Complex Issues of Cardiovascular Diseases最新文献

{"title":"Substantiation of protection of a neurovascular unit in the clinical model of cardiopulmonary bypass","authors":"A. Ivkin, E. V. Grigoriev, A. Morgun","doi":"10.17802/2306-1278-2022-11-4-177-183","DOIUrl":"https://doi.org/10.17802/2306-1278-2022-11-4-177-183","url":null,"abstract":"This analytical review presents data on brain injury in surgical management of congenital heart disease. A brief description of mechanisms of brain injury and methods of its prevention are given, moreover, a clinical case applying such techniques is given. The neurovascular unit in vitro model and its advantages are presented. The protocol for modelling, the further application of the model, and the prospects of using it for studying intraoperative hypoxia and systemic inflammatory response on the patient`s brain are described.","PeriodicalId":227108,"journal":{"name":"Complex Issues of Cardiovascular Diseases","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127293664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical and demographic situation in the Amur region as the basis of health preservation","authors":"A. Kalininskaya, A. Alekhnovich, M. Kizeev, A. V. Lazarev, L. Balzamova, A. A. Smirnov","doi":"10.17802/2306-1278-2022-11-4-167-176","DOIUrl":"https://doi.org/10.17802/2306-1278-2022-11-4-167-176","url":null,"abstract":"Aim. To analyze medical and demographic situation and morbidity in the population of different age groups in the Russian Federation, the Far Eastern Federal District and the Amur Region in order to develop management decisions for the health protection of the population at the regional levels.Methods. Statistical and analytical analysis were conducted. The reports of the Ministry of Health of the Russian Federation and Federal State Statistics Services were used as the material.Results. The mortality rates in the population of the Amur Region are higher than in the Far Eastern Federal District and in the Russian Federation for all years of analysis (2016–2020) and have amounted to 16.2 in 2020; 13.9; 14.6 per 1000 population respectively. In the Amur Region, mortality from injuries, poisoning and some other consequences of external causes is 2 times higher than in the Russian Federation; from diseases of the digestive system 1.6 times higher, from diseases of the respiratory system 1.5 times higher. Mortality from COVID-19 in the Amur Region is 84.3‰00, which is lower than in the Russian Federation (98.8). There is a higher rate of general morbidity in the Amur Region (2020, 162484.1 per 100 thousand population) compared to the Russian Federation (156111.4), and to the Far Eastern Federal District (146365.3), respectively. A significantly high incidence of diseases of the digestive system (16871.3‰00), compared to the Russian Federation (10092.1), and the Far Eastern Federal District (11230.8) has been noted. The incidence of COVID-19 in the Amur Region have decreased from 84678.4 per 100 thousand population (2019) to 80294.8‰00 (2020), while 3141.3‰00 cases have been registered in 2020; a 2.6-fold increase in the incidence of pneumonia has been observed for the first time. At the same time, the primary incidence of circulatory system diseases has decreased by 12.1%, which is the result of lacking dispensary and preventive services associated with the pandemic. The frequency of COVID-19 in the Amur Region in 2020 is 3141.3‰00, in the Russian Federation – 3384.5, in the Far Eastern Federal District – 3394.9, respectively. Higher rates of morbidity (2020) are noted in children – 166656.9 per 100 thousand of the corresponding population compared to the adolescents – 147023.43‰00, which is significantly higher compared to the entire population – 80294.83‰00.Conclusion. The results of the study should be used by government representatives to develop managerial decisions regarding the health of the population, especially the future generation.","PeriodicalId":227108,"journal":{"name":"Complex Issues of Cardiovascular Diseases","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125951095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous non-invasive stimulation: possibilities and prospects of the method in the practice of specialists in internal