{"title":"Preventive Effects of Endurance and Cognitive-Motor Training on TREM2 Expression and IL-33 Levels in Vascular Dementia Rats","authors":"Zahra Margani, Najmeh. A Shojaeian","doi":"10.61186/shefa.12.4.22","DOIUrl":"https://doi.org/10.61186/shefa.12.4.22","url":null,"abstract":"Introduction: Vascular dementia (VaD) is a cognitive impairment that affects the expression of triggering receptor expressed on myeloid cells 2 (TREM2) and interleukin 33 .The present study aimed to investigate the preventive effect of endurance and cognitivemotor dual-task training on the TREM2 and IL-33 expression in rats with VaD. Materials and Methods: Forty middle-aged male Wistar rats were randomly assigned to four groups: healthy control, dementia, endurance training + dementia, and dual cognitive-motor task + dementia.The rats in the endurance training group underwent running exercises, while the cognitive-motor dual-task group participated in the Morris water maze for 8 weeks.Following the interventions and the creation of a vascular dementia model through a 30-minute common carotid artery occlusion, blood samples were collected.IL-33 serum levels were measured using the ELISA method, and TREM2 expression was assessed by Western blotting after extracting the hippocampus.Results: The r esults show that both training methods significantly affected the levels of TREM2 and IL-33.TREM2 levels were significantly higher in both exercise groups compared to the control group and significantly lower compared to the dementia group.Furthermore, IL-33 levels were significantly higher in both exercise groups compared to the control group, with a significant difference observed between the control and dementia groups.Conclusion: Endurance and cognitive-motor dual-task training appear to help maintain appropriate concentrations of TREM2, potentially preventing cognitive and functional decline associated with VaD.However, no significant difference in IL-33 levels was found between the exercise and dementia groups, highlighting the need for further research on the type, intensity, and impact of exercise on this variable.","PeriodicalId":22899,"journal":{"name":"The Neuroscience Journal of Shefaye Khatam","volume":"12 4","pages":"22-32"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://shefayekhatam.ir/files/site1/user_files_a8010a/shojaeian62-A-10-1171-1-1981708.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147919283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Ghasemzadeh, Sedigheh khanjani-Jelodar, F. Nazari-serenjeh, Narjes Lotfi Ghadikolaii
{"title":"The Role of microRNA in the Pathogenesis of Schizophrenia","authors":"Z. Ghasemzadeh, Sedigheh khanjani-Jelodar, F. Nazari-serenjeh, Narjes Lotfi Ghadikolaii","doi":"10.52547/shefa.11.1.119","DOIUrl":"https://doi.org/10.52547/shefa.11.1.119","url":null,"abstract":"","PeriodicalId":22899,"journal":{"name":"The Neuroscience Journal of Shefaye Khatam","volume":"218 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86854838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Esmaili Jami, M. Khalilzadeh, M. Ghoshuni, mohammadmehdi khalilzadeh
{"title":"Estimation of Attention Indices in IVA Tests Using Optical Flow in ERP Brain Maps","authors":"Ali Esmaili Jami, M. Khalilzadeh, M. Ghoshuni, mohammadmehdi khalilzadeh","doi":"10.52547/shefa.11.1.46","DOIUrl":"https://doi.org/10.52547/shefa.11.1.46","url":null,"abstract":"","PeriodicalId":22899,"journal":{"name":"The Neuroscience Journal of Shefaye Khatam","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89898941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
behnood behmanesh, Khadijeh Abolmaali Alhosseini, M. Azadi
{"title":"The Effectiveness of Attachment-based Psycho-Educational Interventions on Reducing the Symptoms of Separation Anxiety Disorder in Preschool Children in Tehran","authors":"behnood behmanesh, Khadijeh Abolmaali Alhosseini, M. Azadi","doi":"10.52547/shefa.11.1.57","DOIUrl":"https://doi.org/10.52547/shefa.11.1.57","url":null,"abstract":"","PeriodicalId":22899,"journal":{"name":"The Neuroscience Journal of Shefaye Khatam","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83927984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Maghbooli, Alemeh Nejhadalirezayi, S. Mazloomzadeh
{"title":"Social Support in Patients with Multiple Sclerosis: A Cross-Sectional Study","authors":"M. Maghbooli, Alemeh Nejhadalirezayi, S. Mazloomzadeh","doi":"10.52547/shefa.11.1.37","DOIUrl":"https://doi.org/10.52547/shefa.11.1.37","url":null,"abstract":"","PeriodicalId":22899,"journal":{"name":"The Neuroscience Journal of Shefaye Khatam","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85738384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Afsaneh Moradi, Farzaneh Pouladi, V. Farnia, M. Alikhani
{"title":"Comparison of Cold Executive Functions in Gambling Addicts, Drug Addicts,\u0000and Normal People","authors":"Afsaneh Moradi, Farzaneh Pouladi, V. Farnia, M. Alikhani","doi":"10.52547/shefa.11.1.13","DOIUrl":"https://doi.org/10.52547/shefa.11.1.13","url":null,"abstract":"","PeriodicalId":22899,"journal":{"name":"The Neuroscience Journal of Shefaye Khatam","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79728097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}