The Japanese journal of surgery最新文献_第2页

The clinical pharmacokinetics of two different preparations of intrarectal ketoprofen following spinal or local anesthesia for anal surgery. 两种不同制剂的直肠内酮洛芬在脊柱或局部麻醉下用于肛门手术的临床药代动力学。

The Japanese journal of surgery Pub Date : 1991-11-01 DOI: 10.1007/BF02471046

K Tazawa, S Takemori, S Hirokawa, K Yamamoto, S Katsuki, H Arai, T Kasagi, S Katsuyama, M Fujimaki

{"title":"The clinical pharmacokinetics of two different preparations of intrarectal ketoprofen following spinal or local anesthesia for anal surgery.","authors":"K Tazawa, S Takemori, S Hirokawa, K Yamamoto, S Katsuki, H Arai, T Kasagi, S Katsuyama, M Fujimaki","doi":"10.1007/BF02471046","DOIUrl":"https://doi.org/10.1007/BF02471046","url":null,"abstract":"Two different preparations of commercially available suppositories containing Ketoprofen (KP) were administered to 49 patients immediately following anal surgery. The KP was prepared as either fatty suppositories (FS) or gelatin capsulated suppositories (GCS) and surgery was performed under either spinal (n = 37) or local anesthesia (n = 12). Similar results were observed in the kinetics of KP after both FS and GCS administration. The extent of bioavailability of the two dosage forms in the patient groups and control subjects (n = 10) were essentially equal. When the pharmacokinetic parameters of KP were compared between patient groups under spinal and local anesthesia, significant differences were found in the values of the peak level (C max), peak time (T max), and terminal phase half-life (t 1/2). The C max decreased by one-half, while the T max and t 1/2 increased twice and four times, respectively, in patient operated on under spinal anesthesia compared to those operated on under local anesthesia. The absorption rate constant (Ka) following spinal anesthesia was significantly less than that following local anesthesia or that of the healthy subjects (p less than 0.01). A \"flip-flop\" phenomena could be seen in the time profiles of plasma KP concentration following spinal anesthesia.","PeriodicalId":22610,"journal":{"name":"The Japanese journal of surgery","volume":"21 6","pages":"621-6"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02471046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12949997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clinical experience of emergency coronary artery bypass grafting following failed percutaneous transluminal coronary angioplasty. 经皮冠状动脉成形术失败后急诊冠状动脉搭桥术的临床体会。

The Japanese journal of surgery Pub Date : 1991-11-01 DOI: 10.1007/BF02471049

Y Kioka, L Dallan, S Oliveira, A Jatene

{"title":"Clinical experience of emergency coronary artery bypass grafting following failed percutaneous transluminal coronary angioplasty.","authors":"Y Kioka, L Dallan, S Oliveira, A Jatene","doi":"10.1007/BF02471049","DOIUrl":"https://doi.org/10.1007/BF02471049","url":null,"abstract":"From July, 1981 to December, 1988, 2431 percutaneous transluminal coronary angioplasties were performed on 1901 patients at the Heart Institute of São Paulo University Medical School. Seventy-six patients (4.0 per cent) underwent emergency coronary artery bypass grafting for failed angioplasty. The incidence of failed angioplasty was significantly higher in the impending myocardial infarction group (11.5 per cent) than in the angina group (4.8 per cent) and the acute myocardial infarction group (1.3 per cent). The mean age of the seventy-six patients was 54.4 years, and 54 patients were male. The operative mortality was 15.8 per cent, being 9 males and 3 females. Patients who had had a left main trunk dissection during angioplasty and those who were hemodynamically unstable following the failed angioplasty or who had had a cardiac arrest necessitating a cardiac massage during transportation to the operating room, had a higher mortality than patients in whom the failure occurred in other sites and those who were hemodynamically stable. Perioperative myocardial infarction was documented in 50 per cent of the patients. Patients who had had a cardiac arrest during the procedure had a higher rate of perioperative myocardial infarction than those whose preoperative hemodynamic condition was stable.","PeriodicalId":22610,"journal":{"name":"The Japanese journal of surgery","volume":"21 6","pages":"643-9"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02471049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12949999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The bacteriology of cholelithiasis--China versus Japan. 胆石症的细菌学研究——中国与日本。

