发布求助
文献互助 智能选刊 最新文献

Translational Oncology最新文献

筛选
英文 中文
Unmasking the expression of PD-L1 in Myeloid Derived Suppressor Cells: A case study in lung cancer to discover new drugs with specific on-target efficacy. 揭示髓系来源抑制细胞中PD-L1的表达:肺癌的一个案例研究，以发现具有特异性靶向疗效的新药。
IF 5 2区 医学
Translational Oncology Pub Date : 2021-01-01 Epub Date: 2020-12-07 DOI: 10.1016/j.tranon.2020.100969
Laura G Rico, Andrés Aguilar Hernández, Michael D Ward, Jolene A Bradford, Jordi Juncà, Rafael Rosell, Jordi Petriz
{"title":"Unmasking the expression of PD-L1 in Myeloid Derived Suppressor Cells: A case study in lung cancer to discover new drugs with specific on-target efficacy.","authors":"Laura G Rico, Andrés Aguilar Hernández, Michael D Ward, Jolene A Bradford, Jordi Juncà, Rafael Rosell, Jordi Petriz","doi":"10.1016/j.tranon.2020.100969","DOIUrl":"https://doi.org/10.1016/j.tranon.2020.100969","url":null,"abstract":"","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tranon.2020.100969","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39114655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Sensitivity of human meningioma cells to the cyclin-dependent kinase inhibitor, TG02 人脑膜瘤细胞对周期蛋白依赖性激酶抑制剂TG02的敏感性
IF 5 2区 医学
Translational Oncology Pub Date : 2019-08-01 DOI: 10.1093/neuonc/noz126.056
C. von Achenbach, É. Le Rhun, F. Sahm, S. Wang, P. Sievers, M. Neidert, E. Rushing, T. Lawhon, Hannah Schneider, A. von Deimling, M. Weller
{"title":"Sensitivity of human meningioma cells to the cyclin-dependent kinase inhibitor, TG02","authors":"C. von Achenbach, É. Le Rhun, F. Sahm, S. Wang, P. Sievers, M. Neidert, E. Rushing, T. Lawhon, Hannah Schneider, A. von Deimling, M. Weller","doi":"10.1093/neuonc/noz126.056","DOIUrl":"https://doi.org/10.1093/neuonc/noz126.056","url":null,"abstract":"Standards of care for meningioma include surgical resection and radiotherapy whereas pharmacotherapy plays almost no role in this disease. We generated primary cultures from surgically removed meningiomas to explore the activity of a novel cyclin-dependent kinase inhibitor, TG02, in meningioma cell cultures. Tumor and cell cultures were characterized by mutation profiling and DNA methylation profiling. DNA methylation data were used to allot each sample to one out of six previously established meningioma methylation classes: benign (ben)-1, 2, 3, intermediate (int)-A, B, and malignant (mal). Four tumors assigned to the methylation class ben-2 showed the same class in culture whereas cultures from five non-ben-2 tumors showed a more malignant class in four patients. Cell cultures were uniformly sensitive to TG02 in the nanomolar range. Assignment of the cell cultures to a more malignant methylation class appeared to be more closely associated with TG02 sensitivity than assignment to a higher WHO grade of the primary tumors. Primary cell cultures from meningioma facilitate the investigation of the anti-meningioma activity of novel agents. TG02, an orally available cyclin-dependent kinase (CDK) inhibitor, warrants further exploration.","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/neuonc/noz126.056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49083502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
A Comprehensive Immunologic Portrait of Triple-Negative Breast Cancer 癌症三阴性的综合免疫学研究
IF 5 2区 医学
Translational Oncology Pub Date : 2017-10-26 DOI: 10.1101/209288
Zhixian Liu, Mengyuan Li, Zehang Jiang, Xiaosheng Wang
