The World Journal of Biological Psychiatry最新文献_第9页

Neural correlates of altered sensorimotor gating in boys with Tourette Syndrome: A combined EMG/fMRI study 图雷特综合症男孩感觉运动门控改变的神经相关因素:EMG/fMRI联合研究

The World Journal of Biological Psychiatry Pub Date : 2016-04-01 DOI: 10.3109/15622975.2015.1112033

Judith Buse, C. Beste, Elisabeth Herrmann, V. Roessner

{"title":"Neural correlates of altered sensorimotor gating in boys with Tourette Syndrome: A combined EMG/fMRI study","authors":"Judith Buse, C. Beste, Elisabeth Herrmann, V. Roessner","doi":"10.3109/15622975.2015.1112033","DOIUrl":"https://doi.org/10.3109/15622975.2015.1112033","url":null,"abstract":"Abstract Objectives: It has been hypothesised that altered sensorimotor gating might be a core problem in Tourette Syndrome (TS). However, the underlying neurophysiological mechanisms are elusive. Methods: We applied functional magnetic resonance imaging (fMRI) to investigate the neural correlates of altered sensorimotor gating by means of prepulse inhibition (PPI) in 22 boys with TS and 22 healthy boys using tactile PPI. The electromyography of the startle response was recorded simultaneously to the acquisition of the fMRI images. Results: As expected, PPI of the startle response was reduced in boys with TS compared to the healthy boys. We found decreased PPI-related blood oxygen level-dependent (BOLD) activity in boys with TS in the middle frontal gyrus, postcentral gyrus, superior parietal cortex, cingulate gyrus and caudate body. In boys with TS PPI of the startle response was positively correlated to PPI-related BOLD activity in the superior parietal cortex. Conclusions: Our findings indicate that deficient sensorimotor gating in boys with TS is associated with reduced recruitment of brain regions responsible for the higher-order integration of somatosensory stimuli. Due to our strict sample selection we were able to reduce confounding by neural adaptation processes, long-term medication, gender or comorbidities.","PeriodicalId":22963,"journal":{"name":"The World Journal of Biological Psychiatry","volume":"1 1","pages":"187 - 197"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75623703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 55

Alpha2C-adrenoceptor Del322-325 polymorphism and risk of psychiatric disorders: significant association with opiate abuse and dependence alpha2c -肾上腺素能受体Del322-325多态性与精神疾病的风险:与阿片类药物滥用和依赖的显著关联

The World Journal of Biological Psychiatry Pub Date : 2016-03-23 DOI: 10.3109/15622975.2016.1142608

