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Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT最新文献

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15 O Studies with Pet 15 . Pet研究
Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT Pub Date : 2021-09-23 DOI: 10.4324/9780429278983-9
E. Meyer
{"title":"15\u0000 O Studies with Pet","authors":"E. Meyer","doi":"10.4324/9780429278983-9","DOIUrl":"https://doi.org/10.4324/9780429278983-9","url":null,"abstract":"","PeriodicalId":231920,"journal":{"name":"Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123314911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Study of Schizophrenia with Spect Spect对精神分裂症的研究
Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT Pub Date : 2021-09-23 DOI: 10.4324/9780429278983-20
J. Pahl, K. Rezai, D. O'Leary, N. Andreasen
{"title":"The Study of Schizophrenia with Spect","authors":"J. Pahl, K. Rezai, D. O'Leary, N. Andreasen","doi":"10.4324/9780429278983-20","DOIUrl":"https://doi.org/10.4324/9780429278983-20","url":null,"abstract":"","PeriodicalId":231920,"journal":{"name":"Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126688689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Vivo Studies of the Central Benzodiazepine Receptors in the Human Brain with Positron Emission Tomography 用正电子发射断层扫描对人脑中枢苯二氮卓受体的体内研究
Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT Pub Date : 2021-09-23 DOI: 10.4324/9780429278983-18
P. Abadie, J. Baron
{"title":"In Vivo Studies of the Central Benzodiazepine Receptors in the Human Brain with Positron Emission Tomography","authors":"P. Abadie, J. Baron","doi":"10.4324/9780429278983-18","DOIUrl":"https://doi.org/10.4324/9780429278983-18","url":null,"abstract":"","PeriodicalId":231920,"journal":{"name":"Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114511560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Kinetic Analysis of Radioligand Binding in Brain in Vivo 脑内放射性配体结合动力学分析
Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT Pub Date : 2021-09-23 DOI: 10.4324/9780429278983-17
A. Gjedde
{"title":"Kinetic Analysis of Radioligand Binding in Brain in Vivo","authors":"A. Gjedde","doi":"10.4324/9780429278983-17","DOIUrl":"https://doi.org/10.4324/9780429278983-17","url":null,"abstract":"","PeriodicalId":231920,"journal":{"name":"Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129807999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Historical Background of Pet Pet的历史背景
Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT Pub Date : 2021-09-23 DOI: 10.4324/9780429278983-1
W. Feindel
{"title":"Historical Background of Pet","authors":"W. Feindel","doi":"10.4324/9780429278983-1","DOIUrl":"https://doi.org/10.4324/9780429278983-1","url":null,"abstract":"","PeriodicalId":231920,"journal":{"name":"Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT","volume":"706 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126923639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kinetic Analysis of Glucose Tracer Uptake and Metabolism by Brain in Vivo 脑内葡萄糖示踪剂摄取和代谢的动力学分析
Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT Pub Date : 2021-09-23 DOI: 10.4324/9780429278983-8
A. Gjedde, H. Kuwabara
{"title":"Kinetic Analysis of Glucose Tracer Uptake and Metabolism by Brain in Vivo","authors":"A. Gjedde, H. Kuwabara","doi":"10.4324/9780429278983-8","DOIUrl":"https://doi.org/10.4324/9780429278983-8","url":null,"abstract":"This chapter examines the interaction between tracer glucose uptake and phosphor-ylation in brain. It derives the equations for the use of labeled deoxyglucose, fluorodeoxyglucose, or glucose itself to calculate brain glucose phosphorylation. The chapter estimates the value of the “lumped constant” as a function of the glucose phosphorylation rate, the plasma glucose concentration, the maximal transport capacity of the cerebral capillary endothelium, and the plasma flow of the brain. The driving force of the loss of tracer from a compartment is the aqueous concentration of the tracer in the compartment, if the tracer is in aqueous solution. Compartmental analysis of tracer uptake in vivo serves to measure the size of the different compartments of the tracer, that is, the relative abundance of its different states, and the magnitude of the transfer coefficient or relaxation constant of each compartment. The brain has two kinetic compartments, the vascular space and an extra-vascular space, separated by a blood-brain barrier.","PeriodicalId":231920,"journal":{"name":"Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124027551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pet Studies of Movement Disorders 宠物运动障碍研究
Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT Pub Date : 2021-09-23 DOI: 10.4324/9780429278983-21
M. Guttman, G. Léger
{"title":"Pet Studies of Movement Disorders","authors":"M. Guttman, G. Léger","doi":"10.4324/9780429278983-21","DOIUrl":"https://doi.org/10.4324/9780429278983-21","url":null,"abstract":"This chapter reviews the current information on the use of Positron emission tomography (PET) and movement disorders. Parkinson’s disease is a degenerative neurological disorder characterized by tremor, rigidity, bradykinesia, and postural instability. Therapy is aimed at replacing the neurochemical defect in this condition. L-dopa, the precursor of dopamine, has been used successfully in the treatment of patients with parkinsonism. Dopamine does not cross the blood brain barrier and cannot be used as a therapeutic agent. Parkinsonism may be present in conditions other than Parkinson’s disease. Disease processes that affect the substantia nigra or caudate nucleus and putamen may present with similar symptoms. Cerebral metabolism studies with fluorodeoxyglucose (FDG) have been performed in patients with unilateral and bilateral parkinsonism. PET may be employed to study the nigrostriatal dopamine pathway during life. PET studies of dopamine receptors in Parkinson’s disease have been very preliminary.","PeriodicalId":231920,"journal":{"name":"Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125216494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of Pet to Evaluate Acute Stroke and Other Cerebrovascular Disorders Pet在评估急性脑卒中及其他脑血管疾病中的应用
Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT Pub Date : 2021-09-23 DOI: 10.4324/9780429278983-11
K. Herholz, W. Heiss
{"title":"Use of Pet to Evaluate Acute Stroke and Other Cerebrovascular Disorders","authors":"K. Herholz, W. Heiss","doi":"10.4324/9780429278983-11","DOIUrl":"https://doi.org/10.4324/9780429278983-11","url":null,"abstract":"","PeriodicalId":231920,"journal":{"name":"Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124388025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regional Cerebral Metabolic and Structural Changes in Normal Aging and Dementia as Detected by PET and MRI PET和MRI检测正常衰老和痴呆的脑区域代谢和结构变化
Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT Pub Date : 2021-09-23 DOI: 10.4324/9780429278983-15
D. W. Weiss, E. Souder, A. Alavi
{"title":"Regional Cerebral Metabolic and Structural Changes in Normal Aging and Dementia as Detected by PET and MRI","authors":"D. W. Weiss, E. Souder, A. Alavi","doi":"10.4324/9780429278983-15","DOIUrl":"https://doi.org/10.4324/9780429278983-15","url":null,"abstract":"","PeriodicalId":231920,"journal":{"name":"Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122203855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances in Radiotracers for Pet Studies of the Brain 放射性示踪剂在Pet脑研究中的最新进展
Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT Pub Date : 2021-09-23 DOI: 10.4324/9780429278983-2
J. Fowler, A. Wolf
{"title":"Recent Advances in Radiotracers for Pet Studies of the Brain","authors":"J. Fowler, A. Wolf","doi":"10.4324/9780429278983-2","DOIUrl":"https://doi.org/10.4324/9780429278983-2","url":null,"abstract":"This chapter provides summary of the technology required to apply positron emission tomography (PET). It describes a number of recent developments in radiotracers for probing neurotransmitter properties, protein synthesis, enzyme activity, cerebral malignancy, and drug binding properties. The chapter focuses on the challenges facing the PET field as more institutions acquire the instrumentation to apply this modality in basic and clinical research. The technology required to apply PET to problems in biology and medicine varies, depending on the particular applications and interests of the program. The most common configuration of a cyclotron PET program consists of a cyclotron, a positron emission tomograph, and a radiotracer chemistry laboratory. Radiotracers whose regional distribution reflects glucose metabolism, neurotransmitter activity, and enzyme activity have all required the development of rapid synthetic methods for the radiotracers themselves as well as the characterization of their biochemical behavior in vivo. Quality control is now gaining greater prominence in PET research.","PeriodicalId":231920,"journal":{"name":"Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125672791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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