TMR Modern Herbal Medicine最新文献

{"title":"Effect of Toosendan Fructus before and after stir-frying process extract on CYP450 enzyme activities in rats in vivo and vitro by cocktail probe drug method","authors":"Yu-Feng Hu, Siddique Ma, Menglin Wang, Shuanghui Shi, Xiaotong Wei, Mingrui Jiang, Huinan Wang, Jingqiu Zhang, Qiangang Liu, Ying-Zi Wang","doi":"10.53388/mhm2023006","DOIUrl":"https://doi.org/10.53388/mhm2023006","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80946173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhalation therapy for pulmonary fibrosis: chemical medicines and herbal medicines","authors":"Xiaoyan Xie, Yao Lu, Xushan Chen, Gulizeba Muhetaer, Hao Tao, Hang Li, Han-Jiao Liu","doi":"10.53388/mhm2023014","DOIUrl":"https://doi.org/10.53388/mhm2023014","url":null,"abstract":"Pulmonary fibrosis (PF) is a chronic, progressive, and irreversible pulmonary interstitial disease with unclear pathogenesis. Currently, there are few treatment options for managing PF. Inhalation therapy, as a routine treatment for respiratory diseases, is being used to study the treatment of PF. Some herbal medicines and their active ingredients have been reported to have anti-PF effects. This review aims to provide an overview of the latest developments in inhalation therapy, focusing on the utilization of chemical medicines and herbal medicines for the treatment of PF in both clinical practice and basic research. The inhalation of chemical drugs such as pirfenidone, nintedanib, N-acetylcysteine, and interferon-γ has been shown to demonstrate anti-PF effects. Additionally, the inhalation of various natural products derived from herbal medicines, encompassing polyphenols, alkaloids, flavonoids, saponins, terpenoids, and herbal extracts, contributes to the therapeutic management of PF through diverse mechanisms. The inhalation of both chemical and herbal medicines presents promising advantages in the treatment of PF. Further clinical trials are required to investigate the effectiveness, safety, and mechanism of action of inhalation therapy utilizing natural products derived from herbal medicines.","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83929091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel patterns for drug synergistic mechanism research","authors":"Tian-Long Liu, Min-Na Liu, Yi Ding","doi":"10.53388/mhm2023017","DOIUrl":"https://doi.org/10.53388/mhm2023017","url":null,"abstract":"Drug combination based on synergistic effect is commonly used in clinical practice, especially in the application of traditional medicine. Exploring the combination mechanism could help to better utilize this synergistic advantage. However, current research focuses more on the efficacy enhancing of drugs, while ignoring the toxicity reducing effects. Here, we established two drug synergy patterns based on the different situations of drugs and targets, in order to better illuminate the synergistic mechanism of drugs.","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"88 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136206900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric analysis and visual atlas of mercury-containing Chinese medicine: Hongfen (hydrargyrum oxydatum crudum)","authors":"Yuk Yin, Yi-fan Cheng, Yi-Qin Chen, M. Ye, Hong-feng Chen","doi":"10.53388/mhm2023a0206002","DOIUrl":"https://doi.org/10.53388/mhm2023a0206002","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"36 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78065691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the mechanism of Huangjing pill in the treatment of Alzheimer’s disease based on network pharmacology and molecular docking","authors":"Shuanghui Shi, Menglin Wang, Xiaotong Wei, Siddique Ma, Yu-Feng Hu, Jingqiu Zhang, Huinan Wang, Meng-Yu Chen, Qian-Qian Liu, Ying-Zi Wang","doi":"10.53388/mhm2023a0209001","DOIUrl":"https://doi.org/10.53388/mhm2023a0209001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85731212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese medicine for the treatment of endometriosis：a comprehensive review of treatment mechanisms","authors":"Chong Feng, Da Zhao, Xiaolong Wang, Man Xiao","doi":"10.53388/mhm20230010","DOIUrl":"https://doi.org/10.53388/mhm20230010","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76024139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant activity of six essential oils and its molecules in Ecuadorian Andean medicinal plants","authors":"P. Noriega, Edison Díaz, Ivana Villegas, K. Pozo, Priscila Guerrero, Pablo Guerra, Christian