The World Journal of Biological Psychiatry最新文献_第2页

The impact of sample processing on inflammatory markers in serum: Lessons learned 样品处理对血清炎症标志物的影响:经验教训

The World Journal of Biological Psychiatry Pub Date : 2019-11-21 DOI: 10.1080/15622975.2019.1696474

A. Pan, E. Ryu, J. Geske, Xinyang Zhou, S. McElroy, M. Cicek, M. Frye, J. Biernacka, A. Andreazza

{"title":"The impact of sample processing on inflammatory markers in serum: Lessons learned","authors":"A. Pan, E. Ryu, J. Geske, Xinyang Zhou, S. McElroy, M. Cicek, M. Frye, J. Biernacka, A. Andreazza","doi":"10.1080/15622975.2019.1696474","DOIUrl":"https://doi.org/10.1080/15622975.2019.1696474","url":null,"abstract":"Abstract Objectives: To investigate the effect of sample handling on inflammatory cytokines in serum and highlight challenges with using samples pre-collected from biobanks for biomarker research. Methods: Cytokine concentrations (IL-1β, IL-2, IL-6, IL-8, IL-10, TNFα, and IFNγ) were measured in serum samples of 205 patients with bipoldar disorder (BD) from the Mayo Clinic Bipolar Disorder Biobank and 205 non-psychiatric controls from the Mayo Clinic Biobank. As cytokine concentrations varied by recruitment site, post-hoc models were used to test the effect of clinical variables and pre-processing time on cytokines. To evaluate the effect of pre-processing time experimentally, cytokines were assayed in serum and plasma from 6 healthy volunteers processed at different time points. Results: Cytokine levels were significantly higher in the BD group. However, both cytokine levels and pre-processing times differed by recruitment site, and post-hoc analyses revealed that pre-processing time was significantly associated with several cytokines. An experiment using samples from healthy volunteers confirmed that concentrations for most cytokines increased with longer pre-processing times. Conclusions: Delays in processing influence cytokine concentrations in blood samples. Given the increasing use of biobanks in research, this study highlights the need to carefully evaluate sample collection and handling methods when designing biomarker studies.","PeriodicalId":22963,"journal":{"name":"The World Journal of Biological Psychiatry","volume":"15 1","pages":"230 - 237"},"PeriodicalIF":0.0,"publicationDate":"2019-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79030485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Dimensions of pain catastrophising and specific structural and functional alterations in patients with chronic pain: Evidence in medication-overuse headache 慢性疼痛患者疼痛灾变和特定结构和功能改变的维度:药物过度使用头痛的证据

The World Journal of Biological Psychiatry Pub Date : 2019-10-16 DOI: 10.1080/15622975.2019.1669822

F. Christidi, E. Karavasilis, L. Michels, F. Riederer, G. Velonakis, E. Anagnostou, P. Ferentinos, S. Kollias, E. Efstathopoulos, N. Kelekis, E. Kararizou

