The MAK-Collection for Occupational Health and Safety最新文献

{"title":"Kresol (alle Isomere). MAK-Begründung, Nachtrag","authors":"A. Hartwig, Michael Arand","doi":"10.34865/MB131977D5_4AD","DOIUrl":"https://doi.org/10.34865/MB131977D5_4AD","url":null,"abstract":"","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"7 1","pages":"1-31"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90301640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Citric acid – Method for the determination in workplace air using high performance liquid chromatography (HPLC). Air Monitoring Method – Translation of the German version from 2019","authors":"A. Hartwig, M. Arand","doi":"10.34865/AM7792E5_1","DOIUrl":"https://doi.org/10.34865/AM7792E5_1","url":null,"abstract":"","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"24 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86383049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N,N-Dimethylformamide. MAK Value Documentation, supplement – Translation of the German version from 2019","authors":"A. Hartwig, M. Arand","doi":"10.34865/MB6812E5_1","DOIUrl":"https://doi.org/10.34865/MB6812E5_1","url":null,"abstract":"The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated N,N -dimethylformamide [68-12‐2] taking into account the increased respiratory volume at the workplace (see List of MAK and BAT Values, Sections I b and I c). N,N -Dimethylformamide is a liver toxin and the maximum concentration at the workplace (MAK value) of 5 ml/m3 was set using data from a two-year study in mice showing liver cell hypertrophy and single cell necrosis at the lowest concentration tested of 25 ml/m3. In this study, rats were less susceptible as regards the liver toxicity of N,N -dimethylformamide. Species differences in toxicokinetics are a plausible explanation for the higher toxicity in mice. As human metabolism of N,N -dimethylformamide is quantitatively similar to that of rats, their susceptibility is expected to be similar to that of rats. On the basis of the NOAEC (no observed adverse effect concentration) of 25 ml/m3 for rats, the MAK value of 5 ml/m3 is retained even taking into account the increased respiratory volume at the workplace. Peak Limitation Category II and the excursion factor of 2 are confirmed. The assignment of N,N -dimethylformamide to Pregnancy Risk Group B is retained. In an earlier assessment, it was concluded that exposure to a concentration of up to 1 ml/m3 is not expected to lead to developmental toxicity. This prerequisite for an assignment of N,N -dimethylformamide to Pregnancy Risk Group C is confirmed, also taking into account the increased respiratory volume at the workplace. The MAK Collection for Occupational Health and Safety 2020, Vol 5, No 1 1 MAK Value Documentations — N,N-Dimethylformamide MAK value (2005) 5 ml/m3 (ppm) ≙ 15 mg/m3 Peak limitation (2011) Category II, excursion factor 2 Absorption through the skin (1969) H","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"89 S1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91423257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trikresylphosphat, Isomere, „frei von o-Isomeren“. MAK-Begründung","authors":"A. Hartwig, Michael Arand","doi":"10.34865/MB133078D5_3OR","DOIUrl":"https://doi.org/10.34865/MB133078D5_3OR","url":null,"abstract":"","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"4 1","pages":"1-27"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83435121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dichloressigsäure und ihre Salze. MAK-Begründung, Nachtrag","authors":"A. Hartwig, Michael Arand","doi":"10.34865/MB7943VERD5_1","DOIUrl":"https://doi.org/10.34865/MB7943VERD5_1","url":null,"abstract":"","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"15 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87490845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Portlandzement-Staub. MAK-Begründung, Nachtrag","authors":"A. Hartwig, Michael Arand","doi":"10.34865/MB6599715D5_4AD","DOIUrl":"https://doi.org/10.34865/MB6599715D5_4AD","url":null,"abstract":"","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"106 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87943024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lead and its compounds (except lead arsenate, lead chromate and alkyl lead compounds) – Addendum for re-evaluation of the BLW. Assessment Values in Biological Material – Translation of the German version from 2019","authors":"A. Hartwig, M. Arand","doi":"10.34865/BB743992PBAE5_4AD","DOIUrl":"https://doi.org/10.34865/BB743992PBAE5_4AD","url":null,"abstract":"In 2018 the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated lead [7439-92-1] and its compounds and has derived a biological guidance value at the workplace (BLW) for the blood concentration of lead. Available publications are described in detail. The re-evaluation is entirely based on studies in humans. The following critical health effects were considered: effects on haem synthesis, behavioural toxicity/neurotoxicity, male fertility, developmental toxicity, nephrotoxicity, cardiovascular effects, geno-toxicity/carcinogenicity. Effects on neurobehaviour and nephrotoxicity have been described at blood levels around 300 µg Pb/l and higher. Therefore, a BLW of 200 µg Pb/l blood has been de-duced. As investigations of lead-exposed workers show no statistically significant increase in lymphocyte micronuclei at this blood level, it is reasonably expected that the proposed BLW will also minimize a lead-induced