The Showa University Journal of Medical Sciences最新文献_第10页

Risk of Drug-Induced Accidents and Injuries in Elderly Patients Treated with Specific Drugs Rather than Polypharmacy : Analyses of the Japanese Adverse Drug Event Report Database 使用特定药物而非多种药物治疗的老年患者药物性事故和伤害的风险:对日本不良药物事件报告数据库的分析

The Showa University Journal of Medical Sciences Pub Date : 2019-01-01 DOI: 10.15369/SUJMS.31.125

T. Haga, Iori Taki-Takemoto, Remi Murase, D. Kamei, S. Iwai

引用次数: 0

Changes in Pediatric Patient Trends in Eating and Swallowing Disorders: A Comparison between the First and Fifth Year after Establishment of the Special Needs Dental Center 儿科患者饮食和吞咽障碍趋势的变化:特殊需要牙科中心成立后第一年和第五年的比较

The Showa University Journal of Medical Sciences Pub Date : 2019-01-01 DOI: 10.15369/sujms.31.329

E. Masuda, Akemi Utsumi, Kentaro Ishikawa, Akiko Ishizaki, K. Kubota, Kohji Murakami, K. Tomita, Mari Takahashi, Luna Osakabe, Ayano Ogawa, Takuya Asami, Megumi Iwauchi, Shinpei Mogami, S. Hironaka

{"title":"Changes in Pediatric Patient Trends in Eating and Swallowing Disorders: A Comparison between the First and Fifth Year after Establishment of the Special Needs Dental Center","authors":"E. Masuda, Akemi Utsumi, Kentaro Ishikawa, Akiko Ishizaki, K. Kubota, Kohji Murakami, K. Tomita, Mari Takahashi, Luna Osakabe, Ayano Ogawa, Takuya Asami, Megumi Iwauchi, Shinpei Mogami, S. Hironaka","doi":"10.15369/sujms.31.329","DOIUrl":"https://doi.org/10.15369/sujms.31.329","url":null,"abstract":"A Special Needs Dental Center (hereafter referred to as the Center) was established at Showa University Dental Hospital in April 2012 to treat patients who need special care. In cooperation with the Division of Dentistry for Persons with Disabilities, the Division of Hygiene and Oral Health is mainly engaged in the treatment of patients with eating and swallowing disorders. It has been ve years since the establishment of the Center. The present study was aimed to establish an effective medical support method through a comparative study of changes in patient trends. A total of 65 patients who visited the Center from April 2017 to March 2018 were examined and their statistics were compared with those of 60 previously reported patients who initially visited the Center for medical examination in 2012. In 2012, many visits occurred during the nursing period; however, in 2017, the number of patients who visited after the weaning period increased. Other noted trends were increased diversity in primary disease, more patient referrals, fewer patients with severe swallowing dysfunction, and more patients with oral dysfunction. The necessity of eating and swallowing practice is thought to increase when lifestyle and oral environment change. The treatment of eating and swallowing disorders is important in the dental profession. Due to the introduction of insurance coverage in Japan in 2018 for developmental insuf ciency of oral function, more pediatric patients with eating and swallowing disorders will likely be treated in the future.","PeriodicalId":23019,"journal":{"name":"The Showa University Journal of Medical Sciences","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83602884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Anti-Inflammatory Analgesics for Mechanical Stress-induced Inflammation in a Human Synovial Sarcoma Cell Line 抗炎镇痛药治疗人滑膜肉瘤细胞系机械应力诱导炎症的比较

The Showa University Journal of Medical Sciences Pub Date : 2019-01-01 DOI: 10.15369/SUJMS.31.51

