Transactions of The Royal Society of South Africa最新文献

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The possibilities and challenges associated with selective targeting Plasmodium falciparum Hsp90 for Malaria. 选择性靶向恶性疟原虫Hsp90治疗疟疾的可能性和挑战。
Transactions of The Royal Society of South Africa Pub Date : 2025-01-01 Epub Date: 2025-02-07 DOI: 10.1080/0035919x.2025.2461304
Thato Matlhodi, Lisema Patrick Makatsela, Njabulo Joyfull Gumede, Fortunate Mokoena
{"title":"The possibilities and challenges associated with selective targeting <i>Plasmodium falciparum</i> Hsp90 for Malaria.","authors":"Thato Matlhodi, Lisema Patrick Makatsela, Njabulo Joyfull Gumede, Fortunate Mokoena","doi":"10.1080/0035919x.2025.2461304","DOIUrl":"10.1080/0035919x.2025.2461304","url":null,"abstract":"<p><p>The causative agent of malaria, <i>Plasmodium falciparum</i>, encodes four heat shock protein 90 isoforms in the cytosol, endoplasmic reticulum, mitochondria and apicoplast. PfHsp90s are considered potential targets for developing antimalarial drugs. However, the similarity between the druggable ATP binding pocket of these isoforms and their human counterparts has hindered efforts in discovering Hsp90-based antimalarial drugs. There is widespread concern that the chemotypes targeting PfHsp90 isoforms may not possess the selectivity required for translatability. Most studies have focused on the cytosolic (canonical Hsp90) and have used various inhibitors of Hsp90 to conduct anti-<i>Plasmodium</i> and mammalian safety studies without considering the on-target enzymatic activity and binding affinity. The extent to which the cytosolic Hsp90 shares common mechanisms with the other isoforms remains elusive. As such, detailed structural comparisons of the Hsp90 isoforms may reveal exploitable differences that could favour preferential binding. It is essential to consider whether molecules that act as pan-inhibitors would put more pressure on the parasite or have detrimental effects. Studies should go beyond molecular docking and whole-cell activity to advance the development of Hsp90 inhibitors as future antimalarials. There is a need also to assess the physicochemical properties, drug metabolism, pharmacokinetics, and <i>In vivo</i> proof-of-concept. We argue that the potential benefits of PfHsp90 isoform inhibitors outweigh the off-target and selectivity risks. Additionally, opportunities for using machine learning and computer-aided drug discovery efforts to design inhibitors that preferentially bind to each isoform, particularly the cytosolic PfHsp90, are highlighted as a means of overcoming the resistance challenge.</p>","PeriodicalId":23255,"journal":{"name":"Transactions of The Royal Society of South Africa","volume":"80 1","pages":"53-70"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12983136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147469347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Professor Michael (MIKE) Richard Perrin 28 December 1946–28 December 2023 迈克尔(MIKE)-理查德-佩兰教授 1946 年 12 月 28 日--2023 年 12 月 28 日
Transactions of The Royal Society of South Africa Pub Date : 2024-06-07 DOI: 10.1080/0035919x.2024.2342169
Michael J. Lawes, Colleen T. Downs, Robert Hart
{"title":"Professor Michael (MIKE) Richard Perrin 28 December 1946–28 December 2023","authors":"Michael J. Lawes, Colleen T. Downs, Robert Hart","doi":"10.1080/0035919x.2024.2342169","DOIUrl":"https://doi.org/10.1080/0035919x.2024.2342169","url":null,"abstract":"","PeriodicalId":23255,"journal":{"name":"Transactions of The Royal Society of South Africa","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141375494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biophysical system perspectives on future change in African mountains 从生物物理系统角度看非洲山区未来的变化
Transactions of The Royal Society of South Africa Pub Date : 2024-05-24 DOI: 10.1080/0035919x.2024.2355455
J. Knight
{"title":"Biophysical system perspectives on future change in African mountains","authors":"J. Knight","doi":"10.1080/0035919x.2024.2355455","DOIUrl":"https://doi.org/10.1080/0035919x.2024.2355455","url":null,"abstract":"","PeriodicalId":23255,"journal":{"name":"Transactions of The Royal Society of South Africa","volume":"5 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141099649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wattles: Australian Acacia species around the world Wattles: Australian Acacia species around the world : edited by D.M. Richardson, J.J. le Roux and Elizabete Marchante, Wallingford, UK, CABI, 2023, 544 pp., 185 Pounds Stirling (hardback), ISBN 978-1-80062-217-3 Wattles:世界各地的澳大利亚金合欢树种 Wattles:由 D.M. Richardson、J.J. le Roux 和 Elizabete Marchante 编辑,英国 Wallingford,CABI,2023,544 页,185 磅 Stirling(精装本),ISBN 978-1-80062-217-3
Transactions of The Royal Society of South Africa Pub Date : 2024-05-15 DOI: 10.1080/0035919x.2024.2342166
G. F. Midgley