G. Rivero, I. Martín-Guerrero, Elena de Prado, A. Gabilondo, L. Callado, J. García-Sevilla, A. García-Orad, J. Meana

{"title":"Alpha2C-adrenoceptor Del322-325 polymorphism and risk of psychiatric disorders: significant association with opiate abuse and dependence","authors":"G. Rivero, I. Martín-Guerrero, Elena de Prado, A. Gabilondo, L. Callado, J. García-Sevilla, A. García-Orad, J. Meana","doi":"10.3109/15622975.2016.1142608","DOIUrl":"https://doi.org/10.3109/15622975.2016.1142608","url":null,"abstract":"Abstract Objectives α2C-adrenoceptors (α2C-AR) are involved in behavioural responses relevant to psychiatric disorders and suicide completion. The genetic polymorphism α2CDel322-325-AR confers a loss-of-function phenotype. Functional human studies have associated α2CDel322-325-AR polymorphism with major depression pathophysiology. The aim of this study was to analyse, for the first time, the association of α2CDel322-325-AR polymorphism with suicide completion and with related psychiatric disorders: major depression, schizophrenia, opiate and alcohol abuse and dependence. Methods Post-mortem brain DNA was extracted (n = 516) and genotyping performed by HaeIII restriction endonuclease digestion of PCR products and DNA fragment analysis on capillary sequencer. Amplified products were sequenced to confirm the presence of the polymorphism. Results The frequency of α2CDel322-325-AR in suicide (9%, n = 236) and non-suicide victims (11%, n = 280) was similar. Genotype frequencies for the α2CDel322-325-AR polymorphism in depressed (15%, n = 39) and schizophrenic subjects (18%, n = 39) were higher than in controls (7%, n = 187), but these differences did not reach statistical significance (P = 0.125 and P = 0.063, respectively). A selective and significant association of α2CDel322-325-AR polymorphism with opiate abuse and dependence was found (23%, n = 35, P = 0.011). Conclusions Our results indicate that α2CDel322-325-AR may play a role in the pathophysiology of opiate abuse and dependence and raise the interest for larger genetic associative studies.","PeriodicalId":22963,"journal":{"name":"The World Journal of Biological Psychiatry","volume":"288 1","pages":"308 - 315"},"PeriodicalIF":0.0,"publicationDate":"2016-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74951348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Strategies to mitigate dissociative and psychotomimetic effects of ketamine in the treatment of major depressive episodes: a narrative review 减轻氯胺酮治疗重度抑郁发作的解离和拟精神效应的策略:一篇叙述性综述

The World Journal of Biological Psychiatry Pub Date : 2016-03-16 DOI: 10.3109/15622975.2016.1139747

M. D. Cooper, J. Rosenblat, D. Cha, Yena Lee, Ron Kakar, R. McIntyre

{"title":"Strategies to mitigate dissociative and psychotomimetic effects of ketamine in the treatment of major depressive episodes: a narrative review","authors":"M. D. Cooper, J. Rosenblat, D. Cha, Yena Lee, Ron Kakar, R. McIntyre","doi":"10.3109/15622975.2016.1139747","DOIUrl":"https://doi.org/10.3109/15622975.2016.1139747","url":null,"abstract":"Abstract Objectives Replicated evidence has demonstrated that ketamine exerts rapid-acting and potent antidepressant effects. Notwithstanding, its promise to mitigate depressive symptoms and suicidality in antidepressant-resistant populations, several limitations and safety concerns accompany ketamine including, but not limited to, the potential for abuse and psychotomimetic/dissociative experiences. The focus of the current narrative review is to synthesise available evidence of strategies that may mitigate and fully prevent treatment-emergent psychotomimetic and dissociative effects associated with ketamine administration. Methods PubMed, Google Scholar and ClinicalTrials.gov were searched for relevant articles. Results Potential avenues investigated to minimise psychotomimetic effects associated with ketamine administration include the following: (1) altering dosing and infusion rates; (2) route of administration; (3) enantiomer choice; (4) co-administration with mood stabilisers of antipsychotics; and (5) use of alternative N-methyl-d-aspartate (NMDA)-modulating agents. Emerging evidence indicates that dissociative experiences can be significantly mitigated by using an intranasal route of administration, lower dosages, or use of alternative NMDA-modulating agents, namely lanicemine (AZD6765) and GLYX-13. Conclusions Currently, intranasal administration presents as the most promising strategy to mitigate dissociative and psychotomimetic effects; however, studies of strategies to mitigate the adverse events of ketamine are limited in number and quality and thus further investigation is still needed.","PeriodicalId":22963,"journal":{"name":"The World Journal of Biological Psychiatry","volume":"33 1","pages":"410 - 423"},"PeriodicalIF":0.0,"publicationDate":"2016-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74698105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Are all first-generation antipsychotics equally effective in treating schizophrenia? A meta-analysis of randomised, haloperidol-controlled trials 所有第一代抗精神病药物在治疗精神分裂症方面是否同样有效?随机、氟哌啶醇对照试验的荟萃分析

The World Journal of Biological Psychiatry Pub Date : 2016-02-26 DOI: 10.3109/15622975.2015.1083616

