Transplantologiya. The Russian Journal of Transplantation最新文献

{"title":"Development of oncological diseases after organ transplantation","authors":"A. V. Babkina, M. Khubutiya","doi":"10.23873/2074-0506-2022-14-4-476-487","DOIUrl":"https://doi.org/10.23873/2074-0506-2022-14-4-476-487","url":null,"abstract":"","PeriodicalId":23229,"journal":{"name":"Transplantologiya. The Russian Journal of Transplantation","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89103367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHENOMENON OF DEMIKHOV. At N.V. Sklifosovsky Institute (1960–1986). V.P. Demikhov and his experiments in the field of organ transplantation in 1969–1970","authors":"S. Glyantsev, Yu. A. Shabunts","doi":"10.23873/2074-0506-2022-14-4-519-534","DOIUrl":"https://doi.org/10.23873/2074-0506-2022-14-4-519-534","url":null,"abstract":"","PeriodicalId":23229,"journal":{"name":"Transplantologiya. The Russian Journal of Transplantation","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88603778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring of chimerism after allogeneic hematopoietic stem cell transplantation","authors":"D. Dubnyak, N. Risinskaya, M. Drokov, A. Sudarikov","doi":"10.23873/2074-0506-2022-14-4-488-499","DOIUrl":"https://doi.org/10.23873/2074-0506-2022-14-4-488-499","url":null,"abstract":"","PeriodicalId":23229,"journal":{"name":"Transplantologiya. The Russian Journal of Transplantation","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87611431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modification of antidote therapy for poisoning due to massive admission of paracetamol","authors":"A. Simonova, M. M. Potskhveriya, M. V. Belova, K. K. Ilyashenko, N. E. Stolbova, Yury Kurilkin","doi":"10.23873/2074-0506-2022-14-4-444-451","DOIUrl":"https://doi.org/10.23873/2074-0506-2022-14-4-444-451","url":null,"abstract":"Background. Paracetamol poisoning is common all over the world, including in Russia. In 20–25% of cases, a massive dose of the drug is observed: more than 30–40 g of paracetamol at a time.The aim of the study was to demonstrate the efficacy of using an increased doses of acetylcysteine in the treatment of a massive paracetamol admission.Results. Patient G., 22 years old, took 70 tablets (35 g) of paracetamol for suicide 3 hours before admission to the hospital. The blood level of paracetamol 4 hours after taking it was 694.94 µg/mL. Upon admission to the hospital, acetylcysteine administering was started according to a 12-hour scheme. Subsequently, the administration of acetylcysteine was continued according to a 20-hour regimen with an increased dosage at the 2nd stage. Laboratory parameters, including aspartate aminotransferase and alanine aminotransferase, remained within the reference values during hospital stay. Conclusion. The case report we have presented shows the efficacy and expediency of using an increased doses of acetylcysteine in case of massive admission of paracetamol, which contributes to the prevention of the development of severe complications and a favorable course and outcome of the disease.","PeriodicalId":23229,"journal":{"name":"Transplantologiya. The Russian Journal of Transplantation","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81300039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relapse of autoimmune diseases after liver transplantation","authors":"V. Syutkin, A. Salienko, O. Olisov, M. Novruzbekov","doi":"10.23873/2074-0506-2022-14-4-421-431","DOIUrl":"https://doi.org/10.23873/2074-0506-2022-14-4-421-431","url":null,"abstract":"Background. The recurrence of autoimmune liver diseases can lead to reduced survival of recipients and grafts.Aim. To study the incidence and impact of the recurrence of autoimmune liver diseases on graft survival; the effect of maintenance immunosuppression on the recurrence of autoimmune diseases in liver transplant recipientsMaterial and methods. Transplantation outcomes in 111 recipients (21 recipients operated on for autoimmune hepatitis, 50 recipients operated on for primary biliary cirrhosis, and 40 recipients operated on for primary sclerosing cholangitis) were analyzed retrospectively.Results. The recurrence of autoimmune hepatitis is observed in 5%, the recurrence of primary biliary cirrhosis is in 10%, and the recurrence of primary sclerosing cholangitis is in 17% of cases. Among patients with recurrence of autoimmune diseases, men accounted for 54%, while for only 31% in the subgroup of patients without relapse (p=0.004). The followup for recipients with relapse (64.5 (42.8;82.0) months) was comparable to the follow-up for recipients without relapse (46.5 (17.9;103.5) months, p=0.54). A ten-year graft survival was significantly higher in the group of recipients with recurrent autoimmune diseases compared with recipients without autoimmune diseases recurrence (p<0.0001).Conclusions. The recurrence of autoimmune diseases leads to a decrease in graft survival. The effect of immunosuppression components on the risk of recurrence of autoimmune diseases in the graft has not been established.","PeriodicalId":23229,"journal":{"name":"Transplantologiya. The Russian Journal of Transplantation","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75880405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHENOMENON OF DEMIKHOV. Heart transplantation in experiment and clinical cases in the USSR and abroad (1968–1972). The Second in the USSR heart transplantation in a Clinic (Solovyev G.M., June 10, 1971)","authors":"S. Glyantsev, Yu. A. Shabunts, M. I. Chernenko","doi":"10.23873/2074-0506-2022-14-3-371-390","DOIUrl":"https://doi.org/10.23873/2074-0506-2022-14-3-371-390","url":null,"abstract":"The article presents materials of Soviet and foreign medical literature of 1968–1972 devoted to heart transplantation in experiment and clinical practice. It is shown that in the USSR after unsuccessful heart transplantation performed by