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Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences最新文献

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miR-3653-3P EXPRESSION IN PERIPHERAL BLOOD OF PATIENTS WITH OVARIAN CARCINOMA miR-3653-3P在卵巢癌患者外周血中的表达
Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences Pub Date : 2022-08-09 DOI: 10.26650/jarhs2021-1136829
Fatma Pektopal Delek, Demet Akdeniz Ödemiş, Özge Şükrüoğlu Erdoğan, Seda Kilic Erciyas, B. Kurt, Ş. Tuncer, H. Yazici
{"title":"miR-3653-3P EXPRESSION IN PERIPHERAL BLOOD OF PATIENTS WITH OVARIAN CARCINOMA","authors":"Fatma Pektopal Delek, Demet Akdeniz Ödemiş, Özge Şükrüoğlu Erdoğan, Seda Kilic Erciyas, B. Kurt, Ş. Tuncer, H. Yazici","doi":"10.26650/jarhs2021-1136829","DOIUrl":"https://doi.org/10.26650/jarhs2021-1136829","url":null,"abstract":"","PeriodicalId":228307,"journal":{"name":"Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences","volume":"131 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127637415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
INVESTIGATION OF METHYLATION AND EXPRESSION STATUS OF PAX1 GENE VIA EPIGENOMIC PROFILING IN ORAL MALIGNANT LESIONS 口腔恶性病变中pax1基因甲基化及表达状态的表观基因组分析
Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences Pub Date : 2022-08-09 DOI: 10.26650/jarhs2021-1142683
Arda Öztan, G. Ak, M. Ulusan, S. Demokan
{"title":"INVESTIGATION OF METHYLATION AND EXPRESSION STATUS OF PAX1 GENE VIA EPIGENOMIC PROFILING IN ORAL MALIGNANT LESIONS","authors":"Arda Öztan, G. Ak, M. Ulusan, S. Demokan","doi":"10.26650/jarhs2021-1142683","DOIUrl":"https://doi.org/10.26650/jarhs2021-1142683","url":null,"abstract":"","PeriodicalId":228307,"journal":{"name":"Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133823434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TRANSCRIPTOMIC DIFFERENCES IN MONOZYGOTIC TWINS WITH OVARIAN CANCER 同卵双胞胎卵巢癌的转录组差异
Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences Pub Date : 2022-08-09 DOI: 10.26650/jarhs2021-1137404
Gözde Kuru Türkcan, Demet Akdeniz Ödemiş, B. Kurt, Ş. Tuncer, Seda Kilic Erciyas, Özge Şükrüoğlu Erdoğan, H. Yazici
{"title":"TRANSCRIPTOMIC DIFFERENCES IN MONOZYGOTIC TWINS WITH OVARIAN CANCER","authors":"Gözde Kuru Türkcan, Demet Akdeniz Ödemiş, B. Kurt, Ş. Tuncer, Seda Kilic Erciyas, Özge Şükrüoğlu Erdoğan, H. Yazici","doi":"10.26650/jarhs2021-1137404","DOIUrl":"https://doi.org/10.26650/jarhs2021-1137404","url":null,"abstract":"Objectives : The most significant barrier to treating epithelial ovarian cancer(EOC), is the late diagnosis and the emergence of chemotherapy resistance in the early stages.The ineffectiveness of standard treatment protocols in advanced-stage cases highlights the value of individualized EOC treatment.Even monozygotic(MZ) twins, with almost the same genotype in nature, can develop different phenotypic characteristics throughout life. Materials-Methods : In this context, the peripheral blood and ovarian tissues of monozygotic twins who are discordant in terms of ovarian cancer and the other healthy sibling who is a BRCA1 mutation carrier were compared in the study to analyze all RNA molecules transcribed at the genome level using next-generation sequencing technology.Through analyzing the molecules transcribed in the whole genome,the genetic variations underlying the development of ovarian cancer in a high-risk family bearing the BRCA1 mutation but only one of whom was found to have ovarian cancer were examined. Results : As a result of the transcriptomic analysis of the total RNA of 6 samples obtained from the ovarian tissues and peripheral blood samples of MZ twins with ovarian cancer and healthy sibling, the protein-encoding protein that shows expression changes in tissue and blood compared to healthy people genes,lncRNAs,precursor-miRNAs and fusion-transcripts have been identified.Filtering procedures and expression change coefficients(log2Fc) were calculated based on the expression data of identified ovarian cancer tumor markers CA125 and CA15-3. Conclusions : According to our study the expression levels of 66 protein-coding genes,23 novel lncRNAs,9 miRNAs and,2 fusion transcripts were found to vary in three groups and,these molecules are thought to be candidate molecules associated with epithelial ovarian cancer.","PeriodicalId":228307,"journal":{"name":"Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129145020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EVALUATION OF EXOSOME-DERIVED CircRNA EXPRESSION PATTERNS IN LUNG CANCER RADIOTHERAPY 肺癌放疗中外泌体衍生环状rna表达模式的评估
Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences Pub Date : 2022-08-09 DOI: 10.26650/jarhs2021-1136760
Saina Rahimi, M. Asadi, Can Müftüoğlu, E. Tavlayan, Özlem Özkaya Akagündüz, U. Mert, Ayşe Caner
