Toxicology letters最新文献_第10页

S13-04 Application of transcriptomics in regulatory toxicology 转录组学在调控毒理学中的应用

IF 3.1 3区医学

Toxicology letters Pub Date : 2026-09-01 Epub Date: 2026-09-07 DOI: 10.1016/j.toxlet.2026.112027

R. Currie

引用次数: 0

S15-04 Linking Local Environmental Exposures to Molecular Signatures of Childhood Asthma 局部环境暴露与儿童哮喘分子特征的联系

IF 3.1 3区医学

Toxicology letters Pub Date : 2026-09-01 Epub Date: 2026-09-07 DOI: 10.1016/j.toxlet.2026.112035

J. Laird, T. Hartung, A. Maertens, F. Sille

引用次数: 0

S06-02 Revisiting “Ten years of research on synergisms and antagonisms in chemical mixtures”: the toxicology of mixtures of chemicals containing pesticides 回顾“化学混合物中协同作用和拮抗作用的十年研究”：含农药的化学混合物的毒理学

IF 3.1 3区医学

Toxicology letters Pub Date : 2026-09-01 Epub Date: 2026-09-07 DOI: 10.1016/j.toxlet.2026.112003

O. Martin

引用次数: 0

S08-03 The glass ceiling of AI performance in toxicology, and the role of data standards in breaking it 毒理学中人工智能性能的玻璃天花板，以及数据标准在打破它中的作用

IF 3.1 3区医学

Toxicology letters Pub Date : 2026-09-01 Epub Date: 2026-09-07 DOI: 10.1016/j.toxlet.2026.112010

P. Whaley

引用次数: 0

CEC01-01 Human liver organoids as emerging tools for drug metabolism and toxicity studies 人类肝脏类器官作为药物代谢和毒性研究的新兴工具

IF 3.1 3区医学

Toxicology letters Pub Date : 2026-09-01 Epub Date: 2026-09-07 DOI: 10.1016/j.toxlet.2026.111952

K. Schneeberger-Verjaal

引用次数: 0

CEC04-04 To TQT or not TQT: Navigating the recent ICH E14/S7B Q&As for Non-Clinical hERG and QTc Assessment 是否TQT：近期ICH E14/S7B关于非临床hERG和QTc评估的问答指南

IF 3.1 3区医学

Toxicology letters Pub Date : 2026-09-01 Epub Date: 2026-09-07 DOI: 10.1016/j.toxlet.2026.111971

T. Mow

引用次数: 0

CEC05-04 Integration of in vitro and in silico approaches for more efficient ED assessments and useful recommendations for leveraging the use of research data in ED assessments 整合体外和计算机方法，提高ED评估的效率，并提出在ED评估中利用研究数据的有用建议

IF 3.1 3区医学

Toxicology letters Pub Date : 2026-09-01 Epub Date: 2026-09-07 DOI: 10.1016/j.toxlet.2026.111977

E. Katsanou

引用次数: 0

Do the Societal Benefits of Plastic Outweigh the Risks of Microplastic Contamination? 塑料的社会效益是否大于微塑料污染的风险？

IF 3.1 3区医学

Toxicology letters Pub Date : 2026-09-01 Epub Date: 2026-09-07 DOI: 10.1016/j.toxlet.2026.111948

R. Pieters, P. Stapleton

引用次数: 0

High-throughput toxicological assessment of heated tobacco product aerosols using RNA sequencing-based concentration-response modeling 基于RNA测序的浓度-反应模型对加热烟草制品气溶胶的高通量毒理学评估。

IF 3.1 3区医学

Toxicology letters Pub Date : 2026-08-01 Epub Date: 2026-07-20 DOI: 10.1016/j.toxlet.2026.113167