Haruna Shirako, Yuko Udaka, Akiko Sasaki, S. Nakamura, Mayumi Tsuji, Y. Kiuchi

{"title":"Comparison of Anti-Inflammatory Analgesics for Mechanical Stress-induced Inflammation in a Human Synovial Sarcoma Cell Line","authors":"Haruna Shirako, Yuko Udaka, Akiko Sasaki, S. Nakamura, Mayumi Tsuji, Y. Kiuchi","doi":"10.15369/SUJMS.31.51","DOIUrl":"https://doi.org/10.15369/SUJMS.31.51","url":null,"abstract":": Osteoarthritis is a complicated clinical condition affected by age, mechanical stress, cartilage hypertrophy, cytokines, and genetic predisposition. In this study, we compared the effects of various anti-inflammatory analgesics on mechanical stress-induced inflammation in a synovial sarcoma cell line （ SW982 cells ） . SW982 cells exposed to mechanical stress by shaking with hydroxyapatite-simulating bone chips were treated with acetaminophen, ketoprofen, triamcinolone acetonide, celecoxib, or neurotrophin for 48 hr. The expression of integrin α 5 β 1 receptor, observed in fibroblasts and synovium, was evaluated. Levels of the transcription factor, nuclear factor- κ B, the inflammatory cytokine, tumor necrosis factor- α , the proteolytic enzyme, matrix metalloproteinase-3, and prostaglandin E 2 , which is associated with pain and arachidonate cascade product levels, were measured by ELISA. The expression of integrin α 5 β 1 was significantly increased by mechanical stress. Activation of nuclear factor- κ B by mechanical stress was significantly suppressed by celecoxib only. Mechanical stress-induced increases in tumor necrosis factor- α and matrix metalloproteinase-3 levels were significantly suppressed by acetaminophen, triamcinolone acetonide, and neurotrophin. mechanical stress-induced increase in prostaglandin E 2 levels was significantly suppressed by acetaminophen, ketoprofen, and celecoxib. 1, a membrane receptor protein that binds to fibronectin and the extracellular matrix, and is involved in cell proliferation, differentiation, and neovascularization in osteoarthritis, was significantly upregulated. Following evaluation using this model, acetaminophen was found to possess anti-inflammatory, analgesic, and joint-destruction suppression properties. This drug may, therefore, have applications in the treatment of mechanical stress-induced inflammation.","PeriodicalId":23019,"journal":{"name":"The Showa University Journal of Medical Sciences","volume":"138 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77391210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of Glucose and Blood Pressure Variability with Cardiac Diastolic Function in Patients with Type 2 Diabetes Mellitus and Hypertension: A Retrospective Observational Study 2型糖尿病合并高血压患者的血糖和血压变异性与心脏舒张功能的关系:一项回顾性观察研究

The Showa University Journal of Medical Sciences Pub Date : 2019-01-01 DOI: 10.15369/SUJMS.31.139

S. Goto, Makoto Ohara, Naoya Osaka, Tomoki Fujikawa, Yo Kohata, H. Nagaike, Ayako Fukase, Hideki Kushima, Munenori Hiromura, Takeshi Yamamoto, Toshiyuki Hayashi, Tomoyasu Fukui, T. Hirano

