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Rapid Screening of Blood Mitochondrial D310 and D315 Mutations in Breast Cancer Patients 乳腺癌患者血线粒体D310和D315突变的快速筛选
The Journal of Cancer Research Pub Date : 2020-05-17 DOI: 10.12691/JCRT-8-1-1
F. Akter, S. H. Israfil, Mohammad Ali, A. Rouf, M. Alam, M. Rahman, G. Sultana
{"title":"Rapid Screening of Blood Mitochondrial D310 and D315 Mutations in Breast Cancer Patients","authors":"F. Akter, S. H. Israfil, Mohammad Ali, A. Rouf, M. Alam, M. Rahman, G. Sultana","doi":"10.12691/JCRT-8-1-1","DOIUrl":"https://doi.org/10.12691/JCRT-8-1-1","url":null,"abstract":"Aims: 'Poly C' stretch extending from 303 to 315 nucleotide positions known as (D310) by GeneBank within the non-coding region HVR-II of mitochondrial DNA (mtDNA) has been identified as a mutational hotspot of primary cancer. We aimed to find this mutation in Bangladeshi breast cancer patients and control samples for screening the changes in poly C stretches. Materials and Methods: We have analyzed a total of 98 breast cancer blood samples and 98 healthy control blood samples and extracted DNA from blood samples for direct sequencing using ABI®3130 Genetic Analyzer. Results: We observed 70.41% C insertion at 310 regions (P<0.001, OR = 16.30 and 95% CI=7.83-33.93) in breast cancer patient whereas it is present only in 12.24% healthy individuals. No alterations were observed in 29.59% breast cancer samples. We also check the mutation pattern at D315 regions, but no significant observation was found (P=1.00). Conclusions: This is the first study from Bangladeshi breast cancer (BC) patients indicating a relatively high frequency of D310 mutations, which suggests that mtDNA instability at D310 may be a common characteristic of BC, study also supports the hypothesis that mtDNA D310 screening may represent additional blood based biomarker for breast cancer prognosis.","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"37 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2020-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81084344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discussion on the Application Value of Coagulation and Blood Lipid in Endometrial Carcinoma 凝血和血脂在子宫内膜癌中的应用价值探讨
The Journal of Cancer Research Pub Date : 2020-05-11 DOI: 10.12677/wjcr.2020.103008
李苗皊, 阿吉古丽·麦麦提敏, 阿比达·阿布都卡德尔
{"title":"Discussion on the Application Value of Coagulation and Blood Lipid in Endometrial Carcinoma","authors":"李苗皊, 阿吉古丽·麦麦提敏, 阿比达·阿布都卡德尔","doi":"10.12677/wjcr.2020.103008","DOIUrl":"https://doi.org/10.12677/wjcr.2020.103008","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"284 1","pages":"53-58"},"PeriodicalIF":0.0,"publicationDate":"2020-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73050532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research Progress of Ultra-High Dose Rate Radiotherapy (FLASH-RT) 超高剂量率放射治疗(FLASH-RT)研究进展
The Journal of Cancer Research Pub Date : 2020-03-27 DOI: 10.12677/wjcr.2020.102006
奇贤 张
{"title":"Research Progress of Ultra-High Dose Rate Radiotherapy (FLASH-RT)","authors":"奇贤 张","doi":"10.12677/wjcr.2020.102006","DOIUrl":"https://doi.org/10.12677/wjcr.2020.102006","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"54 1","pages":"41-46"},"PeriodicalIF":0.0,"publicationDate":"2020-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73490394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adenoid Cystic Carcinoma-Symptoms, Diagnosis and Treatment 腺样囊性癌的症状、诊断和治疗
The Journal of Cancer Research Pub Date : 2020-01-01 DOI: 10.35248/2684-1266.20.6.126
S. Vale
{"title":"Adenoid Cystic Carcinoma-Symptoms, Diagnosis and Treatment","authors":"S. Vale","doi":"10.35248/2684-1266.20.6.126","DOIUrl":"https://doi.org/10.35248/2684-1266.20.6.126","url":null,"abstract":"Adenoid cystic carcinoma is a rare form of adenocarcinoma, which is a type of cancer. It can exist in many different body sites and most often occurs in the areas of the head and neck in particular the salivary glands. Adenoid cystic carcinoma has also been reported in the breast, lacrimal gland of the eye, lung, brain, bartholin gland, and trachea. Here symptoms, diagnosis and treatment of Adenoid Cystic Carcinoma (AdCC) are discussed.","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"4 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79196500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Open the Therapeutic Revolution Door of Antiviral Antitumor with Improving Body Systemic Nonspecific Immunity 提高机体非特异性免疫，开启抗病毒抗肿瘤治疗革命之门
The Journal of Cancer Research Pub Date : 2020-01-01 DOI: 10.12677/wjcr.2020.104010
林 海祥
