Therapeutic Advances in Chronic Disease最新文献

{"title":"Is <i>Helicobacter pylori</i> infection associated with pancreatic cancer? A systematic review and meta-analysis of observational studies.","authors":"Ben-Gang Zhou,&nbsp;Yu-Zhou Mei,&nbsp;Jing-Shu Wang,&nbsp;Jian-Lei Xia,&nbsp;Xin Jiang,&nbsp;Sheng-Yong Ju,&nbsp;Yan-Bing Ding","doi":"10.1177/20406223231155119","DOIUrl":"https://doi.org/10.1177/20406223231155119","url":null,"abstract":"<p><strong>Background and objectives: </strong>Recent observational studies have investigated the association between <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection and pancreatic cancer with conflicting data. Therefore, we conducted a systematic review and meta-analysis to assess the potential association.</p><p><strong>Design: </strong>This is a systematic review and meta-analysis.</p><p><strong>Methods: </strong>We searched three databases (PubMed, Embase, and Web of Science) from inception to 30 August 2022. The summary results as odds ratio (OR) or hazard ratio (HR) with 95% confidence interval (CI) were pooled by generic inverse variance method based on random-effects model.</p><p><strong>Results: </strong>A total of 20 observational studies involving 67,718 participants were included in the meta-analysis. Meta-analysis of data from 12 case-control studies and 5 nested case-control studies showed that there was no significant association between <i>H. pylori</i> infection and the risk of pancreatic cancer (OR = 1.20, 95% CI = 0.95-1.51, <i>p</i> = 0.13). Similarly, we also did not find significant association between cytotoxin-associated gene A (CagA) positive strains, CagA negative strains, vacuolating cytotoxin gene A (VacA) positive strains <i>H. pylori</i> infection, and the risk of pancreatic cancer. Meta-analysis of data from three cohort studies showed that <i>H. pylori</i> infection was not significantly associated with an increased risk of incident pancreatic cancer (HR = 1.26, 95% CI = 0.65-2.42, <i>p</i> = 0.50).</p><p><strong>Conclusion: </strong>We found insufficient evidence to support the proposed association between <i>H. pylori</i> infection and increased risk of pancreatic cancer. To better understand any association, future evidence from large, well-designed, high-quality prospective cohort studies that accounts for diverse ethnic populations, certain <i>H. pylori</i> strains, and confounding factors would be useful to settle this controversy.</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"14 ","pages":"20406223231155119"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4f/a4/10.1177_20406223231155119.PMC9986679.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9081328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of postoperative radiotherapy on survival in patients with completely resected and pathologically confirmed stage N2 non-small-cell lung cancer: a systematic review and meta-analysis.","authors":"Lin Wang,&nbsp;Wenyu Chen,&nbsp;Xiaofei Xu,&nbsp;Wenbo Chen,&nbsp;Derong Bao,&nbsp;Ye Zhang,&nbsp;Yufen Xu","doi":"10.1177/20406223231195622","DOIUrl":"https://doi.org/10.1177/20406223231195622","url":null,"abstract":"<p><strong>Background: </strong>The role of postoperative radiotherapy (PORT) for patients with completely resected stage N2 non-small-cell lung cancer (NSCLC) has been controversial. This study aimed to investigate the efficacy of PORT and prognosis in these patients.</p><p><strong>Objectives: </strong>An updated meta-analysis was conducted in this study to investigate the efficacy of PORT and prognosis in patients with completely resected and pathologically confirmed stage N2 NSCLC.</p><p><strong>Design: </strong>This study is a systematic review and meta-analysis.</p><p><strong>Data source and methods: </strong>Databases were searched up to 2 March 2022. All trials on patients with completely resected and pathologically confirmed stage N2 NSCLC undergoing PORT were screened, and data indicators in the PORT and non-PORT groups were extracted, respectively. The effect of PORT on overall survival (OS), disease-free survival (DFS), local recurrence-free survival (LRFS), and distant metastasis-free survival (DMFS) was estimated. Subgroup and sensitivity analyses were performed.</p><p><strong>Results: </strong>In all, 20 studies involving 6340 patients were finally included. The PORT significantly increased OS [hazard ratio (HR) = 0.77, 95% CI: 0.71-0.84, <i>p</i> < 0.001), LRFS (HR = 0.63, 95% CI: 0.52-0.76, <i>p</i> < 0.001), and DFS (HR = 0.72, 95% CI: 0.63-0.82, <i>p</i> < 0.001) while it showed no significant difference in improving DMFS (HR = 0.86, 95% CI: 0.71-1.05, <i>p</i> = 0.14).