{"title":"Associations of Glucose and Blood Pressure Variability with Cardiac Diastolic Function in Patients with Type 2 Diabetes Mellitus and Hypertension: A Retrospective Observational Study","authors":"S. Goto, Makoto Ohara, Naoya Osaka, Tomoki Fujikawa, Yo Kohata, H. Nagaike, Ayako Fukase, Hideki Kushima, Munenori Hiromura, Takeshi Yamamoto, Toshiyuki Hayashi, Tomoyasu Fukui, T. Hirano","doi":"10.15369/SUJMS.31.139","DOIUrl":"https://doi.org/10.15369/SUJMS.31.139","url":null,"abstract":"We evaluated the effects of glucose metabolism and blood pressure (BP) variability on cardiac diastolic function in patients with type 2 diabetes mellitus(T2DM) and hypertension. A total of 23 inpatients with T2DM underwent ambulatory BP monitoring(ABPM) and echocardiography. BP variability was assessed by measuring the mean BP and the standard deviation(SD) of systolic and diastolic BP over 24 hours, as well as daytime and nighttime ABPM. Cardiac diastolic function was assessed using the echocardiography E/e′ ratio. Participants had a mean age of 69.0±10.6 years, disease duration of 11.0±10.5 years, glycated hemoglobin(HbA1c) of 8.2%±1.3%, and glycated albumin(GA) of 22.0%± 4.2%. Univariate analysis showed that the nighttime systolic BP, nighttime SDs of systolic and diastolic BP, urinary albumin, estimated glomerular ltration rate, and GA / HbA1c ratio were all signi cantly correlated with the E/e′ ratio. Moreover, stepwise multiple regression analysis identi ed nighttime SD of diastolic BP, urinary albumin, and GA / HbA1c ratio as independent contributors to the E/e′ ratio. In patients with T2DM and hypertension, cardiac diastolic function was associated with nighttime diastolic BP variability and the GA / HbA1c ratio.","PeriodicalId":23019,"journal":{"name":"The Showa University Journal of Medical Sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91224456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Construction of an All-in-one Double-conditional shRNA Expression Vector 一体化双条件shRNA表达载体的构建

The Showa University Journal of Medical Sciences Pub Date : 2019-01-01 DOI: 10.15369/SUJMS.31.41

Yoshiko Kudo, H. Oyamada, Tomoyuki Matsuoka, Ayami Inagaki, Hiromichi Tsuchiya, Yoko Ao, Atsushi Michael Kimura, Mayumi Tsuji, K. Oguchi, Y. Kiuchi

引用次数: 0

The Synergistic Antitumor Effect of Combined Anti-Human Epidermal Growth Factor Receptor 2 Antibody and Gamma Interferon Therapy on Antibody-resistant Breast Cancer Cells 抗人表皮生长因子受体2抗体联合γ干扰素治疗对抗体耐药乳腺癌细胞的协同抗肿瘤作用

The Showa University Journal of Medical Sciences Pub Date : 2019-01-01 DOI: 10.15369/sujms.31.237

Toshihiko Gocho, Hiromichi Tsuchiya, Shotaro Kamijo, Y. Yamazaki, Akiko Sasaki, Y. Kiuchi

{"title":"The Synergistic Antitumor Effect of Combined Anti-Human Epidermal Growth Factor Receptor 2 Antibody and Gamma Interferon Therapy on Antibody-resistant Breast Cancer Cells","authors":"Toshihiko Gocho, Hiromichi Tsuchiya, Shotaro Kamijo, Y. Yamazaki, Akiko Sasaki, Y. Kiuchi","doi":"10.15369/sujms.31.237","DOIUrl":"https://doi.org/10.15369/sujms.31.237","url":null,"abstract":"The anti-human epidermal growth factor receptor 2 (HER2) antibody (Ab) is a molecularly targeted Ab for cancer therapy. In the eld of breast cancer, approximately 20% overexpress HER2 protein. However, the recurrence rate is 30% and the metastasis rate is 18% one year after treatment of anti-HER2 Ab for HER2 positive breast cancer. The resistance to Ab treatment is a major problem for patients. We previously reported that anti-HER2 Ab and Gamma Interferon (IFN-γ) combined therapy show a higher anti-tumor effect than typical therapy in in vitro and in vivo mouse experiments. In this study, we evaluated whether anti-HER2 Ab and IFN-γ combined therapy shows a good synergistic effect against drug-resistant HER2 positive breast cancer cells and a higher antitumor effect than chemotherapy as a conventional clinical treatment. Further, we evaluated a synergy effect with the PD-L1 as a new check point inhibitor. The resistant cell lines were made under the continuous presence of Ab until cell growth was not affected by the drug. The resistant cells were divided into the appropriate number of groups, and then treated with anti-cancer therapy. We evaluated the antitumor effect for both the in vitro study and in vivo mouse xenograft model prepared with the same immunogenicity. The differences of immuno uorescence staining of CD8, Gr-1 and PDL-1 in tissues were investigated, especially in relation to the immune system. The combined therapy showed a signi cantly higher antitumor effect than other groups in in vitro and in vivo experiments. The combined therapy affected anti-tumor immunity in this immunofluorescence experiment. Taken together, we showed the possibility that combined therapy could be an effective treatment option for anti-HER2 Ab resistant breast cancer, thus helping patients suffering from cancer progression after developing treatment resistance.","PeriodicalId":23019,"journal":{"name":"The Showa University Journal of Medical Sciences","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90700477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studies on the Constituents of the Dioscorea tokoro Rhizome 薯蓣根茎成分的研究

