Translational Oncology最新文献_第5页

Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas. 挖掘STAT家族在头颈部鳞状细胞癌中的表达及临床意义。

IF 5 2区医学

Translational Oncology Pub Date : 2021-01-01 Epub Date: 2020-12-10 DOI: 10.1016/j.tranon.2020.100976

Haosheng Ni, Hui Sun, Miaosen Zheng, Tingting Bian, Jian Liu, Xiaoli Li, Jianguo Zhang, Yifei Liu

{"title":"Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas.","authors":"Haosheng Ni, Hui Sun, Miaosen Zheng, Tingting Bian, Jian Liu, Xiaoli Li, Jianguo Zhang, Yifei Liu","doi":"10.1016/j.tranon.2020.100976","DOIUrl":"https://doi.org/10.1016/j.tranon.2020.100976","url":null,"abstract":"Background: Head and neck squamous cell carcinomas (HNSC) are among the most common malignant tumors with high incidence, relapse, and mortality rate. STAT proteins are implicated in various biological processes, including cell proliferation, metastasis, and immune regulation.Method: Various bioinformatics tools were used to explore the role of the STAT family in HNSC.Result: The mRNA levels of STAT1/2/4/5A/6 were significantly upregulated in HNSC tissues. The levels of STAT1/2/4/5A/6 could be used for the detection of HNSC. HNSC patients with a high level of STAT5A had a poor overall survival and relapse-free survival. A moderate to high correlation was obtained between the STAT family and HNSC. Genetic alteration revealed that STAT1/2/3/4/5A/5B/6 were altered in 6%, 5%, 7%, 8%, 6%, 6%, and 4% of the queried TCGA HNSC samples, respectively. Immune infiltrations analysis suggested a significant association between STAT5A expression and abundance of specific immune cells. Further, copy number alteration of STAT5A could certainly inhibit infiltration level. Moreover, a close correlation was obtained between STAT5A level and the expression of immune markers in HNSC. Several kinase targets and transcription factor targets of STAT5A in HNSC were also identified. Enrichment analysis suggested that STAT5A and co-expression genes were mainly responsible for adaptive immune response, T cell activation, cytokine-cytokine receptor interaction, chemokine signaling pathway, cell-adhesion molecules, and ribosome and RNA transport.Conclusion: Our results provided additional data for the expression and clinical significance of the STAT family in HNSC, and further study should be performed to verify these.","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":"14 1","pages":"100976"},"PeriodicalIF":5.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tranon.2020.100976","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39114656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Rewiring Tumor Cell State in Cancer Therapy: Comment on '9-cis-UAB30, a Novel Rexinoid Agonist, Decreases Tumorigenicity and Cancer Cell Stemness of Human Neuroblastoma Patient-Derived Xenografts' by 'Elizabeth Beierle et al.' 在癌症治疗中重新连接肿瘤细胞状态:Elizabeth Beierle等人对“9-顺式- uab30，一种新型Rexinoid激动剂，降低人类神经母细胞瘤患者来源的异种移植物的致瘤性和癌细胞干性”的评论。

IF 5 2区医学

Translational Oncology Pub Date : 2021-01-01 Epub Date: 2020-12-01 DOI: 10.1016/j.tranon.2020.100967

Abhishek A Chakraborty

引用次数: 0

Get rid of pancreatic cancer by inhibiting garbage disposal?: Comment on "UAE1 Inhibition mediates the unfolded protein response, DNA damage and caspase-dependent cell death in pancreatic cancer" by Rehemtulla et al. 通过抑制垃圾处理来摆脱胰腺癌?Rehemtulla等人对“UAE1抑制介导胰腺癌未折叠蛋白反应、DNA损伤和caspase依赖性细胞死亡”的评论。

IF 5 2区医学

Translational Oncology Pub Date : 2021-01-01 Epub Date: 2020-12-04 DOI: 10.1016/j.tranon.2020.100968

Claudia Geismann, Alexander Arlt

引用次数: 0

Thymic function affects breast cancer development and metastasis by regulating expression of thymus secretions PTMα and Tβ15b1. 胸腺功能通过调节胸腺分泌物PTMα和Tβ15b1的表达影响乳腺癌的发展和转移。

IF 5 2区医学

Translational Oncology Pub Date : 2021-01-01 Epub Date: 2020-12-11 DOI: 10.1016/j.tranon.2020.100980