M. Dold, M. Tardy, M. Samara, Chunbo Li, S. Kasper, S. Leucht

{"title":"Are all first-generation antipsychotics equally effective in treating schizophrenia? A meta-analysis of randomised, haloperidol-controlled trials","authors":"M. Dold, M. Tardy, M. Samara, Chunbo Li, S. Kasper, S. Leucht","doi":"10.3109/15622975.2015.1083616","DOIUrl":"https://doi.org/10.3109/15622975.2015.1083616","url":null,"abstract":"Abstract Objectives: Narrative, unsystematic reviews revealed no differences in efficacy between the various first-generation antipsychotics (FGAs) resulting in the psychopharmacological assumption of comparable efficacy between the different FGAs. We sought to determine if the assumption of comparable efficacy of all FGAs can be regarded as evidence-based using meta-analytic statistics. Methods: A systematic literature survey (Cochrane Schizophrenia Group trial register) was applied to identify all RCTs that compared oral haloperidol with another oral FGA in schizophrenia. Primary outcome was dichotomous treatment response. Secondary outcomes were symptom severity measured by rating scales, discontinuation rates, and specific adverse effects. Results: Altogether, 79 RCTs with 4343 participants published between 1962 and 1999 were included. We found a significant between-group difference only between haloperidol and nemonapride, but not for the remaining 19 investigated FGAs. There were no significant differences for discontinuation rates. Conclusions: As most of the single meta-analytic comparisons can be regarded as underpowered, the evidence for the assumption of comparable efficacy of all FGAs is inconclusive. We therefore cannot confirm or reject the statements of previous narrative, unsystematic reviews in this regard. Our findings were limited by the small sample size in the individual comparisons and the low methodological quality in many included studies.","PeriodicalId":22963,"journal":{"name":"The World Journal of Biological Psychiatry","volume":"66 1","pages":"210 - 220"},"PeriodicalIF":0.0,"publicationDate":"2016-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90652390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Ninety-six hour ketamine infusion with co-administered clonidine for treatment-resistant depression: A pilot randomised controlled trial 96小时氯胺酮输注与联合给予可乐定治疗难治性抑郁症:一项先导随机对照试验

The World Journal of Biological Psychiatry Pub Date : 2016-02-26 DOI: 10.3109/15622975.2016.1142607

E. Lenze, N. Farber, E. Kharasch, J. Schweiger, Michael D Yingling, J. Olney, J. Newcomer

{"title":"Ninety-six hour ketamine infusion with co-administered clonidine for treatment-resistant depression: A pilot randomised controlled trial","authors":"E. Lenze, N. Farber, E. Kharasch, J. Schweiger, Michael D Yingling, J. Olney, J. Newcomer","doi":"10.3109/15622975.2016.1142607","DOIUrl":"https://doi.org/10.3109/15622975.2016.1142607","url":null,"abstract":"ABSTRACT Objectives We examined the feasibility of a high-dose, 96-h infusion of ketamine in treatment-resistant depression. Methods Ten participants were randomised to receive a 96-h ketamine infusion, titrated as tolerated to a target rate of 0.6 mg/kg/h, while 10 received a 40-min ketamine infusion (0.5 mg/kg). Both groups received clonidine, titrated to a maximum of 0.6 mg orally daily, during the infusion to mitigate side effects of ketamine. Participants were followed for 8 weeks to examine potential antidepressant effects. Results All 20 participants completed the infusion. Most participants tolerated the infusion well, with minimal psychotomimetic symptoms or blood pressure elevation despite achieving high ketamine concentrations (mean 424 ng/ml for 96-h arm, 156 ng/ml for 40-min arm). There was no rebound hypertension upon discontinuing clonidine. Rapid and sustained improvement in depressive symptoms was observed in both study groups. Higher ketamine concentration was associated with sustained antidepressant response, and was not with greater psychotomimetic side effects, in the 96-h arm. Conclusions This study provides evidence for the feasibility of prolonged ketamine infusions in treatment-resistant depression. Co-administration of clonidine appeared to mitigate ketamine’s psychotomimetic effects. Further study is required to investigate the extent to which prolonged ketamine infusions could provide both rapid and sustained improvements in treatment-resistant depression. Clinicaltrials.gov identifier NCT01179009","PeriodicalId":22963,"journal":{"name":"The World Journal of Biological Psychiatry","volume":"115 1","pages":"230 - 238"},"PeriodicalIF":0.0,"publicationDate":"2016-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86203699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Brain structural correlates of obsessive–compulsive disorder with and without preceding stressful life events 大脑结构与有或没有压力生活事件的强迫症的相关性

