发布求助
文献互助 智能选刊 最新文献

Therapeutic immunology最新文献

筛选
英文 中文
Blocking of adhesion molecules in vivo as anti-inflammatory therapy. 阻断黏附分子的体内抗炎治疗。
Therapeutic immunology Pub Date : 1994-06-01
P A Ward, M S Mulligan
{"title":"Blocking of adhesion molecules in vivo as anti-inflammatory therapy.","authors":"P A Ward, M S Mulligan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23039,"journal":{"name":"Therapeutic immunology","volume":"1 3","pages":"165-71"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18590278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Xenobiotics, chimerism and the induction of tolerance following organ transplantation. 异种药物、嵌合和器官移植后耐受的诱导。
Therapeutic immunology Pub Date : 1994-06-01
C P Delaney, A W Thomson, A J Demetris, T E Starzl
{"title":"Xenobiotics, chimerism and the induction of tolerance following organ transplantation.","authors":"C P Delaney,&nbsp;A W Thomson,&nbsp;A J Demetris,&nbsp;T E Starzl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The successful results seen after organ transplantation are largely attributable to the potency and specificity of modern immunosuppressive agents. Although drug-free unresponsiveness to graft alloantigens has not been routinely achieved in clinical practice, recent appreciation of the importance of cell chimerism, which develops after the migration from donor to host of leukocytes contained in solid organ grafts, has introduced a concept which may explain the mechanism of graft tolerance. Recent evidence has indicated that immunosuppressive drugs may have a common potential to induce graft tolerance, even though they act through diverse mechanisms, and that this potential may be mediated by a permissive effect on the migration and survival of donor-derived leukocytes. This review briefly examines the mechanisms by which immunosuppressive drugs function and analyses the different methods which these agents might use to induce chimerism associated with graft tolerance. Furthermore, we describe ongoing clinical studies in which the chimerism produced after solid organ transplantation is augmented with donor bone marrow in an attempt to facilitate the induction of tolerance.</p>","PeriodicalId":23039,"journal":{"name":"Therapeutic immunology","volume":"1 3","pages":"153-64"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993237/pdf/nihms250645.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18590279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of FK506 and dexamethasone on rat thymocyte differentiation. FK506和地塞米松对大鼠胸腺细胞分化的影响。
Therapeutic immunology Pub Date : 1994-06-01
M Tsuchida, K Takai, K Jojima, K Naito, Y Fujikura, T Fukumoto
{"title":"The effects of FK506 and dexamethasone on rat thymocyte differentiation.","authors":"M Tsuchida,&nbsp;K Takai,&nbsp;K Jojima,&nbsp;K Naito,&nbsp;Y Fujikura,&nbsp;T Fukumoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We investigated the effects of FK506 and glucocorticoids (GC) on rat thymocytes using flow cytofluorometry. Rats were treated with GC (0.1 mg/body, by single injection), with FK506 (1 mg/kg/day, for 7 days), or with FK506 and GC. GC alone significantly decreased the percentage of CD4+8+ thymocytes and increased the percentages of CD4-8-, CD4+8- and CD4-8+ thymocytes on day 7. FK decreased the percentage of CD4+8- and CD4-8+ thymocytes and increased the percentage of CD4+8+ thymocytes on days 5 to 14. FK and GC induced a significant decrease in the number of CD4+8+ thymocytes greater than that seen with GC alone on day 7. The absolute number of TCR alpha beta high MHC class Ihigh thymocytes after FK and GC was significantly lower than that of the control group, and was slightly lower than that after FK alone on day 14. These results suggest that combined treatment with FK506 and GC acts complexly to decrease rat CD4+8+ thymocytes and prevents thymocyte differentiation and maturation.</p>","PeriodicalId":23039,"journal":{"name":"Therapeutic immunology","volume":"1 3","pages":"135-41"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18589722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapid induction of cytolytic T cells via CD28 stimulation for cellular immunotherapy. 通过CD28刺激快速诱导细胞溶解性T细胞用于细胞免疫治疗。
Therapeutic immunology Pub Date : 1994-06-01
S Blum, R Milesi, J Tratkiewicz, D Olive, H Gallati, J C Cerottini, V von Fliedner