Kazushi Matsumura

{"title":"High-throughput toxicological assessment of heated tobacco product aerosols using RNA sequencing-based concentration-response modeling","authors":"Kazushi Matsumura","doi":"10.1016/j.toxlet.2026.113167","DOIUrl":"10.1016/j.toxlet.2026.113167","url":null,"abstract":"<div><div>Heated tobacco products (HTPs) operate without combustion and are designed to reduce exposure to harmful constituents compared to cigarettes. Within the HTP category, rapid consumer-led technological development has resulted in a growing diversity of heating approaches across products, including the incorporation of multiple heating modes within individual devices. In this study, to gain deeper insight into the molecular mechanisms underlying biological responses to HTP aerosols, high-throughput transcriptomics was used to evaluate acute transcriptomic responses in human bronchial epithelial cells exposed to the extract of aerosols from multiple HTPs across all operable heating modes. Eleven emission constituents, including nine cigarette smoke constituents proposed for mandated reduction by the World Health Organization and combustion markers defined by British Standards Institution, were analyzed. HTP aerosols contained fewer detectable constituents and lower levels of measurable analytes than smoke from the reference cigarette (1R6F), confirming reduced combustion-related toxicants and non-combustion operation. Consistent with these chemical differences, HTP aerosols elicited weaker cytotoxic and transcriptomic responses than 1R6F smoke at comparable concentrations. While concentration-response modeling identified comparable transcriptomic perturbation patterns between HTP aerosols and 1R6F smoke, transcriptomic amplitudes were uniformly lower in response to HTP aerosols and no product-specific pathways were detected under the tested conditions. Transcriptomic points of departure (PoD) demonstrated greater sensitivity than cytotoxicity-based PoD, supporting their utility for evaluating the potential toxicological effects of HTPs at lower exposure levels than those identified by conventional cytotoxicity endpoints.</div></div>","PeriodicalId":23206,"journal":{"name":"Toxicology letters","volume":"423 ","pages":"Article 113167"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sulfur mustard-induced acute lung injury: Mechanistic insights into oxidative stress and inflammatory response interactions 硫芥菜诱导的急性肺损伤：氧化应激和炎症反应相互作用的机制见解。

IF 3.1 3区医学

Toxicology letters Pub Date : 2026-08-01 Epub Date: 2026-07-17 DOI: 10.1016/j.toxlet.2026.113166

Zifeng Deng, Minjie Shi, Zhengyuan Zhao, Weihua Yu, Deqin Kong

{"title":"Sulfur mustard-induced acute lung injury: Mechanistic insights into oxidative stress and inflammatory response interactions","authors":"Zifeng Deng, Minjie Shi, Zhengyuan Zhao, Weihua Yu, Deqin Kong","doi":"10.1016/j.toxlet.2026.113166","DOIUrl":"10.1016/j.toxlet.2026.113166","url":null,"abstract":"<div><div>Sulfur mustard (SM), a highly toxic vesicant chemical warfare agent, can induce severe acute lung injury and poses a substantial threat to human health. Oxidative stress and inflammatory responses play central roles in the pathogenesis of SM-induced lung injury, and these two processes interact in complex and mutually reinforcing ways. This review systematically summarizes recent research advances and elucidates the role of oxidative stress in SM-induced pulmonary injury from three key aspects: oxidative stress–mediated DNA damage, the stimulation of inflammatory cytokine production, and cellular apoptosis. In addition, the major components of the inflammatory response are examined, including inflammatory cell activation and infiltration, the release of inflammatory mediators, and the ability of inflammation to further amplify oxidative stress. Building on this foundation, the mechanisms underlying the interaction between oxidative stress and inflammatory responses are discussed in depth from three perspectives: ROS/RNS-mediated crosstalk, regulation of signal transduction pathways, and interactions within apoptotic signaling pathways. This review aims to provide a conceptual framework for advancing the mechanistic understanding of SM-induced lung injury and to support the development of effective therapeutic strategies.</div></div>","PeriodicalId":23206,"journal":{"name":"Toxicology letters","volume":"423 ","pages":"Article 113166"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148473011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0