diseases","authors":"O. Drapkina, O. Dzhioeva, E. A. Rogozhkina, E. N. Shvarts, A. R. Kiselev","doi":"10.17802/2306-1278-2022-11-4-191-200","DOIUrl":"https://doi.org/10.17802/2306-1278-2022-11-4-191-200","url":null,"abstract":"The article provides an overview of key studies on vagus nerve stimulation. The vagus nerve stimulation method affects the nerve fibers of the internal and external nerve plexuses, enhancing the parasympathetic effect. The positive therapeutic effect has been achieved in various experimental and clinical studies on the treatment of neurological and cardiac diseases, metabolic syndrome, and obesity. It has been shown that vagus nerve stimulation reduces epileptic seizures frequency, cardiac arrhythmias, and is prognostically favorable for the treatment of ischemia and reperfusion injury of the myocardium. Recent studies have examined the inflammatory reflex involved in the pathogenesis of obesity. The role of bioelectronic vagus nerve stimulation is being actively investigated for the treatment of obesity and metabolic syndrome.","PeriodicalId":227108,"journal":{"name":"Complex Issues of Cardiovascular Diseases","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117182357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotype of patients with pulmonary hypertension due to left heart disease: features of pathophysiology and differential diagnosis","authors":"I. N. Lyapina, Yu. E. Teplova, T. Martynyuk","doi":"10.17802/2306-1278-2022-11-4-118-129","DOIUrl":"https://doi.org/10.17802/2306-1278-2022-11-4-118-129","url":null,"abstract":"The cohort of patients with postcapillary pulmonary hypertension (PH), associated with the left heart diseases, is the most numerous, but is still not fully understood. This review presents the pathophysiological aspects of the PH group 2 development as well as the influence of comorbid pathology on the course of the PH. The features of the differential diagnosis of post-capillary PH and combined post-/ precapillary PH, as well as methods of the differential diagnosis of these forms of PH with pulmonary arterial hypertension using modern non-invasive and invasive approaches are discussed.","PeriodicalId":227108,"journal":{"name":"Complex Issues of Cardiovascular Diseases","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126282567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implantable cardioverter-defibrillators for primary and secondary prevention of sudden cardiac death in clinical practice: analysis of the clinical and anamnestic characteristics of patients according to the Kuzbass registry","authors":"N. Lebedeva, I. W. Talibullin, P. G. Parfenov, S. Mamchur, O. Barbarash","doi":"10.17802/2306-1278-2022-11-4-139-150","DOIUrl":"https://doi.org/10.17802/2306-1278-2022-11-4-139-150","url":null,"abstract":"Aim. To study clinical and anamnestic data of patients with implantable cardioverterdefibrillators (ICD) for primary or secondary prevention of sudden cardiac death (SCD) based on the data from the Kuzbass ICD registry.Methods. Retrospective analysis of demographic, clinical and anamnestic data from the “Kuzbass Registry of Patients with Implanted Cardioverter-Defibrillator”, which includes 286 patients admitted at the Kuzbass Cardiology Center in 2015–2019, was carried out.Results. The age of patients included in the registry was 59 (53; 66) years, 239 (83.6%) were men; all patients were diagnosed with heart failure. ICD for primary prevention of SCD was prescribed in 171 (63.6%) patients (group 1) and for secondary prevention in 98 (36.4%) patients (group 2). The groups were comparable in age, sex, main nosology (coronary artery disease), left ventricular ejection fraction (31.4 (26; 35) and 30 (10; 68)%, p = 0.389). Compared with the group 2, the group 1 had fewer working patients, higher incidence of heart defects, severe heart failure, higher incidence of paroxysmal supraventricular tachycardia (68.7% versus 44.8%, p = 0.001), and higher rates of revascularization (48, 9% and 31.7%, respectively, p = 0.006). Before ICD implantation for heart failure, 210 (73.4%) patients were receiving renin angiotensin aldosterone system inhibitors, 259 (90.6%) – beta-blockers, 167 (58.4%) – mineralocorticoid receptor antagonists. There were no differences in prescribed treatment between the groups. Only 137 (47.9%) patients, 86 (47.3%) patients in the group 1 and 51 (49.0%) patients in the group 2 received triple neurohormonal blockade. Remote monitoring was