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When is an AVM not an AVM? 什么时候反车辆地雷不是反车辆地雷？
IF 9 1区 医学
Thorax Pub Date : 2024-08-19 DOI: 10.1136/thorax-2024-221458
Alice Parry, Amir Awwad, Geoffrey Lie, Matt Matson, William Martin Ricketts
{"title":"When is an AVM not an AVM?","authors":"Alice Parry, Amir Awwad, Geoffrey Lie, Matt Matson, William Martin Ricketts","doi":"10.1136/thorax-2024-221458","DOIUrl":"10.1136/thorax-2024-221458","url":null,"abstract":"","PeriodicalId":23284,"journal":{"name":"Thorax","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic-informed proteome-wide scan reveals potential causal plasma proteins for idiopathic pulmonary fibrosis. 基于基因的全蛋白质组扫描揭示了特发性肺纤维化的潜在致病血浆蛋白。
IF 9 1区 医学
Thorax Pub Date : 2024-08-19 DOI: 10.1136/thorax-2024-221398
Jiahao Zhu, Houpu Liu, Rui Gao, Ruicheng Gong, Jing Wang, Dan Zhou, Min Yu, Yingjun Li
{"title":"Genetic-informed proteome-wide scan reveals potential causal plasma proteins for idiopathic pulmonary fibrosis.","authors":"Jiahao Zhu, Houpu Liu, Rui Gao, Ruicheng Gong, Jing Wang, Dan Zhou, Min Yu, Yingjun Li","doi":"10.1136/thorax-2024-221398","DOIUrl":"10.1136/thorax-2024-221398","url":null,"abstract":"<p><p>Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease for which there are no reliable biomarkers or disease-modifying drugs. Here, we integrated human genomics and proteomics to investigate the causal associations between 2769 plasma proteins and IPF. Our Mendelian randomisation analysis identified nine proteins associated with IPF, of which three (FUT3, ADAM15 and USP28) were colocalised. ADAM15 emerged as the top candidate, supported by expression quantitative trait locus analysis in both blood and lung tissue. These findings provide novel insights into the aetiology of IPF and offer translational opportunities in response to the clinical challenges of this devastating disease.</p>","PeriodicalId":23284,"journal":{"name":"Thorax","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the occupational hazards: exploring the association between organic dust exposure and hypersensitivity pneumonitis and other interstitial lung diseases. 揭开职业危害的面纱：探索有机粉尘接触与超敏性肺炎和其他间质性肺病之间的关联。
IF 9 1区 医学
Thorax Pub Date : 2024-08-19 DOI: 10.1136/thorax-2024-221864
Sheikh M Alif, Geza Benke
{"title":"Unveiling the occupational hazards: exploring the association between organic dust exposure and hypersensitivity pneumonitis and other interstitial lung diseases.","authors":"Sheikh M Alif, Geza Benke","doi":"10.1136/thorax-2024-221864","DOIUrl":"10.1136/thorax-2024-221864","url":null,"abstract":"","PeriodicalId":23284,"journal":{"name":"Thorax","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Xpert Ultra for diagnosing tuberculosis at bronchoscopy: thoughts on practical applications. 在支气管镜检查中诊断肺结核的 Xpert Ultra：对实际应用的思考。
IF 9 1区 医学
Thorax Pub Date : 2024-08-19 DOI: 10.1136/thorax-2024-221571
Graham Bothamley
{"title":"Xpert Ultra for diagnosing tuberculosis at bronchoscopy: thoughts on practical applications.","authors":"Graham Bothamley","doi":"10.1136/thorax-2024-221571","DOIUrl":"10.1136/thorax-2024-221571","url":null,"abstract":"","PeriodicalId":23284,"journal":{"name":"Thorax","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fixing lung health in the UK: accelerating respiratory research and innovation. 解决英国肺部健康问题：加快呼吸系统研究与创新。
IF 9 1区 医学
Thorax Pub Date : 2024-08-19 DOI: 10.1136/thorax-2024-221939
Cheryl Routley, Samantha Walker, Eric Wfw Alton, Ian P Hall
{"title":"Fixing lung health in the UK: accelerating respiratory research and innovation.","authors":"Cheryl Routley, Samantha Walker, Eric Wfw Alton, Ian P Hall","doi":"10.1136/thorax-2024-221939","DOIUrl":"10.1136/thorax-2024-221939","url":null,"abstract":"","PeriodicalId":23284,"journal":{"name":"Thorax","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inequalities in care and the burden of wheeze and asthma in young children from diverse socioeconomic and ethnic backgrounds. 来自不同社会经济和种族背景的幼儿在护理方面的不平等以及喘息和哮喘的负担。
IF 9 1区 医学
Thorax Pub Date : 2024-08-17 DOI: 10.1136/thorax-2024-222111
Björn Nordlund
{"title":"Inequalities in care and the burden of wheeze and asthma in young children from diverse socioeconomic and ethnic backgrounds.","authors":"Björn Nordlund","doi":"10.1136/thorax-2024-222111","DOIUrl":"https://doi.org/10.1136/thorax-2024-222111","url":null,"abstract":"","PeriodicalId":23284,"journal":{"name":"Thorax","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implications of the hypobaric cabin environment during commercial air travel for passenger fitness to fly. 商业航空旅行中低气压客舱环境对乘客身体状况的影响。
IF 9 1区 医学
Thorax Pub Date : 2024-08-17 DOI: 10.1136/thorax-2024-221468
Peter D Hodkinson, Thomas G Smith
