Journal of Pulmonology Research & Reports最新文献

{"title":"The Conundrum of Thoracic Radiological Signs in Patients Having Chronic Kidney Disease (CKD) Who are on Haemodialysis","authors":"Amit Sharma, Devesh Chauhan","doi":"10.47363/jprr/2023(5)133","DOIUrl":"https://doi.org/10.47363/jprr/2023(5)133","url":null,"abstract":"It is quite common in the practice of a pulmonologist to come across patients having pulmonary symptoms in the background of chronic kidney disease (CKD). This is also owing to the fact that advances in the medical field such as haemodialysis result in significant prolongation of survival in these terminally ill patients. However, this leads to emergence of a newer plethora of systemic manifestations which require further investigation and management.","PeriodicalId":229002,"journal":{"name":"Journal of Pulmonology Research & Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131114640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An In-Silico Reverse Vaccinology Approach in Predicting Vaccine Candidate Against Mycobacterium tuberculosis CCDC5180","authors":"V. Jha, Kunal Gharat","doi":"10.47363/jprr/2022(4)132","DOIUrl":"https://doi.org/10.47363/jprr/2022(4)132","url":null,"abstract":"A quarter of the world’s population is thought to be latently infected with Mycobacterium tuberculosis, creating a vast pool of possible future illnesses. Combined with the rising prevalence of multi-drug resistant Mycobacterium tuberculosis (Mtb) strains, TB poses one of the biggest challenges for world health, and the TB epidemic can only be eradicated with a new and more effective vaccine strategy. Since the Bacille Calmette-Guérin (BCG) vaccine is the only one used to treat tuberculosis (TB), Reverse vaccine technology aims to accelerate the development of subunit vaccines by identifying specific proteins in a pathogenic bacterial proteome that may be protective antigens. This approach was employed on four extracellular proteins namely Secreted fibronectin-binding protein C antigen 85-C, PE-PGRS family protein, Invasion protein RipA, and Invasion protein RipB. The shortlisted proteins were subjected to B-cell, CTL, and HTL epitope prediction. To further identify the most promising epitopes, specialized filtering techniques were employed to narrow down CTL epitopes that were non-allergenic, non-toxic, and antigenic as well as B-cell epitopes that produced antibodies. Similarly, HTL epitopes that generate IFN- γ but not IL-10 were selected. The analysis revealed invasion protein RipA as a potential candidate for Mycobacterium tuberculosis CCDC5180 immunization.","PeriodicalId":229002,"journal":{"name":"Journal of Pulmonology Research & Reports","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132892825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What do we Need to do to Avoid Intubation in Patients with Respiratory Failure Due to SARS-CoV-2 Infection?","authors":"Huang Wei Ling","doi":"10.47363/jprr/2022(4)131","DOIUrl":"https://doi.org/10.47363/jprr/2022(4)131","url":null,"abstract":"Since the beginning of the COVID-19 pandemic at the end of 2019, we have been experiencing another phase of our planet in which the presence of a new infectious agent has brought many doubts and uncertainties regarding the way to treat it, as the best medicine is still not known to use to treat this infection.","PeriodicalId":229002,"journal":{"name":"Journal of Pulmonology Research & Reports","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130377865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hereditary Hemorrhagic Telangiectasia – Osler-Weber-Rendu Syndrome: About A Case","authors":"Christian Pérez-Calvo","doi":"10.47363/jprr/2022(4)129","DOIUrl":"https://doi.org/10.47363/jprr/2022(4)129","url":null,"abstract":"","PeriodicalId":229002,"journal":{"name":"Journal of Pulmonology Research & Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128935179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Catamenial Pneumothorax After Multiple Chest Tube Placements, Pleurodesis and Vats","authors":"Mitesh Chauhan","doi":"10.47363/jprr/2022(4)128","DOIUrl":"https://doi.org/10.47363/jprr/2022(4)128","url":null,"abstract":"Catamenial pneumothorax is characterized by spontaneous pneumothorax occurring 72 hours before or after onset of menstruation in a reproductive aged woman. It is an extremely rare condition, and although generally thought to be due to abnormal migration of