发布求助
文献互助 智能选刊 最新文献

Toxicology and Environmental Health Sciences最新文献

筛选
英文 中文
Circulating miRNA-21 Levels in Breast Cancer Patients Before and After Chemotherapy and Its Association with Clinical Improvement. 乳腺癌患者化疗前后的循环 miRNA-21 水平及其与临床改善的关系
IF 2.1
Toxicology and Environmental Health Sciences Pub Date : 2024-04-01 Epub Date: 2023-03-30 DOI: 10.1007/s12291-023-01129-0
Sanchi Sukhija, Purvi Purohit, Puneet Pareek, Pawan Kumar Garg, Jeewan Ram Vishnoi, Poonam Abhay Elhence, Shobhan Babu Varthya, Praveen Sharma, Sneha Ambwani, Jaykaran Charan
{"title":"Circulating miRNA-21 Levels in Breast Cancer Patients Before and After Chemotherapy and Its Association with Clinical Improvement.","authors":"Sanchi Sukhija, Purvi Purohit, Puneet Pareek, Pawan Kumar Garg, Jeewan Ram Vishnoi, Poonam Abhay Elhence, Shobhan Babu Varthya, Praveen Sharma, Sneha Ambwani, Jaykaran Charan","doi":"10.1007/s12291-023-01129-0","DOIUrl":"10.1007/s12291-023-01129-0","url":null,"abstract":"<p><p>Breast cancer is the most frequent type of cancer in women, many patients experience recurrences and metastasis. miR-21 (microRNA-21) as biomarker is under investigation for breast cancer. At present, there is very limited information available regarding effect of chemotherapy on miR-21 expression in breast cancer and its correlation with the clinical improvement. Hence, this study was planned to evaluate the effect of chemotherapy on miR-21 in metastatic breast cancer and its relationship with the clinical outcome. Females, aged-18-90 years diagnosed with Invasive Ductal Carcinoma of breast and candidate of neoadjuvant chemotherapy including Adriamycin (60 mg/m<sup>2</sup>), Cyclophosphamide (600 mg/m<sup>2</sup>) with or without Taxane (75-175 mg/m<sup>2</sup>) were included in the study. Before and after 42 days of staring of chemotherapy sample was collected for circulatory miR-21 and RECIST 1.1 criteria was applied to assess the clinical status. Blood samples for routine clinical biomarkers including liver function test and renal function tests was also collected. miR-21 expression before and after chemotherapy was assessed using standard method based on real time PCR. Expression of miR-21, RECIST criteria and other liver and kidney related biomarkers were compared before and after chemotherapy. After neoadjuvant chemotherapy expression of miR-21 was significantly increased by 5.65-fold. There was significant improvement in clinical scores based on RECIST criteria (0.046). No significant correlation was observed between miR-21 expression and difference in RECIST score (r = - 0.122, <i>p</i> = 0.570). Neoadjuvant chemotherapy causes clinical improvement in breast cancer patients however it is not correlated with the miR-21 expression which significantly increased after chemotherapy.</p>","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"9 1","pages":"214-220"},"PeriodicalIF":2.1,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10987404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74542635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antioxidant compounds from the Arthrospira platensis protect against Bisphenol A-induced nephrotoxicity in rats 节肢动物中的抗氧化化合物可防止双酚 A 诱导的大鼠肾毒性
IF 1.7
Toxicology and Environmental Health Sciences Pub Date : 2024-01-09 DOI: 10.1007/s13530-023-00203-7
Khadidja Chouala, Kahina Boudjema, Yahia Khelef, Sadok Nani, Kheireddine Ouali, M. Boumendjel, A. Boumendjel, M. Messarah
