCC progression. Furthermore, we found G-LERP/miR-374i-b attenuated hepatic inflammation by downregulating the nuclear factor kappa-B pathway, thereby reducing HIRI and the risk of HCC recurrence.</p><p><strong>Conclusions: </strong>This research is the first to demonstrate miR-374b-5p as a dual therapeutic target during LT and postoperative recurrence of HCC. Preintervention of miR-374b-5p using an esterase-responsive gene delivery system during the preoperative period simultaneously alleviates IRI and suppresses HCC progression.</p>","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":"e469-e483"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking miRNA Therapeutics: Protecting Liver Grafts and Suppressing HCC Recurrence.","authors":"Daniel G Maluf, Valeria R Mas","doi":"10.1097/TP.0000000000005392","DOIUrl":"10.1097/TP.0000000000005392","url":null,"abstract":"","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":"e429-e430"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Current Status of Liver Transplant in Mexico.","authors":"Alondra Rosales-Padrón, David Aguirre-Villarreal, Froylan David Martínez-Sánchez, Fátima Manzo-Santana, Liz Toapanta-Yanchapaxi, Pilar Leal-Leyte, Luis A Rosales-Rentería, Daniel Zamora-Valdés, Ignacio García-Juárez","doi":"10.1097/TP.0000000000005454","DOIUrl":"10.1097/TP.0000000000005454","url":null,"abstract":"","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":"e425-e428"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy After Solid Organ Transplantation: Review of the Evidence and Recommendations.","authors":"Goni Katz-Greenberg, Yalda Afshar, Julie Bonn, Jillian Casale, Serban Constantinescu, Ersilia M DeFilippis, Roshan P George, Ana Iltis, Shilpanjali Jesudason, Michelle Kittleson, Deborah J Levine, Michael J Moritz, Monika Sarkar, Silvi Shah, Kimberly Uccellini, Lisa A Coscia, Ana P Rossi","doi":"10.1097/TP.0000000000005341","DOIUrl":"https://doi.org/10.1097/TP.0000000000005341","url":null,"abstract":"<p><p>Solid organ transplantation (SOT) offers people with end-stage organ disease an increased quality of life, which includes the return of fertility and the potential for pregnancy. Although the number of pregnancies has increased, definitive recommendations have been lacking. To address reproductive health in SOT recipients, the American Society of Transplantation Women's Health Community of Practice held a virtual Controversies Conference with subject matter experts gathered to discuss topics of contraception, immunosuppression, and pregnancy in SOT recipients and pregnancy post-living donation. This publication is a synthesis of expert guidance and available data regarding pregnancy management and outcomes after all types of SOTs.</p>","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":"109 9","pages":"1483-1494"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12354071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline Allograft Dysfunction in Single-lung Transplant Recipients: More Questions Than Answers?","authors":"Marie Spaes, Clément Picard, Natalia Belousova, Jonathan Messika","doi":"10.1097/TP.0000000000005470","DOIUrl":"10.1097/TP.0000000000005470","url":null,"abstract":"","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":"e528"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Ex Situ Liver Function by Indocyanine Green Clearance During Clinical Normothermic Machine Perfusion of Extended Criteria Grafts.","authors":"Ivo J Schurink, Stefan H Luijmes, Jorke Willemse, Femke H C de Goeij, Puck C Groen, Efrayim H Küçükerbil, Roberto Broere, Marco M Pascale, Robert J Porte, Andrei N Tintu, Luc J W van der Laan, Wojciech G Polak, Jeroen de Jonge","doi":"10.1097/TP.0000000000005350","DOIUrl":"10.1097/TP.0000000000005350","url":null,"abstract":"<p><strong>Background: </strong>Normothermic machine perfusion (NMP) enables pretransplantation assessment of donor liver viability to increase donor liver utilization. However, unambiguous objective criteria to determine integrated liver function during NMP to decide upon acceptance are still lacking. This study investigates whether the indocyanine green (ICG) elimination test can be applied to assess liver function during NMP.</p><p><strong>Methods: </strong>Donor livers underwent dual-hypothermic oxygenated machine perfusion and NMP. The ICG elimination test was improved during an optimization phase (n = 10) and tested against current functional perfusion parameters and posttransplantation outcomes in clinically perfused livers (n = 32).</p><p><strong>Results: </strong>The ICG plasma disappearance rate (PDR) during NMP was dependent on perfusion blood flow and liver weight. The corrected PDR (NMP-PDR) was correlated to the hepatic extraction rate ( R  = 0.923; P  > 0.001) and ATP content in liver biopsies at 2 h of NMP ( R  = 0.692; P  = 0.027). In the clinical phase, the length of the functional warm ischemia time in the donation process was inversely correlated to the NMP-PDR ( P  = 0.042). Both individual acceptance criteria (lactate clearance, ability of self-regulate pH, Δbicarbonate, and ΔpH) and overall hepatocellular and cholangiocellular acceptance criteria were correlated to the NMP-PDR. The NMP-PDR was higher in the cohort accepted for transplantation (n = 18; 18.1%/L·kg [14.0% to 22.7%/L·kg]) than in the nontransplanted cohort (n = 14; 11.8%/L·kg [8.8% to 12.9%/L·kg]; P  < 0.0001). Furthermore, the NMP-PDR correlated with the liver graft assessment following transplantation at 7 d score posttransplantation ( R  = -0.551; P  = 0.027).