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Translational Oncology最新文献

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A Comprehensive Immunologic Portrait of Triple-Negative Breast Cancer 癌症三阴性的综合免疫学研究
IF 5 2区 医学
Translational Oncology Pub Date : 2017-10-26 DOI: 10.1101/209288
Zhixian Liu, Mengyuan Li, Zehang Jiang, Xiaosheng Wang
{"title":"A Comprehensive Immunologic Portrait of Triple-Negative Breast Cancer","authors":"Zhixian Liu, Mengyuan Li, Zehang Jiang, Xiaosheng Wang","doi":"10.1101/209288","DOIUrl":"https://doi.org/10.1101/209288","url":null,"abstract":"Background Triple-negative breast cancer (TNBC) is a high-risk malignancy due to its high capacity for invasion and lack of targeted therapy. Immunotherapy continues to demonstrate efficacy in a variety of cancers, and thus may be a promising strategy for TNBC given the limited therapeutic options currently available for TNBC. In this study, we performed a comprehensive portrait of immunologic landscape of TNBC based on 2 large-scale breast cancer genomic data. Methods We compared expression levels of immune-related genes and gene-sets among TNBC, non-TNBC, and normal tissue, and within TNBCs of different genotypic or phenotypic features. Moreover, we explored the association of immune-related genes or gene-sets expression and survival prognosis in TNBC patients. Results We found that almost all analyzed immune-related gene-sets had significantly higher expression levels in TNBC than non-TNBC. These highly expressed gene-sets in TNBC included 15 immune cell type and function, human leukocyte antigen (HLA), cancer testis (CT), tumor-infiltrating lymphocytes (TILs), immune cell infiltrate, regulatory T (Treg) cells, immune checkpoint, cytokine and cytokine receptor, metastasis-promoting, pro-inflammatory and parainflammation (PI) gene-sets. Moreover, TP53-mutated, TNBC had significantly higher expression levels of the immune checkpoint, Treg, PI, and CT gene-sets, and lower expression levels of the immune cell infiltrate gene-set than TP53-wildtype TNBC. Furthermore, we found that elevated expression of most of the immune-related genes in TNBC was associated with the ER-status, while some were associated with both ER-and HER2-status. Elevated expression of the immune-related genes in TNBC was also associated with the high tumor mutation burden (TMB) in TNBC. Finally, elevated expression of the immune-related gene-sets was likely to be associated with better survival prognosis in TNBC. Conclusions Our findings suggest that TNBC is a breast cancer subtype with particularly strong immunogenicity, and therefore could be propitious to immunotherapeutic options.","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":"11 1","pages":"311 - 329"},"PeriodicalIF":5.0,"publicationDate":"2017-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48902319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 176
Apps for Radiation Oncology. A Comprehensive Review1 放射肿瘤学应用程序。综合评价
IF 5 2区 医学
Translational Oncology Pub Date : 2017-02-01 DOI: 10.1016/j.tranon.2016.08.008
J. Calero, L. Otón, C. Otón
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引用次数: 9
Clinical Features of Brain Metastases in Small Cell Lung Cancer: an Implication for Hippocampal Sparing Whole Brain Radiation Therapy1 小细胞肺癌脑转移的临床特征:保留海马全脑放疗的意义[j]
IF 5 2区 医学
Translational Oncology Pub Date : 2016-12-08 DOI: 10.1016/j.tranon.2016.11.002
Wenlong Guo, Zhen-Yu He, Yue Chen, Dong Zhou, Kai Tang, Peng Wang, Sheng-quan Zhan, San-Gang Wu
