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Combinatorial Studies to Overcome Resistance to Immunotherapy最新文献

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Abstract P064: Dual effect of epigenetic inhibitor and CAR-NK cell therapy in bladder cancer P064:表观遗传抑制剂与CAR-NK细胞治疗膀胱癌的双重作用
Combinatorial Studies to Overcome Resistance to Immunotherapy Pub Date : 2022-01-01 DOI: 10.1158/2326-6074.tumimm21-p064
L. Morales, Sandra P Nunes, E. Munera-Maravilla, J. Casado, P. Río, A. Valeri, E. S. José-Enériz, Xavier Agirre, F. Prósper, J. Paramio
{"title":"Abstract P064: Dual effect of epigenetic inhibitor and CAR-NK cell therapy in bladder cancer","authors":"L. Morales, Sandra P Nunes, E. Munera-Maravilla, J. Casado, P. Río, A. Valeri, E. S. José-Enériz, Xavier Agirre, F. Prósper, J. Paramio","doi":"10.1158/2326-6074.tumimm21-p064","DOIUrl":"https://doi.org/10.1158/2326-6074.tumimm21-p064","url":null,"abstract":"","PeriodicalId":232585,"journal":{"name":"Combinatorial Studies to Overcome Resistance to Immunotherapy","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128789825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P065: Effects of targeted radiotherapy on tumor immune landscape in diverse murine tumor models P065:靶向放疗对多种小鼠肿瘤模型肿瘤免疫景观的影响
Combinatorial Studies to Overcome Resistance to Immunotherapy Pub Date : 2022-01-01 DOI: 10.1158/2326-6074.tumimm21-p065
Tristan Wirtz, Catherine T. Lee, Tao Xie, Lisa K Manzuk, M. Kraus, Christopher Dillon, T. Affolter, A. Giddabasappa
{"title":"Abstract P065: Effects of targeted radiotherapy on tumor immune landscape in diverse murine tumor models","authors":"Tristan Wirtz, Catherine T. Lee, Tao Xie, Lisa K Manzuk, M. Kraus, Christopher Dillon, T. Affolter, A. Giddabasappa","doi":"10.1158/2326-6074.tumimm21-p065","DOIUrl":"https://doi.org/10.1158/2326-6074.tumimm21-p065","url":null,"abstract":"","PeriodicalId":232585,"journal":{"name":"Combinatorial Studies to Overcome Resistance to Immunotherapy","volume":"179 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122842830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P061: Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits the efficacy of immune checkpoint blockade 摘要P061:在错配修复熟练的结直肠癌肝转移中，树突状细胞的缺乏限制了免疫检查点阻断的效果
Combinatorial Studies to Overcome Resistance to Immunotherapy Pub Date : 2022-01-01 DOI: 10.1158/2326-6074.tumimm21-p061
William W. Ho, I. Gomes-Santos, S. Aoki, Meenal Datta, K. Kawaguchi, Nilesh P. Talele, S. Roberge, Jun Ren, Hao Liu, Ivy X. Chen, P. Andersson, Sampurna Chatterjee, A. Kumar, Zohreh Amoozgar, Qixian Zhang, Peigen Huang, M. Ng, Vikash P Chauhan, Lei Xu, D. Duda, Jeffrey W. Clark, M. Pittet, D. Fukumura, R. Jain
{"title":"Abstract P061: Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits the efficacy of immune checkpoint blockade","authors":"William W. Ho, I. Gomes-Santos, S. Aoki, Meenal Datta, K. Kawaguchi, Nilesh P. Talele, S. Roberge, Jun Ren, Hao Liu, Ivy X. Chen, P. Andersson, Sampurna Chatterjee, A. Kumar, Zohreh Amoozgar, Qixian Zhang, Peigen Huang, M. Ng, Vikash P Chauhan, Lei Xu, D. Duda, Jeffrey W. Clark, M. Pittet, D. Fukumura, R. Jain","doi":"10.1158/2326-6074.tumimm21-p061","DOIUrl":"https://doi.org/10.1158/2326-6074.tumimm21-p061","url":null,"abstract":"","PeriodicalId":232585,"journal":{"name":"Combinatorial Studies to Overcome Resistance to Immunotherapy","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114955793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P058: Tumor-targeted IL-2 by engineered mesenchymal stem cells reinvigorates CD8+ T cells P058:肿瘤靶向IL-2工程化间充质干细胞使CD8+ T细胞再生
Combinatorial Studies to Overcome Resistance to Immunotherapy Pub Date : 2022-01-01 DOI: 10.1158/2326-6074.tumimm21-p058
J. Bae, Longchao Liu, C. Timmerman, Eric J Hsu, A. Zhang, Jiankun Zhu, yang-xin fu
{"title":"Abstract P058: Tumor-targeted IL-2 by engineered mesenchymal stem cells reinvigorates CD8+ T cells","authors":"J. Bae, Longchao Liu, C. Timmerman, Eric J Hsu, A. Zhang, Jiankun Zhu, yang-xin fu","doi":"10.1158/2326-6074.tumimm21-p058","DOIUrl":"https://doi.org/10.1158/2326-6074.tumimm21-p058","url":null,"abstract":"","PeriodicalId":232585,"journal":{"name":"Combinatorial Studies to Overcome Resistance to Immunotherapy","volume":"183 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115552819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract IA20: What does not kill it makes it stronger: Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy 摘要:对抗mapk靶向治疗的获得性耐药赋予了免疫逃避肿瘤微环境和对免疫治疗的交叉耐药
Combinatorial Studies to Overcome Resistance to Immunotherapy Pub Date : 2022-01-01 DOI: 10.1158/2326-6074.tumimm21-ia20
A. Obenauf