{"title":"Dimensions of pain catastrophising and specific structural and functional alterations in patients with chronic pain: Evidence in medication-overuse headache","authors":"F. Christidi, E. Karavasilis, L. Michels, F. Riederer, G. Velonakis, E. Anagnostou, P. Ferentinos, S. Kollias, E. Efstathopoulos, N. Kelekis, E. Kararizou","doi":"10.1080/15622975.2019.1669822","DOIUrl":"https://doi.org/10.1080/15622975.2019.1669822","url":null,"abstract":"Abstract Objectives We examined the neuroanatomical substrate of different pain catastrophising (PC) dimensions (i.e. rumination; magnification; helplessness) in patients with medication-overuse headache (MOH). Methods We included 18 MOH patients who were administered the Pain Catastrophizing Scale (PCS) and scanned in a 3T-MRI. We conducted whole-brain volumetric and resting-state functional connectivity (FC) analysis to examine the association between grey matter (GM) density and FC strength and PCS dimensions controlling for depression and anxiety. Results Higher total PCS score was associated with decreased GM density in precentral and inferior temporal gyrus, increased FC between middle temporal gyrus and cerebellum and reduced FC between precuneus and inferior temporal gyrus, as well as between frontal pole and temporal fusiform cortex. Regarding PCS dimensions, we mainly observed the involvement of (1) somatosensory cortex, supramarginal gyrus, basal ganglia, core default-mode network (DMN) in rumination; (2) somatosensory cortex, core DMN, dorsal medial prefrontal cortex (DMPFC)-DMN subsystem and cerebellum in magnification; and (3) temporal regions, DMN and basal ganglia in helplessness. Conclusions PC dimensions are associated with a specific structural and functional neuroanatomical pattern, which is different from the pattern observed when PC is considered as a single score. The involvement of basal ganglia and cerebellum needs further investigation.","PeriodicalId":22963,"journal":{"name":"The World Journal of Biological Psychiatry","volume":"1 1","pages":"726 - 738"},"PeriodicalIF":0.0,"publicationDate":"2019-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89381872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Drugs used in the treatment of bipolar disorder and their effects on cholesterol biosynthesis – A possible therapeutic mechanism 治疗双相情感障碍的药物及其对胆固醇生物合成的影响——一种可能的治疗机制

The World Journal of Biological Psychiatry Pub Date : 2019-10-16 DOI: 10.1080/15622975.2019.1669823

Srisaiyini Kidnapillai, C. Bortolasci, B. Panizzutti, Briana Spolding, T. Connor, K. Bonifácio, A. Sanigorski, O. Dean, T. Crowley, S. Jamain, L. Gray, M. Leboyer, M. Berk, K. Walder

{"title":"Drugs used in the treatment of bipolar disorder and their effects on cholesterol biosynthesis – A possible therapeutic mechanism","authors":"Srisaiyini Kidnapillai, C. Bortolasci, B. Panizzutti, Briana Spolding, T. Connor, K. Bonifácio, A. Sanigorski, O. Dean, T. Crowley, S. Jamain, L. Gray, M. Leboyer, M. Berk, K. Walder","doi":"10.1080/15622975.2019.1669823","DOIUrl":"https://doi.org/10.1080/15622975.2019.1669823","url":null,"abstract":"Abstract Objectives: To understand the therapeutic mechanisms of bipolar disorder (BD) drugs at molecular and cellular levels. Methods: Next generation sequencing was used to determine the transcriptional effects of a combination of four commonly prescribed BD drugs (lithium, valproate, lamotrigine and quetiapine) or vehicle (0.2% DMSO) in NT2-N (human neuronal) cells and rats. Differential expression of genes and pathway analysis were performed using edgeR in R and Gene Set Enrichment Analysis software respectively. Free cholesterol levels and neurite outgrowth were quantified in NT2-N cells following combination and individual BD drug treatments. Results: Pathway analysis showed up-regulation of many elements of the cholesterol biosynthesis pathway in NT2-N cells and oxidative phosphorylation in rat brains. Intracellular cholesterol transport genes were upregulated (NPC1, NPC2 and APOE), while the cholesterol efflux gene (ABCA1) was downregulated. BD drug combination tended to increase intracellular cholesterol levels and neurite outgrowth, but these effects were not seen for the drugs when used individually. Conclusions: These data suggest that BD drug combination is increasing cholesterol biosynthesis and the newly synthesised cholesterol is being utilised within the cells, possibly for synthesis of new membranes to facilitate neurite outgrowth. This mechanism possibly underpins clinical efficacy in individuals with BD treated with polypharmacy.","PeriodicalId":22963,"journal":{"name":"The World Journal of Biological Psychiatry","volume":"62 1","pages":"766 - 777"},"PeriodicalIF":0.0,"publicationDate":"2019-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86846413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Predicting individual responses to lithium with oxidative stress markers in drug-free bipolar disorder 用氧化应激标志物预测无药双相情感障碍患者对锂的个体反应

The World Journal of Biological Psychiatry Pub Date : 2019-10-09 DOI: 10.1080/15622975.2019.1663929