</p><p><strong>Conclusion: </strong>Our results suggest that in the postoperative treatment of patients with completely resected and pathologically confirmed stage N2 NSCLC, the addition of PORT provides better local recurrence control and survival benefit, but no benefit for distant metastases. The PORT may be incorporated into the postoperative treatment options for some patients with high-risk factors. However, it needs to be validated by more prospective studies in the future.</p><p><strong>Trail registration: </strong>CRD42022314095.</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"14 ","pages":"20406223231195622"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a3/e3/10.1177_20406223231195622.PMC10501070.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10672527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum trace elements and sleep disturbance in patients with decompensated cirrhosis.","authors":"Ziyue Zhang,&nbsp;Yangyang Hui,&nbsp;Wanting Yang,&nbsp;Gaoyue Guo,&nbsp;Binxin Cui,&nbsp;Chaoqun Li,&nbsp;Xiaoyu Wang,&nbsp;Xiaofei Fan,&nbsp;Chao Sun","doi":"10.1177/20406223231192829","DOIUrl":"https://doi.org/10.1177/20406223231192829","url":null,"abstract":"<p><strong>Background: </strong>Sleep disturbance and trace elements imbalance are common features in patients with decompensated cirrhosis, partially sharing similar mechanistic contributors and linking to adverse outcomes. However, there is a paucity of data concerning their relationship.</p><p><strong>Objectives: </strong>To investigate the association between serum trace elements levels and sleep quality in the context of cirrhosis.</p><p><strong>Design: </strong>Cross-sectional study.</p><p><strong>Methods: </strong>We consecutively enrolled 160 patients with decompensated cirrhosis. The sleep disturbance was determined by the Pittsburgh Sleep Quality Index (PSQI > 5). Serum trace elements [magnesium, calcium, iron, copper (Cu), zinc (Zn), lead, and manganese] was measured by inductively coupled plasma mass spectrometry. Association of examined trace elements levels and sleep disturbance was analyzed by multiple linear (global PSQI scores) and multivariate logistic (dichotomized PSQI categories) regression models, respectively.</p><p><strong>Results: </strong>In total, 91 patients (56.88%) represented PSQI-defined sleep disturbance, characterized by female preponderance, lower body mass index levels, and higher serum Cu levels (all <i>p</i> < 0.05). Looking into its clinical relevance with debilitating conditions, we showed that Cu/Zn ratio (CZr) is significantly higher in cirrhosis with poor sleep quality (1.77 <i>versus</i> 1.48, <i>p</i> = 0.003). Diagnostic performance analysis indicated CZr > 1.62 to exhibit better discrimination relative to respective Cu. Both multiple linear (β = 0.355, <i>p</i> < 0.001) and multivariate logistic regression (odds ratio = 2.364, <i>p</i> = 0.019) identified higher CZr as an independent risk factor associated with sleep disturbance.</p><p><strong>Conclusion: </strong>Our findings implied an association between higher CZr and the presence of sleep disturbance in patients with decompensated cirrhosis.</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"14 ","pages":"20406223231192829"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5c/89/10.1177_20406223231192829.PMC10439724.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10106050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recalcitrant nodular scabies showing excellent response to tofacitinib: five case reports.","authors":"Yu-Kun Zhao,&nbsp;Jing-Fa Lu,&nbsp;Juan-Hua Liu,&nbsp;Hui-Hui Wu,&nbsp;Lu-Li Song,&nbsp;Chun-Lei Wan,&nbsp;Di-Qing Luo","doi":"10.1177/20406223231195632","DOIUrl":"https://doi.org/10.1177/20406223231195632","url":null,"abstract":"<p><p>Scabies is a contagious skin condition caused by <i>Sarcoptes scabiei</i>, and it is always associated with an intense, unbearable, nocturnal deteriorating itch. Its presentations include classic burrows, erythema, pruritic papules, pustules, vesicles, and inflammatory nodules, with diffuse or localized distribution on the finger webs, wrist flexors, elbows, axillae, buttocks, genitalia, and breasts. Nodular scabies is an uncommon clinical variant of scabies. Its management is still challenging for some patients up to date, although topical, intralesional or systemic corticosteroids, topical calcineurin inhibitors, and crotamiton as well as cryotherapy alone or in different combinations are used. We here report five male patients of nodular scabies, aged between 14 and 25 years, who had classical scabies that had been cured by sulfur ointment for at least 4 weeks except for their itching nodules, and their residual pruritic nodules also failed in previous treatments including antihistamines, topical applying and intralesional injection of steroids as well as topical tacrolimus in different combinations before being recruited to this study. The patients were administered tofacitinib 5 mg, twice a day, which led to excellent and rapid improvement for both lesions and symptoms after 1-4 weeks of treatment, respectively, without any associations. During 6 months of follow-up, only one had re-infection of scabies associated with nodules that were cured by sulfur ointment and tofacitinib again. No adverse reaction was observed. The present results suggested that tofacitinib might be a potential agent for nodular scabies with excellent response.