{"title":"Determination of andrographolide sodium bisulfite in renal microdialysis fluid of rats and toxicokinetic study","authors":"Dongming Chen, Jie Chen, Y. Tao, Hong Lu","doi":"10.1080/02772248.2020.1776286","DOIUrl":"https://doi.org/10.1080/02772248.2020.1776286","url":null,"abstract":"Abstract Andrographolide sodium bisulfite (ASB) widely used for intestinal infections and respiratory tract infections. It has been reported to frequently cause acute renal failure in clinical practice. The purpose of this study was to evaluate the nephrotoxicity and toxicokinetics in Sprague-Dawley rats after a single-dose injection of ASB administered at 100, 600, and 1000 mg/kg via intravenous tail injections. The concentrations in plasma and kidney microdialysates were analyzed by high-performance liquid chromatography. Blood urea nitrogen and creatinine levels in plasma were determined and toxicokinetic parameters were observed. In plasma and kidney, the elimination constant and clearance were decreased and the half-time was increased with increasing dose. Blood urea nitrogen and creatinine were positively correlated with ASB concentration indicating the potential for accumulation in kidney that can eventually lead to damage.","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"21 1","pages":"197 - 207"},"PeriodicalIF":0.0,"publicationDate":"2020-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73987296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mitochondrial toxicity and in vitro biological effects of ambient PM2.5 from an urban site in China","authors":"Zhi-Jing Lin, Jinzhuo Li, Qianwen Zeng, R. Sun","doi":"10.1080/02772248.2020.1767780","DOIUrl":"https://doi.org/10.1080/02772248.2020.1767780","url":null,"abstract":"Abstract The roles of PM2.5-induced mitochondrial damage and oxidative stress on mast cell degranulation were examined in vitro. Mast cells were treated with suspensions of PM2.5 in Dulbecco’s modified Eagle’s medium at concentrations from 25 to 200 mg/L in the absence or presence of 10 mmol/L N-acetyl-L-cysteine. Biological effects and mitochondrial function were assessed by determining cell viability, β-hexosaminidase release, interleukin-4 secretion, reactive oxygen species generation, adenosine triphosphate production, potential alteration of mitochondrial membrane, and activities of mitochondrial electron transport chain complexes I and III. Exposure of mast cells to PM2.5 induced reduction of adenosine triphosphate production, collapse of mitochondrial membrane potential, and inhibition of the activity of complex III. Co-treatment of mast cells exposed to PM2.5 with N-acetyl-L-cysteine attenuated cytotoxicity and the production of reactive oxygen species, and decreased the release of β-hexosaminidase and interleukin-4. Evidently, PM2.5-induced oxidative stress plays an essential role in mitochondrial toxicity and mast cell activation.","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"13 1","pages":"170 - 185"},"PeriodicalIF":0.0,"publicationDate":"2020-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78390943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Embiale, B. Chandravanshi, F. Zewge, E. Sahle-Demessie
{"title":"Health risk assessment of trace elements through exposure of particulate matter-10 during the cooking of Ethiopian traditional dish sauces","authors":"A. Embiale, B. Chandravanshi, F. Zewge, E. Sahle-Demessie","doi":"10.1080/02772248.2020.1770257","DOIUrl":"https://doi.org/10.1080/02772248.2020.1770257","url":null,"abstract":"Abstract This study was aimed to analyze trace elements in the particulate matter-10 and evaluate their health risks during the cooking of the most widely consumed Ethiopian traditional dish sauces (Wots) using charcoal, kerosene and electricity stoves. The trace elements (iron, cadmium, arsenic, chromium, lead, boron, nickel, cobalt, tin, copper and zinc) in the particulate matter-10 were found in the range 0.001–0.175 µg m−3. The human health risk assessment has done based on the United States Environmental Protection Agency prescription. The hazard quotient and hazard index values using charcoal, kerosene and electricity stoves were found below 1. This result showed that the inhabitants stay at any of these three microenvironments has no likelihood to have non-cancer health problems. In addition, the life time cancer values for all trace elements were below the tolerable range set by United States Environmental Protection Agency, except chromium, cadmium and arsenic which were found within the tolerable range. Furthermore, the total sum of eleven determined elements was calculated, and the highest concentration was observed using kerosene stove followed by charcoal and electricity stoves, respectively. The use of kerosene and charcoal stove were not the recommended stove as compared to electricity stove for the cooking of Wot.","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"6 1","pages":"151 - 169"},"PeriodicalIF":0.0,"publicationDate":"2020-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79146303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Florea, V. Drumea, R. Nita, A. Bicu, L. Olariu, L. E. Duțu, C. Gîrd