The Japanese journal of surgery Pub Date : 1991-11-01 DOI: 10.1007/BF02471044

R X Guo, S G He, K Shen

{"title":"The bacteriology of cholelithiasis--China versus Japan.","authors":"R X Guo, S G He, K Shen","doi":"10.1007/BF02471044","DOIUrl":"https://doi.org/10.1007/BF02471044","url":null,"abstract":"Cholelithiasis differs considerably from area to area in the world. Calcium bilirubinate stones or brown pigment stones are said to predominate in the Orient, however, this situation may differ within the Orient. In order to compare cases in China and Japan, 102 consecutive cases of cholelithiasis operated on in Shenyang, China were analyzed for the composition of gallstones and bacterial species isolated from bile in relation to the location and composition of gallstones. In Shenyang, calcium bilirubinate stones predominated, occurring in 49.0 per cent of the cholelithiasis cases. This was much higher than in Japan, which had 17.5 per cent. The incidence of bacteria was also very high, ranging from 20 to 96 per cent, with an average of 66.7 per cent depending on the kind of gallstone present. Bacterial species possessing beta-glucuronidase activity were present in nearly all the cases of calcium bilirubinate stones (92.0 per cent). The incidence of bacteria with beta-glucuronidase activity especially of E. coli was much higher than in Japan (50.8 per cent versus 21.8 per cent) in concordance with the higher incidence of calcium bilirubinate stones in China (49.0 versus 17.5 per cent).","PeriodicalId":22610,"journal":{"name":"The Japanese journal of surgery","volume":"21 6","pages":"606-12"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02471044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12949996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Resection and double ileostomy as an alternative approach for superior mesenteric venous thrombosis in poor risk patients: a case report. 切除和双回肠造口术作为治疗低危患者肠系膜上静脉血栓形成的替代方法:1例报告。

The Japanese journal of surgery Pub Date : 1991-11-01 DOI: 10.1007/BF02471061

T Fujita, M Ito, H Fukunari, K Kitago, K Tsukada, Y Mishima

引用次数: 2

The problems encountered in the surgical management of primary hyperparathyroidism. 原发性甲状旁腺功能亢进手术治疗中遇到的问题。

The Japanese journal of surgery Pub Date : 1991-11-01 DOI: 10.1007/BF02471051

S Kobayashi, A Sugenoya, Y Kasuga, H Masuda, M Fujimori, M Komatsu, S Takahashi, T Shimizu, S Yokoyama, F Iida

引用次数: 0

Dysphagia resulting from an upper esophageal web--a case report. 食管上网引起的吞咽困难1例报告。

The Japanese journal of surgery Pub Date : 1991-11-01 DOI: 10.1007/BF02471054

R Nakamura, M Watanabe, M Terashima, K Saito, T Iwasaki

引用次数: 0

Neoadjuvant chemotherapy with cyclophosphamide, doxorubicin and 5-fluorouracil (CAF) or cyclophosphamide, methotrexate and 5-fluorouracil (CMF) in 69 cases of locally advanced (stage IIIb) breast cancer. 环磷酰胺、阿霉素和5-氟尿嘧啶(CAF)或环磷酰胺、甲氨蝶呤和5-氟尿嘧啶(CMF)联合新辅助化疗治疗局部晚期(IIIb期)乳腺癌69例

The Japanese journal of surgery Pub Date : 1991-11-01 DOI: 10.1007/BF02471048

P Gupta, L Bijlani, G K Rath, A Misra, M C Mishra, N K Shukla, A Kriplani, B M Kapur