{"title":"Antioxidant compounds from the Arthrospira platensis protect against Bisphenol A-induced nephrotoxicity in rats","authors":"Khadidja Chouala, Kahina Boudjema, Yahia Khelef, Sadok Nani, Kheireddine Ouali, M. Boumendjel, A. Boumendjel, M. Messarah","doi":"10.1007/s13530-023-00203-7","DOIUrl":"https://doi.org/10.1007/s13530-023-00203-7","url":null,"abstract":"","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"11 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139443462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the readiness of environmental health teams in facing the crisis after the implementation of the operational maneuver: a case study of Tehran, Iran 评估环境卫生团队在实施行动演习后应对危机的准备情况：伊朗德黑兰案例研究
IF 1.7
Toxicology and Environmental Health Sciences Pub Date : 2024-01-03 DOI: 10.1007/s13530-023-00204-6
Norouz Mahmoudi, Yousef Alimohamadi, Abouzar Alidadi
{"title":"Evaluating the readiness of environmental health teams in facing the crisis after the implementation of the operational maneuver: a case study of Tehran, Iran","authors":"Norouz Mahmoudi, Yousef Alimohamadi, Abouzar Alidadi","doi":"10.1007/s13530-023-00204-6","DOIUrl":"https://doi.org/10.1007/s13530-023-00204-6","url":null,"abstract":"","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"29 16","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139388745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined effects of microplastics and methylmercury on the activity of ATP-binding cassette (ABC) transporter in the brackish water flea Diaphanosoma celebensis 微塑料和甲基汞对咸水蚤ATP结合盒（ABC）转运体活性的综合影响
IF 1.7
Toxicology and Environmental Health Sciences Pub Date : 2024-01-02 DOI: 10.1007/s13530-023-00201-9
Je-won Yoo, Youn-Ha Lee, Sanghyun Cho, Young-Mi Lee
{"title":"Combined effects of microplastics and methylmercury on the activity of ATP-binding cassette (ABC) transporter in the brackish water flea Diaphanosoma celebensis","authors":"Je-won Yoo, Youn-Ha Lee, Sanghyun Cho, Young-Mi Lee","doi":"10.1007/s13530-023-00201-9","DOIUrl":"https://doi.org/10.1007/s13530-023-00201-9","url":null,"abstract":"","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"122 45","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139391137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The study of genotoxicity and immunotoxicity in workers occupationally exposed to cyanide 研究职业接触氰化物的工人的遗传毒性和免疫毒性
IF 1.7
Toxicology and Environmental Health Sciences Pub Date : 2024-01-02 DOI: 10.1007/s13530-023-00202-8
Azhar M. Haleem, N. N. Hussein
{"title":"The study of genotoxicity and immunotoxicity in workers occupationally exposed to cyanide","authors":"Azhar M. Haleem, N. N. Hussein","doi":"10.1007/s13530-023-00202-8","DOIUrl":"https://doi.org/10.1007/s13530-023-00202-8","url":null,"abstract":"","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"90 2","pages":"1-7"},"PeriodicalIF":1.7,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139390407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospects and application of multivariate and reliability analyses to one health risk assessments of toxic elements 多变量和可靠性分析在有毒元素健康风险评估中的前景和应用
IF 1.7
Toxicology and Environmental Health Sciences Pub Date : 2023-12-19 DOI: 10.1007/s13530-023-00199-0
Sylvester Chibueze Izah, Glory Richard, Herbert Okechukwu Stanley, M. Ogwu, Wisdom Ebiye Sawyer, Onyebuchi Remy Uwaeme
{"title":"Prospects and application of multivariate and reliability analyses to one health risk assessments of toxic elements","authors":"Sylvester Chibueze Izah, Glory Richard, Herbert Okechukwu Stanley, M. Ogwu, Wisdom Ebiye Sawyer, Onyebuchi Remy Uwaeme","doi":"10.1007/s13530-023-00199-0","DOIUrl":"https://doi.org/10.1007/s13530-023-00199-0","url":null,"abstract":"","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"112 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138959572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comparative analysis of phytochemicals versus synthetic drugs/nanomedicines in the treatment of uterine fibroid: a systematic review 植物化学物质与合成药物/纳米药物治疗子宫肌瘤的比较分析：系统性综述