used only within the framework of research programs.Conclusion. The primary cohort of patients with ICD is the primary SCD prevention group. Regardless of the type of SCD prevention, the underlying disease is coronary artery disease. Current guidelines for optimal drug therapy and myocardial revascularization are not always followed prior to ICD implantation. The creation of registries of patients with ICD is an effective way to identify existing problems in ICD patient selection and to optimize follow-up and treatment.","PeriodicalId":227108,"journal":{"name":"Complex Issues of Cardiovascular Diseases","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132530545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roleofoxytocinin the protective function of the cardiovascular system","authors":"O. V. Borovleva, D. Kaskayeva, M. M. Petrova, O. Lopatina, A. V. Borovleva","doi":"10.17802/2306-1278-2022-11-4-130-138","DOIUrl":"https://doi.org/10.17802/2306-1278-2022-11-4-130-138","url":null,"abstract":"Oxytocin is synthesized in endothelial cells of the cardiovascular system and exerts its effects by oxytocin receptors. The effect of oxytocin on vascular tone, blood pressure, vascular growth and remodeling, as well as participation in cardiovascular regulation has been proven. The positive effect of oxytocin on infarct size and recovery of contractile function in reperfusion is well studied. It should be noted that the mechanisms of this cardioprotective effect have not yet been studied. Research evidence suggests that oxytocin therapy significantly improves cardiac function, reduces inflammation and apoptosis, and improves scar vascularization. Oxytocin stimulates the transformation of stem cells into clones of cardiomyocytes. Oxytocin promotes angiogenesis by stimulating the formation of endothelial and smooth muscle cells. Increased consumption of glucose by cardiomyocytes, inhibition of cardiomyocyte hypertrophy, and a decrease in oxidative stress are the reasons for the positive effects of oxytocin. Oxytocin reduces inflammation, improves cardiovascular and metabolic function. This is the manifestation of the cardioprotective effect of oxytocin. Potential treatment of cardiovascular diseases with oxytocin is possible due to the pleiotropic nature of oxytocin effects. This review indicates the likely mechanisms of oxytocin action at the cellular level that are involved in cardioprotection.","PeriodicalId":227108,"journal":{"name":"Complex Issues of Cardiovascular Diseases","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128209949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography as a method for assessing the conduit-anastomosis-artery system in patients after coronary artery bypass grafting","authors":"N. Kochergin, N. Zagorodnikov, A. Frolov, R. Tarasov, V. Ganyukov","doi":"10.17802/2306-1278-2022-11-4-151-157","DOIUrl":"https://doi.org/10.17802/2306-1278-2022-11-4-151-157","url":null,"abstract":"Background. Coronary artery bypass grafting (CABG) remains the most common cardiac surgery in the world. In the long-term follow-up period after surgery, graft failure occurs in a substantial proportion of CABG conduits and is a complex pathomorphological process. Optical coherence tomography (OCT) is a high-resolution intravascular imaging modality that allows to assess in-vivo endothelial integrity.Aim. To substantiate the efficacy and safety of OCT assessment of the conduitanastomosis-artery system in CABG patients.Methods. The prospective observational cohort study included 21 patients with chronic coronary artery disease who underwent CABG. 3–5 days after CABG, patients underwent OCT and angiography of arterial and vein grafts, including distal anastomosis and nearby segment of the target coronary artery. At 12-month follow-up, all patients underwent repeated OCT and angiography of the conduitanastomosis-artery system to assess the changes. The primary endpoint of the study was graft failure; secondary endpoints of the study included unplanned repeat myocardial revascularization, cardiac death, and myocardial infarction due to graft failure.Results. At 12-month follow-up, 14.3% of graft failure and 9.5% of cases of unplanned repeated myocardial revascularization were registered. In most cases of graft failure, primary OCT revealed pronounced changes in the conduit and the native coronary artery (conduit/artery diameter ratio was more than 2 mm), whereas the diameter of the coronary artery anastomosis was less than 2.5 mm. Myocardial infarctions and death within 12 months were not registered.Conclusion. Thus, OCT is an effective and safe intravascular imaging technique for assessing coronary arteries and the conduit-anastomosis-artery system. OCT makes it possible to identify morphological changes in coronary bypass grafts, which can predict their early failure. The conduit/artery diameter ratio greater than 2 and target coronary artery diameter less than 2.5 mm was associated with graft failure within 12 months after CABG.","PeriodicalId":227108,"journal":{"name":"Complex Issues of Cardiovascular Diseases","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116067848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene expression of proinflammatory cytokines in human coronary artery smooth muscle cells exposed to alkylating mutagen","authors":"M. Sinitsky, A. Sinitskaya, D. Shishkova, M. Khutornaya, M. Asanov, A. Ponasenko","doi":"10.17802/2306-1278-2022-11-4-158-166","DOIUrl":"https://doi.org/10.17802/2306-1278-2022-11-4-158-166","url":null,"abstract":"Background. It is known that DNA damage in smooth muscle cells can trigger their clonal expansion and transformation into foam cells. Thus, the study of the molecular genetic mechanisms of the vascular smooth muscle cells response to genotoxic exposure is important and relevant in the context of an in-depth understanding of atherogenesis.Aim. To study mRNA level and concentration of proinflammatory cytokines IL6 and IL8 in the human coronary artery smooth muscle cells exposed to alkylating mutagen.Methods. Gene expression signature of studied cytokines in the human coronary artery smooth muscle cells was accessed by quantitative polymerase chain reaction in the two timepoints – immediately after six-hour exposure to mitomycin C (point 1) and after six-hour exposure to mitomycin C followed by 24 hours of cells being cultivated on mitomycin C-free cell growth medium (point 2). Smooth muscle cells cultured according to the above scheme without genotoxin were used as controls. HPRT1, GAPDH and B2M were used as the reference genes. Gene expression level was calculated by ΔCt method. IL6 and IL8 concentration was evaluated in the culture media in points 1 and 2 by enzyme-linked immunosorbent assay. Statistical analysis was performed in GraphPad Prism 9 software.Results. Immediately after mutagenic exposure (point 1) we discovered no significant changes in the expression level of IL6 and IL8 in the mitomycin C exposed smooth muscle cells compared to controls. Removal of mutagen increased expression of IL6 and IL8 in the experimental group (0,36- and 0,67-fold, respectively). At the same time, we discovered no significant differences in the studied cytokines concentration in the culture medium of mutagen-exposed cells compared to the nonexposed controls.Conclusion. Genotoxic stress in human coronary artery smooth muscle cells exposed to alkylating mutagen (mitomycin C) leads to differential expression but not secretion of proinflammatory cytokines IL6 and IL8. Thus, exposure of smooth muscle cells to mitomycin C do not trigger their proinflammatory phenotype. ","PeriodicalId":227108,"journal":{"name":"Complex Issues of Cardiovascular Diseases","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126793694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of shear stress on the properties of colonyforming endothelial cells in comparison with coronary artery endothelial cells","authors":"E. Velikanova, V. Matveeva, M. Khanova, L. Antonova","doi":"10.17802/2306-1278-2022-11-4-90-97","DOIUrl":"https://doi.org/10.17802/2306-1278-2022-11-4-90-97","url":null,"abstract":"Highlights. It is assumed that pre-colonization by endothelial cells of the inner surface of tissue-engineered vessels of small diameter can serve as an effective way to prevent thrombosis. The question of choosing the optimal source of endothelial cells for use in tissue engineering remains debatable. The paper considers the features of the culture of colony-forming endothelial cells obtained from the peripheral blood of patients with coronary heart disease, in comparison with mature endothelial cells from the coronary artery.Aim. To study the effect of laminar flow on the morphological and functional