{"title":"Wattles: Australian Acacia species around the world\u0000 Wattles: Australian Acacia species around the world\u0000 : edited by D.M. Richardson, J.J. le Roux and Elizabete Marchante, Wallingford, UK, CABI, 2023, 544 pp., 185 Pounds Stirling (hardback), ISBN 978-1-80062-217-3","authors":"G. F. Midgley","doi":"10.1080/0035919x.2024.2342166","DOIUrl":"https://doi.org/10.1080/0035919x.2024.2342166","url":null,"abstract":"","PeriodicalId":23255,"journal":{"name":"Transactions of The Royal Society of South Africa","volume":"7 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140972817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A systematic review on remote sensing of wetland environments 湿地环境遥感系统综述
Transactions of The Royal Society of South Africa Pub Date : 2024-03-27 DOI: 10.1080/0035919x.2024.2322946
Oshneck Mupepi, T. Marambanyika, M. Matsa, Timothy Dube
{"title":"A systematic review on remote sensing of wetland environments","authors":"Oshneck Mupepi, T. Marambanyika, M. Matsa, Timothy Dube","doi":"10.1080/0035919x.2024.2322946","DOIUrl":"https://doi.org/10.1080/0035919x.2024.2322946","url":null,"abstract":"","PeriodicalId":23255,"journal":{"name":"Transactions of The Royal Society of South Africa","volume":"23 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140377200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing plant utilisation by communities bordering a protected area in Zimbabwe using utilitarian diversity metrics 利用功用多样性指标评估津巴布韦保护区周边社区的植物利用情况
Transactions of The Royal Society of South Africa Pub Date : 2024-03-22 DOI: 10.1080/0035919x.2024.2326101
G. Dowo, S. Kativu, M. De Garine-Witchatitsky
{"title":"Assessing plant utilisation by communities bordering a protected area in Zimbabwe using utilitarian diversity metrics","authors":"G. Dowo, S. Kativu, M. De Garine-Witchatitsky","doi":"10.1080/0035919x.2024.2326101","DOIUrl":"https://doi.org/10.1080/0035919x.2024.2326101","url":null,"abstract":"","PeriodicalId":23255,"journal":{"name":"Transactions of The Royal Society of South Africa","volume":" 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140216928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An assessment of the perceptions of local communities in the Eastern Free State Region of South Africa regarding the impacts of climate change on livelihoods 评估南非东部自由州地区当地社区对气候变化对生计影响的看法
Transactions of The Royal Society of South Africa Pub Date : 2024-03-21 DOI: 10.1080/0035919x.2024.2322939
Lokuthula Msimanga, Geoffrey Mukwada
{"title":"An assessment of the perceptions of local communities in the Eastern Free State Region of South Africa regarding the impacts of climate change on livelihoods","authors":"Lokuthula Msimanga, Geoffrey Mukwada","doi":"10.1080/0035919x.2024.2322939","DOIUrl":"https://doi.org/10.1080/0035919x.2024.2322939","url":null,"abstract":"","PeriodicalId":23255,"journal":{"name":"Transactions of The Royal Society of South Africa","volume":"20 S2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140222157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temperature thresholds to guide choice of freshwater species for monitoring onset of chronic thermal stress impacts in rivers 用温度阈值指导淡水物种的选择,以监测河流中慢性热应力影响的发生
Transactions of The Royal Society of South Africa Pub Date : 2024-03-21 DOI: 10.1080/0035919x.2024.2329920
N. Rivers-Moore
{"title":"Temperature thresholds to guide choice of freshwater species for monitoring onset of chronic thermal stress impacts in rivers","authors":"N. Rivers-Moore","doi":"10.1080/0035919x.2024.2329920","DOIUrl":"https://doi.org/10.1080/0035919x.2024.2329920","url":null,"abstract":"","PeriodicalId":23255,"journal":{"name":"Transactions of The Royal Society of South Africa","volume":" 32","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140388140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The faunistic diversity of spiders (Arachnida: Araneae) of the South African Cape Floristic Kingdom 南非开普花卉王国蜘蛛(蛛形纲:Araneae)的动物多样性
Transactions of The Royal Society of South Africa Pub Date : 2024-03-07 DOI: 10.1080/0035919x.2024.2324912
A. Dippenaar-Schoeman, C. Haddad, S. Foord, L. N. Lotz
{"title":"The faunistic diversity of spiders (Arachnida: Araneae) of the South African Cape Floristic Kingdom","authors":"A. Dippenaar-Schoeman, C. Haddad, S. Foord, L. N. Lotz","doi":"10.1080/0035919x.2024.2324912","DOIUrl":"https://doi.org/10.1080/0035919x.2024.2324912","url":null,"abstract":"","PeriodicalId":23255,"journal":{"name":"Transactions of The Royal Society of South Africa","volume":"54 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140258808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Climate smart Kalahari melon ( Citrullus lanatus ): understanding its seeds hydration kinetics 气候智能卡拉哈里甜瓜(Citrullus lanatus):了解其种子水合动力学
Transactions of The Royal Society of South Africa Pub Date : 2024-01-18 DOI: 10.1080/0035919x.2024.2302627
K. Nantanga, W. Embashu
{"title":"Climate smart Kalahari melon (\u0000 Citrullus lanatus\u0000 ): understanding its seeds hydration kinetics","authors":"K. Nantanga, W. Embashu","doi":"10.1080/0035919x.2024.2302627","DOIUrl":"https://doi.org/10.1080/0035919x.2024.2302627","url":null,"abstract":"","PeriodicalId":23255,"journal":{"name":"Transactions of The Royal Society of South Africa","volume":"104 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139614758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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