A.A. Vishnevsky on November 4, 1968, experimental studies on isolated heart preservation in order to preserve its viability were conducted; models of orthotopic and heterotopic heart transplantation on large and small animals were created; morphological, physiological, biochemical and immunological changes in the transplanted heart were studied. The second heart transplantation in this country was performed by G.M. Solovyev on June 10, 1971, but it was also unsuccessful. It’s remarkable that the 20-year experience of V.P. Demikhov in experimental heart transplantation was used only partially: a number of surgeons applied the cardiopulmonary complex isolated according to V.P. Demikhov's technique for biological heart preservation in experimental animals. At the same time after the successful heart transplantation performed by C. Barnard on December 3, 1967, the world boom of clinical transplantation began. In 1969, 101 such operations were performed. For example, D. Cooley performed them on 21 patients and on another one performed two surgeries. There were observations that patients operated on in 1968 lived 800–900 days or more. The best results were shown by R. Lower, M. DeBakey and N. Shumway. However, the vast majority of heart transplants resulted in lethal outcomes in the immediate or distant postoperative period. This led to the fact that the euphoria of successful transplants gradually began to diminish: in 1969 only 47 operations were performed, and in 1970–1971 only 17 surgeries per year.","PeriodicalId":23229,"journal":{"name":"Transplantologiya. The Russian Journal of Transplantation","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80348068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Easy to say, hard to do. To the anniversary of two fundamental discoveries. Part 1","authors":"A. Y. Anisimov","doi":"10.23873/2074-0506-2022-14-3-357-370","DOIUrl":"https://doi.org/10.23873/2074-0506-2022-14-3-357-370","url":null,"abstract":"On the eve of the anniversaries of two historical events: the 145th anniversary of the experiments in which Eck's fistula was performed and the 55th anniversary of the successful clinical approbation of the selective distal splenorenal anastomosis, a retrospective analysis of the key historical stages in the development of portal hypertension surgery from the first attempts to describe the anatomy of the hepatic vascular system, explaining its purpose in the body, the development of direct portocaval anastomosis, the widespread use of selective splenorenal anastomoses, to the Transjugular Intrahepatic Portosystemic Shunt procedure and orthotopic liver transplantation. At the same time, the emphasis is focused on the most colorful characters of researchers and clinicians who passed this path. The expediency of an integrated approach in solving the problems of portal hypertension with the development of both fundamental and applied clinical and organizational aspects is substantiated. It is shown that the discoveries born from the generalization of the results achieved by numerous researchers have contributed to a better understanding of this field of medicine, have become a solid foundation for what we have today and are a reliable platform for a successful start into the future.","PeriodicalId":23229,"journal":{"name":"Transplantologiya. The Russian Journal of Transplantation","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87196724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elimination of factors contributing to the development of colo-esophageal anastomotic dehiscence following retrosternal colonic esophagoplasty performed for esophageal atresia correction","authors":"A. Kivva, M. Chepurnoy, B. M. Belik, Y. Tyshlek, M. Shtilman, A. A. Kivva, I. R. Chumburidze","doi":"10.23873/2074-0506-2022-14-3-322-330","DOIUrl":"https://doi.org/10.23873/2074-0506-2022-14-3-322-330","url":null,"abstract":"Aim. Development of methodology that would allow surgeons to decrease the risk of colo-esophageal anastomotic dehiscence following esophagoplasty through prevention of colonic transplant compression in the retrosternal tunnel and surgery facilitation.Material and methods. Ultrasound examination was carried out on 43 infants (22 boys and 21 girls) without sternal pathologies. The dorsal sternal angle and thickness of the upper and lower parts of the sternal manubrium were evaluated. The prominence and structure of muscular arrangement in various parts of the dorsal side of the sternal manubrium were examined in 15 infant patients. The results of treatment based on the method developed in accordance with the RF invention patent No. 2552095 were analyzed for infant patients (8 boys and 7 girls) suffering from esophageal atresia. 9 patients had fenestration of the sternal manubrium performed across its entire length, 6 children – in its upper segment only. X-ray control was used to detect colonic transplant compression. Significant difference between the variables in question in the examined groups was evaluated using the Mann-Whitney U test (M-W) for data measured on an ordinal scale.Results. The upper part of the sternal manubrium (above the attachment of the first rib) was found to exert the highest pressure on the transplant as it is statistically significantly thicker (M-W=4.44; p<0.01), being covered with a more prominent muscular layer (M-W=6.71; p<0.001) over a larger area (M-W=4.42; p<0.01) and considerably reclined. In infant age, the dorsal sternal angle is 164.9±0.8 degrees. Its value was consistently (M-W=2.66; p<0.01) higher in the girls' group with significant individual variations. Based on the collected data, an original technique was developed for individual approach to the resection of the manubrium sterni applied during retrosternal colonic esophagoplasty in 15 patients with esophageal atresia. No signs of colo-esophageal anastomotic dehiscence or transplant compression were revealed in any