</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"14 ","pages":"20406223231195632"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3a/1f/10.1177_20406223231195632.PMC10467300.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10128095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical and functional remodeling of left ventricle in patients with primary aldosteronism and concomitant albuminuria.","authors":"Ting-Wei Kao,&nbsp;Xue-Ming Wu,&nbsp;Che-Wei Liao,&nbsp;Cheng-Hsuan Tsai,&nbsp;Zheng-Wei Chen,&nbsp;Yi-Yao Chang,&nbsp;Bo-Ching Lee,&nbsp;Yu-Wei Chiu,&nbsp;Tai-Shuan Lai,&nbsp;Vin-Cent Wu,&nbsp;Yen-Hung Lin,&nbsp;Chi-Sheng Hung","doi":"10.1177/20406223221143253","DOIUrl":"https://doi.org/10.1177/20406223221143253","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Primary aldosteronism (PA) is the leading cause of secondary hypertension globally and is associated with adverse cardiovascular outcomes. However, the cardiac impact of concomitant albuminuria remains unknown.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To compare anatomical and functional remodeling of left ventricle (LV) in PA patients with or without albuminuria.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design: &lt;/strong&gt;Prospective cohort study.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The cohort was separated into two arms according to the presence or absence of albuminuria (&gt;30 mg/g of morning spot urine). Propensity score matching with age, sex, systolic blood pressure, and diabetes mellitus was performed. Multivariate analysis was conducted with adjustments for age, sex, body mass index, systolic blood pressure, duration of hypertension, smoking, diabetes mellitus, number of antihypertensive agents, and aldosterone level. A local-linear model with bandwidth of 2.07 was used to study correlations.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 519 individuals with PA were enrolled in the study, of whom 152 had albuminuria. After matching, the albuminuria group had a higher creatinine level, at baseline. With regard to LV remodeling, albuminuria was independently associated with a significantly higher interventricular septum (1.22 &gt; 1.17 cm, &lt;i&gt;p&lt;/i&gt; = 0.030), LV posterior wall thickness (1.16 &gt; 1.10 cm, &lt;i&gt;p&lt;/i&gt; = 0.011), LV mass index (125 &gt; 116 g/m&lt;sup&gt;2&lt;/sup&gt;, &lt;i&gt;p&lt;/i&gt; = 0.023), and medial E/e' ratio (13.61 &gt; 12.30, &lt;i&gt;p&lt;/i&gt; = 0.032), and a lower medial early diastolic peak velocity (5.70 &lt; 6.36 cm/s, &lt;i&gt;p&lt;/i&gt; = 0.016). Multivariate analysis further revealed that albuminuria was an independent risk factor for elevated LV mass index (&lt;i&gt;p&lt;/i&gt; &lt; 0.001) and medial E/e' ratio (&lt;i&gt;p&lt;/i&gt; = 0.010). Non-parametric kernel regression also demonstrated that the level of albuminuria was positively correlated with LV mass index. The remodeling of LV mass and diastolic function under the presence of albuminuria distinctly improved after PA treatment.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The presence of concomitant albuminuria in patients with PA was associated with pronounced LV hypertrophy and compromised LV diastolic function. These alterations were reversible after treatment for PA.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Plain language summary: &lt;/strong&gt;&lt;b&gt;Cardiac Impact of Primary Aldosteronism and Albuminuria&lt;/b&gt; Primary aldosteronism and albuminuria has been, respectively, demonstrated to bring about left ventricular remodeling, but the aggregative effect was unknown. We constructed a prospective single-center cohort study in Taiwan. We proposed the presence of concomitant albuminuria was associated with left ventricular hypertrophy and compromised diastolic function. Intriguingly, management of primary aldosteronism was able to restore these alterations. Our study delineated the cardiorenal crosstalk in the setting of secondary hypertension and the role of albuminuria for left ventricula","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"14 ","pages":"20406223221143253"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ce/a3/10.1177_20406223221143253.PMC9969461.