Larenas","doi":"10.53388/mhm2023011","DOIUrl":"https://doi.org/10.53388/mhm2023011","url":null,"abstract":"Background : This research values the antioxidant activity and its responsible molecules in six essential oils from medicinal plants in the Ecuadorian Andes. Methods : The chemical composition of essential oils was determined using gas chromatography coupled mass spectrometry. For evaluated the antioxidant activity of essential oils was use tree spectrophotometric methods: diphenyl-1-picrylhydrazyl (DPPH), 2,2’-Azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and β-Carotene bleaching test. The essential oils with good activity were determined the responsible molecules using the Bioautographic HP-TLC-DPPH method. Results : The scavenging capacity of the radicals was assessed with DPPH and ABTS methods, the best results were found in the oils of M. mollis IC 50 DPPH 2.80 mg/ml and IC 50 ABTS 0.205 mg/mL and in A. glutinosa IC 50 DPPH 12.972 mg/mL and IC 50 ABTS 0.321 mg/mL, the results were compared with a pattern of natural reference in this case, the essential oil of T. vulgaris IC 50 DPPH 0.474 mg/mL and IC 50 ABTS 0.272 mg/mL. The evaluation of the antioxidant activity was determined by the β-carotene bleaching test, the most notable activity results were from M. mollis IC 50 0.119 mg/mL, A. glutinosa IC 50 0.062 mg/mL and B. latifolia IC 50 0,064 mg/mL. DPPH bioautography revealed the active molecules antioxidants in oils for M. mollis were thymol acetate (7.73%) and carvacrol acetate (24.52%), for A. glutinosa was γ-muurolene (2.68%), and for B. latifolia Z-caryophyllene (2.99%), aristolochene (0.11%) and cis-cadin-4-en-7-ol (4.11%). Conclusion : The results of antioxidant activity shown in descending order that the essential oils of: M. mollis , A. glutinosa and B. latifolia , are those with the highest activity using the DPPH and ABTS methods. The β-Carotene bleaching test method confirms the 3 oils as the most active in the following order: A. glutinosa , B. latifolia and M. mollis . An antioxidant bioautographic study identified the molecules responsible for the activity in three essential oils with good activity.","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85923235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the scientific rationality of “Different dosage forms of the same prescription” base on Q-markers of pulvis and pill of Chuanxiong Chatiao Prescription","authors":"Ying Liu, Xiao-Fei Zhang, Dongyan Guo, Bing-tao Zhai, Junbo Zou, Yajun Shi","doi":"10.53388/mhm2023012","DOIUrl":"https://doi.org/10.53388/mhm2023012","url":null,"abstract":"Objective: To predict and analyze the potential Q-markers of Chuanxiong Chatiao Prescription, and the pharmacokinetic properties of pulvis and pills in vivo were studied, which provided a basis for the rational evaluation of the phenomenon of “Different Dosage Forms of the Same Prescription”. Methods and Material: Q-markers analysis of Chuanxiong Chatiao Prescription based on the “Five Principles” (traceability and transmissibility, specificity, effectiveness, prescription compatibility and testability). The content determination method of Q-markers in Chuanxiong Chatiao Prescription was established by UPLC, and the content difference of Q-markers in the two dosage forms ware determined and compared. The Q-markers in rabbit plasma was determined by LC-MS / MS method, and the pharmacokinetic parameters of Q-markers in pulvis and pills were analyzed. Results: A total of 16 potential Q-markers from the “Five Principles” were used, nine components of tetramethylprazine, ferulic acid, glycyrrhizin, glycyrrhizic acid, luteolin, cimicifugoside, senkyunolide Ⅰ, isoimperatorin, nodakenin were identified as Q-markers of Chuanxiong Chatiao Presciption. The content of tetramethylprazine and other components in the pulvis form was found to be significantly higher than that in the pills, while the content of senkyunolide Ⅰ was lower than that in the pills, which may be related to the preparation process of the dosage form and the physicochemical properties of the components. Compared with pulvis, the Tmax and t 1/2 of ferulic acid and other components in pills were significantly prolonged. To a certain extent, it can explain the classical theory of traditional Chinese medicine “Components in pulvis release quickly and take effect in fast-acting manner, while in pills release slowly and take effect in slow-acting”. Meanwhile, the Cmax and AUC0-t of tetramethylprazine and other components in pills were higher than those in pulvis, which showed unexpected pharmacokinetic characteristics, indicating the complexity of compounding and the importance of dosage