IF 1.7
Toxicology and Environmental Health Sciences Pub Date : 2023-12-12 DOI: 10.1007/s13530-023-00198-1
Sonal Upadhyay, Vivek Pandey, A. Tripathi, A. Sahu, Anjali Rani, Amita Diwakar, Lavina Chaubey, Rashmi Gupta, Pawan K. Dubey
{"title":"A comparative analysis of phytochemicals versus synthetic drugs/nanomedicines in the treatment of uterine fibroid: a systematic review","authors":"Sonal Upadhyay, Vivek Pandey, A. Tripathi, A. Sahu, Anjali Rani, Amita Diwakar, Lavina Chaubey, Rashmi Gupta, Pawan K. Dubey","doi":"10.1007/s13530-023-00198-1","DOIUrl":"https://doi.org/10.1007/s13530-023-00198-1","url":null,"abstract":"","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"3 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139010201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Teratogenic effect of Aesculus hippocastanum L. extract on fetal development in rats 海马提取物对大鼠胎儿发育的致畸作用
IF 1.7
Toxicology and Environmental Health Sciences Pub Date : 2023-12-01 DOI: 10.1007/s13530-023-00200-w
Marjan Shariatpanahi, Rand Kulab, S. B. Jameie, Mahsa Sabernavaei, Mehdi Aghsami, Mahdi Tavakolizadeh
{"title":"Teratogenic effect of Aesculus hippocastanum L. extract on fetal development in rats","authors":"Marjan Shariatpanahi, Rand Kulab, S. B. Jameie, Mahsa Sabernavaei, Mehdi Aghsami, Mahdi Tavakolizadeh","doi":"10.1007/s13530-023-00200-w","DOIUrl":"https://doi.org/10.1007/s13530-023-00200-w","url":null,"abstract":"","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"66 s94","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138627514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between exposure to air pollutants and allergic diseases among residents near the Gwangyang industrial complex in Korea 韩国光阳工业园区附近居民接触空气污染物与过敏性疾病之间的关系
Toxicology and Environmental Health Sciences Pub Date : 2023-10-31 DOI: 10.1007/s13530-023-00193-6
Sunghyeon Jung, Jae-Hyoun Kim, Seung-Woo Jeong, Jong-Wha Lee, Bu-Soon Son
{"title":"Association between exposure to air pollutants and allergic diseases among residents near the Gwangyang industrial complex in Korea","authors":"Sunghyeon Jung, Jae-Hyoun Kim, Seung-Woo Jeong, Jong-Wha Lee, Bu-Soon Son","doi":"10.1007/s13530-023-00193-6","DOIUrl":"https://doi.org/10.1007/s13530-023-00193-6","url":null,"abstract":"","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"1 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135870375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential bioactivity of Algerian olive pomace hydro-ethanolic extract: phytochemical investigation, antioxidant activity, and acute toxicity 阿尔及利亚橄榄渣水乙醇提取物的潜在生物活性:植物化学研究、抗氧化活性和急性毒性
Toxicology and Environmental Health Sciences Pub Date : 2023-10-31 DOI: 10.1007/s13530-023-00197-2
Fatiha Benmeliani, Baya Guermouche, Hadjer Chenini-Bendiab, Nahida Haddam, Yamna Kherraf, Nesrine Benousser, Fatima Zahra Tahir, Zouleykha Badi, Hafida Merzouk, Nabila Belyagoubi-Benhammou
{"title":"Potential bioactivity of Algerian olive pomace hydro-ethanolic extract: phytochemical investigation, antioxidant activity, and acute toxicity","authors":"Fatiha Benmeliani, Baya Guermouche, Hadjer Chenini-Bendiab, Nahida Haddam, Yamna Kherraf, Nesrine Benousser, Fatima Zahra Tahir, Zouleykha Badi, Hafida Merzouk, Nabila Belyagoubi-Benhammou","doi":"10.1007/s13530-023-00197-2","DOIUrl":"https://doi.org/10.1007/s13530-023-00197-2","url":null,"abstract":"","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"46 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135871258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信