endometrial tissue to the pleural space, the mechanism of this migration is unclear. We present a case of recurrent catamenial pneumothorax after chest tube placements, pleurodesis and videoassisted thoracoscopic surgery (VATS).","PeriodicalId":229002,"journal":{"name":"Journal of Pulmonology Research & Reports","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133264675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tezepelumab: A Novel Modality of Treatment in Refractory Asthma?","authors":"J. Zakhour","doi":"10.47363/jprr/2022(4)130","DOIUrl":"https://doi.org/10.47363/jprr/2022(4)130","url":null,"abstract":"","PeriodicalId":229002,"journal":{"name":"Journal of Pulmonology Research & Reports","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132847743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energy Alterations in Patients with Pulmonary Artery Thrombosis After COVID-19 Treatment","authors":"Huang Wl","doi":"10.47363/jprr/2022(4)125","DOIUrl":"https://doi.org/10.47363/jprr/2022(4)125","url":null,"abstract":"Introduction: There are some studies in the literature reporting cases of pulmonary thrombosis after treatment of acute phase of SARS-CoV-2 infection. Purpose: The purpose of this study is to show that patients that have pulmonary thrombosis has in the back ground prior to COVID-19, energy deficiency in the five internal massive organs, responsible for the production of energy necessary to keep the Blood flowing normally inside the Blood vessels. The treatment used nowadays to treat patient with SARS-CoV-2 infection can reduce even more this energy and can cause Blood stagnation inside the blood vessels in any part of the body, in this case, in the pulmonary vessels. Methods: Through one case report of 36 years-old female patient with history of SARS-CoV-2 infection on February 2nd 2021. In the beginning of her symptoms, she presented only runny nose and flu-like symptoms. She evolves to body pain and headache and in the third day, she tested positive to SARSCoV-2. It was prescribed Ivermectin and Azithromycin and she stayed 14 days isolated at home. On 16th day since the first manifestation, she returned to work and began to feel left chest pain. She did many exams to see if the Heart was compromised but nothing was found. There was only alteration in the pulmonary artery pressure and after it was diagnosed pulmonary thrombosis after performing Angio tomography. She started to use Rivaroxaban (Xarelto) and after this treatment, she improved and the symptoms disappeared but she is still using the medication until today. She went to my clinic in January 2022 to treat anxiety and she told me about all history of SARS-CoV-2 infection and complications. I performed to measurement of her internal massive organs through a crystal-pendulum using radiesthesia procedure. Results: what I found was a complete lack of energy inside the five internal massive organs (Liver, Heart, Spleen, Lungs, Kidney) responsible for the production of Yin, Yang, Qi and Blood to keep the blood flowing inside the blood vessels. Conclusion: The conclusion of this study is that patients with pulmonary artery thrombosis post COVID-19 symptoms can have energy deficiency inside the five internal massive organs and the use of highly concentrated medications to treat this condition and many other clinical conditions can worse more this reduction in energy and cause stagnation of Blood inside the blood vessels and cause in this case, pulmonary thrombosis.","PeriodicalId":229002,"journal":{"name":"Journal of Pulmonology Research & Reports","volume":"107 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116092236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acoustic Epidemiology of Pulmonary Tuberculosis (TB) & Covid19 Leveraging explainable AI/ML","authors":"R. Pathri","doi":"10.47363/jprr/2022(4)126","DOIUrl":"https://doi.org/10.47363/jprr/2022(4)126","url":null,"abstract":"Involuntary cough is a prominent symptom for many a Lung Ailments ranging from Infectious to non-Infectious diseases. Early research around human cough established that the spectral signatures do not vary between Involuntary and Voluntary coughs. The study aimed at evaluating voluntary human cough sounds recorded under a stringent clinical protocol. India’s ambitious goal to eliminate and eradicate TB by 2025 shall be facilitated by Machine Learning tools that address subjectivity in that the healthcare worker can now