{"title":"EVALUATION OF EXOSOME-DERIVED CircRNA EXPRESSION PATTERNS IN LUNG CANCER RADIOTHERAPY","authors":"Saina Rahimi, M. Asadi, Can Müftüoğlu, E. Tavlayan, Özlem Özkaya Akagündüz, U. Mert, Ayşe Caner","doi":"10.26650/jarhs2021-1136760","DOIUrl":"https://doi.org/10.26650/jarhs2021-1136760","url":null,"abstract":"","PeriodicalId":228307,"journal":{"name":"Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130821724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
INVESTIGATION OF THE ANTIMETASTATIC POTENTIAL OF T. SPICATA IN HUMAN BREAST ADENOCARCINOMA CELLS COMBINED WITH STANDARD CHEMOTHERAPY spicata在人乳腺腺癌细胞中联合标准化疗抗转移潜能的研究
Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences Pub Date : 2022-08-09 DOI: 10.26650/jarhs2021-1145563
T. Salman, A. Yıldırım, Yağmur Kaya, H. Koçdor
{"title":"INVESTIGATION OF THE ANTIMETASTATIC POTENTIAL OF T. SPICATA IN HUMAN BREAST ADENOCARCINOMA CELLS COMBINED WITH STANDARD CHEMOTHERAPY","authors":"T. Salman, A. Yıldırım, Yağmur Kaya, H. Koçdor","doi":"10.26650/jarhs2021-1145563","DOIUrl":"https://doi.org/10.26650/jarhs2021-1145563","url":null,"abstract":"","PeriodicalId":228307,"journal":{"name":"Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125912938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PRECISION ONCOLOGY- BASIC TO BEDSIDE 精准肿瘤学——从基础到床边
Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences Pub Date : 2022-08-09 DOI: 10.26650/jarhs2021-1138049
A. Verma
{"title":"PRECISION ONCOLOGY- BASIC TO BEDSIDE","authors":"A. Verma","doi":"10.26650/jarhs2021-1138049","DOIUrl":"https://doi.org/10.26650/jarhs2021-1138049","url":null,"abstract":"","PeriodicalId":228307,"journal":{"name":"Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123844651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LIPOPOLYSACCHARIDE INHIBITS AUTOPHAGY IN HUMAN DERMAL FIBROBLASTS IN VITRO 脂多糖对体外人真皮成纤维细胞自噬的抑制作用
Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences Pub Date : 2022-08-09 DOI: 10.26650/jarhs2021-1140330
Keyvan Hemmatvand, Mehtap Yüksel Eğrilmez, Ufkay Karabay
{"title":"LIPOPOLYSACCHARIDE INHIBITS AUTOPHAGY IN HUMAN DERMAL FIBROBLASTS IN VITRO","authors":"Keyvan Hemmatvand, Mehtap Yüksel Eğrilmez, Ufkay Karabay","doi":"10.26650/jarhs2021-1140330","DOIUrl":"https://doi.org/10.26650/jarhs2021-1140330","url":null,"abstract":"","PeriodicalId":228307,"journal":{"name":"Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122904626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
REAL WORLD EVIDENCE AND BIG DATA 真实世界的证据和大数据
Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences Pub Date : 2022-08-09 DOI: 10.26650/jarhs2021-1132473
M. Günver
{"title":"REAL WORLD EVIDENCE AND BIG DATA","authors":"M. Günver","doi":"10.26650/jarhs2021-1132473","DOIUrl":"https://doi.org/10.26650/jarhs2021-1132473","url":null,"abstract":"","PeriodicalId":228307,"journal":{"name":"Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127823833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
microRNA AS A PROMISING POTENTIAL BIOMARKER FOR COLORECTAL CANCER microRNA作为结直肠癌的潜在生物标志物
Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences Pub Date : 2022-08-09 DOI: 10.26650/jarhs2021-1136752
M. Asadi, Ayşe Caner, V. Zafari, Ahmed Al Omar, Can Müftüoğlu, Tuoraj Asvadi Kermani
{"title":"microRNA AS A PROMISING POTENTIAL BIOMARKER FOR COLORECTAL CANCER","authors":"M. Asadi, Ayşe Caner, V. Zafari, Ahmed Al Omar, Can Müftüoğlu, Tuoraj Asvadi Kermani","doi":"10.26650/jarhs2021-1136752","DOIUrl":"https://doi.org/10.26650/jarhs2021-1136752","url":null,"abstract":"","PeriodicalId":228307,"journal":{"name":"Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127903924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EFFECT OF THYMOQUINONE IN COMBINATION WITH NIVOLUMAB ON EXPERIMENTAL RENAL CELL CANCER MODELS 百里醌联合纳武单抗对实验性肾细胞癌模型的影响
Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences Pub Date : 2022-08-09 DOI: 10.26650/jarhs2021-1133817
A. Dirican, S. Aktaş, T. Aktas, Aylin Erol, Ö. Gökbayrak, H. Kolatan, E. Serinan, Z. Altun, I. Somalı, O. Yılmaz
{"title":"EFFECT OF THYMOQUINONE IN COMBINATION WITH NIVOLUMAB ON EXPERIMENTAL RENAL CELL CANCER MODELS","authors":"A. Dirican, S. Aktaş, T. Aktas, Aylin Erol, Ö. Gökbayrak, H. Kolatan, E. Serinan, Z. Altun, I. Somalı, O. Yılmaz","doi":"10.26650/jarhs2021-1133817","DOIUrl":"https://doi.org/10.26650/jarhs2021-1133817","url":null,"abstract":"","PeriodicalId":228307,"journal":{"name":"Sağlık Bilimlerinde İleri Araştırmalar Dergisi / Journal of Advanced Research in Health Sciences","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128974299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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