form design. Conclusions: A method for the determination of Q-markers content was established by UPLC, which provide reference for the quality control of Chuanxiong Chatiao Prescription. In vivo studies have found the pharmacokinetic parameters indicate the absorption and distribution characteristics of pulvis and pills. However, it is also found that the release behavior of different components not only affected by the dosage form but also closely related to their own physical and chemical properties","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"104 51","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91407982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential distribution of authenticity results of different varieties of refined honey based on stable isotope ratio method","authors":"Siddique Ma, Yu-Feng Hu, Xiao-Tong Wei, Menglin Wang, Shuang-Hui Shi, Ming-Rui Jiang, Hui-Nan Wang, Jing-Qiu Zhang, Ying-Zi Wang, Dao-Bing Wang","doi":"10.53388/mhm2023015","DOIUrl":"https://doi.org/10.53388/mhm2023015","url":null,"abstract":"Objective Using the stable isotope ratio method for the authenticity identification and variety identification of refined honey. Methods In this paper, a total of 17 samples of different varieties of refined honey were used to obtain refined honey proteins by precipitation with sodium tungstate solution and sulphuric acid solution. The isotope mass spectrometer was used to simultaneously detect the δ 13 C values of refined honey proteins and refined honey as well as the δ 18 O and δ 2 H values of refined honey, processed of the results obtained, analysed the authenticity of the samples and conduct a variety identification study. Results Tested of the resulting honey samples, the results showed that four batches of refined honey did not up to standard, two batches of C-4 vegetable syrup were detected as adulterated, and two batches of protein were not detected. The δ 18 O and δ 2 H values of refined honey were also found to be effective in distinguishing the varietal origin of refined honey to a certain extent. Conclusions The stable isotope ratio method is useful in the authenticity identification of refined honey, and provides new ideas to further promote the authenticity of refined honey and variety identification research.","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85099691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effects of Astragali Radix on diabetic foot: a clinical randomized controlled trial","authors":"Zhengang Du, Honggang Ni, Qian Guo, Li-dan Zhang","doi":"10.53388/mhm2023013","DOIUrl":"https://doi.org/10.53388/mhm2023013","url":null,"abstract":"Objective: This study was conducted to evaluate the efficacy of Astragalus on diabetic foot, as well as the effects on the levels of serum VEGF, bFGF, MMP-2, and inflammatory factors in patients, and to provide a scientific basis for the treatment of diabetic foot with the traditional Chinese medicine Astragalus . Methods: By taking 100 cases of diabetic foot patients who were admitted to the metabolic internal medicine division of the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine and met the criteria of natriuresis during April 2021–April 2023 as the study subjects, and according to the random number method, all patients were divided into the control group and the observation group, with 50 cases in each group. In the control group, only basic treatment was carried out, while in the observation group, Astragalus injection was added based on the control group. After 8 weeks of treatment, the clinical efficacy, serum VEGF, bFGF, MMP-2, and inflammatory factor levels of the patients in the two groups were compared, respectively. Results: The total clinical efficiency of patients in the observation group was significantly better than that in the control group ( χ 2 =5.01, P < 0.05). The inflammatory factor indexes decreased substantially in both groups. However, the decrease in the observation group was significantly higher than in the control group ( P < 0.05). Compared with the control group, serum VEGF and bFGF were considerably higher in the observation group, while MMP-2 was significantly lower ( P < 0.05). Conclusion: Astragali Radix is clinically effective in the diabetic foot, which can induce vascular endothelial repair and reduce the level of inflammatory factors, to improve the inflammatory state of patients and promote the restoration of ulcerated wound tissue, which is worth promoting in clinical practice.","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84512663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}