{"title":"Clinical Features of Brain Metastases in Small Cell Lung Cancer: an Implication for Hippocampal Sparing Whole Brain Radiation Therapy1","authors":"Wenlong Guo, Zhen-Yu He, Yue Chen, Dong Zhou, Kai Tang, Peng Wang, Sheng-quan Zhan, San-Gang Wu","doi":"10.1016/j.tranon.2016.11.002","DOIUrl":"https://doi.org/10.1016/j.tranon.2016.11.002","url":null,"abstract":"","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":"26 1","pages":"54 - 58"},"PeriodicalIF":5.0,"publicationDate":"2016-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tranon.2016.11.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55289442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
AMPKα Is Suppressed in Bladder Cancer through Macrophage-Mediated Mechanisms12 巨噬细胞介导的AMPKα在膀胱癌中的抑制作用
IF 5 2区 医学
Translational Oncology Pub Date : 2016-12-01 DOI: 10.1016/j.tranon.2016.07.007
Stavros Kopsiaftis, P. Hegde, John A. Taylor, K. Claffey
{"title":"AMPKα Is Suppressed in Bladder Cancer through Macrophage-Mediated Mechanisms12","authors":"Stavros Kopsiaftis, P. Hegde, John A. Taylor, K. Claffey","doi":"10.1016/j.tranon.2016.07.007","DOIUrl":"https://doi.org/10.1016/j.tranon.2016.07.007","url":null,"abstract":"","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":"9 1","pages":"606 - 616"},"PeriodicalIF":5.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tranon.2016.07.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55287992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
High Expression of PHGDH Predicts Poor Prognosis in Non–Small Cell Lung Cancer1 PHGDH高表达预示非小细胞肺癌预后不良1
IF 5 2区 医学
Translational Oncology Pub Date : 2016-12-01 DOI: 10.1016/j.tranon.2016.08.003
Jinhong Zhu, Jianqun Ma, Xudong Wang, Tianjiao Ma, S. Zhang, W. Wang, Xiaoyu Zhou, Jiahai Shi
{"title":"High Expression of PHGDH Predicts Poor Prognosis in Non–Small Cell Lung Cancer1","authors":"Jinhong Zhu, Jianqun Ma, Xudong Wang, Tianjiao Ma, S. Zhang, W. Wang, Xiaoyu Zhou, Jiahai Shi","doi":"10.1016/j.tranon.2016.08.003","DOIUrl":"https://doi.org/10.1016/j.tranon.2016.08.003","url":null,"abstract":"","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":"9 1","pages":"592 - 599"},"PeriodicalIF":5.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tranon.2016.08.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55288075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 56
Preoperative Monocyte-to-Lymphocyte Ratio in Peripheral Blood Predicts Stages, Metastasis, and Histological Grades in Patients with Ovarian Cancer12 术前外周血单核细胞与淋巴细胞比值预测卵巢癌患者的分期、转移和组织学分级12
IF 5 2区 医学
Translational Oncology Pub Date : 2016-11-24 DOI: 10.1016/j.tranon.2016.10.006
Jiangdong Xiang, Lina Zhou, Xing Li, W. Bao, Taizhong Chen, X. Xi, Yinyan He, X. Wan
{"title":"Preoperative Monocyte-to-Lymphocyte Ratio in Peripheral Blood Predicts Stages, Metastasis, and Histological Grades in Patients with Ovarian Cancer12","authors":"Jiangdong Xiang, Lina Zhou, Xing Li, W. Bao, Taizhong Chen, X. Xi, Yinyan He, X. Wan","doi":"10.1016/j.tranon.2016.10.006","DOIUrl":"https://doi.org/10.1016/j.tranon.2016.10.006","url":null,"abstract":"","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":"10 1","pages":"33 - 39"},"PeriodicalIF":5.0,"publicationDate":"2016-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tranon.2016.10.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55289319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 86
Correlations Between DCE MRI and Histopathological Parameters in Head and Neck Squamous Cell Carcinoma1 头颈部鳞状细胞癌DCE MRI与组织病理学参数的相关性
IF 5 2区 医学