{"title":"A Comprehensive Immunologic Portrait of Triple-Negative Breast Cancer","authors":"Zhixian Liu, Mengyuan Li, Zehang Jiang, Xiaosheng Wang","doi":"10.1101/209288","DOIUrl":"https://doi.org/10.1101/209288","url":null,"abstract":"Background Triple-negative breast cancer (TNBC) is a high-risk malignancy due to its high capacity for invasion and lack of targeted therapy. Immunotherapy continues to demonstrate efficacy in a variety of cancers, and thus may be a promising strategy for TNBC given the limited therapeutic options currently available for TNBC. In this study, we performed a comprehensive portrait of immunologic landscape of TNBC based on 2 large-scale breast cancer genomic data. Methods We compared expression levels of immune-related genes and gene-sets among TNBC, non-TNBC, and normal tissue, and within TNBCs of different genotypic or phenotypic features. Moreover, we explored the association of immune-related genes or gene-sets expression and survival prognosis in TNBC patients. Results We found that almost all analyzed immune-related gene-sets had significantly higher expression levels in TNBC than non-TNBC. These highly expressed gene-sets in TNBC included 15 immune cell type and function, human leukocyte antigen (HLA), cancer testis (CT), tumor-infiltrating lymphocytes (TILs), immune cell infiltrate, regulatory T (Treg) cells, immune checkpoint, cytokine and cytokine receptor, metastasis-promoting, pro-inflammatory and parainflammation (PI) gene-sets. Moreover, TP53-mutated, TNBC had significantly higher expression levels of the immune checkpoint, Treg, PI, and CT gene-sets, and lower expression levels of the immune cell infiltrate gene-set than TP53-wildtype TNBC. Furthermore, we found that elevated expression of most of the immune-related genes in TNBC was associated with the ER-status, while some were associated with both ER-and HER2-status. Elevated expression of the immune-related genes in TNBC was also associated with the high tumor mutation burden (TMB) in TNBC. Finally, elevated expression of the immune-related gene-sets was likely to be associated with better survival prognosis in TNBC. Conclusions Our findings suggest that TNBC is a breast cancer subtype with particularly strong immunogenicity, and therefore could be propitious to immunotherapeutic options.","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2017-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48902319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 176
Apps for Radiation Oncology. A Comprehensive Review1 放射肿瘤学应用程序。综合评价
IF 5 2区 医学
Translational Oncology Pub Date : 2017-02-01 DOI: 10.1016/j.tranon.2016.08.008
J. Calero, L. Otón, C. Otón
{"title":"Apps for Radiation Oncology. A Comprehensive Review1","authors":"J. Calero, L. Otón, C. Otón","doi":"10.1016/j.tranon.2016.08.008","DOIUrl":"https://doi.org/10.1016/j.tranon.2016.08.008","url":null,"abstract":"","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tranon.2016.08.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47333179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Clinical Features of Brain Metastases in Small Cell Lung Cancer: an Implication for Hippocampal Sparing Whole Brain Radiation Therapy1 小细胞肺癌脑转移的临床特征:保留海马全脑放疗的意义[j]
IF 5 2区 医学
Translational Oncology Pub Date : 2016-12-08 DOI: 10.1016/j.tranon.2016.11.002
Wenlong Guo, Zhen-Yu He, Yue Chen, Dong Zhou, Kai Tang, Peng Wang, Sheng-quan Zhan, San-Gang Wu
{"title":"Clinical Features of Brain Metastases in Small Cell Lung Cancer: an Implication for Hippocampal Sparing Whole Brain Radiation Therapy1","authors":"Wenlong Guo, Zhen-Yu He, Yue Chen, Dong Zhou, Kai Tang, Peng Wang, Sheng-quan Zhan, San-Gang Wu","doi":"10.1016/j.tranon.2016.11.002","DOIUrl":"https://doi.org/10.1016/j.tranon.2016.11.002","url":null,"abstract":"","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2016-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tranon.2016.11.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55289442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
AMPKα Is Suppressed in Bladder Cancer through Macrophage-Mediated Mechanisms12 巨噬细胞介导的AMPKα在膀胱癌中的抑制作用
IF 5 2区 医学
Translational Oncology Pub Date : 2016-12-01 DOI: 10.1016/j.tranon.2016.07.007
Stavros Kopsiaftis, P. Hegde, John A. Taylor, K. Claffey