The World Journal of Biological Psychiatry Pub Date : 2016-02-26 DOI: 10.3109/15622975.2016.1142606

E. Real, M. Subirà, P. Alonso, C. Segalàs, J. Labad, C. Orfila, C. López-Solà, I. Martínez-Zalacaín, E. Via, N. Cardoner, S. Jiménez-Murcia, C. Soriano-Mas, J. Menchón

{"title":"Brain structural correlates of obsessive–compulsive disorder with and without preceding stressful life events","authors":"E. Real, M. Subirà, P. Alonso, C. Segalàs, J. Labad, C. Orfila, C. López-Solà, I. Martínez-Zalacaín, E. Via, N. Cardoner, S. Jiménez-Murcia, C. Soriano-Mas, J. Menchón","doi":"10.3109/15622975.2016.1142606","DOIUrl":"https://doi.org/10.3109/15622975.2016.1142606","url":null,"abstract":"Abstract Objectives There is growing evidence supporting a role for stressful life events (SLEs) at obsessive–compulsive disorder (OCD) onset, but neurobiological correlates of such effect are not known. We evaluated regional grey matter (GM) changes associated with the presence/absence of SLEs at OCD onset. Methods One hundred and twenty-four OCD patients and 112 healthy controls were recruited. Patients were split into two groups according to the presence (n = 56) or absence (n = 68) of SLEs at disorder’s onset. A structural magnetic resonance image was acquired for each participant and pre-processed with Statistical Parametric Mapping software (SPM8) to obtain a volume-modulated GM map. Between-group differences in sociodemographic, clinical and whole-brain regional GM volumes were assessed. Results SLEs were associated with female sex, later age at disorder’s onset, more contamination/cleaning and less hoarding symptoms. In comparison with controls, patients without SLEs showed GM volume increases in bilateral dorsal putamen and the central tegmental tract of the brainstem. By contrast, patients with SLEs showed specific GM volume increases in the right anterior cerebellum. Conclusions Our findings support the idea that neuroanatomical alterations of OCD patients partially depend on the presence of SLEs at disorder’s onset.","PeriodicalId":22963,"journal":{"name":"The World Journal of Biological Psychiatry","volume":"3 1","pages":"366 - 377"},"PeriodicalIF":0.0,"publicationDate":"2016-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85337679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Serotonin transporter gene polymorphism in eating disorders: Data from a new biobank and META-analysis of previous studies 饮食失调中的5 -羟色胺转运体基因多态性:来自新生物库的数据和先前研究的荟萃分析

The World Journal of Biological Psychiatry Pub Date : 2016-02-19 DOI: 10.3109/15622975.2015.1126675

Marco Solmi, D. Gallicchio, E. Collantoni, Christoph U. Correll, Maurizio Clementi, C. Pinato, M. Forzan, Matteo Cassina, F. Fontana, Valeria Giannunzio, I. Piva, R. Siani, P. Salvo, P. Santonastaso, E. Tenconi, N. Veronese, A. Favaro