The Showa University Journal of Medical Sciences Pub Date : 2019-01-01 DOI: 10.15369/SUJMS.31.151

Y. Hirai

引用次数: 1

Involvement of Vascular Endothelial Cells in the Anti-atherogenic Effects of Liraglutide in Diabetic Apolipoprotein E-null Mice 血管内皮细胞参与利拉鲁肽对糖尿病载脂蛋白e缺失小鼠的抗动脉粥样硬化作用

The Showa University Journal of Medical Sciences Pub Date : 2019-01-01 DOI: 10.15369/SUJMS.31.115

M. Koshibu, Y. Mori, Hideki Kushima, Munenori Hiromura, Kyoko Kohashi, Michishige Terasaki, Naoya Osaka, Tomoki Fujikawa, Tomoyasu Fukui, T. Hirano

{"title":"Involvement of Vascular Endothelial Cells in the Anti-atherogenic Effects of Liraglutide in Diabetic Apolipoprotein E-null Mice","authors":"M. Koshibu, Y. Mori, Hideki Kushima, Munenori Hiromura, Kyoko Kohashi, Michishige Terasaki, Naoya Osaka, Tomoki Fujikawa, Tomoyasu Fukui, T. Hirano","doi":"10.15369/SUJMS.31.115","DOIUrl":"https://doi.org/10.15369/SUJMS.31.115","url":null,"abstract":": Glucagon-like peptide 1 receptor agonists （ GLP-1RAs ） have been shown to exert anti-atherosclerotic effects via multiple mechanisms on different types of cells. However, it is unclear which of these mechanisms are crucial. We investigated the role of vascular endothelial cells （ VECs ） in the anti-atherogenic effects of the GLP-1RA liraglutide in a mouse model of atherosclerosis. were randomly assigned to treatment with either vehicle （ saline ） or liraglutide （ 107 nmol/kg/day ） , and were subjected to femoral artery wire injury to remove VECs. glucose ＞ 300 hemoglobin A1c levels of ＞ 9 ％ , indicating the had induced severe hyperglycemia. cholesterol, and triglycerides between the and plaques were observed ; however, severe plaque formation occurred in femoral arteries that had been injured by wire insertion to remove VECs. Unlike in the uninjured aorta, liraglutide treatment did not affect plaque volume or arterial remodeling （ intimal and medial thinning, and arterial dilation ） in wire-injured femoral arteries. Of the various cells that liraglutide affects, VECs play a central role in liraglutide ʼ s anti-atherogenic effects in diabetic mice.","PeriodicalId":23019,"journal":{"name":"The Showa University Journal of Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87160698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Olecranon Stress Fracture Caused by Throwing Motion 投掷运动致鹰嘴应力骨折1例

The Showa University Journal of Medical Sciences Pub Date : 2019-01-01 DOI: 10.15369/sujms.31.293

Masayori Fujita, T. Yamamura, K. Inagaki

引用次数: 0

Antimicrobial Property of Titanium Plates Treated with Silica-Bound Protamine 二氧化硅结合鱼精蛋白处理钛板的抗菌性能

The Showa University Journal of Medical Sciences Pub Date : 2019-01-01 DOI: 10.15369/SUJMS.31.159

H. Owada, H. Narusawa, Y. Kataoka, T. Miyazaki

引用次数: 0