{"title":"Rapid induction of cytolytic T cells via CD28 stimulation for cellular immunotherapy.","authors":"S Blum,&nbsp;R Milesi,&nbsp;J Tratkiewicz,&nbsp;D Olive,&nbsp;H Gallati,&nbsp;J C Cerottini,&nbsp;V von Fliedner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>One approach to adoptive cancer immunotherapy is based on the use of bispecific monoclonal antibodies (mAb) capable to redirect ex vivo generated cytolytic T lymphocytes (CTL) onto tumour cells. The efficiency of the CD28 T-cell activation pathway to induce CD3-dependent cytolytic activity was investigated while avoiding modulation of the TCR/CD3 complex needed for targeting by bispecific mAb. When used e.g. in conjunction with anti-CD2 antibodies or diacylglycerol derivatives, the in vitro stimulation of T cells with anti-CD28 mAb resulted within 36 h in high levels of CD3-dependent cytolysis (tested on a FcR+ target in the presence of anti-CD3 mAb) and sustained lymphokine production, such as TNF alpha, IFN gamma and IL-2, which may affect tumour growth when delivered locally by the transferred T cells. Rapid activation may reduce costly in vitro procedures, preserve homing capacities of retransfused T cells, and thus facilitate implementation of clinical trials based on the use of bispecific antibodies.</p>","PeriodicalId":23039,"journal":{"name":"Therapeutic immunology","volume":"1 3","pages":"143-52"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18590277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Induction of donor-specific tolerance by transplantation of bone marrow. 骨髓移植诱导供者特异性耐受。
Therapeutic immunology Pub Date : 1994-04-01
C L Kaufman, S T Ildstad
{"title":"Induction of donor-specific tolerance by transplantation of bone marrow.","authors":"C L Kaufman,&nbsp;S T Ildstad","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23039,"journal":{"name":"Therapeutic immunology","volume":"1 2","pages":"101-11"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18589715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interleukin-I antagonists. Interleukin-I拮抗剂。
Therapeutic immunology Pub Date : 1994-04-01
S K Dower, W Fanslow, C Jacobs, S Waugh, J E Sims, M B Widmer
{"title":"Interleukin-I antagonists.","authors":"S K Dower,&nbsp;W Fanslow,&nbsp;C Jacobs,&nbsp;S Waugh,&nbsp;J E Sims,&nbsp;M B Widmer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23039,"journal":{"name":"Therapeutic immunology","volume":"1 2","pages":"113-22"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18589716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human recombinant TNF-alpha on localization of 90Y-radioantibody in human tumour xenografts. 人重组tnf - α对人肿瘤移植中90y放射抗体定位的影响。
Therapeutic immunology Pub Date : 1994-04-01
T Matsushita, T W Griffin, Z Yao, H Delichatsios, A B Brill
{"title":"Human recombinant TNF-alpha on localization of 90Y-radioantibody in human tumour xenografts.","authors":"T Matsushita,&nbsp;T W Griffin,&nbsp;Z Yao,&nbsp;H Delichatsios,&nbsp;A B Brill","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of recombinant human tumour necrotic factor-alpha (TNF-alpha) on the intratumour and whole-body distributions of 90Y-labelled C110 anticarcinoembryonic antigen (CEA) monoclonal antibody (MAb) was studied using nude mice bearing two different tumours. The nude mice were injected subcutaneously with the CEA-positive LS174T colorectal cancer xenograft and the CEA-negative H-MESO-1 malignant mesothelioma xenograft. One hour before injection of radiolabelled MAb, mice were injected intravenously with human recombinant TNF-alpha (3 mg per mouse) or saline, and biodistributions of radiolabel were determined by tissue counting and whole-body autoradiography (ARG). Twenty-four hours after injection, TNF-alpha administration increased radioactivity in the LS174T tumour by 57% (17.30 +/- 1.61 vs. 9.83 +/- 1.55% ID g-1, P < 0.01), while decreasing radioactivity in blood and other normal organs. Diminished but similar effects on radioantibody biodistribution were seen at 48 and 72 hours. TNF-alpha did not affect specific MAb localization in the control H-MESO xenograft. Tumour:blood ratios were increased from 0.7 to 1.7 at 24 h with TNF-alpha administration. Pretreatment with TNF-alpha may be of value in increasing specific localization of monoclonal antibodies in tumour tissue.</p>","PeriodicalId":23039,"journal":{"name":"Therapeutic immunology","volume":"1 2","pages":"71-6"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18589718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of anti-CD5 ricin A chain immunoconjugate for prevention of acute graft-vs.-host disease after HLA-identical marrow transplantation. 抗cd5蓖麻毒素A链免疫偶联物预防急性移植物vs的研究。同种hla骨髓移植后的-宿主病。