Qin-yu Lv, Yanhong Guo, Minghuan Zhu, Ruijie Geng, Xiaoyan Cheng, Chenxi Bao, Yingyi Wang, Xinxin Huang, Chen Zhang, Y. Hao, Zezhi Li, Z. Yi

{"title":"Predicting individual responses to lithium with oxidative stress markers in drug-free bipolar disorder","authors":"Qin-yu Lv, Yanhong Guo, Minghuan Zhu, Ruijie Geng, Xiaoyan Cheng, Chenxi Bao, Yingyi Wang, Xinxin Huang, Chen Zhang, Y. Hao, Zezhi Li, Z. Yi","doi":"10.1080/15622975.2019.1663929","DOIUrl":"https://doi.org/10.1080/15622975.2019.1663929","url":null,"abstract":"Abstract Objectives: This is the first study to investigate the oxidative stress (OxS) levels in drug-free bipolar disorder (BD) patients and their association with lithium response. Methods: A total of 61 drug-free BD patients and 49 controls were included. Patients treated with lithium were followed-up for 6 weeks. The levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and malondialdehyde (MDA) were measured at baseline and at the end of the sixth week. Results: Compared to controls, the SOD levels were lower, whereas the MDA were higher in the BD-depression (BD-D) group (both P < 0.001). GSH-Px levels were higher in both the BD-D and the BD-mania (BD-M) group (both P < 0.001). Both GSH-Px and MDA levels in the BD (P = 0.009, P < 0.001) and the BD-D subgroup (P = 0.006, P = 0.001) decreased significantly after the 6-week treatment with lithium. Interestingly, both GSH-Px and MDA levels decreased in responders (P = 0.03, P = 0.002) but not in the non-responders of BD-D (both p > 0.05). Moreover, the reduction in the MDA levels were associated with lithium response (B = 1.47, Wald statistic = 5.94, P = 0.015, odds ratio = 4.35, 95% confidence interval 1.33-14.20). Conclusions: Our study demonstrates an imbalance of OxS in drug-free BD, especially BD-D. Lithium reduces the GSH-Px and MDA levels in BD patients. The reduction in MDA levels may predict individual responsiveness to lithium.","PeriodicalId":22963,"journal":{"name":"The World Journal of Biological Psychiatry","volume":"11 1","pages":"778 - 789"},"PeriodicalIF":0.0,"publicationDate":"2019-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87772857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Higher fasting ghrelin serum levels in active smokers than in former and never-smokers 活跃吸烟者空腹胃饥饿素水平高于戒烟者和不吸烟者

The World Journal of Biological Psychiatry Pub Date : 2019-10-04 DOI: 10.1080/15622975.2019.1671610

D. Wittekind, J. Kratzsch, R. Mergl, C. Enzenbach, V. Witte, A. Villringer, M. Kluge

{"title":"Higher fasting ghrelin serum levels in active smokers than in former and never-smokers","authors":"D. Wittekind, J. Kratzsch, R. Mergl, C. Enzenbach, V. Witte, A. Villringer, M. Kluge","doi":"10.1080/15622975.2019.1671610","DOIUrl":"https://doi.org/10.1080/15622975.2019.1671610","url":null,"abstract":"Abstract Objectives Ghrelin, an orexigenic peptide hormone, promotes drug reward and is suspected to play a role in nicotine dependence. However, there is little data on whether ghrelin levels are associated with active and/or former smoking. The relationship between ghrelin serum levels and smoking status in a population-based sample of individuals was studied. Methods Total ghrelin was determined after an overnight fast in 1519 subjects participating in a population-based cohort study (‘LIFE-Adult’). Tobacco consumption was assessed using both the questionnaire and interview. Generalised linear models with gamma distribution and log-link function were performed to analyse the association of total serum ghrelin with smoking status and the association between serum ghrelin and the amount of tobacco consumed in active smokers. Results Ghrelin levels were positively associated with active, but not former smoking (OR = 1.095; p = .002). This association was not moderated by sex (interaction of ‘active smoking’ and sex: p = .346). Ghrelin levels were not associated with the amount of tobacco consumed in active smokers. Conclusions This study provides evidence that total ghrelin serum levels are positively associated with active smoking. No association was found for former smokers. A unique feature of the study is the large sample size.","PeriodicalId":22963,"journal":{"name":"The World Journal of Biological Psychiatry","volume":"13 1","pages":"748 - 756"},"PeriodicalIF":0.0,"publicationDate":"2019-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73164021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

