{"title":"Immune Checkpoint Myocarditis from Adjuvant Treatment of Melanoma","authors":"J. Dasher, Lavanya Kondapalli, C. Lenneman","doi":"10.31487/J.GCCR.2020.01.05","DOIUrl":"https://doi.org/10.31487/J.GCCR.2020.01.05","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) are effective therapy for many metastatic cancers and are now being\u0000used as adjuvant treatment for many stage III cancers to reduce the high risk of reoccurrence. ICIs activate\u0000a patient’s own T-cells to fight cancer, but in some cases, immune-related adverse events (irAEs) with\u0000inflammation of many organs can occur. Rare cases of myocarditis have been reported. More data is needed\u0000to improve our ability to monitor, diagnose and treat irAEs.\u0000","PeriodicalId":225479,"journal":{"name":"Global Clinical Case Reports","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125148495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of Rehabilitation in Peripheral Paralysis of the Facial Nerve: A Case Report of a Patient Treated with a Neuro-Cognitive Approach","authors":"M. Ciriello, M. Calabrese","doi":"10.31487/j.gccr.2020.01.02","DOIUrl":"https://doi.org/10.31487/j.gccr.2020.01.02","url":null,"abstract":"Peripheral paralysis of the facial nerve is a pathology that, although not involves any risks for the patient's\u0000life, significantly affects not only motor, but also communicative, psychological, and social aspects, having\u0000an important impact on the quality of life. The most widely used therapeutic proposals do not always respond\u0000to the need to intervene on all the functional components related to the facial nerve, but to prevent and treat\u0000complications. The neuro-cognitive proposal, although not found in the literature or in the biomedical\u0000databases, takes into account the motor, communicative, verbal and non-verbal functions related to facial\u0000mimic, as well as the cognitive-exploratory function of some districts of the face and intervenes following\u0000the phases of nervous recovery limiting an abnormal reinnervation. The case reported concerns a patient\u0000with a paralysis caused by surgical removal of acoustic neuroma (vestibular schwannoma), with grade III\u0000on the House-Brackmann scale, seems to be an example of how an approach of this type is constructed in\u0000such a way as to follow the various phases of recovery of the peripheral nerve injury, promoting the recovery\u0000of the various functions related to the facial. The patient evaluated with the Sunnybrook Facial Grading\u0000System (SFGS) went from 21/100 to 92/100 and did not develop synkinesias after about 5 months of\u0000treatment. The neuro-cognitive approach would seem to progressively improve the quality of movement.\u0000Moreover, being selective with respect to muscle recruitment and inserted in a functional perspective that\u0000respects recovery times, it would seem to limit the appearance of pathological sequelae such as synkinesias\u0000and spasms.","PeriodicalId":225479,"journal":{"name":"Global Clinical Case Reports","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116044850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Kinking of Disposable Fiberoptic Bronchoscope During Difficult Nasal Awake Intubation","authors":"L. Bordenave, C. Motamed, M. Abdellaoui","doi":"10.31487/j.gccr.2019.01.03","DOIUrl":"https://doi.org/10.31487/j.gccr.2019.01.03","url":null,"abstract":"Background: disposable fiberoptic for intubation are more and more available in operating room We hereby\u0000report a complication of a difficult fiberoptic intubation performed with a disposable fiberscope.\u0000Case: Under remifentanil sedation Visualizing the glottis was easy while advancing the endotracheal tube\u0000through the fiberscope was mildly difficult. Removing the fiberscope was impossible as was the removal of\u0000the endotracheal tube. The patient was becoming uncomfortable. Under local anesthesia we performed a jet\u0000ventilation after puncture of the cricothyroid membrane followed by total intravenous anesthesia. A\u0000cervicofacial surgeon visualized the kinking of the fiberscope at the tip of the endotracheal tube. The\u0000fiberscope was removed under direct vision with a rigid bronchoscope.\u0000Conclusion: Because of more flexibility disposable fiberscopes may kink during the introduction of the\u0000endotracheal tube.\u0000","PeriodicalId":225479,"journal":{"name":"Global Clinical Case Reports","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115892384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synchronous Bilateral Breast Cancer: Implications for Adjuvant Radiation","authors":"N. Gerber, S. Nguy","doi":"10.31487/j.gccr.2019.01.04","DOIUrl":"https://doi.org/10.31487/j.gccr.2019.01.04","url":null,"abstract":"We present the case of a 55-year old postmenopausal female with bilateral early stage clinically node negative breast cancer who was treated with bilateral lumpectomy with axillary lymph node dissection revealing N1a nodal disease in her right breast with extra-nodal extension and micrometastatic disease in her left breast. Given the controversy in management for low nodal burden for macroscopic and microscopic nodal disease, we review the key trials in regional nodal management that have included patients with low nodal burden to explain our reasoning for treatment decisions. Our patient was treated with both hypofractionation and conventional treatment. She is an excellent teaching case to demonstrate how much of an impact the decision regarding fractionation can have on long term breast cosmesis and toxicity.","PeriodicalId":225479,"journal":{"name":"Global Clinical Case Reports","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121827887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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