Therapeutic immunology Pub Date : 1994-04-01
D Przepiorka, C F LeMaistre, Y O Huh, M Luna, E A Saria, C T Brown, R E Champlin
{"title":"Evaluation of anti-CD5 ricin A chain immunoconjugate for prevention of acute graft-vs.-host disease after HLA-identical marrow transplantation.","authors":"D Przepiorka,&nbsp;C F LeMaistre,&nbsp;Y O Huh,&nbsp;M Luna,&nbsp;E A Saria,&nbsp;C T Brown,&nbsp;R E Champlin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Anti-CD5 ricin A chain immunoconjugate (XZ-CD5) is an immunotoxin that inhibits proliferative and cytotoxic responses to alloantigen in vitro and has activity in the treatment of acute graft-vs.-host disease (GVHD). To determine if XZ-CD5 could be used to prevent acute GVHD, 11 adult recipients of HLA-identical allogeneic marrow received XZ-CD5 0.1 mg kg-1 day-1 intravenously with high-dose methyl-prednisolone for 10, 14 or 17 doses early post-transplant. Six additional patients received 17 doses of XZ-CD5 and cyclosporine (CSA). All patients engrafted. Severe capillary leak syndrome was the most common serious toxicity and occurred more frequently in patients receiving CSA (5/5 vs. 3/11, P = 0.03). All evaluable patients developed acute GVHD; 88% had grade II-IV GVHD. Flow cytometric analysis demonstrated a substantial number of circulating CD5+ and CD3+ lymphocytes during and early after administration of XZ-CD5. These results suggest that the immunotoxin did not eliminate alloreactive T cells in this setting.</p>","PeriodicalId":23039,"journal":{"name":"Therapeutic immunology","volume":"1 2","pages":"77-82"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18589719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The production and preclinical characterization of a chimeric anti-breast-cancer antibody, cBC2. 嵌合抗乳腺癌抗体cBC2的制备及临床前鉴定。
Therapeutic immunology Pub Date : 1994-04-01
V R Sutton, J Burgess, G A Pietersz, W J Li, I F McKenzie, J A Trapani
{"title":"The production and preclinical characterization of a chimeric anti-breast-cancer antibody, cBC2.","authors":"V R Sutton,&nbsp;J Burgess,&nbsp;G A Pietersz,&nbsp;W J Li,&nbsp;I F McKenzie,&nbsp;J A Trapani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A chimeric (mouse-human) BC2 antibody (cBC2) was produced which may be used in the diagnosis and treatment of breast cancer. The BC2 variable region genes were amplified by polymerase chain reaction (PCR), using oligonucleotide primers homologous to the framework sequences of mouse VH and V kappa genes. The PCR products were used to create cBC2 expression vectors containing the mouse BC2 VH and V kappa and human constant region (IgG1 and K) genes. Chimeric antibody was produced following transfection of these constructs into Sp2/0 myeloma cells. Binding assays in vitro demonstrated that cBC2 had the same specificity for human milk fat globule membrane (HMFGM) and MUC1+ cells as mBC2, and bound antigen with a similar affinity (cBC2, Ka 5.53 +/- 2.09 x 10(8); mBC2, Ka 1.44 +/- 0.98 x 10(9)). Functionally, only cBC2 (5-25 micrograms ml-1), was able to mediate antibody-dependent cellular cytotoxicity (ADCC) with human effector cells, with 25% maximal specific lysis of MUC1+ cells at an E/T ratio of 100:1. Human complement-mediated lysis was minimal (10-15% specific lysis) with both mBC2 and cBC2. Neither cBC2 nor mBC2 was able to inhibit tumour growth in vivo in the absence of covalently coupled anticancer drugs. However, biodistribution studies demonstrated that both antibodies preferentially targeted MUC1+ tumour cells, with 17% of the injected dose of cBC2, as compared to 27% of mBC2, localized to the MUC1+ tumour at 24 h (less than 6% detected in any other tissue).</p>","PeriodicalId":23039,"journal":{"name":"Therapeutic immunology","volume":"1 2","pages":"83-93"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18589720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphocyte development in genetically manipulated mice. 基因处理小鼠的淋巴细胞发育。
Therapeutic immunology Pub Date : 1994-04-01
N Killeen, D R Littman
{"title":"Lymphocyte development in genetically manipulated mice.","authors":"N Killeen,&nbsp;D R Littman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23039,"journal":{"name":"Therapeutic immunology","volume":"1 2","pages":"123-33"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18589717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信