The Cardiology最新文献_第5页

Still seeking the missing patients with familial hypercholesterolemia 仍在寻找失踪的家族性高胆固醇血症患者

The Cardiology Pub Date : 2018-09-19 DOI: 10.15761/jccr.1000101

D. Ansell

引用次数: 0

The mystery of a deadly recurrent constrictive pericarditis: TB or not TB? 致命复发性缩窄性心包炎之谜:结核还是非结核?

The Cardiology Pub Date : 2017-01-01 DOI: 10.35841/CARDIOLOGY.1.2.31-33

K. Mezue, Seyedhesamaldin Mostafavitoroghi, Pradhum Ram, ParasuramKrishnamoorthy, Majorie Stanek, Edwin Tulloch-Reid, E. Madu

引用次数: 1

It?s time to focus on decreasing cardiovascular mortality in NAFLDpopulation: potential use of statins and PCSK9 inhibitors. 它吗?是时候关注降低nafld人群心血管死亡率了:他汀类药物和PCSK9抑制剂的潜在应用。

The Cardiology Pub Date : 2017-01-01 DOI: 10.35841/CARDIOLOGY.1.2.55-59

Tarek Ajam, Anuj Chhaparia, Z. Oman, A. Mehdirad

引用次数: 2

Modern immunosuppressive agents after heart transplantation 心脏移植后的现代免疫抑制剂

The Cardiology Pub Date : 2017-01-01 DOI: 10.35841/cardiology.1.2.39-46

MaraviÄ-StojkoviÄ Vera, S. Branislav, PeriÄ Miodrag

{"title":"Modern immunosuppressive agents after heart transplantation","authors":"MaraviÄ-StojkoviÄ Vera, S. Branislav, PeriÄ Miodrag","doi":"10.35841/cardiology.1.2.39-46","DOIUrl":"https://doi.org/10.35841/cardiology.1.2.39-46","url":null,"abstract":"The purpose of this article is to give an insight into current trends of immunosuppression in heart transplantation. Presently available classes of drugs: steroids, antimetabolites, polyclonal and monoclonal antibodies, calcineurin inhibitors, proliferation signal inhibitors have been described closely. These drugs are in use either in a prophylactic manner or as the part of the maintenance immunosuppressive regimen. Induction therapy provides immune suppression as key point to induce graft tolerance. The backbone of immunosuppression in organ transplant recipient: cyclosporine A and tacrolimus have been widely used as maintenance therapy in combination with adjunctive immunosuppressant. We also mentioned the immunosuppressive agents in development: lymphocyte modulation therapy, tolerance induction drugs, gene therapy possibilities and xenotransplantation as option to overcome the organ shortage. After heart transplantation immunosuppressive medications are used to reduce the risk of donor`s organ rejection. The focus is to prevent graft rejection, since host immune system is programmed to attack foreign antigens which could cause injuries and lifethreatening conditions. The possibility of rejection is everlasting, which inevitably demands the use of immunosuppressive drugs and raise the risk of unwanted side effects. Post-operative complications include hyper acute, acute or chronic rejection, as well as post-transplant lymphoprolipherative disorders, and permanent susceptibility to various infections. Unfortunately, some recipients developed the renal failure or malignant diseases due to the aggressive immunosuppression. Immunosuppressant agents differ not only in mechanism of action but also in undesirable side effects. This offers an opportunity to combine drugs with synergistic actions and chance to successfully tailor anti-rejection therapy after heart transplantation.","PeriodicalId":22442,"journal":{"name":"The Cardiology","volume":"46 1","pages":"39-46"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74502321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Do actual medical literature depict a satisfactory view of Left ventricularassistant device and Right ventricular failure 实际的医学文献对左心室辅助装置和右心室衰竭的看法是否令人满意

The Cardiology Pub Date : 2017-01-01 DOI: 10.35841/CARDIOLOGY.1.2.21-30

Elio Aloia, M. Cameli, Aleks, er Dokollari, Gianluigi Buccoliero, M. Stricagnoli, C. Rizzo, M. GiuliaElena, Olì, Aladino Ibrahim, M. Maccherini, S. Mondillo