characteristics of mature endothelial cells and peripheral blood-derived endothelial colony-forming cells.Methods. Coronary artery endothelial cells were purchased from the Cell Applications, Inc. Colony-forming endothelial cells were obtained from the peripheral blood of patients with coronary artery disease who underwent percutaneous coronary intervention. The cells were isolated using a Ficoll gradient and cultured in EGM-2MV culture medium containing 5% fetal bovine serum. The cells of the experimental group were cultured in µ-Luer plates in a perfusion system with a shear stress of 3 dyn/cm2 . The cultivation time was 2 days. The cells of the control group were cultured under static conditions. At the end of the cultivation we performed immunofluorescent staining for CD31, KDR/CD309, CD144, vWF, type IV collagen, F-actin.Results. Colony-forming endothelial cells and coronary artery endothelial cells retained high density and viability both under static and laminar flow conditions. Shear stress stimulated a change in the phenotype of colony-forming endothelial cells towards a mature endothelial cells, in particular, a significant increased the expression of KDR/CD309 and CD31. The action of laminar flow reduced the synthesis of von Willebrand factor, stimulated the synthesis of type IV collagen. Shear stress promoted the development of structural rearrangements in cells in response to transduction, which manifested in a change in F-actin fibrils orientation on the flow direction.Conclusion. Colony-forming endothelial cells showed a characteristic response to the action of shear stress, consisting in a change in morphology, phenotype, and secretory activity of cells, comparable to that of coronary artery endothelial cells.","PeriodicalId":227108,"journal":{"name":"Complex Issues of Cardiovascular Diseases","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127266062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation of Notch signaling in endothelium cause upregulation of N-terminal acetylated histone 1","authors":"A. Lobov, D. Perepletchikova, E. Repkin, A. Malashicheva","doi":"10.17802/2306-1278-2022-11-4-98-104","DOIUrl":"https://doi.org/10.17802/2306-1278-2022-11-4-98-104","url":null,"abstract":"Highlights. Notch signaling is known to be important regulator of endothelium homeostasis and cardiovascular disease. Particularly, Notch seems to be associated with pathological changes in endothelium epigenome although no such Notch effects have been found. We have discovered that activation of Notch signaling alters histone 1 repertoire in the human endothelial cells and this is the first example of epigenomic Notch targets.Aim. The disturbance of blood flow and alteration of physiological shear stress is one of the main reasons for endothelial dysfunction. Mechanosensitive and dosedependent Notch pathway is assumed to be an important player of endothelial dysfunction progression, but the molecular mechanisms of the influence of Notch dysregulation on endothelium are still not understood. In particular, there is no data about possible targets of Notch in the endothelial epigenome.Methods. Here we focused on the analysis of changes in histone code of human umbilical vein endothelial cells (HUVEC) after activation of Notch. For this purpose, we transduced cells by lentiviruses with construction for Notch 1 intracellular domain (N1ICD) overexpression or by empty vector (control). Then we isolated histone enriched fraction and secretome proteins and performed their shotgun proteomics analysis on timsToF Pro instrument. Proteomics data are available via ProteomeXchange with identifier PXD032978.Results. We found the shift in proteomics profile of HUVEC caused by Notch activation and, particularly, the increase in the levels of N-terminal acetylated forms of histone 1: H1-0, H1-3, H1-4, H1-5, H1-10. We also found changes in the cell secretome profile which are associated with the decrease in proangiogenic effect of HUVEC secretome.Conclusion. Our data identified epigenomic Notch targets and we assume that changes in H1 repertoire might be associated with cardiovascular disease progression in vivo.","PeriodicalId":227108,"journal":{"name":"Complex Issues of Cardiovascular Diseases","volume":"141 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128186055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}