Dongling Shi, Yanmei Shui, Xie Xu, Kai He, Fengqing Yang, Jianli Gao

{"title":"Thymic function affects breast cancer development and metastasis by regulating expression of thymus secretions PTMα and Tβ15b1.","authors":"Dongling Shi, Yanmei Shui, Xie Xu, Kai He, Fengqing Yang, Jianli Gao","doi":"10.1016/j.tranon.2020.100980","DOIUrl":"https://doi.org/10.1016/j.tranon.2020.100980","url":null,"abstract":"Breast cancer is currently one of the most common malignant tumors in women. Our previous research found that thymic dysfunction has a certain relationship with the occurrence and development of breast cancer. In order to explore whether the functional status of thymus is related to the development and metastasis of breast cancer, we use BALB/c wild type mice (BALB wt), BALB/c nude mice (BALB nu), BALB wt mice implanted with 4T1 cells (wt 4T1), BALB nu with 4T1 (nu 4T1), D-galactose treatment wt 4T1 mice (D-Gal), Thymalfasin treatment wt 4T1 mice (Tα1), Cyclophosphamide treatment wt 4T1 mice (CTX), Doxorubicin treatment wt 4T1 mice (Dox) in the research. As a result, nu 4T1, D-Gal and DOX had earlier lung metastases. Gene chip results showed that PTMα and Tβ15b1 were the most up-regulated and down-regulated genes in thymosin-related genes, respectively. Overexpression or silencing of PTMα and Tβ15b1 genes did not affect the proliferation of 4T1 cells. PTMα gene silenced, cell migration and invasion ability enhanced, while PTMα gene overexpression, the cell invasion ability weaken. In vivo, PTMα gene overexpression promotes tumor growth and lung metastasis in the early stage, but has no significant effect in the later stage. Tβ15b1 overexpression also promotes tumor growth in the early stage, but suppresses in the later stage. Tβ15b1 gene silencing inhibits tumor lung metastasis. Thus, our findings demonstrated that thymic function affects breast cancer development and metastasis by regulating expression of thymus secretions PTMα and Tβ15b1. Our study provided new directions for breast cancer therapy.","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":"14 1","pages":"100980"},"PeriodicalIF":5.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tranon.2020.100980","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39114652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Unmasking the expression of PD-L1 in Myeloid Derived Suppressor Cells: A case study in lung cancer to discover new drugs with specific on-target efficacy. 揭示髓系来源抑制细胞中PD-L1的表达:肺癌的一个案例研究，以发现具有特异性靶向疗效的新药。

IF 5 2区医学

Translational Oncology Pub Date : 2021-01-01 Epub Date: 2020-12-07 DOI: 10.1016/j.tranon.2020.100969

Laura G Rico, Andrés Aguilar Hernández, Michael D Ward, Jolene A Bradford, Jordi Juncà, Rafael Rosell, Jordi Petriz

引用次数: 3

Sensitivity of human meningioma cells to the cyclin-dependent kinase inhibitor, TG02 人脑膜瘤细胞对周期蛋白依赖性激酶抑制剂TG02的敏感性

IF 5 2区医学

Translational Oncology Pub Date : 2019-08-01 DOI: 10.1093/neuonc/noz126.056

C. von Achenbach, É. Le Rhun, F. Sahm, S. Wang, P. Sievers, M. Neidert, E. Rushing, T. Lawhon, Hannah Schneider, A. von Deimling, M. Weller

{"title":"Sensitivity of human meningioma cells to the cyclin-dependent kinase inhibitor, TG02","authors":"C. von Achenbach, É. Le Rhun, F. Sahm, S. Wang, P. Sievers, M. Neidert, E. Rushing, T. Lawhon, Hannah Schneider, A. von Deimling, M. Weller","doi":"10.1093/neuonc/noz126.056","DOIUrl":"https://doi.org/10.1093/neuonc/noz126.056","url":null,"abstract":"Standards of care for meningioma include surgical resection and radiotherapy whereas pharmacotherapy plays almost no role in this disease. We generated primary cultures from surgically removed meningiomas to explore the activity of a novel cyclin-dependent kinase inhibitor, TG02, in meningioma cell cultures. Tumor and cell cultures were characterized by mutation profiling and DNA methylation profiling. DNA methylation data were used to allot each sample to one out of six previously established meningioma methylation classes: benign (ben)-1, 2, 3, intermediate (int)-A, B, and malignant (mal). Four tumors assigned to the methylation class ben-2 showed the same class in culture whereas cultures from five non-ben-2 tumors showed a more malignant class in four patients. Cell cultures were uniformly sensitive to TG02 in the nanomolar range. Assignment of the cell cultures to a more malignant methylation class appeared to be more closely associated with TG02 sensitivity than assignment to a higher WHO grade of the primary tumors. Primary cell cultures from meningioma facilitate the investigation of the anti-meningioma activity of novel agents. TG02, an orally available cyclin-dependent kinase (CDK) inhibitor, warrants further exploration.","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":"13 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/neuonc/noz126.056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49083502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A Comprehensive Immunologic Portrait of Triple-Negative Breast Cancer 癌症三阴性的综合免疫学研究