{"title":"Serotonin transporter gene polymorphism in eating disorders: Data from a new biobank and META-analysis of previous studies","authors":"Marco Solmi, D. Gallicchio, E. Collantoni, Christoph U. Correll, Maurizio Clementi, C. Pinato, M. Forzan, Matteo Cassina, F. Fontana, Valeria Giannunzio, I. Piva, R. Siani, P. Salvo, P. Santonastaso, E. Tenconi, N. Veronese, A. Favaro","doi":"10.3109/15622975.2015.1126675","DOIUrl":"https://doi.org/10.3109/15622975.2015.1126675","url":null,"abstract":"Objectives Growing interest focuses on the association between 5-HTTLPR polymorphism and eating disorders (ED), but published findings have been conflicting. Methods The Italian BIO.VE.D.A. biobank provided 976 samples (735 ED patients and 241 controls) for genotyping. We conducted a literature search of studies published up to 1 April 2015, including studies reporting on 5HTTLPR genotype and allele frequencies in obesity and/or ED. We ran a meta-analysis, including data from BIO.VE.D.A. – comparing low and high-functioning genotype and allele frequencies in ED vs. controls. Results Data from 21 studies, plus BIO.VE.D.A., were extracted providing information from 3,736 patients and 2,707 controls. Neither low- nor high-functioning genotype frequencies in ED patients, with both bi- and tri-allelic models, differed from controls. Furthermore, neither low- nor high-functioning allele frequencies in ED or in BN, in both bi- and triallelic models, differed from control groups. After sensitivity analysis, results were the same in AN vs. controls. Results remained unaltered when investigating recessive and dominant models. Conclusions 5HTTLPR does not seem to be associated with ED in general, or with AN or BN in particular. Future studies in ED should explore the role of ethnicity and psychiatric comorbidity as a possible source of bias.","PeriodicalId":22963,"journal":{"name":"The World Journal of Biological Psychiatry","volume":"22 1","pages":"244 - 257"},"PeriodicalIF":0.0,"publicationDate":"2016-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89705279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Reviewers of the year 2015 2015年度评审员

The World Journal of Biological Psychiatry Pub Date : 2016-02-17 DOI: 10.3109/15622975.2016.1150090

引用次数: 0

Assessment and management of agitation in psychiatry: Expert consensus 精神病学中躁动的评估和管理:专家共识

The World Journal of Biological Psychiatry Pub Date : 2016-02-17 DOI: 10.3109/15622975.2015.1132007

M. Garriga, I. Pacchiarotti, S. Kasper, S. Zeller, M. Allen, G. Vázquez, L. Baldaçara, L. San, R. H. McAllister-Williams, K. Fountoulakis, P. Courtet, D. Naber, Esther W. Chan, A. Fagiolini, H. Möller, H. Grunze, P. Llorca, R. Jaffe, L. Yatham, D. Hidalgo-Mazzei, M. Passamar, T. Messer, M. Bernardo, E. Vieta

{"title":"Assessment and management of agitation in psychiatry: Expert consensus","authors":"M. Garriga, I. Pacchiarotti, S. Kasper, S. Zeller, M. Allen, G. Vázquez, L. Baldaçara, L. San, R. H. McAllister-Williams, K. Fountoulakis, P. Courtet, D. Naber, Esther W. Chan, A. Fagiolini, H. Möller, H. Grunze, P. Llorca, R. Jaffe, L. Yatham, D. Hidalgo-Mazzei, M. Passamar, T. Messer, M. Bernardo, E. Vieta","doi":"10.3109/15622975.2015.1132007","DOIUrl":"https://doi.org/10.3109/15622975.2015.1132007","url":null,"abstract":"Abstract Background Psychomotor agitation is associated with different psychiatric conditions and represents an important issue in psychiatry. Current recommendations on agitation in psychiatry are not univocal. Actually, an improper assessment and management may result in unnecessary coercive or sedative treatments. A thorough and balanced review plus an expert consensus can guide assessment and treatment decisions. Methods An expert task force iteratively developed consensus using the Delphi method. Initial survey items were based on systematic review of the literature. Subsequent surveys included new, re-worded or re-rated items. Results Out of 2175 papers assessing psychomotor agitation, 124 were included in the review. Each component was assigned a level of evidence. Integrating the evidence and the experience of the task force members, a consensus was reached on 22 statements on this topic. Conclusions Recommendations on the assessment of agitation emphasise the importance of identifying any possible medical cause. For its management, experts agreed in considering verbal de-escalation and environmental modification techniques as first choice, considering physical restraint as a last resort strategy. Regarding pharmacological treatment, the “ideal” medication should calm without over-sedate. Generally, oral or inhaled formulations should be preferred over i.m. routes in mildly agitated patients. Intravenous treatments should be avoided.","PeriodicalId":22963,"journal":{"name":"The World Journal of Biological Psychiatry","volume":"98 1","pages":"128 - 86"},"PeriodicalIF":0.0,"publicationDate":"2016-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75938012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 199