</p><p><strong>Conclusions: </strong>We demonstrate that the NMP-PDR correlates with both liver function during NMP and short-term posttransplantation outcomes. This simple objective test has the potential to increase donor liver utilization rate, while preventing hepatocellular dysfunction posttransplantation.</p>","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":"e484-e493"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-living Liver Donation Diaphragmatic Hernia: A Life-threatening Complication Emphasizing the Need for Long-term Postdonation Care.","authors":"Ashwin Rammohan, Rajesh Rajalingam, Mohamed Rela","doi":"10.1097/TP.0000000000005382","DOIUrl":"10.1097/TP.0000000000005382","url":null,"abstract":"","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":"1481-1482"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Spectrum of Mitral Regurgitation in Lung Transplant Recipients: A Systematic Review.","authors":"George Bcharah, Juan M Farina, J Asher Jenkins, Rawan M Zeineddine, Andrew G Saleeb, Estefana Bcharah, Kenan A Shawwaf, Brian W Hardaway, Pedro Reck Dos Santos, Jonathan D'Cunha, Ashraf Omar","doi":"10.1097/TP.0000000000005359","DOIUrl":"10.1097/TP.0000000000005359","url":null,"abstract":"<p><p>Mitral regurgitation (MR) in lung transplant (LTx) recipients is a rare but complex cardiopulmonary phenomenon. The overlap between symptoms of MR and post-LTx complications, such as primary graft dysfunction, complicates its diagnosis and management. This systematic review aims to characterize the incidence, pathophysiology, presentation, and management of MR in LTx patients. We conducted a literature search in PubMed, Web of Science, Scopus, and Embase. The search yielded 133 studies, of which 11 were included. Data regarding MR development, clinical presentation, echocardiographic findings, and management strategies were extracted and analyzed. Perioperative MR, occurring during or immediately post-LTx, was frequently attributed to the systolic anterior motion of the mitral valve (MV) occurring in the setting of hypovolemia and/or inotrope usage. Later postoperative MR, on the other hand, was associated with reverse ventricular remodeling and mitral annular dilation, although some variability in the literature was present. Preexisting MR or ventricular dysfunction, elongated MV leaflets, and bilateral LTx procedure appeared to be risk factors for MR development. Management was dependent on the timing of MR and its pathophysiology, where systolic anterior motion-related MR was treated with medical therapy, whereas postoperative MR often required MV interventions. In conclusion, the diagnosis of MR in LTx patients is complicated by its symptomatic overlap with other post-LTx complications. Echocardiographic monitoring in patients with preexisting MR, regardless of severity, is essential for early identification and management. Further research is needed to better understand the underlying mechanisms and refine management strategies for MR in this population.</p>","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":"e455-e468"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Kidney Disease in Heart Transplant Patients: A National Delphi Survey-based Consensus Expert Paper.","authors":"María Dolores García-Cosío Carmena, Marta Farrero, María Teresa Blasco Peiró, Marta Crespo, Juan Delgado Jiménez, Beatriz Díaz Molina, Constantino Fernández Rivera, Iris Paula Garrido Bravo, Verónica López Jiménez, Edoardo Melilli, Sonia Mirabet Pérez, María Lourdes Pérez Tamajón, Diego Rangel Sousa, Emilio Rodrigo, Josep María Cruzado, Domingo Hernández Marrero","doi":"10.1097/TP.0000000000005302","DOIUrl":"10.1097/TP.0000000000005302","url":null,"abstract":"<p><p>Kidney disease is a common complication in heart transplant recipients and requires a comprehensive and personalized approach. The interplay between preexisting kidney disease, perioperative factors, immunosuppression, and cardiovascular complications makes the management of kidney dysfunction challenging in these patients. The objective of this expert consensus was to look for agreements for the management of chronic kidney disease in heart transplant recipients. A panel of Spanish cardiologists and nephrologists with expertise in heart and kidney transplantation reviewed the evidence related to the current management of chronic kidney disease in heart transplant recipients and consensus statements were developed using a 2-round Delphi methodology. Consensus statements were proposed covering key topics, including the identification and management of kidney disease in heart transplant recipients and the indications for kidney transplantation. These statements provide additional expert guidance for the management of kidney disease in patients undergoing heart transplantation where published clinical evidence is scarce.</p>","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":"e431-e445"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Benefits of Adding Low-dose Tacrolimus to a Belatacept-based Regimen After Kidney Transplantation.","authors":"Kalathil K Sureshkumar, Stalin Canizares, Bhavna Chopra","doi":"10.1097/TP.0000000000005469","DOIUrl":"10.1097/TP.0000000000005469","url":null,"abstract":"","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":"e529"},"PeriodicalIF":5.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}