IF 5 2区医学

Translational Oncology Pub Date : 2017-10-26 DOI: 10.1101/209288

Zhixian Liu, Mengyuan Li, Zehang Jiang, Xiaosheng Wang

{"title":"A Comprehensive Immunologic Portrait of Triple-Negative Breast Cancer","authors":"Zhixian Liu, Mengyuan Li, Zehang Jiang, Xiaosheng Wang","doi":"10.1101/209288","DOIUrl":"https://doi.org/10.1101/209288","url":null,"abstract":"Background Triple-negative breast cancer (TNBC) is a high-risk malignancy due to its high capacity for invasion and lack of targeted therapy. Immunotherapy continues to demonstrate efficacy in a variety of cancers, and thus may be a promising strategy for TNBC given the limited therapeutic options currently available for TNBC. In this study, we performed a comprehensive portrait of immunologic landscape of TNBC based on 2 large-scale breast cancer genomic data. Methods We compared expression levels of immune-related genes and gene-sets among TNBC, non-TNBC, and normal tissue, and within TNBCs of different genotypic or phenotypic features. Moreover, we explored the association of immune-related genes or gene-sets expression and survival prognosis in TNBC patients. Results We found that almost all analyzed immune-related gene-sets had significantly higher expression levels in TNBC than non-TNBC. These highly expressed gene-sets in TNBC included 15 immune cell type and function, human leukocyte antigen (HLA), cancer testis (CT), tumor-infiltrating lymphocytes (TILs), immune cell infiltrate, regulatory T (Treg) cells, immune checkpoint, cytokine and cytokine receptor, metastasis-promoting, pro-inflammatory and parainflammation (PI) gene-sets. Moreover, TP53-mutated, TNBC had significantly higher expression levels of the immune checkpoint, Treg, PI, and CT gene-sets, and lower expression levels of the immune cell infiltrate gene-set than TP53-wildtype TNBC. Furthermore, we found that elevated expression of most of the immune-related genes in TNBC was associated with the ER-status, while some were associated with both ER-and HER2-status. Elevated expression of the immune-related genes in TNBC was also associated with the high tumor mutation burden (TMB) in TNBC. Finally, elevated expression of the immune-related gene-sets was likely to be associated with better survival prognosis in TNBC. Conclusions Our findings suggest that TNBC is a breast cancer subtype with particularly strong immunogenicity, and therefore could be propitious to immunotherapeutic options.","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":"11 1","pages":"311 - 329"},"PeriodicalIF":5.0,"publicationDate":"2017-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48902319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 176

Apps for Radiation Oncology. A Comprehensive Review1 放射肿瘤学应用程序。综合评价

IF 5 2区医学

Translational Oncology Pub Date : 2017-02-01 DOI: 10.1016/j.tranon.2016.08.008

J. Calero, L. Otón, C. Otón

引用次数: 9

Clinical Features of Brain Metastases in Small Cell Lung Cancer: an Implication for Hippocampal Sparing Whole Brain Radiation Therapy1 小细胞肺癌脑转移的临床特征:保留海马全脑放疗的意义[j]

IF 5 2区医学

Translational Oncology Pub Date : 2016-12-08 DOI: 10.1016/j.tranon.2016.11.002

Wenlong Guo, Zhen-Yu He, Yue Chen, Dong Zhou, Kai Tang, Peng Wang, Sheng-quan Zhan, San-Gang Wu

引用次数: 12

AMPKα Is Suppressed in Bladder Cancer through Macrophage-Mediated Mechanisms12 巨噬细胞介导的AMPKα在膀胱癌中的抑制作用

IF 5 2区医学

Translational Oncology Pub Date : 2016-12-01 DOI: 10.1016/j.tranon.2016.07.007

Stavros Kopsiaftis, P. Hegde, John A. Taylor, K. Claffey

引用次数: 11