{"title":"Do actual medical literature depict a satisfactory view of Left ventricularassistant device and Right ventricular failure","authors":"Elio Aloia, M. Cameli, Aleks, er Dokollari, Gianluigi Buccoliero, M. Stricagnoli, C. Rizzo, M. GiuliaElena, Olì, Aladino Ibrahim, M. Maccherini, S. Mondillo","doi":"10.35841/CARDIOLOGY.1.2.21-30","DOIUrl":"https://doi.org/10.35841/CARDIOLOGY.1.2.21-30","url":null,"abstract":"Background: Incidence and prevalence of heart failure are rising up. In patients with advanced heart failure (AHF), Left Ventricular (LV) assist devices (LVADs) are an increasingly common therapy for AHF. Right ventricular failure (RVF) and device related issues make this therapy a challenge to apply to a broader population. On the other hand, RVF, after LVAD implantation, is associated with an increased incidence of perioperative mortality, prolonged length of stay and worst survival. Waiting for a randomized multicentre study, we just have to rely on clinical judgment of multidisciplinary experts, so the main goal of this review is to find out the relationship among LVAD and RVF. Methods: We performed a meticulous online research on PubMed looking for the lateststudies on LVAD and BiVAD implantation, predictors of RVF and patients selectioncriteria in way to relate these variables with clinical outcomes. Results: many studies were not randomized nor stratificated and there was aninhomogenity in the definition of RVF. In addition, no single variable adequately discriminates or is reliable for patient selection and BiVAD selection criteria were subjective and not objective in many cases. Conclusions: We are far from a completely and clear knowledge about the prognosis of our patients It is time to find out new methods of evaluations in way to forsee RVF in patients that are going to be implanted with LVAD or BiVAD. Furthermore, new patients selection criteria must be established in way to overcome the increasing rate of RVF in implanted patients.","PeriodicalId":22442,"journal":{"name":"The Cardiology","volume":"30 1","pages":"21-30"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83585057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effect of ventricular relaxation performance on blood flow profiles in fontancirculation. 心室舒张性能对正循环血流谱的影响。

The Cardiology Pub Date : 2017-01-01 DOI: 10.35841/CARDIOLOGY.1.2.49-54

H. Senzaki, K. Sugamoto, Y. Iwamoto, Shun Matsumura, H. Ishido, S. Masutani

{"title":"Effect of ventricular relaxation performance on blood flow profiles in fontancirculation.","authors":"H. Senzaki, K. Sugamoto, Y. Iwamoto, Shun Matsumura, H. Ishido, S. Masutani","doi":"10.35841/CARDIOLOGY.1.2.49-54","DOIUrl":"https://doi.org/10.35841/CARDIOLOGY.1.2.49-54","url":null,"abstract":"Flow profiles in the pulmonary veins (PVs) and arteries (PAs), Fontan conduit (conduit), and superior vena cava (SVC) were examined using phase-contrast magnetic resonance imaging. The relationship of the ratio of systolic forward flow volume and diastolic forward flow volume (FV-S/D) with ventricular relaxation time constant (tau) was then investigated. According to the flow profiles in the PVs, the forward flow volumes in diastole were dominant over those in systole. The FV-S/D was significantly negatively correlated with tau, not only in the PVs but also in the PAs and conduit. Moreover, tau was positively correlated with pulmonary wedge pressures, while pulmonary wedge pressures were significantly negatively correlated with FV-S/D in the PVs. In contrast, the FV-S/D in the SVC was also negatively correlated with tau, but the correlation coefficient of this relationship was lower than that of the other relationships. Lastly, the FV-S/D in the SVC correlated more significantly with the ejection fraction of the ventricle rather than with tau. On the basis of our findings, we believe that the flow profiles in the PVs are influenced by the ventricular relaxation performance. Moreover, the ventricular relaxation performance influences the flow profiles in the PAs and conduit, both of which are located upstream of pulmonary circulation. On the contrary, the flow profiles in the SVC seem to be influenced by ventricular contraction rather than ventricular relaxation.","PeriodicalId":22442,"journal":{"name":"The Cardiology","volume":"23 1","pages":"49-54"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89509529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Drugs used to treat of heart failure with reduced ejection fraction 用于治疗射血分数降低的心力衰竭的药物

The Cardiology Pub Date : 2017-01-01 DOI: 10.35841/CARDIOLOGY.1.1.8-11

L. Roever, E. Resende, Anaisa Silva Roerver Borges, G. Biondi‐Zoccai

引用次数: 0

Do DPP-4 inhibitors improve endothelial cell function? DPP-4抑制剂能改善内皮细胞功能吗?

The Cardiology Pub Date : 2017-01-01 DOI: 10.35841/cardiology.1.1.12-14

H. Nomoto, H. Miyoshi, A. Nakamura, T. Atsumi, N. Manda, Y. Kurihara, S. Aoki

引用次数: 2

Current understanding of the electrocardiographic manifestations of the?athlete?s heart?. 目前对运动员心电图表现的认识年代的心?。

The Cardiology Pub Date : 2017-01-01 DOI: 10.35841/CARDIOLOGY.1.2.60-68

G. Parry-Williams, Sanjay Sharma