Involvement of NRN1 gene in schizophrenia-spectrum and bipolar disorders and its impact on age at onset and cognitive functioning NRN1基因在精神分裂症谱系和双相情感障碍中的参与及其对发病年龄和认知功能的影响

The World Journal of Biological Psychiatry Pub Date : 2016-02-17 DOI: 10.3109/15622975.2015.1093658

M. Fatjó-Vilas, C. Prats, E. Pomarol-Clotet, L. Lázaro, C. Moreno, I. Gonzalez-ortega, S. Lera-Miguel, S. Miret, M. J. Muñoz, I. Ibáñez, S. Campanera, M. Giralt-López, M. Cuesta, V. Peralta, G. Ortet, M. Parellada, A. González-Pinto, P. McKenna, L. Fañanás

{"title":"Involvement of NRN1 gene in schizophrenia-spectrum and bipolar disorders and its impact on age at onset and cognitive functioning","authors":"M. Fatjó-Vilas, C. Prats, E. Pomarol-Clotet, L. Lázaro, C. Moreno, I. Gonzalez-ortega, S. Lera-Miguel, S. Miret, M. J. Muñoz, I. Ibáñez, S. Campanera, M. Giralt-López, M. Cuesta, V. Peralta, G. Ortet, M. Parellada, A. González-Pinto, P. McKenna, L. Fañanás","doi":"10.3109/15622975.2015.1093658","DOIUrl":"https://doi.org/10.3109/15622975.2015.1093658","url":null,"abstract":"Abstract Objectives Neuritin 1 gene (NRN1) is involved in neurodevelopment processes and synaptic plasticity and its expression is regulated by brain-derived neurotrophic factor (BDNF). We aimed to investigate the association of NRN1 with schizophrenia-spectrum disorders (SSD) and bipolar disorders (BPD), to explore its role in age at onset and cognitive functioning, and to test the epistasis between NRN1 and BDNF. Methods The study was developed in a sample of 954 SSD/BPD patients and 668 healthy subjects. Genotyping analyses included 11 SNPs in NRN1 and one functional SNP in BDNF. Results The frequency of the haplotype C-C (rs645649–rs582262) was significantly increased in patients compared to controls (P = 0.0043), while the haplotype T-C-C-T-C-A (rs3763180–rs10484320–rs4960155–rs9379002–rs9405890–rs1475157) was more frequent in controls (P = 3.1 × 10−5). The variability at NRN1 was nominally related to changes in age at onset and to differences in intelligence quotient, in SSD patients. Epistasis between NRN1 and BDNF was significantly associated with the risk for SSD/BPD (P = 0.005). Conclusions Results suggest that: (i) NRN1 variability is a shared risk factor for both SSD and BPD, (ii) NRN1 may have a selective impact on age at onset and intelligence in SSD, and (iii) the role of NRN1 seems to be not independent of BDNF.","PeriodicalId":22963,"journal":{"name":"The World Journal of Biological Psychiatry","volume":"3 1","pages":"129 - 139"},"PeriodicalIF":0.0,"publicationDate":"2016-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89642303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20