{"title":"Abstract IA20: What does not kill it makes it stronger: Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy","authors":"A. Obenauf","doi":"10.1158/2326-6074.tumimm21-ia20","DOIUrl":"https://doi.org/10.1158/2326-6074.tumimm21-ia20","url":null,"abstract":"","PeriodicalId":232585,"journal":{"name":"Combinatorial Studies to Overcome Resistance to Immunotherapy","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121636423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P059: An increase in eosinophils is associate with response to chemo-immunotherapy in metastatic triple negative breast cancer P059:嗜酸性粒细胞的增加与转移性三阴性乳腺癌对化学免疫治疗的反应有关
Combinatorial Studies to Overcome Resistance to Immunotherapy Pub Date : 2022-01-01 DOI: 10.1158/2326-6074.tumimm21-p059
H. Ghebeh, M. Elshenawy, Adher Al-Sayed, T. Al-Tweigeri
{"title":"Abstract P059: An increase in eosinophils is associate with response to chemo-immunotherapy in metastatic triple negative breast cancer","authors":"H. Ghebeh, M. Elshenawy, Adher Al-Sayed, T. Al-Tweigeri","doi":"10.1158/2326-6074.tumimm21-p059","DOIUrl":"https://doi.org/10.1158/2326-6074.tumimm21-p059","url":null,"abstract":"","PeriodicalId":232585,"journal":{"name":"Combinatorial Studies to Overcome Resistance to Immunotherapy","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132880166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PR09: Macrophage promotion of anti-androgen resistance in prostate cancer bone disease PR09:巨噬细胞促进前列腺癌骨病抗雄激素抵抗
Combinatorial Studies to Overcome Resistance to Immunotherapy Pub Date : 2022-01-01 DOI: 10.1158/2326-6074.tumimm21-pr09
Xue-Feng Li, C. Selli, A. Unciti-Broceta, N. Carragher, Hai-Yan Hu, C. Sawyers, Binzhi Qian
{"title":"Abstract PR09: Macrophage promotion of anti-androgen resistance in prostate cancer bone disease","authors":"Xue-Feng Li, C. Selli, A. Unciti-Broceta, N. Carragher, Hai-Yan Hu, C. Sawyers, Binzhi Qian","doi":"10.1158/2326-6074.tumimm21-pr09","DOIUrl":"https://doi.org/10.1158/2326-6074.tumimm21-pr09","url":null,"abstract":"","PeriodicalId":232585,"journal":{"name":"Combinatorial Studies to Overcome Resistance to Immunotherapy","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115351259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract IA22: Immunotherapy for melanoma: Checkpoint blockade combinations IA22:黑色素瘤的免疫治疗:检查点阻断联合治疗
Combinatorial Studies to Overcome Resistance to Immunotherapy Pub Date : 2022-01-01 DOI: 10.1158/2326-6074.tumimm21-ia22
J. Wolchok
{"title":"Abstract IA22: Immunotherapy for melanoma: Checkpoint blockade combinations","authors":"J. Wolchok","doi":"10.1158/2326-6074.tumimm21-ia22","DOIUrl":"https://doi.org/10.1158/2326-6074.tumimm21-ia22","url":null,"abstract":"","PeriodicalId":232585,"journal":{"name":"Combinatorial Studies to Overcome Resistance to Immunotherapy","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124357649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract P062: PI3Kγδ inhibitor plus radiation enhances the antitumor immune effect of PD-1 blockade in syngenic murine breast cancer and humanized patient-derived xenograft model 摘要P062: PI3Kγδ抑制剂加放疗可增强PD-1阻断在同基因小鼠乳腺癌和人源异种移植瘤模型中的抗肿瘤免疫作用
Combinatorial Studies to Overcome Resistance to Immunotherapy Pub Date : 2022-01-01 DOI: 10.1158/2326-6074.tumimm21-p062
I. Kim, M. Han, B. Jang, M. Kang
{"title":"Abstract P062: PI3Kγδ inhibitor plus radiation enhances the antitumor immune effect of PD-1 blockade in syngenic murine breast cancer and humanized patient-derived xenograft model","authors":"I. Kim, M. Han, B. Jang, M. Kang","doi":"10.1158/2326-6074.tumimm21-p062","DOIUrl":"https://doi.org/10.1158/2326-6074.tumimm21-p062","url":null,"abstract":"","PeriodicalId":232585,"journal":{"name":"Combinatorial Studies to Overcome Resistance to Immunotherapy","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130800329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PR10: Inhibition of MEK1/2 overcomes resistance to aPD-1 blockade in pancreatic ductal adenocarcinoma through modulation of NETosis in tumor-associated neutrophils 摘要:抑制MEK1/2通过调节肿瘤相关中性粒细胞的NETosis来克服胰腺导管腺癌对aPD-1阻断的抗性
Combinatorial Studies to Overcome Resistance to Immunotherapy Pub Date : 2022-01-01 DOI: 10.1158/2326-6074.tumimm21-pr10
B. Herbst, E. Jaffee, Lei Zheng
{"title":"Abstract PR10: Inhibition of MEK1/2 overcomes resistance to aPD-1 blockade in pancreatic ductal adenocarcinoma through modulation of NETosis in tumor-associated neutrophils","authors":"B. Herbst, E. Jaffee, Lei Zheng","doi":"10.1158/2326-6074.tumimm21-pr10","DOIUrl":"https://doi.org/10.1158/2326-6074.tumimm21-pr10","url":null,"abstract":"","PeriodicalId":232585,"journal":{"name":"Combinatorial Studies to Overcome Resistance to Immunotherapy","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131958922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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