SIRT1 mediates improvement of cardiac surgery-induced postoperative cognitive dysfunction via the TLR4/NF-κB pathway SIRT1通过TLR4/NF-κB通路介导心脏外科术后认知功能障碍的改善

The World Journal of Biological Psychiatry Pub Date : 2019-09-11 DOI: 10.1080/15622975.2019.1656820

Jing Shi, X. Zou, Ke Jiang, Feng Wang

{"title":"SIRT1 mediates improvement of cardiac surgery-induced postoperative cognitive dysfunction via the TLR4/NF-κB pathway","authors":"Jing Shi, X. Zou, Ke Jiang, Feng Wang","doi":"10.1080/15622975.2019.1656820","DOIUrl":"https://doi.org/10.1080/15622975.2019.1656820","url":null,"abstract":"Abstract Objectives Clinically, there is no effective therapy for postoperative cognitive dysfunction (POCD). Inflammation after surgery is closely associated with POCD. Methods In this study, we explored the role of sirtuin 1 (SIRT1) in POCD. POCD in mice was induced by cardiac surgery. The mRNA and protein levels of related genes were determined by real-time polymerase chain reaction and western blot, respectively. Plasma concentrations of inflammatory factors were measured using an ELISA kit. Novel object and novel location recognition tests were carried out to measure recognition ability. The Morris water maze (MWM) test was performed to measure learning and memory ability. Results There was a clear decrease in SIRT1 expression after POCD. The SIRT1 activator SRT1720 promoted recognition, learning, and memory ability of mice with POCD. Moreover, SRT1720 treatment greatly inhibited plasma inflammatory cytokine levels and TLR4 and P65 protein expression in the hippocampus of POCD mice. The effect of SRT1720 on POCD was in a TLR4-dependent manner. Conclusions SIRT1 mediates the improvement of cardiac surgery-induced postoperative cognitive dysfunction via the TLR4/NF-κB pathway.","PeriodicalId":22963,"journal":{"name":"The World Journal of Biological Psychiatry","volume":"8 1","pages":"757 - 765"},"PeriodicalIF":0.0,"publicationDate":"2019-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86987787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Results of the European Group for the Study of Resistant Depression (GSRD) — basis for further research and clinical practice 欧洲抗抑郁研究小组(GSRD)的结果-进一步研究和临床实践的基础

The World Journal of Biological Psychiatry Pub Date : 2019-07-03 DOI: 10.1080/15622975.2019.1635270

L. Bartova, M. Dold, A. Kautzky, C. Fabbri, M. Spies, A. Serretti, D. Souery, J. Mendlewicz, J. Zohar, S. Montgomery, A. Schosser, S. Kasper