take the solution as a screening modality to the last mile as a part of outreach programs without having to rely on infrastructure & connectivity. In this paper we present the findings of Clinical Trials for Pulmonary TB registered at CTRI/2019/02/017672 conducted independently and included Covid19 during the pandemic as a part of Bi-Directional screening modality. The reference standards used were CBNAAT (Cartridge based nucleic acid amplification test) & CXR (Chest X-Ray) for TB while for Covid19; RT-PCR was used as the reference standard. As a non-invasive and contactless screening modality, a sophisticated third-party Microphone Array was used to record the cough under a stringent infection control protocol. Sensitivity achieved across the sites for TB ranged between 80% - 83% and Specificity was to the tune of 92% while using CBNAAT as a reference standard. CXR when used as a reference standard for TB achieved a sensitivity and specificity of 59% and 60% respectively. Covid19 achieved a sensitivity & specificity of 92% and 96% while using RT-PCR as the reference standard. The study was primarily focused on the Frequency domain that paved way for feature extraction and explainable Machine Learning Models operating upon lossless WAV files hypothesizing acoustic theory and demographic inputs. The solution titled “TimBre” can now be added to the healthcare workers arsenal in situations where a RT-PCR or CXR is not available and seamlessly conduct bidirectional screening with a single recording of cough and also offer insights into Non-Communicable diseases as a part of differential diagnosis","PeriodicalId":229002,"journal":{"name":"Journal of Pulmonology Research & Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127021130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygen from the Atmosphere Cannot Pass Through the Lung Tissues and Reach the Bloodstream. The Unexpected Capacity of Human Body to Dissociate the Water Molecule","authors":"Arturo Solís Herrera, María del Carmen Arias Esparza","doi":"10.47363/jprr/2022(4)124","DOIUrl":"https://doi.org/10.47363/jprr/2022(4)124","url":null,"abstract":"Oxygen seems of fundamental importance to survival. Thereby, transportation exchange, and regulation of necessary gases is critical. The prevalent dogma indicates that the exchange from atmospheric oxygen in the lungs is by simple diffusion, caused by the differential pressure of gases involved in respiration. Gases tend to move from a high-pressure area to a low-pressure one. Theoretically, at the end of the process, oxygen passes from the blood to the tissue fluid and carbon dioxide from tissue fluid into the blood. Apparently, blood stream is a well-developed system for the transportation of gases. However, our finding about the unsuspected intrinsic property of human body to dissociate the water molecule, breaks in thousand pieces the ancient dogma about living beings can absorbs atmospheric oxygen.","PeriodicalId":229002,"journal":{"name":"Journal of Pulmonology Research & Reports","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121814147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coagulopathy and Thromboembolism in Covid-19- A Review","authors":"Filipa Ribeiro Lucas","doi":"10.47363/jprr/2022(4)123","DOIUrl":"https://doi.org/10.47363/jprr/2022(4)123","url":null,"abstract":"The emergence of the novel coronavirus, SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has resulted in a major global pandemic posing various challenges to the worldwide health care systems. Clinical course of the infection, known as coronavirus disease of 2019 (COVID-19, ranges from mild subclinical disease to a life-threatening systemic illness. Common symptoms include a flu-like illness with fever and inflammation, and in severe cases pneumonia and systemic inflammation that results in morbidity and mortality. One of the complications of COVID-19 is its disruption of normal hemostasis resulting coagulopathy and thromboembolism. In this following review, we discuss present knowledge; summarize existing published information on the underlying mechanisms of action for COVID-19-associated coagulopathy; and propose algorithms for screening, management, and prevention of COVID-19 patients.","PeriodicalId":229002,"journal":{"name":"Journal of Pulmonology Research & Reports","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128778339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}