Translational Oncology Pub Date : 2016-11-24 DOI: 10.1016/j.tranon.2016.10.001
A. Surov, H. Meyer, M. Gawlitza, A. Höhn, A. Boehm, T. Kahn, P. Stumpp
{"title":"Correlations Between DCE MRI and Histopathological Parameters in Head and Neck Squamous Cell Carcinoma1","authors":"A. Surov, H. Meyer, M. Gawlitza, A. Höhn, A. Boehm, T. Kahn, P. Stumpp","doi":"10.1016/j.tranon.2016.10.001","DOIUrl":"https://doi.org/10.1016/j.tranon.2016.10.001","url":null,"abstract":"","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":"10 1","pages":"17 - 21"},"PeriodicalIF":5.0,"publicationDate":"2016-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tranon.2016.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55289170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 52
A Prediction Model Based on Biomarkers and Clinical Characteristics for Detection of Lung Cancer in Pulmonary Nodules12 基于生物标志物和临床特征的肺结节癌检测预测模型[j]
IF 5 2区 医学
Translational Oncology Pub Date : 2016-11-24 DOI: 10.1016/j.tranon.2016.11.001
Jie Ma, Maria A. Guarnera, Wenxian Zhou, Hongbin Fang, F. Jiang
{"title":"A Prediction Model Based on Biomarkers and Clinical Characteristics for Detection of Lung Cancer in Pulmonary Nodules12","authors":"Jie Ma, Maria A. Guarnera, Wenxian Zhou, Hongbin Fang, F. Jiang","doi":"10.1016/j.tranon.2016.11.001","DOIUrl":"https://doi.org/10.1016/j.tranon.2016.11.001","url":null,"abstract":"","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":"10 1","pages":"40 - 45"},"PeriodicalIF":5.0,"publicationDate":"2016-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tranon.2016.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55289409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Prognostic Value of Tumor-Infiltrating Lymphocytes for Patients With Head and Neck Squamous Cell Carcinoma12 肿瘤浸润淋巴细胞对头颈部鳞状细胞癌的预后价值
IF 5 2区 医学
Translational Oncology Pub Date : 2016-11-23 DOI: 10.1016/j.tranon.2016.10.005
Q. Xu, Chong Wang, Xiaohong Yuan, Zhien Feng, Zhengxue Han
{"title":"Prognostic Value of Tumor-Infiltrating Lymphocytes for Patients With Head and Neck Squamous Cell Carcinoma12","authors":"Q. Xu, Chong Wang, Xiaohong Yuan, Zhien Feng, Zhengxue Han","doi":"10.1016/j.tranon.2016.10.005","DOIUrl":"https://doi.org/10.1016/j.tranon.2016.10.005","url":null,"abstract":"","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":"10 1","pages":"10 - 16"},"PeriodicalIF":5.0,"publicationDate":"2016-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tranon.2016.10.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55289294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 48
Activity of Pan-Class I Isoform PI3K/mTOR Inhibitor PF-05212384 in Combination with Crizotinib in Ovarian Cancer Xenografts and PDX1 Pan-Class I亚型PI3K/mTOR抑制剂PF-05212384联合克唑替尼在卵巢癌异种移植物和PDX1中的活性
IF 5 2区 医学
Translational Oncology Pub Date : 2016-10-01 DOI: 10.1016/j.tranon.2016.08.011
A. Iezzi, E. Caiola, M. Broggini
{"title":"Activity of Pan-Class I Isoform PI3K/mTOR Inhibitor PF-05212384 in Combination with Crizotinib in Ovarian Cancer Xenografts and PDX1","authors":"A. Iezzi, E. Caiola, M. Broggini","doi":"10.1016/j.tranon.2016.08.011","DOIUrl":"https://doi.org/10.1016/j.tranon.2016.08.011","url":null,"abstract":"","PeriodicalId":23244,"journal":{"name":"Translational Oncology","volume":"9 1","pages":"458 - 465"},"PeriodicalIF":5.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tranon.2016.08.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55288231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
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