{"title":"Transfer rate of pesticide residues from medicinal plants in different types of extractive solutions","authors":"A. Florea, V. Drumea, R. Nita, A. Bicu, L. Olariu, L. E. Duțu, C. Gîrd","doi":"10.1080/02772248.2020.1773466","DOIUrl":"https://doi.org/10.1080/02772248.2020.1773466","url":null,"abstract":"Abstract Starting from the suspicion that the medicinal herbs may contain traces of pesticides and taking into account the risks of patients being exposed to contaminated products, the aim of this research was to evaluate the pesticide residues and the degree of their transfer (%) in three types of preparations (infusion, decoctionand cold maceration), for four medicinal plant species very often used in phytotherapy (Rosmarini folium, Menthae folium, Saturejae herba and Basilica herba). For each type of plant product, four samples were purchased from different manufacturers and they have been analyzed using gas chromatography- tandem mass spectrometry. One out of four samples of the same plant species contain at least one pesticide residue above the maximum level and shows a significant transfer of these residues in aqueous extractive solutions during extraction. The highest rate of pesticide transfer from medicinal plants was identified in infusions, recommended by many manufacturers.","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"40 1","pages":"37 - 61"},"PeriodicalIF":0.0,"publicationDate":"2020-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84277203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhuoqun Meng, Yixuan Huang, Yan Chen, Siyu Tao, Meitong Liu, Jing Lu, S. Guan
{"title":"Carbon black-benzo(a)pyrene complex-induced apoptosis and autophagy blockage in rat alveolar macrophages","authors":"Zhuoqun Meng, Yixuan Huang, Yan Chen, Siyu Tao, Meitong Liu, Jing Lu, S. Guan","doi":"10.1080/02772248.2020.1766044","DOIUrl":"https://doi.org/10.1080/02772248.2020.1766044","url":null,"abstract":"Abstract Cooking of foods and the burning of biomass and fossil fuels in stoves are the main sources of cooking fumes, with carbon black and polycyclic aromatic hydrocarbons as main components. The toxicity of carbon black and polycyclic aromatic hydrocarbons has been well studied individually, but the combined toxicity is much less understood. Carbon black can adsorb benzo(a)pyrene to form a complex which displays an altered physical form which in this study has been constructed to simulate particles in the cooking fumes and explore the combined toxic effect on rat alveolar macrophages. The complex-induced cell apoptosis and blocked cell autophagy flux compared with both individually. The mechanism of toxicity may be by intracellular reactive oxygen species generation, impairing the mitochondrial membrane potential and activating apoptosis signaling pathways. Graphical Abstract","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"113 1","pages":"132 - 150"},"PeriodicalIF":0.0,"publicationDate":"2020-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79739436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Kundu, A. Mandal, S. Saha, P. Prabhakaran, S. Walia
{"title":"Fungicidal activity and molecular modeling of fusarubin analogues from Fusarium oxysporum","authors":"A. Kundu, A. Mandal, S. Saha, P. Prabhakaran, S. Walia","doi":"10.1080/02772248.2020.1770253","DOIUrl":"https://doi.org/10.1080/02772248.2020.1770253","url":null,"abstract":"Abstract Fusarubin analogues of Fusarium oxysporum f. sp. ciceris were investigated for antifungal activity in vitro against five soil borne phytopathogenic fungi. 3-O-Methyl-8-O-methyl-fusarubin was inhibitory towards S. sclerotiorum (EC50 0.33 mmol L−1) and Sclerotium rolfsii (EC50 0.38 mmol L−1). A structure–antifungal activity relationship of fusarubin analogues was established from their activity performance. Possible mechanism of action of these compounds was studied using molecular docking and simulations against three target enzymes which revealed receptor ligand binding affinity. Docking of 3-O-methyl-8-O-methyl-fusarubin into the succinate dehydrogenase site revealed formation of salt bridge, hydrogen bond, π–anion, π–alkyl, and Van der Waals interactions.","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"31 1","pages":"78 - 91"},"PeriodicalIF":0.0,"publicationDate":"2020-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80965615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahsa Akbarzadeh, Aboozar Soltani, M. Moemenbellah-Fard, M. Khoshnoud, K. Azizi