genotoxic/carcinogenic risk. For women a Biological Reference Value (BAR) of 70 μg Pb/l blood is proposed, based on the 95 th percentile of lead blood levels of the general population in Germany. Because of the long persistence of lead in the body, the sampling time is not fixed. the lead levels of the general population the a 95 th percentile of 40 µg lead/l for the female general in the = and of 60 µg lead/l for the male population","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"97 1","pages":"1-22"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76452776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1-Butanethiol. MAK Value Documentation, supplement – Translation of the German version from 2019","authors":"A. Hartwig, M. Arand","doi":"10.34865/MB10979E5_4AD","DOIUrl":"https://doi.org/10.34865/MB10979E5_4AD","url":null,"abstract":"The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated the maximum concentration at the work place (MAK value) of ethanethiol [75-08-1]. No new studies are available for ethanethiol itself. Therefore, the MAK value is derived by read-across with the structurally similar methyl mercaptan for which the MAK value of 0.5 ml/m 3 is based on slight behavioural changes at 2 ml/m 3 in a 90-day inhalation study in rats. The MAK value of 0.5 ml/m 3 for ethanethiol is supported by a limited inhalation study with 3 volunteers,","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"31 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77254399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methylamin. MAK-Begründung, Nachtrag","authors":"A. Hartwig, Michael Arand","doi":"10.34865/MB7489D5_2AD","DOIUrl":"https://doi.org/10.34865/MB7489D5_2AD","url":null,"abstract":"The German Commission for the Investigation of Health Hazards of Chemical Com-pounds in the Work Area has re-evaluated methylamine [74-89-5]. The critical effect is irritation of the nasal airways as observed in a 2-week study in rats with a NOAEC of 75 ml/m 3 . The RD 50 data for methylamine show that its irritation potency","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"50 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85988217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2-Mercaptobenzothiazol – Bestimmung von 2-Mercaptobenzothiazol in Urin mittels LC-MS/MS. Biomonitoring-Methode","authors":"A. Hartwig, Michael Arand","doi":"10.34865/BI14930D5_3OR","DOIUrl":"https://doi.org/10.34865/BI14930D5_3OR","url":null,"abstract":"The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area developed and verified the presented biomonitoring method. This method enables the selective detection of the vulcanisation accelerator 2‐mercaptobenzothiazole (MBT) in urine. After adding a labelled internal standard (MBT‐d4), the samples are enzymatically hydrolysed to release free MBT from the conjugated MBT compounds. After online purification and enrichment, the analytes are separated from accompanying components by liquid chromatography and analysed using tandem mass spectrometry. Calibration standards are prepared in pooled urine and processed in the same way as the samples to be analysed. The MAK Collection for Occupational Health and Safety 2020, Vol 5, No 3 1 Biomonitoring-Methoden – 2-Mercaptobenzothiazol in Urin 1 Kenndaten der Methode Matrix Urin Analytisches Messprinzip LC-MS/MS Parameter und entsprechende Arbeitsstoffe Arbeitsstoff CAS-Nr. Parameter CAS-Nr. 2‐Mercaptobenzothiazol (MBT) 149-30‐4 Zinksalz des 2‐Mercaptobenzothiazols 155-04‐4 MBT 149-30‐4 Zuverlässigkeitskriterien der Methode 2-Mercaptobenzothiazol (MBT) Standardabweichung (rel.) sw = 2,3 %, 1,9 % bzw. 1,6 % Streubereich u = 5,1 %, 4,2 % bzw. 3,6 % Präzision in der Serie: bei einer dotierten Konzentration von 10 μg, 100 μg bzw. 1000 μg MBT pro Liter Urin und n = 10 Bestimmungen Standardabweichung (rel.) sw = 4,3 %, 5,8 % bzw. 3,4 % Streubereich u = 9,6 %, 13,0 % bzw. 7,6 % Präzision von Tag zu Tag: bei einer dotierten Konzentration von 10 μg, 100 μg bzw. 1000 μg MBT pro Liter Urin und n = 10 Bestimmungen Wiederfindungsrate (rel.) r = 86 %, 96 % bzw. 96 % Richtigkeit: bei einer Sollkonzentration von 10 μg, 100 μg bzw. 1000 μg MBT pro Liter Urin und n = 10 Bestimmungen Nachweisgrenze: 0,4 μg MBT pro Liter Urin Bestimmungsgrenze: 1,2 μg MBT pro Liter Urin 2 Allgemeine Informationen zu 2-Mercaptobenzothiazol 2‐Mercaptobenzothiazol (MBT) ist eine organische Verbindung aus der Gruppe der Heteroaromaten. Die Substanz liegt unter Normalbedingungen in Form von leicht gelblichen Kristallen vor, die in Wasser schwer löslich sind. Die industrielle Herstellung erfolgt durch Umsetzung von Anilin, Schwefelkohlenstoff und Schwefel unter Hochdruck bei hohen Temperaturen von etwa 230 °C (Greim 1999; IARC 2018). MBT wird hauptsächlich als Vulkanisationsbeschleuniger in der Reifenproduktion und der Herstellung von technischen Gummiartikeln eingesetzt. Zusätzlich kommen das Zinksalz des Mercaptobenzothiazols sowie die Sulfenamide, eine vom MBT ausgehende Verbindungsklasse, als mögliche Quelle für MBT in Frage. So ist MBT potentiell in vielen täglichen Gebrauchsgegenständen zu finden, wie z. B. in Reifen, Kabeln, Gummihandschuhen, GummiThe MAK Collection for Occupational Health and Safety 2020, Vol 5, No 3 2 Biomonitoring-Methoden – 2-Mercaptobenzothiazol in Urin bändern und -dichtungen, sowie Bohrund Schneidölen. Weiterhin","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"64 1","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76623475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}