{"title":"Results of the European Group for the Study of Resistant Depression (GSRD) — basis for further research and clinical practice","authors":"L. Bartova, M. Dold, A. Kautzky, C. Fabbri, M. Spies, A. Serretti, D. Souery, J. Mendlewicz, J. Zohar, S. Montgomery, A. Schosser, S. Kasper","doi":"10.1080/15622975.2019.1635270","DOIUrl":"https://doi.org/10.1080/15622975.2019.1635270","url":null,"abstract":"Abstract Objectives: The overview outlines two decades of research from the European Group for the Study of Resistant Depression (GSRD) that fundamentally impacted evidence-based algorithms for diagnostics and psychopharmacotherapy of treatment-resistant depression (TRD). Methods: The GSRD staging model characterising response, non-response and resistance to antidepressant (AD) treatment was applied to 2762 patients in eight European countries. Results: In case of non-response, dose escalation and switching between different AD classes did not show superiority over continuation of original AD treatment. Predictors for TRD were symptom severity, duration of the current major depressive episode (MDE), suicidality, psychotic and melancholic features, comorbid anxiety and personality disorders, add-on treatment, non-response to the first AD, adverse effects, high occupational level, recurrent disease course, previous hospitalisations, positive family history of MDD, early age of onset and novel associations of single nucleoid polymorphisms (SNPs) within the PPP3CC, ST8SIA2, CHL1, GAP43 and ITGB3 genes and gene pathways associated with neuroplasticity, intracellular signalling and chromatin silencing. A prediction model reaching accuracy of above 0.7 highlighted symptom severity, suicidality, comorbid anxiety and lifetime MDEs as the most informative predictors for TRD. Applying machine-learning algorithms, a signature of three SNPs of the BDNF, PPP3CC and HTR2A genes and lacking melancholia predicted treatment response. Conclusions: The GSRD findings offer a unique and balanced perspective on TRD representing foundation for further research elaborating on specific clinical and genetic hypotheses and treatment strategies within appropriate study-designs, especially interaction-based models and randomized controlled trials.","PeriodicalId":22963,"journal":{"name":"The World Journal of Biological Psychiatry","volume":"5 1","pages":"427 - 448"},"PeriodicalIF":0.0,"publicationDate":"2019-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90053274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 90

Letter from the new Editor-in-Chief 新主编的来信

The World Journal of Biological Psychiatry Pub Date : 2019-07-03 DOI: 10.1080/15622975.2019.1655226

D. Rujescu

引用次数: 0

Reviewers of the year 2018 2018年度评审员

The World Journal of Biological Psychiatry Pub Date : 2019-02-07 DOI: 10.1080/15622975.2019.1586366

引用次数: 0

Is there a role for cannabidiol in psychiatry? 大麻二酚在精神病学中有作用吗?

The World Journal of Biological Psychiatry Pub Date : 2019-02-01 DOI: 10.1080/15622975.2017.1285049

J. M. Khoury, Maila de Castro Lourenço das Neves, M. A. Roque, Daniela Alves de Brito Queiroz, André Augusto Corrêa de Freitas, Â. de Fátima, F. Moreira, F. Garcia

{"title":"Is there a role for cannabidiol in psychiatry?","authors":"J. M. Khoury, Maila de Castro Lourenço das Neves, M. A. Roque, Daniela Alves de Brito Queiroz, André Augusto Corrêa de Freitas, Â. de Fátima, F. Moreira, F. Garcia","doi":"10.1080/15622975.2017.1285049","DOIUrl":"https://doi.org/10.1080/15622975.2017.1285049","url":null,"abstract":"Abstract Objectives: Understanding whether cannabidiol (CBD) is useful and safe for the treatment of psychiatric disorders is essential to empower psychiatrists and patients to take good clinical decisions. Our aim was to conduct a systematic review regarding the benefits and adverse events (AEs) of CBD in the treatment of schizophrenia, psychotic disorders, anxiety disorders, depression, bipolar disorder and substance-use disorders. Methods: We conducted a literature search in PubMed, Scielo, and Clinicaltrials.gov databases. Evidence was classified according to the WFSBP task forces standards. Results: Bibliographic research yielded 692 records. After analysis, we included six case reports and seven trials, comprising 201 subjects. Most the studies published presented several drawbacks and did not reach statistical significance. We have not found evidence regarding major depressive and bipolar disorders. The level of evidence for cannabis withdrawal is B; cannabis addiction is C2; treatment of positive symptoms in schizophrenia and anxiety in social anxiety disorder is C1. Discrete or no AEs were reported. The most frequently reported AEs are sedation and dizziness. Conclusions: The evidence regarding efficacy and safety of CBD in psychiatry is still scarce. Further larger well-designed randomised controlled trials are required to assess the effects of CBD in psychiatric disorders.","PeriodicalId":22963,"journal":{"name":"The World Journal of Biological Psychiatry","volume":"14 1","pages":"101 - 116"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87740796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31