of those cases.Conclusion. The suggested method allows surgeons to assess in every case the narrowness of retrosternal space and individually select the scope of sternal manubrium resection to eliminate important factors contributing to the development of colo-esophageal anastomotic dehiscence after retrosternal esophagoplasty in cases of esophageal atresia thus facilitating the surgery and preventing transplant compression in the retrosternal tunnel.","PeriodicalId":23229,"journal":{"name":"Transplantologiya. The Russian Journal of Transplantation","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77708346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burdened urological history as a risk factor in kidney transplantation for older age group recipients","authors":"B. Z. Khubutiya, M. Khubutiya, A. Evseev, A. V. Babkina","doi":"10.23873/2074-0506-2022-14-3-331-343","DOIUrl":"https://doi.org/10.23873/2074-0506-2022-14-3-331-343","url":null,"abstract":"Introduction. Chronic renal failure develops more often in elderly patients after previous repeated urological operations. Urological diseases are an important additional factor that multiply complicates kidney transplantation due to the need for preliminary correction of existing disorders. Not to mention the fact that the recipient's advanced age contributes to the risk of developing graft dysfunction due to the presence of concomitant diseases that worsen the immediate and long-term results of transplantation.Material and methods. We carried out the analysis of clinical observations and studies performed in 124 patients who underwent cadaveric renal allotransplantation at the N.V. Sklifosovsky Research Institute for Emergency Medicine, including from suboptimal donors. Of these, 69 (55.6%) recipients older than 60 years were included in the main group (group 1), and 55 recipients younger than 60 years (44.4%) – in the comparison group (group 2). From the patients of group 1, patients with urological diseases that led to the development of terminal chronic renal failure, or with previously undergone surgeries for urological diseases (subgroup 1A, 43 patients) were isolated. The remaining 26 patients who did not have urological diseases were put in subgroup 1B.Results. The analysis showed that in the early postoperative period in the recipients of group 1, complications developed in almost all the patients (80 complications in 64 of 69 patients, that is, 92.8% of patients in this group), whereas in group 2, complications developed only in 30.9% of patients (27 complications in 17 of 55 patients). At the same time, on average, 1.2 complications per 1 patient were noted in group 1, and 0.5 complications per 1 patient in group 2, a significant part of the complications occurred in the subgroup of patients with a burdened urological history (subgroup 1A). Late complications also developed statistically significantly more often (almost 2 times) in recipients with a burdened urological history.Conclusions. Complications of the early and late postoperative period develop statistically significantly more often in elderly recipients. The presence of a burdened urological history in elderly recipients significantly increases the risk of early and late postoperative complications.","PeriodicalId":23229,"journal":{"name":"Transplantologiya. The Russian Journal of Transplantation","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74485598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selection of an optimal cryoprotectant for long-term storage of human tendon allografts","authors":"A. A. Budaev, N. Borovkova, A. M. Fayn, M. Makarov, M. V. Storozheva, Y. Andreev, A. Mironov","doi":"10.23873/2074-0506-2022-14-3-312-321","DOIUrl":"https://doi.org/10.23873/2074-0506-2022-14-3-312-321","url":null,"abstract":"Introduction. Tendon grafts are widely demanded in reconstructive plastic surgery. Allogeneic tendons potentially have a number of advantages. However, the method of long-term storage of allogeneic tendons has not been optimized to date.Aim. Selection of an optimal cryoprotectant for the storage of human tendon allografts at ultra-low temperatures, which allows preserving the native tissue structure.Material and methods. We studied M. tibialis anterior tendon grafts taken from tissue donors. Endocellular/penetrating cryoprotectants (dimethyl sulfoxide, polyethylene glycol-400, glycerol) and exocellular/non-penetrating cryoprotectants (glucose solution, albumin solution) were used in the cryopreservation process. Tendon mechanical properties were evaluated using rupture and stretching-shear test, the general morphology of tendons, topography, dense and integrity of collagen fibers, preservation of cellular elements were microscopically evaluated.Results. Histological analysis showed that the safety of collagen and elastin fibers differed depending on the cryoprotectant used. At the same time, micro-fractures of collagen fibers were microscopically detected in all the experiments. In the presence of dimethyl sulfoxide, polyethylene glycol-400 and their combination the structure of collagen fibers and cells did not undergo visible changes compared to the control, whereas in all the experiments with non-penetrating cryoprotectants the topography and orientation of the fibers were clearly disturbed, deformation of many cells in the tendons was also observed.Conclusions. Cryoprotectants based on dimethyl sulfoxide, polyethylene glycol and their combinations allowed us to preserve the structural integrity of allogeneic tendons. Non-penetrating cryoprotectants did not effectively preserve the integrity of collagen fibers and cells in the tendons and cannot be recommended for cryopreservation.","PeriodicalId":23229,"journal":{"name":"Transplantologiya. The Russian Journal of Transplantation","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83413067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}