{"title":"Implications of the hypobaric cabin environment during commercial air travel for passenger fitness to fly.","authors":"Peter D Hodkinson, Thomas G Smith","doi":"10.1136/thorax-2024-221468","DOIUrl":"https://doi.org/10.1136/thorax-2024-221468","url":null,"abstract":"","PeriodicalId":23284,"journal":{"name":"Thorax","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Untangling the web between menopause and respiratory disease. 解开更年期与呼吸系统疾病之间的联系。
IF 9 1区 医学
Thorax Pub Date : 2024-08-17 DOI: 10.1136/thorax-2024-221856
Hannah Whittaker
{"title":"Untangling the web between menopause and respiratory disease.","authors":"Hannah Whittaker","doi":"10.1136/thorax-2024-221856","DOIUrl":"https://doi.org/10.1136/thorax-2024-221856","url":null,"abstract":"","PeriodicalId":23284,"journal":{"name":"Thorax","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial stone silicosis: a UK case series. 人造石矽肺病：英国病例系列。
IF 9 1区 医学
Thorax Pub Date : 2024-08-17 DOI: 10.1136/thorax-2024-221715
Johanna Feary, Anand Devaraj, Matthew Burton, Felix Chua, Robina K Coker, Arnab Datta, Richard J Hewitt, Maria Kokosi, Vaslis Kouranos, Carl Jonathan Reynolds, Clare L Ross, Veronica Smith, Katie Ward, Melissa Wickremasinghe, Joanna Szram
{"title":"Artificial stone silicosis: a UK case series.","authors":"Johanna Feary, Anand Devaraj, Matthew Burton, Felix Chua, Robina K Coker, Arnab Datta, Richard J Hewitt, Maria Kokosi, Vaslis Kouranos, Carl Jonathan Reynolds, Clare L Ross, Veronica Smith, Katie Ward, Melissa Wickremasinghe, Joanna Szram","doi":"10.1136/thorax-2024-221715","DOIUrl":"10.1136/thorax-2024-221715","url":null,"abstract":"<p><p>Silicosis due to artificial stone (AS) has emerged over the last decade as an increasing global issue. We report the first eight UK cases. All were men; median age was 34 years (range 27-56) and median stone dust exposure was 12.5 years (range 4-40) but in 4 cases was 4-8 years. One is deceased; two were referred for lung transplant assessment. All cases were dry cutting and polishing AS worktops with inadequate safety measures. Clinical features of silicosis can closely mimic sarcoidosis. UK cases are likely to increase, with urgent action needed to identify cases and enforce regulations.</p>","PeriodicalId":23284,"journal":{"name":"Thorax","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary fibrosis may begin in infancy: from childhood to adult interstitial lung disease. 肺纤维化可能始于婴儿期：从儿童期到成年期的间质性肺病。
IF 9 1区 医学
Thorax Pub Date : 2024-08-17 DOI: 10.1136/thorax-2024-221772
Matthias Griese, Geoffrey Kurland, Michal Cidon, Robin R Deterding, Ralph Epaud, Nadia Nathan, Nicolaus Schwerk, David Warburton, Jason P Weinman, Lisa R Young, Gail H Deutsch
{"title":"Pulmonary fibrosis may begin in infancy: from childhood to adult interstitial lung disease.","authors":"Matthias Griese, Geoffrey Kurland, Michal Cidon, Robin R Deterding, Ralph Epaud, Nadia Nathan, Nicolaus Schwerk, David Warburton, Jason P Weinman, Lisa R Young, Gail H Deutsch","doi":"10.1136/thorax-2024-221772","DOIUrl":"https://doi.org/10.1136/thorax-2024-221772","url":null,"abstract":"<p><strong>Background: </strong>Childhood interstitial lung disease (chILD) encompasses a group of rare heterogeneous respiratory conditions associated with significant morbidity and mortality. Reports suggest that many patients diagnosed with chILD continue to have potentially progressive or fibrosing disease into adulthood. Over the last decade, the spectrum of conditions within chILD has widened substantially, with the discovery of novel entities through advanced genetic testing. However, most evidence is often limited to small case series, with reports disseminated across an array of subspecialty, clinical and molecular journals. In particular, the frequency, management and outcome of paediatric pulmonary fibrosis is not well characterised, unlike in adults, where clear diagnosis and treatment guidelines are available.</p><p><strong>Methods and results: </strong>This review assesses the current understanding of pulmonary fibrosis in chILD. Based on registry data, we have provisionally estimated the occurrence of fibrosis in various manifestations of chILD, with 47 different potentially fibrotic chILD entities identified. Published evidence for fibrosis in the spectrum of chILD entities is assessed, and current and future issues in management of pulmonary fibrosis in childhood, continuing into adulthood, are considered.</p><p><strong>Conclusions: </strong>There is a need for improved knowledge of chILD among pulmonologists to optimise the transition of care from paediatric to adult facilities. Updated evidence-based guidelines are needed that incorporate recommendations for the diagnosis and management of immune-mediated disorders, as well as chILD in older children approaching adulthood.</p>","PeriodicalId":23284,"journal":{"name":"Thorax","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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