{"title":"Neoadjuvant chemotherapy with cyclophosphamide, doxorubicin and 5-fluorouracil (CAF) or cyclophosphamide, methotrexate and 5-fluorouracil (CMF) in 69 cases of locally advanced (stage IIIb) breast cancer.","authors":"P Gupta, L Bijlani, G K Rath, A Misra, M C Mishra, N K Shukla, A Kriplani, B M Kapur","doi":"10.1007/BF02471048","DOIUrl":"https://doi.org/10.1007/BF02471048","url":null,"abstract":"Sixty nine patients with a median age of 45 years, 62.3 per cent of whom were premenopausal, with locally advanced breast cancer (T 4, N 0-3, M 0; Stage IIIb) were treated with 3 cycles of either neoadjuvant cyclophosphamide, doxorubicin and 5-fluorouracil, being the CAF group: 36 patients, or cyclophosphamide, methotrexate and 5-fluorouracil, being the CMF group: 33 patients. Patients achieving complete response or with residual disease of less than 2 cm in diameter received radical radiotherapy while those with more residual disease underwent radical mastectomy. Nine cycles of adjuvant chemotherapy were administered. Complete responses and disease control by radiotherapy with complete breast preservation were more frequently observed after CAF than CMF, being 25 per cent vs 3 per cent (p = 0.025) and 48.5 per cent vs 12 per cent (p = 0.002), respectively. Overall response rates, adverse effects, disease control following radiotherapy/surgery, local relapses and metastases were similar for both regimes. Relapsing patients were young, with a median age of 38 years, 68.4 per cent of relapses occurred at metastatic sites and 42 per cent of relapses occurred during adjuvant chemotherapy. This study suggests that in locally advanced breast cancer, a greater proportion of patients can be rendered disease free after neoadjuvant CAF and radiotherapy compared to neoadjuvant CMF and radiotherapy.","PeriodicalId":22610,"journal":{"name":"The Japanese journal of surgery","volume":"21 6","pages":"637-42"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02471048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12949998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pharyngoesophageal bypass using a free jejunal graft for corrosive stricture--a case report. 利用游离空肠移植术治疗腐蚀性狭窄咽食管绕道1例。

The Japanese journal of surgery Pub Date : 1991-11-01 DOI: 10.1007/BF02471055

H Fujita, Y Inoue, T Kakegawa, H Yamana, Y Tai, M Hirano

引用次数: 3

Experimental studies on the prediction and prevention of stress ulcers using tonometry, reflectance spectrophotometry and oxygenated perfluorochemicals. 利用血压计、反射分光光度法和含氧全氟化学品预测和预防应激性溃疡的实验研究。

The Japanese journal of surgery Pub Date : 1991-11-01 DOI: 10.1007/BF02471052

A F Matin, S Baba, N A Choudhury

{"title":"Experimental studies on the prediction and prevention of stress ulcers using tonometry, reflectance spectrophotometry and oxygenated perfluorochemicals.","authors":"A F Matin, S Baba, N A Choudhury","doi":"10.1007/BF02471052","DOIUrl":"https://doi.org/10.1007/BF02471052","url":null,"abstract":"The present study investigates whether oxygenated perfluorochemicals protect the gastric mucosa against hemorrhage-induced stress ulceration. The influence of oxygenated perfluorochemicals on both macroscopic and microscopic lesion formation, gastric intramural pH, index of oxygen saturation and index of hemoglobin saturation of the gastric mucosa was studied. To assess the severity of gastric mucosal ischemia, intramural pH was directly measured using a pH sensitive microelectrode and indirectly by utilizing hollow viscus tonometry, and the indices of oxygen saturation and hemoglobin saturation were measured by reflectance spectrophotometry. Oxygenated perfluorochemicals (30 ml/kg/h) significantly protected the gastric mucosa against both gross (lesion index 0.85 +/- 0.2 vs 2.23 +/- 0.31) and microscopic (lesion index 0.52 +/- 0.02 vs 2.04 +/- 0.03) injuries. This protection was associated with a significantly decreased acidification of the mucosa during shock (intramural pH 7.24 +/- 0.02 vs 6.97 +/- 0.02) and significantly increased oxygen saturation of the gastric mucosa (30 +/- 6 vs 5 +/- 2). These data indicate that topical oxygenated perfluorochemicals protect the gastric mucosa against mucosal damage provoked by hemorrhagic shock, and this protection seems to be mediated by an increased oxygen saturation of the gastric mucosa. Tonometry and reflectance spectrophotometry thus are able to predict the critical level of gastric mucosal ischemia.","PeriodicalId":22610,"journal":{"name":"The Japanese journal of surgery","volume":"21 6","pages":"661-8"},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02471052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12949934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Omental bleeding with spontaneously derotated torsion--a case report. 网膜出血伴自发性扭转1例报告。

The Japanese journal of surgery Pub Date : 1991-11-01 DOI: 10.1007/BF02471059

Z Nihei, K Kojima, K Uehara, S Sawai, M Kakihana, R Hirayama, Y Mishima

引用次数: 23