{"title":"Larvicidal, repellent, and histopathologic effects of Citrullus colocynthis against the malaria vector","authors":"Mahsa Akbarzadeh, Aboozar Soltani, M. Moemenbellah-Fard, M. Khoshnoud, K. Azizi","doi":"10.1080/02772248.2020.1770254","DOIUrl":"https://doi.org/10.1080/02772248.2020.1770254","url":null,"abstract":"Abstract This research is conducted to determine the larvicidal, repellent and pathological effects of fruit extracts of C. colocynthis on malaria vector mosquito, Anopheles stephensi Liston, 1901. The fruit water and ethanol extract of C. colocynthis were concentrated for larvicidal and repellent activities on human volunteer against An. stephensi. The temephos larvicide was tested as the positive control. A concentration of 300 mg/L had full-scale mortality and the most toxic effect. The LC50 and LC90 values of C. colocynthis water and ethanol extracts were 180and 283 mg/L, respectively. The LC50 and LC90 values of temephos were 0.2706 and 1.6932 mg/L, respectively. The ED50 and ED90 values of the plant extract were 0.2 and 1.3 mg/cm2, respectively. Thin sections from treated larvae exhibited gross histopathologic effects of C. colocynthis fruit extracts on gut epithelial cell layer by vacuolization of foregut cuboidal and midgut columnar cells. This study suggested that the fruit extracts of C. colocynthis had significant larvicidal and repellent activity to be used as an ideal approach to control the malaria vector mosquito.","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"43 2 1","pages":"104 - 92"},"PeriodicalIF":0.0,"publicationDate":"2020-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90930530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Sujetovienė, Kotryna Gasauskaitė, J. Žaltauskaitė
{"title":"Toxicity of a phenoxy herbicide on the lichen Ramalina fraxinea","authors":"G. Sujetovienė, Kotryna Gasauskaitė, J. Žaltauskaitė","doi":"10.1080/02772248.2020.1747466","DOIUrl":"https://doi.org/10.1080/02772248.2020.1747466","url":null,"abstract":"2-Methyl-4-chlorophenoxyacetic acid has been widely used as herbicide in the United States and Europe. This study aims to quantify its effects at concentrations of 0–100 mg/L for up to 48 h on the ...","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"25 1","pages":"497-507"},"PeriodicalIF":0.0,"publicationDate":"2019-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87879816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Kirichenko, I. Vakhniuk, R. Rogulin, A. V. Kirichenko, A. Gridasov, D. Kosyanov, V. Drozd, A. S. Kholodov, W. Piekoszewski, K. Golokhvast
{"title":"Characteristics of fume sedimentation in the working zone during arc welding with covered electrodes","authors":"K. Kirichenko, I. Vakhniuk, R. Rogulin, A. V. Kirichenko, A. Gridasov, D. Kosyanov, V. Drozd, A. S. Kholodov, W. Piekoszewski, K. Golokhvast","doi":"10.1080/02772248.2020.1747465","DOIUrl":"https://doi.org/10.1080/02772248.2020.1747465","url":null,"abstract":"In order to develop effective protection measures and reduce the number of diseases in the welding industry, a detailed study of the mechanism of propagation of welding fumes in the working zone is...","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"35 1","pages":"463-474"},"PeriodicalIF":0.0,"publicationDate":"2019-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88319473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of uranium, radium and thorium speciation on the removal of radioactivity from acid mine drainage using ion exchange","authors":"Thulani C. Dlamini, V. Tshivhase, P. Maleka","doi":"10.1080/02772248.2020.1747464","DOIUrl":"https://doi.org/10.1080/02772248.2020.1747464","url":null,"abstract":"Acid mine drainage samples were collected from the central basin of the Witwatersrand basin in South Africa to study the removal of radioactivity. The samples were analyzed for gross alpha/beta act...","PeriodicalId":23210,"journal":{"name":"Toxicological & Environmental Chemistry","volume":"458 ","pages":"475-485"},"PeriodicalIF":0.0,"publicationDate":"2019-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91519693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}