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10812819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periprocedural, short-term, and long-term outcomes following transcatheter tricuspid valve repair: a systemic review and meta-analysis.","authors":"Zexuan Wu,&nbsp;Wengen Zhu,&nbsp;Wulamiding Kaisaier,&nbsp;Miriding Kadier,&nbsp;Runkai Li,&nbsp;Gulpari Tursun,&nbsp;Yugang Dong,&nbsp;Chen Liu,&nbsp;Yili Chen","doi":"10.1177/20406223231158607","DOIUrl":"https://doi.org/10.1177/20406223231158607","url":null,"abstract":"<p><strong>Background: </strong>There has been an increasing use of transcatheter tricuspid valve repair (TTVR) recently. However, the periprocedural, short-term, and long-term outcomes of TTVR remain unclear.</p><p><strong>Objectives: </strong>To determine the clinical outcomes in patients with significant tricuspid regurgitation undergoing TTVR.</p><p><strong>Design: </strong>Systematic review and meta-analysis.</p><p><strong>Data source and methods: </strong>The systematic review and meta-analysis is reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed and EMBASE were searched for clinical trials and observational studies until March 2022. Studies reporting the incidence of clinical outcomes after TTVR were included. The clinical outcomes included periprocedural, short-term (in-hospital or within 30 days), and long-term (>6-month follow-up) outcomes. The primary outcome was all-cause mortality whereas the secondary outcomes included technical success, procedural success, cardiovascular mortality, rehospitalization for heart failure (HHF), major bleeding, and single leaflet device attachment. The incidence of these outcomes across studies was pooled by a random-effects model.</p><p><strong>Results: </strong>A total of 21 studies with 896 patients were included. A total of 729 (81.4%) patients underwent isolated TTVR while only 167 (18.6%) patients underwent combined mitral and tricuspid valve repair. Over 80% of the patients used coaptation devices while approximately 20% used annuloplasty devices. The median follow-up duration was 365 days. Technical and procedural success was high at 93.9% and 82.1%, respectively. The pooled perioperative, short-term, and long-term all-cause mortality for patients undergoing TTVR was 1.0%, 3.3%, and 14.1%, respectively. The long-term cardiovascular mortality rate was 5.3% while the HHF rate was 21.5%. Major bleeding and single leaflet device attachment were two major complications, accounting for 14.3% and 6.4%, respectively, during long-term follow-up.</p><p><strong>Conclusion: </strong>TTVR is associated with high procedural success and low procedural and short-term mortality. However, all-cause mortality, cardiovascular mortality, and HHF rates remain high during long-term follow-up.</p><p><strong>Registration: </strong>PROSPERO (CRD42022310020).</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"14 ","pages":"20406223231158607"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/da/e1/10.1177_20406223231158607.PMC9989399.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9437718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hair repigmentation and regrowth in a dupilumab-treated paediatric patient with alopecia areata and atopic dermatitis: a case report.","authors":"Xin Yan,&nbsp;Munire Tayier,&nbsp;Sin Tong Cheang,&nbsp;Zhongmin Liao,&nbsp;Yi Dong,&nbsp;Yifeng Yang,&nbsp;Yanting Ye,&nbsp;Xingqi Zhang","doi":"10.1177/20406223231191049","DOIUrl":"https://doi.org/10.1177/20406223231191049","url":null,"abstract":"<p><p>Alopecia areata (AA) is a chronic inflammatory disease mainly involving Th1 immunoreaction, but Th2 is also involved. A 9-year-old girl presented to our clinic with severe alopecia for 2 months and pruritus-related rashes for 8 years. She was diagnosed with AA and atopic dermatitis (AD), and the Severity of Alopecia Tool (SALT) score was 98. She used a 0.05% halometasone cream (occlusive dressing) topically applied overnight (6 days weekly) for 10 months. After 2 months of treatment, she had regrowth of both black and white hair. However, relapse occurred and she gradually lost all black terminal hair, but white terminal hair remained, with a SALT score of 70. Continuous topical occlusion resulted in white hair regrowth with a SALT score of 20 at the end of month 10. Dupilumab was initially prescribed as a 600-mg subcutaneous injection and maintained at 300 mg every 4 weeks thereafter. Hair repigmentation (10% of whole hair density) started, with black hair shaft appearing at the proximal end in parietal-occipital and occipital areas after three injections at week 12 of dupilumab therapy, with a SALT score of 10. After seven injections at week 28, the percentage of black hair shaft reached up to 90, and she regained her black hair and the pigmented section of hair shaft continued to grow longer at the rate of normal hair growth. Nevertheless, 4 months after termination of dupilumab therapy, the black terminal hair began to fall off, and white vellus hair gradually regrew on the scalp, with a SALT score of 80. Dupilumab induces hair regrowth and repigmentation of white terminal hair without disturbing the anagen phase of hair follicles. Therefore, melanocytes in AA may be a potential target of Th2-related factors. Persistent regrowth of white hair may be used as a signal of Th2 dominance in AA management.