{"title":"AMPKα Is Suppressed in Bladder Cancer through Macrophage-Mediated Mechanisms12","authors":"Stavros Kopsiaftis, P. Hegde, John A. Taylor, K. Claffey","doi":"10.1016/j.tranon.2016.07.007","DOIUrl":"https://doi.org/10.1016/j.tranon.2016.07.007","url":null,"abstract":"","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tranon.2016.07.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55287992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
High Expression of PHGDH Predicts Poor Prognosis in Non–Small Cell Lung Cancer1 PHGDH高表达预示非小细胞肺癌预后不良1
IF 5 2区 医学
Translational Oncology Pub Date : 2016-12-01 DOI: 10.1016/j.tranon.2016.08.003
Jinhong Zhu, Jianqun Ma, Xudong Wang, Tianjiao Ma, S. Zhang, W. Wang, Xiaoyu Zhou, Jiahai Shi
{"title":"High Expression of PHGDH Predicts Poor Prognosis in Non–Small Cell Lung Cancer1","authors":"Jinhong Zhu, Jianqun Ma, Xudong Wang, Tianjiao Ma, S. Zhang, W. Wang, Xiaoyu Zhou, Jiahai Shi","doi":"10.1016/j.tranon.2016.08.003","DOIUrl":"https://doi.org/10.1016/j.tranon.2016.08.003","url":null,"abstract":"","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tranon.2016.08.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55288075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 56
Preoperative Monocyte-to-Lymphocyte Ratio in Peripheral Blood Predicts Stages, Metastasis, and Histological Grades in Patients with Ovarian Cancer12 术前外周血单核细胞与淋巴细胞比值预测卵巢癌患者的分期、转移和组织学分级12
IF 5 2区 医学
Translational Oncology Pub Date : 2016-11-24 DOI: 10.1016/j.tranon.2016.10.006
Jiangdong Xiang, Lina Zhou, Xing Li, W. Bao, Taizhong Chen, X. Xi, Yinyan He, X. Wan
{"title":"Preoperative Monocyte-to-Lymphocyte Ratio in Peripheral Blood Predicts Stages, Metastasis, and Histological Grades in Patients with Ovarian Cancer12","authors":"Jiangdong Xiang, Lina Zhou, Xing Li, W. Bao, Taizhong Chen, X. Xi, Yinyan He, X. Wan","doi":"10.1016/j.tranon.2016.10.006","DOIUrl":"https://doi.org/10.1016/j.tranon.2016.10.006","url":null,"abstract":"","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2016-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tranon.2016.10.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55289319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 86
Correlations Between DCE MRI and Histopathological Parameters in Head and Neck Squamous Cell Carcinoma1 头颈部鳞状细胞癌DCE MRI与组织病理学参数的相关性
IF 5 2区 医学
Translational Oncology Pub Date : 2016-11-24 DOI: 10.1016/j.tranon.2016.10.001
A. Surov, H. Meyer, M. Gawlitza, A. Höhn, A. Boehm, T. Kahn, P. Stumpp
{"title":"Correlations Between DCE MRI and Histopathological Parameters in Head and Neck Squamous Cell Carcinoma1","authors":"A. Surov, H. Meyer, M. Gawlitza, A. Höhn, A. Boehm, T. Kahn, P. Stumpp","doi":"10.1016/j.tranon.2016.10.001","DOIUrl":"https://doi.org/10.1016/j.tranon.2016.10.001","url":null,"abstract":"","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2016-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tranon.2016.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55289170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 52
A Prediction Model Based on Biomarkers and Clinical Characteristics for Detection of Lung Cancer in Pulmonary Nodules12 基于生物标志物和临床特征的肺结节癌检测预测模型[j]
IF 5 2区 医学
Translational Oncology Pub Date : 2016-11-24 DOI: 10.1016/j.tranon.2016.11.001
Jie Ma, Maria A. Guarnera, Wenxian Zhou, Hongbin Fang, F. Jiang
{"title":"A Prediction Model Based on Biomarkers and Clinical Characteristics for Detection of Lung Cancer in Pulmonary Nodules12","authors":"Jie Ma, Maria A. Guarnera, Wenxian Zhou, Hongbin Fang, F. Jiang","doi":"10.1016/j.tranon.2016.11.001","DOIUrl":"https://doi.org/10.1016/j.tranon.2016.11.001","url":null,"abstract":"","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2016-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tranon.2016.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55289409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信