{"title":"Open the Therapeutic Revolution Door of Antiviral Antitumor with Improving Body Systemic Nonspecific Immunity","authors":"林 海祥","doi":"10.12677/wjcr.2020.104010","DOIUrl":"https://doi.org/10.12677/wjcr.2020.104010","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"18 1","pages":"65-77"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85602550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invasive Lobular Carcinoma (ILC): Symptoms, Diagnosis and Treatment 浸润性小叶癌(ILC):症状、诊断和治疗
The Journal of Cancer Research Pub Date : 2020-01-01 DOI: 10.35248/2684-1266.20.6.127
A. Purkayastha
{"title":"Invasive Lobular Carcinoma (ILC): Symptoms, Diagnosis and Treatment","authors":"A. Purkayastha","doi":"10.35248/2684-1266.20.6.127","DOIUrl":"https://doi.org/10.35248/2684-1266.20.6.127","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"82 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84008733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do the Canadian Triage Guidelines Identify the Urgency of Oncological Emergencies 加拿大分诊指南是否确定肿瘤紧急情况的紧迫性
The Journal of Cancer Research Pub Date : 2020-01-01 DOI: 10.35248/2684-1266.20.6.121
Anas Alsharawneh, Joy Maddigan
{"title":"Do the Canadian Triage Guidelines Identify the Urgency of Oncological Emergencies","authors":"Anas Alsharawneh, Joy Maddigan","doi":"10.35248/2684-1266.20.6.121","DOIUrl":"https://doi.org/10.35248/2684-1266.20.6.121","url":null,"abstract":"Background: Triage in an emergency department (ED) plays a pivotal role as the volume of ED visitors is unpredictable. All ED patients are triaged to make sure that patients with urgent or life-threatening conditions are seen immediately while others with more stable conditions are safe to wait. Purpose: To examine the Canadian Triage and Acuity Scale (CTAS) guidelines to determine if the urgency of oncological emergencies can be prioritized appropriately using the CTAS guidelines. Methods: We used the Complaint Oriented Triage (COT 2012), which is an interactive computerized CTAS tool, to triage select oncological emergencies; superior vena cava syndrome, cardiac tamponade, tumor lysis syndrome, and febrile neutropenia. Results: Patients with cancer have a higher acuity compared to many other ED patients. However, most of the oncological emergencies can be subtle and nonspecific. The CTAS guidelines need to be strengthened to better represent the urgency of these life-threatening conditions. Conclusion: Although revisions have been implemented and the reliability of the CTAS tool has improved, the guidelines are designed to be generic and cannot address every health situation. Febrile neutropenia is an excellent example of the additional supports needed at triage to accurately determine the patient’s health status. Knowledge of the signs and symptoms of these emergencies will enable triage nurses to accurately differentiate the urgency of the different presenting complaints. Formalized education that prepares triage nurses to better understand the complexity of the symptom presentation and the needed care for patients with different oncological emergencies is essential.","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"3 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83399085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Clinical Indication Analysis of Avoiding Chest Tube Placement after Lobectomia Pulmonalis 肺叶切除后避免置管的临床指征分析
The Journal of Cancer Research Pub Date : 2020-01-01 DOI: 10.12677/wjcr.2020.103009
王 炯杰
{"title":"Clinical Indication Analysis of Avoiding Chest Tube Placement after Lobectomia Pulmonalis","authors":"王 炯杰","doi":"10.12677/wjcr.2020.103009","DOIUrl":"https://doi.org/10.12677/wjcr.2020.103009","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"99 ","pages":"59-63"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91444397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Value of DNA Ploidy Analysis in the Diagnosis of Bronchial Malignancy DNA倍体分析在支气管恶性肿瘤诊断中的临床价值
The Journal of Cancer Research Pub Date : 2020-01-01 DOI: 10.12677/wjcr.2020.102007
维军 柳
{"title":"Clinical Value of DNA Ploidy Analysis in the Diagnosis of Bronchial Malignancy","authors":"维军 柳","doi":"10.12677/wjcr.2020.102007","DOIUrl":"https://doi.org/10.12677/wjcr.2020.102007","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"38 1","pages":"47-51"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91392161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Latest updates in Cancer and Immuno-oncology 癌症和免疫肿瘤学的最新进展
The Journal of Cancer Research Pub Date : 2020-01-01 DOI: 10.35248/2684-1266.20.6.E104
Xiaowei Liu
{"title":"Latest updates in Cancer and Immuno-oncology","authors":"Xiaowei Liu","doi":"10.35248/2684-1266.20.6.E104","DOIUrl":"https://doi.org/10.35248/2684-1266.20.6.E104","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"6 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74380016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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