</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"14 ","pages":"20406223231191049"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d0/50/10.1177_20406223231191049.PMC10403978.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10305908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State of the art: non-invasive electrical stimulation for the treatment of chronic tinnitus.","authors":"Shanwen Chen,&nbsp;Maoshan Du,&nbsp;Yang Wang,&nbsp;Yifan Li,&nbsp;Busheng Tong,&nbsp;Jianxin Qiu,&nbsp;Feihu Wu,&nbsp;Yehai Liu","doi":"10.1177/20406223221148061","DOIUrl":"https://doi.org/10.1177/20406223221148061","url":null,"abstract":"<p><p>Subjective tinnitus is the perception of sound in the absence of external stimulation. Neuromodulation is a novel method with promising properties for application in tinnitus management. This study sought to review the types of non-invasive electrical stimulation in tinnitus to provide the foothold for further research. PubMed, EMBASE, and Cochrane databases were searched for studies on the modulation of tinnitus by non-invasive electrical stimulation. Among the four forms of non-invasive electrical modulation, transcranial direct current stimulation, transcranial random noise stimulation, and transauricular vagus nerve stimulation yielded promising results, whereas the effect of transcranial alternating current stimulation in the treatment of tinnitus has not been confirmed. Non-invasive electrical stimulation can effectively suppress tinnitus perception in some patients. However, the heterogeneity in parameter settings leads to scattered and poorly replicated findings. Further high-quality studies are needed to identify optimal parameters to develop more acceptable protocols for tinnitus modulation.</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"14 ","pages":"20406223221148061"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/39/31/10.1177_20406223221148061.PMC9969452.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10812825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inheritance and innovation of the diagnosis of peripheral pulmonary lesions.","authors":"Yang Xia,&nbsp;Qin Li,&nbsp;Changgao Zhong,&nbsp;Kopen Wang,&nbsp;Shiyue Li","doi":"10.1177/20406223221146723","DOIUrl":"https://doi.org/10.1177/20406223221146723","url":null,"abstract":"<p><p>As the leading cause of cancer-related deaths worldwide, early detection and diagnosis are crucial to reduce the mortality of lung cancer. To date, the diagnosis of the peripheral pulmonary lesions (PPLs) remains a major unmet clinical need. The urgency of diagnosing PPLs has driven a series of development of the advanced bronchoscopy-guided techniques in the past decades, such as radial probe-endobronchial ultrasonography (RP-EBUS), virtual bronchoscopy navigation (VBN), electromagnetic navigation bronchoscopy (ENB), bronchoscopic transparenchymal nodule access (BTPNA), and robotic-assisted bronchoscopy. However, these techniques also have their own limitations. In this review, we would like to introduce the development of diagnostic techniques for PPLs, with a special focus on biopsy approaches and advanced guided bronchoscopy techniques by discussing their advantages, limitations, and future prospects.</p>","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"14 ","pages":"20406223221146723"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/92/23/10.1177_20406223221146723.PMC9896091.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9214698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Asia Pacific Pediatric Association (APPA) position statement on the MAFLD definition of fatty liver disease.","authors":"Iqbal A Memon,&nbsp;Arit Parkash,&nbsp;Kamran Sadiq,&nbsp;Naglaa M Kamal,&nbsp;Mortada H F El-Shabrawi","doi":"10.1177/20406223231164523","DOIUrl":"https://doi.org/10.1177/20406223231164523","url":null,"abstract":"","PeriodicalId":22960,"journal":{"name":"Therapeutic Advances in Chronic Disease","volume":"14 ","pages":"20406223231164523"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8d/76/10.1177_20406223231164523.PMC10084573.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9358946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}