{"title":"Potato inhibitors of intrinsic prothrombin activators.","authors":"K Worowski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The potato protease inhibitors inhibit intrinsic prothrombin activators and trypsin activation of prothrombin. The inhibitors 5a and 5b are responsible for the intrinsic prothrombin activator inhibition. This inhibition is progressive. No inhibition by these inhibitors of tissue thromboplastin activation of prothrombin or thrombin activity was observed.</p>","PeriodicalId":23068,"journal":{"name":"Thrombosis et diathesis haemorrhagica","volume":"34 3","pages":"763-9"},"PeriodicalIF":0.0,"publicationDate":"1975-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12387005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Collagen-induced platelet aggregation: the role of adenine nucleotides and the release reaction.","authors":"H Kattlove, M H Gomez","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Collagen-induced platelet aggregation is associated with the release of ADP and the catabolism of radioactive ATP. These studies demonstrate that the amount of human platelet ADP released and ATP catabolized increase with time of stirring of the collagen-platelet rich plasma (PRP) mixture and with increasing amounts of collagen. These changes in adenine nucleotides occurred simultaneously with the aggregation. No early changes preceding aggregation were noted. Stirring the collagen-PRP mixture maximized ADP release and ATP catabolism; some ADP release and ATP catabolism occurred with minimal agitation. Incubation of PRP with metabolid poisons (2-deoxyglucose with either KCN or oligomycin), which lowered platelet ATP content, also reduced collagen-induced release of ADP and aggregation. However, platelet adhesion to collagen was unaffected by metabolic poisons. These data suggest that collagen directly stimulates ADP release. The demonstration of release in EDTA-PRP further suggest that platelet aggregation is not required for collagen-induced ADP release.</p>","PeriodicalId":23068,"journal":{"name":"Thrombosis et diathesis haemorrhagica","volume":"34 3","pages":"795-805"},"PeriodicalIF":0.0,"publicationDate":"1975-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12000312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter: A more uniform measurement of factor VIII inhibitors.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23068,"journal":{"name":"Thrombosis et diathesis haemorrhagica","volume":"34 3","pages":"869-72"},"PeriodicalIF":0.0,"publicationDate":"1975-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12387012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter: The buffering of anticoagulants for blood collection.","authors":"R Godfrey, T W Barrowcliffe","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23068,"journal":{"name":"Thrombosis et diathesis haemorrhagica","volume":"34 3","pages":"879-82"},"PeriodicalIF":0.0,"publicationDate":"1975-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12387016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On the structure of fibrinogen related to its plasmic degradation products D and E.","authors":"G Marguerie, G Hudry-Clergeon, M Suscillon","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23068,"journal":{"name":"Thrombosis et diathesis haemorrhagica","volume":"34 3","pages":"664-70"},"PeriodicalIF":0.0,"publicationDate":"1975-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11348706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Proceedings: Fibrinogen degradation of normal and fibrinolytic plasma.","authors":"M F Scully, V V Kakkar","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23068,"journal":{"name":"Thrombosis et diathesis haemorrhagica","volume":"34 2","pages":"584"},"PeriodicalIF":0.0,"publicationDate":"1975-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11276545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Molecular biology of human plasminogen. I. Physiochemical properties and microheterogeneity.","authors":"D Collen, L de Maeyer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23068,"journal":{"name":"Thrombosis et diathesis haemorrhagica","volume":"34 2","pages":"396-402"},"PeriodicalIF":0.0,"publicationDate":"1975-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11225591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Proceedings: Indications and results of fibrinolytic treatment with streptokinase in chronic arterial stenoses and occlusions; a multicentre trial of 708 patients.","authors":"R Schmutzler","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23068,"journal":{"name":"Thrombosis et diathesis haemorrhagica","volume":"34 2","pages":"569"},"PeriodicalIF":0.0,"publicationDate":"1975-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12285380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Proceedings: Comparative investigations on time dependent changes of enhanced aggregation.","authors":"I Scharrer, K Breddin, M Ziemen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23068,"journal":{"name":"Thrombosis et diathesis haemorrhagica","volume":"34 2","pages":"575"},"PeriodicalIF":0.0,"publicationDate":"1975-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12375110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}